27th European Symposium on Computer Aided Process Engineering

1. Cover - p. xxiii 2. Title page - p. xxiii 3. Table of Contents - p. xxiii 4. Copyright - p. xxiii 5. Preface - p. xxiii 6. International Scientific Committee - p. xxv 7. Plenary Lectures - p. xxviii 8. Evolution of Process Systems Engineering and Future Trends in Research - p. xxviii 9. Prospects and Challenges for Process Systems Engineering in Healthcare - p. 1 10. Process Integration: Current Status and Future Challenges - p. 7 11. Modeling and Simulation - p. 12 12. Investigation of Hydrodynamic Behaviour in random packing using CFD simulation - p. 12 13. CFD Analysis of Liquid-Liquid Extraction Pulsed Sieve-Plate Extraction Columns - p. 18 14. CFD Simulation of Spray Drying with Ultrasonic Dispersion - p. 24 15. Size-Based Particle Separation in Coiled Channel Flow of Non-Circular Cross-Section - p. 30 16. CFD simulation of sieve tray hydraulics using the lattice Boltzmann method - p. 36 17. Methodology and Pitfalls when Calibrating a PBM: the Case of Twin-Screw Wet Granulation - p. 42 18. A CAPE-Taguchi combined method to optimize a NPK fertilizer plant including population balance modeling of granulation-drying rotary drum reactor - p. 48 19. Local vs Global Estimability Analysis of Population Balance Models for Crystallization Processes - p. 54 20. CFD modelling of pulsed sieve plate liquid extraction columns using OPOSPM as a reduced population balance model - p. 60 21. Population balance modelling of pulsed packed bed extraction columns using PPBLab software - p. 66 22. Large Eddy Simulation of Microbubble Transport in Vertical Channel Flows - p. 72 23. Particle Size Effects on Collision and Agglomeration in Turbulent Channel Flows - p. 78 24. Modelling of Droplet Absorption and Evaporation during Pharmaceutical Tablet Coating - p. 84 25. Random porous network generation and 1D mass transfer simulation for gamma-alumina supports - p. 90 26. Graybox Models - New Opportunities for the Optimization of Entire Processes - p. 96 27. Rate-based hydrodynamics and reaction performance of a high-pressure reactive distillation column for the production of biodiesel fuel - p. 102 28. Sequential-based process modelling of a circulating fluidized bed reactor - p. 108 29. Modelling of an adiabatic trickle-bed reactor with phase change - p. 114 30. Model of an Industrial Reactor for Formaldehyde Production with Catalyst Deactivation - p. 120 31. Physics-Based Surrogate Models for Optimal Control of a CO2 Methanation Reactor - p. 126 32. Systematic Generation of Chemical Reactions and Reaction Networks subject to Energetic Constraints - p. 132 33. Effect of Physical Properties on Accuracy Enhancement of Free Radical Polymerization Model in Tubular Reactors - p. 138 34. Model-based design of experiments under structural model uncertainty - p. 144 35. Constrained Global Sensitivity Analysis: Sobol’ indices for problems in non-rectangular domains - p. 150 36. A Novel Approach for Risk Minimization in Life-Cycle Oil Production Optimization - p. 156 37. Uncertainty and Sensitivity Analysis for an Ibuprofen Synthesis Model Based on Hoechst Path - p. 162 38. Model Based Estimation of 2D Crystallization Kinetics From Concentration and CLD Measurements - p. 168 39. Molecular Dynamics Simulations of Gas-Expanded Liquids - p. 174 40. Prediction of structure changes of organic-silica aerogels during pyrolysis - p. 180 41. Development and Optimization of a Single Column Analog Model for a Multi-Column Counter-Current Solvent Gradient Purification Process - p. 186 42. Dynamic hybrid model for ultrafiltration membrane processes - p. 193 43. Software Tool for Computing and Visualization of Enhanced Residue Curve Maps - p. 199 44. A Systematic Identification Method for Thermodynamic Property Modelling - p. 204 45. Numerical models for phase transition of polymers used in latent heat thermal energy storages - p. 210 46. Modelling the physical properties of ionic liquid/metal salt mixtures with the soft-SAFT equation of state: application to carbon monoxide reactive separation - p. 216 47. Characterisation of axial dispersion in a Meso-scale Oscillatory Baffled Crystalliser using a Numerical Approach - p. 222 48. Univolatility curves in ternary mixtures: geometry and numerical computation - p. 228 49. Robust Flash Calculations through Nonsmooth Inside-Out Algorithms - p. 234 50. Evaluation of the accuracy of modelling the separation of highly non-ideal mixtures: extractive heterogeneous-azeotropic distillation - p. 240 51. Data Validation and Modelling of Thermodynamic Properties of Systems with Active Pharmaceutical Ingredients (APIs) in Complex Media for Skin Absorption Processes - p. 246 52. Unbiased Selection of Decision Variables for Optimization - p. 252 53. Real-time Hybrid Monte Carlo Method for Modelling of 4 Monomer Semi-Batch Emulsion Copolymerization - p. 258 54. A two-layer identification strategy for the development of stochastic models of the travelling traders’ exchange problem - p. 264 55. Comparison of DLA and RLA Silica-Based Aerogel Structure Modelling Methods - p. 270 56. Model Reduction by Term Elimination and Optimal Selection - p. 276 57. Realistic Assessment of Parameter Uncertainty in Dynamic Parameter Estimation - p. 282 58. Identifiability of the glyceride transesterification kinetics via alkaline catalysis - p. 288 59. Identifiability Analysis and Model Reduction of a Semi-batch Emulsion Polymerization Process Model - p. 294 60. A Kinetic Study for the Fenton and Photo-Fenton Paracetamol Degradation in a Pilot Plant Reactor - p. 300 61. Subspace identification for MIMO systems in the presence of trends and outliers - p. 306 62. Estimation of Data Uncertainty in the Absence of Repetition Experiments - p. 312 63. Design of Optimal Experiments for Dynamic MIMO Identification - p. 318 64. Experience with large-scale dynamic model validation – application to industrial plant - p. 324 65. Modelling of the oxy-combustion fluid catalytic cracking units - p. 330 66. A Comprehensive Model for the Simulation of Ethylene Decomposition in High-Pressure LDPE Autoclaves - p. 336 67. Modeling of a pyrolysis process for the elimination of epoxy resin from embedded nuclear fuels - p. 342 68. Crystallization of Calcium Carbonate and Magnesium Hydroxide in the Heat Exchangers of Once-through Multistage Flash Process Desalination - p. 348 69. Mathematical Modelling of Intensified Extraction for Spent Nuclear Fuel Reprocessing - p. 354 70. Process Modeling and Analysis of Manufacturing Pathways for Producing Ethylene and Propylene from Wet Shale Gas and Naphtha - p. 360 71. Process Modelling and Optimization of Thickness Dependent Physical Aging in Polymeric Membranes - p. 366 72. Flowsheet Simulation of Cobalt–Nickel Separation Using Ionic Liquid Cyphos 101 - p. 372 73. Integrated treatment processes for coal-gasification wastewater with high concentration of phenol and ammonia - p. 378 74. Technical Feasibility of AG2S™ Process Revamping - p. 384 75. Reverse osmosis for water purification and reuse in the biotechnological industry: Process design, operation and economic guidelines - p. 390 76. Distillation Sequence Efficiency (DSE) for Suitable Liquid-Liquid Extraction Solvents: Acetic Acid Extraction with TOA - p. 396 77. Process Design for production of 1,3-Butadiene and Methyl Ethyl Ketone from Dehydration of 2,3-Butanediol - p. 402 78. Fouling Modelling in Crude Oil Preheat Systems - p. 408 79. Numerical simulation of fixed bed for CO2 capture in a fossil fuel emission points by Pressure Swing Adsorption system - p. 414 80. Energy Efficient Hybrid Gas Separation with Ionic Liquids - p. 420 81. Enhanced Procedure for Simultaneous Synthesis of an entire Total Site - p. 426 82. Data-Driven Dynamic Modeling of Batch Processes Having Different Initial Conditions and Missing Measurements - p. 431 83. Measuring the effect on chemical processes due to uncertain input states: Uncertainty-cum-sensitivity analysis using a gPC approach - p. 438 84. Use of Latent Variables to Reduce the Dimension of Surrogate Models - p. 444 85. Mixed-Integer MultiParametric Approach based on Machine Learning Techniques - p. 450 86. Efficient Surrogate Model Development: Optimum Model Form Based on Input Function Characteristics - p. 456 87. Automatic Generation of Simulation Code for Embedding Custom Unit Operations in CAPE Software - p. 462 88. Modelling of Aerogels Structures Using Intelligent System «AeroGen Structure» - p. 468 89. PU foams: Modelling of heat insulation properties and their degradation in time - p. 474 90. Surrogate Models combined with a Support Vector Machine for the Optimized Design of a Crude Oil Distillation Unit using Genetic Algorithms - p. 480 91. Sequential Multi-Scale Modelling Concepts Applied to the Polyurethane Foaming Process - p. 486 92. Modeling stability of double emulsions - p. 492 93. Multi-Objective Optimization of Renewable Energy-Driven Desalination Systems - p. 498 94. Introducing Green GDP as an Objective to Account for Changes in Global Ecosystem Services Due to Biofuel Production - p. 504 95. Modeling Amine Aerosol Growth in CO2 Capture Absorption Process - p. 510 96. Modelling of Drying of Biomass Wastes in a Conical Spouted Bed Dryer - p. 516 97. Biogas: a Possible New Pathway to Methanol? - p. 522 98. Carbon Arbitrage with Stationary Batteries in the City of London - p. 528 99. Material Flow Analysis (MFA) and Life Cycle Assessment Study for Sustainable Management of PVC Wastes in Thailand (Phase III) - p. 534 100. Sustainable supply chain design and planning: the importance of life cycle scope definition - p. 540 101. Model identification, calibration and validation of the aerobic stage in water remediation of a paper mill effluent - p. 546 102. Modelling and Simulation of Advanced Oxidation Processes: Application to the Treatment of Ciprofloxacin in Aqueous Solution by Ozonation Process - p. 552 103. Numerical analysis of hydrogen ventilation in a confined facility with various opening sizes, positions and leak quantities - p. 558 104. Computational Fluid Dynamics (CFD) Simulation of Fuel Gas and Steam Mixtures to Decrease NOx Emissions of Industrial Burners - p. 564 105. Multistage Membrane Distillation for the Treatment of Shale Gas Flowback Water: Multi-Objective Optimization under Uncertainty - p. 570 106. Sustainability Assessment of an Integrated Economic-Ecologic-Social Model under Time-Dependent Uncertainties - p. 576 107. Smart software framework for the prediction of accidents consequences in process industries - p. 582 108. Using MFM methodology to generate and define major accident scenarios for quantitative risk assessment studies - p. 588 109. Managing supply chain disruptions: an integrated agent-oriented approach - p. 594 110. Synthesis and Design - p. 600 111. Stochastic Multi-Objective Process Optimization by using the Composite Objective Function - p. 600 112. A Mixed Integer Linear Programming (MILP) Model for Optimal Operation of Industrial Resource Conservation Networks (RCNs) Under Abnormal Conditions - p. 606 113. Robust Design of Chemical Processes Based on a One-Shot Sparse Polynomial Chaos Expansion Concept - p. 612 114. An Optimisation-based Framework for Simultaneous Process Synthesis and Heat Integration - p. 618 115. Integrated Synthesis of Batch Plants and Utility Systems - p. 624 116. Infeasible Path Global Flowsheet Optimization Using McCormick Relaxations - p. 630 117. A MOO approach towards sustainable process design: integrating the three pillars of sustainability - p. 636 118. Process Flow-Sheet Synthesis: Systems-Level Design applied to Synthetic Crude Production - p. 642 119. New Method and Software for Computer-Aided Flowsheet Design and Analysis - p. 648 120. Modelling of the hydrotreating process to produce renewable aviation fuel from micro-algae oil - p. 654 121. Energy Integration and Optimization of the Separation Section in a Hydrotreating Process for the Production of Biojet Fuel - p. 660 122. Methodology for biomass blending for the production of power and fuels from biogas - p. 666 123. Optimal synthesis of integrated process for co-production of biodiesel and hydrotreated vegetable oil (HVO) diesel from hybrid oil feedstocks - p. 672 124. A Dual Methodology for Synthesis of Woody Biomass to Liquid (BtL) Thermochemical Conversion Routes and Bio-oil Upgrading - p. 678 125. Bio-conversion targeting using a model-based systems approach - p. 684 126. Synthesis of a Biomass-to-Liquids (BTL) Process using a Hybrid Pyrolysis-Gasification System - p. 690 127. A Framework for an Optimized Sustainable Product and Process Design: Acetone-Butanol-Ethanol Separation and Purification - p. 696 128. Feasibility Study of New Synthesis Route of Tetraethoxysilane from Rice Hull Ash - p. 702 129. Computer Aided Synthesis of Innovative Processes: Renewable Adipic Acid Production - p. 708 130. Optimization-based early phase design of a homogeneously catalysed process in a thermomorphic solvent system - p. 714 131. Multi-objective Optimization of a Methanol Synthesis Process Superstructure with Two-step Carbon Dioxide Consumption - p. 720 132. Two-stage Stochastic Optimization of Carbon Dioxide Supply Chain and Utilization Model through Carbon Dioxide Capturing Process - p. 726 133. Topside process design for the liquid CO2 Injection - p. 732 134. Optimal Structure Synthesis of Ternary Distillation Processes Using a Stepwise VLE Description - p. 738 135. Production Zone Method: a New Non-ideal Shortcut Method for Distillation Column Design - p. 744 136. Distillation Sequence Efficiency (DSE) Applied to Trains of Columns with Recycle Streams - p. 750 137. Planning of biobutanol production considering raw material availability: economic and environmental optimization - p. 756 138. Simultaneous Optimization of Cooler Network, Pump Network, and Cooling Tower - p. 762 139. Targeting and Design of Organic Rankine Cycle Systems for Multiple Heat Sources with Simultaneous Working Fluid Selection - p. 768 140. Heat Exchanger Network Retrofit with Fouling Effects - p. 774 141. Multi-objective optimization of utility systems and heat exchanger networks: method and application to the solar assisted hydrothermal gasification case - p. 780 142. Modelling, Simulation and Economical Evaluation of Dry Food Manufacture at Different Production Scales - p. 786 143. Locating Heat Exchangers in an EIP-wide Heat Integration Network - p. 792 144. Heat Exchanger Design Optimization Considering Threshold Fouling Modelling - p. 798 145. Design of a New Sustainable Methanol Plant Coupled to an Ethanol Distillery - p. 804 146. Synthesis of a New Route for Methanol Production by Syngas Arising from Sugarcane Vinasse - p. 810 147. Mitigation of Fouling in Crude Preheat Trains by Simultaneous Dynamic Optimization of Flow Rate and Velocity Distribution - p. 816 148. Simulation-optimisation-based Design of Crude Oil Distillation Systems with Preflash Units - p. 822 149. Integration of Bio-refinery Concepts in Oil Refineries - p. 828 150. Model Based Analysis of a Petroleum Refinery Plant with Hydrotreating as a Pre-treatment Unit - p. 834 151. Optimal Design of Refinery Hydrogen Network with Mixed Pattern Configuration - p. 839 152. Dynamic Modelling and Optimization of Acetylene Hydrogenation Reactor to Improve Overall Economics of Ethylene Plant - p. 846 153. Integrated Process Design Optimization Accounting for Co-Digestion of Sludge and Municipal Solid Waste - p. 852 154. Methodology for Plantwide Design and Optimization of Wastewater Treatment Plants - p. 858 155. Optimal Design of a Wastewater Treatment Plant using Advanced Technologies - p. 864 156. Design of a wheat straw supply chain network in Lower Saxony, Germany through optimization - p. 870 157. Optimal Design of Poly (3-hydroxybutyrate) Production using alternative Carbon Sources - p. 876 158. Design and Operation of a Supply Chain Model for Electric and Plug-in Hybrid Electric Vehicles: Snapshot Model - p. 882 159. Superstructural economic optimization of sugarcane bagasse exploitation in an ethanol distillery connected to Rankine cycle, BIGCC system and second generation ethanol process - p. 888 160. Techno-economic assessment of the effects of biogas rate fluctuations on industrial applications of solid-oxide fuel cells - p. 894 161. Designing Integrated Biorefineries Supply Chain: Combining Stochastic Programming Models with Scenario Reduction Methods - p. 900 162. Location-dependent optimal biorefinery synthesis - p. 906 163. Food Manufacturing & Economies of Scale: a Modelling Approach - p. 912 164. Dynamic Programming for Optimal Synthesis of Water Networks in Batch Processes - p. 918 165. Design of desalinated water distribution networks including energy recovery devices - p. 924 166. Process integration for the supercritical production of biodiesel and the production of lignocellulosic bioethanol - p. 930 167. Optimal Design of Cogeneration Systems Based on Flaring and Venting Streams and Accounting for the Involved Uncertainty - p. 936 168. Optimal Shale Gas Flowback Water Desalination under Correlated Data Uncertainty - p. 942 169. A Target Oriented Robust Optimization Model for Selection of Engineering Project Portfolio under Uncertainty - p. 948 170. A meta-heuristic approach for financial risks management in heat exchanger networks - p. 954 171. Biobased Supply Chain Optimisation Model under Uncertainties - p. 960 172. A Fuzzy Analytic Hierarchy Process Approach for Multi-objective Molecular Design Problem - p. 966 173. Computational chemical product design problems under property uncertainties - p. 972 174. The Chemical Product Simulator – ProCAPD - p. 978 175. An Integrated Methodology for Emulsified Cosmetic Product Formulation Using Integer Programming with Logical Constraints - p. 984 176. The Systematic Screening Methodology for Surfactant Flooding Chemicals in Enhanced Oil Recovery - p. 990 177. Comparison of Tree Based Ensemble Machine Learning Methods for Prediction of Rate Constant of Diels-Alder Reaction - p. 996 178. gSAFT: Advanced physical property prediction for process modelling - p. 1002 179. PU foams: Mathematical modelling of morphology development - p. 1008 180. A Fuzzy Programming Approach to Multi-Objective Optimization for Geopolymer Product Design - p. 1014 181. Modeling the drug release from ionic and covalent co-cross-linked chitosan hydrogels - p. 1020 182. Biobutanol Purification by Hybrid Extraction-Divided Wall Column Configurations - p. 1026 183. An industrial application of process intensification in the manufacture of dimethyl and diphenyl carbonate - p. 1032 184. Modelling and Intensification of Biocatalytic Production of Natural Compounds Performed in Hybrid Systems - p. 1038 185. Efficient optimization-based design of energy-intensified azeotropic distillation processes - p. 1044 186. Hedging Against Uncertain Feedstock Compositions in Shale Gas Processing System Designs with Intensified Equipment Capacities - p. 1050 187. Computational studies on flow maldistribution of Newtonian liquids in periodic packed beds - p. 1056 188. A study on the periodic operation of an ethanol fermentation process - p. 1062 189. Novel Reactive Distillation Processes to produce Diphenyl Carbonate: Multi-Objective Optimization involving Cost and Controllability Criteria - p. 1068 190. Design and Control of a Separation Process for Bioethanol Purification by Reactive Distillation - p. 1074 191. Development of an Intensified Reactive Distillation Process for the Synthesis of Dioxolane Products - p. 1080 192. Design and Control of Processes for 2-Ethylhexyl Acrylate Production - p. 1086 193. Retrofitting via Intensification: Application to Formic Acid Process - p. 1092 194. Recovery of succinic acid in fermentation broth via reactive LL extraction: effect of chemical kinetics and solvent choice - p. 1098 195. Stability Study of a Hybrid Reactor with Liquid-Liquid Extraction for ABE Production - p. 1104 196. Innovative design and simulation of a castor oil biorefinery - p. 1110 197. Membrane–cryogenic Distillation Hybrid Processes for Cost-effective Argon Production from Air - p. 1116 198. Optimal Production of Ethyl Tert-butyl Ether using Pervaporation-based Hybrid Processes through the Analysis of Process Flowsheet - p. 1122 199. Design of a Hybrid Nanofiltration/Electrooxidation Process for the Removal of Perfluorohexanoic Acid (PFHxA) - p. 1128 200. Intensification of ethylene glycol production process - p. 1134 201. Solvent Recycle and Impurity Purge Evaluation for Organosolv Pretreatment Method for Bioethanol Production from Lignocellulosic Biomass - p. 1140 202. Model-Based Analysis and Integration of Synthetic Methane Production and Methane Oxidative Coupling - p. 1146 203. Computer-aided design for high efficiency latent heat storage – a case study of a novel domestic solar hot water process - p. 1152 204. General Superstructure Synthesis and Bi-level Solution Strategy for Industrial Heat Pumping - p. 1158 205. Steady-State Plug Flow Reactor Analysis by means of Minimum Entropy - p. 1164 206. Simultaneous Process Synthesis and Process Intensification using Building Blocks - p. 1170 207. A simplified kinetic and mass transfer modelling of the thermal hydrolysis of vegetable oils - p. 1176 208. Computational Analysis of a Two-Phase Continuous-Flow Magnetophoretic Microsystem for Particle Separation from Biological Fluids - p. 1182 209. Computational analysis of facilitated transport in a microfluidic device - p. 1188 210. Evaluation of an Immiscible Drop Separation System in Micro-channels using CFD - p. 1194 211. Numerical investigation of viscous effect on Taylor bubble formation in co-flow microchannel - p. 1200 212. Dropwise Additive Manufacturing using Particulate Suspensions: Feasible Operating Space and Throughput Rates - p. 1206 213. Re-entrant structural evolution using electrically heterogeneous patterned electrode - p. 1212 214. Plant-wide design and control of an epichlorohydrin synthesis process by reacting allyl chloride and hydrogen peroxide - p. 1218 215. Smart software system solution for model-based hazard identification of complex industrial processes - p. 1224 216. Design and Operability Analysis of Membrane Module based on Volumetric Flexibility - p. 1230 217. Systematic Methods for Inherently Safer Process Design: Comparison among Inherent Safety Indexes by Dimensionality Reduction - p. 1236 218. Inherent Safety Evaluation for Process Flowsheets of Natural/Shale Gas Processes - p. 1242 219. Copyright - p. 1248 220. Planning and Scheduling - p. 1248 221. Enterprise-Wide Optimization for Operations of Crude-Oil Refineries: Closing the Procurement and Scheduling Gap - p. 1248 222. Mixed-integer Models for Simultaneous Optimization of Inventory Policies and Supply Chain Planning - p. 1254 223. Condition-based operational optimization of industrial combined heat and power plants under timesensitive electricity prices - p. 1260 224. A Novel Decision-Making Approach for Supplier Selection under Risks - p. 1266 225. Closed loop integration of planning, scheduling and control via exact multi-parametric nonlinear programming - p. 1272 226. Optimal Planning of a Solar Cells Manufacturing System involving Economic Aspects - p. 1278 227. Inventory planning and control in ‘green’ pharmacies supply chains – A System Dynamics modelling perspective - p. 1284 228. Dynamic Optimization and Control Strategy for the Planning of a Waste Management System involving Multiple Cities - p. 1290 229. Multiperiod and Multiproduct Model for the Optimal Production Planning in the Gases Sector: Application to an Industrial Case Study - p. 1295 230. Continuous-Time Heuristic Model for Medium-Term Capacity Planning of a Multi-Suite, Multi-Product Biopharmaceutical Facility - p. 1302 231. Optimal production planning and crude oil blending in a conventional oilfield - p. 1308 232. Optimal planning of energy production involving carbon capture systems through a multi-stakeholder scheme - p. 1314 233. A Hybrid Slot-Based/General Precedence Approach for Planning Crude Oil Supplies - p. 1320 234. Hierarchical Waste Incineration Planning and Scheduling System for Industrial Operation Support - p. 1326 235. Rolling Horizon Condition-based Planning of Production and Utility Systems in Process Industries - p. 1332 236. Stochastic Modeling Approach for Downstream Oil Supply Chain - p. 1338 237. Hedging Against Uncertainty in Process Planning: A Data-Driven Adaptive Nested Robust Optimization Approach - p. 1344 238. A Bi-objective two step Simulated Annealing Algorithm for Production Scheduling - p. 1350 239. Tank Management in a Multi-Product Bottling Facility - p. 1356 240. Water Security and Clean Energy, Co-benefits of an Integrated Water and Energy Management - p. 1363 241. Energy-Efficient and Labor-Aware Production Scheduling based on Multi-Objective Optimization - p. 1368 242. Resource-constrained formulation for production scheduling and maintenance - p. 1374 243. New Continuous-Time Scheduling Formulation for Multiproduct Pipelines - p. 1380 244. A decomposition framework for distribution of fluid products by a vendor-managed-inventory methodology - p. 1386 245. A decomposition algorithm for the simultaneous batching and scheduling of multistage batch facilities - p. 1392 246. Decision Automation for Oil and Gas Well Startup Scheduling Using MILP - p. 1398 247. Towards a software engineering approach to the deployment and implementation of scheduling systems - p. 1404 248. An Efficient Way to Tackle Uncertainty in the Scheduling of a Continuous Evaporation System - p. 1410 249. Recovery Scheduling for Industrial Processes Using Graph Constraints - p. 1416 250. Optimal scheduling for power-intensive processes under time-sensitive electricity prices - p. 1422 251. Efficient Precedence-Based Multistage Batch Scheduling Formulation with Nontrivial Tightening Constraints - p. 1428 252. The Application of Reservoir Simulation to the Optimization of Shale Gas Supply Chain Design and its Water Management Structure - p. 1434 253. Optimal Design of Multi-Enterprise Industrial Waste-to-Energy Networks - p. 1440 254. Synthesis of Supply Networks over Multiple Time Frames: A Case Study of Electricity Production from Biogas - p. 1446 255. CLSC design with simultaneous consideration of product design for manufacturing and remanufacturing - p. 1452 256. Process Monitoring and Control - p. 1458 257. EKF-NN based Hybrid Estimator for Ethylene Polymerization Process - p. 1458 258. Online DEKF for State Estimation in Semi-Batch Free-Radical Polymerization Reactors - p. 1464 259. Optimising and Predicting Performance of Industrial Filtrations using Process Data - p. 1470 260. Unscented Kalman Filter. Application of the robust approach to polymerization processes - p. 1476 261. Comparison of Particle Filter and Extended Kalman Filter Algorithms for Monitoring of Bioprocesses - p. 1482 262. A model for subsea oil-water gravity separator to estimate unmeasured disturbances - p. 1488 263. Nonlinear Dynamic Process Monitoring: The Case Study of a Multiphase Flow Facility - p. 1494 264. Profile-driven Features for Offline Quality Prediction in Batch Processes - p. 1500 265. Optimal Sensor Network Design to Monitor the Energy Performances of a Process Plant - p. 1506 266. Resource efficiency indicators usefulness for decision-making process of operators: refinery hydrogen network case study - p. 1512 267. A Hierarchical Aggregation Concept for Resource Efficiency in Continuous Production Complexes - p. 1518 268. A robust methodology for the sensor fault detection and classification of systematic observation errors - p. 1524 269. Smith predictor for slug control with large valve stroke time - p. 1530 270. Rethinking Boilers Control - p. 1536 271. An efficient and rigorous thermodynamic library and optimal-control of a cryogenic air separation unit - p. 1542 272. Process control of a heat pump assisted extractive DWC for bioethanol dehydration - p. 1548 273. Effect of Fouling on Control and Energy Recovery in an Industrial CDU Column - p. 1554 274. Dynamic simulation of thermal energy storage integrated with small-scale solar power plant and organic Rankine cycle - p. 1560 275. Wastewater treatment plants operation optimization using economic dynamic real time optimization strategies - p. 1566 276. Economic Predictive Control of a Pasteurization Plant using a Linear Parameter Varying Model - p. 1573 277. Economic Model Predictive Control of Aeration Systems in a Full Scale Biological Wastewater Treatment Plant - p. 1578 278. Advanced Robust MPC Design of a Heat Exchanger: Modeling and Experiments - p. 1584 279. A multi-parametric bi-level optimization strategy for hierarchical model predictive control - p. 1590 280. A novel back-up control structure to manage non-routine steam upsets in industrial methanol distillation columns - p. 1596 281. Coordination of distributed MPC systems through dynamic real-time optimization with closed-loop prediction - p. 1602 282. Identification and Model Predictive Control Design of a Polymer Extrusion Process - p. 1608 283. Modeling and nonlinear MPC of a dividing-wall column for separation of Benzene-Toluene-p-Xylene: a simulation case study - p. 1614 284. Expectation constrained stochastic nonlinear model predictive control of a batch bioreactor - p. 1620 285. IQC analysis of constrained MPC of large-scale systems - p. 1626 286. Tuning of PI controllers by Differential Evolution with Tabu List method - p. 1632 287. Robust model-based design of experiments for guaranteed parameter estimation - p. 1638 288. Set point tracking of a biogas plant coupled to a methanation reactor - p. 1644 289. Enhanced global self-optimizing control - p. 1650 290. Toward Online Explore of Concept Drift for Fault Detection of Chemical Processes - p. 1656 291. Sliding Dynamic Data Window: Improving Properties of the Incremental Learning Methods - p. 1662 292. Process Fault Isolation via Bayesian Lasso-based Reconstruction Analysis - p. 1668 293. An Efficient Polynomial Chaos Expansion Strategy for Active Fault Identification of Chemical Processes - p. 1674 294. Improved Fault Diagnosis in Online Process Monitoring of Complex Networked Processes: a Data-Driven Approach - p. 1680 295. Active Fault Detection and Identification using Transient Data - p. 1686 296. Root cause diagnosis of disturbances propagation paths by using improved convergent cross mapping - p. 1692 297. Use of Discrete-Event Dynamic Systems for HAZOP Analysis - p. 1698 298. Actuator and Sensor Fault Tolerant Control of a Crude Distillation Unit - p. 1704 299. Comparison of regression data selection strategies for quadratic approximation in RTO - p. 1710 300. Effective Model Adaptation in Iterative RTO - p. 1716 301. Efficient Nested Modifier Adaptation for RTO using Lagrangian functions - p. 1722 302. Modifier-Adaptation Based on Transient Measurements Applied to a Laboratory-Scale Flotation Column - p. 1728 303. Resource efficient operation of an evaporator network in the viscose fiber production - p. 1734 304. Dynamic Real-time Optimization of a Batch Polymerization Process - p. 1740 305. Stochastic Approximation in Online Steady State Optimization Under Noisy Measurements - p. 1746 306. Gas Lift Optimization under Uncertainty - p. 1752 307. Economic Optimizing Control for Single-Cell Protein Production in a U-Loop Reactor - p. 1758 308. Integrated and Holistic approaches for decision support - p. 1764 309. Integrated process and solvent design using COSMO-RS for the production of CO from CO2 and H2 - p. 1764 310. Systematic decision making methodology for chemical product design in integrated biorefineries - p. 1770 311. Integrated computer-aided framework for chemical product and process application design and optimization for waste heat recovery - p. 1776 312. Design and optimization of Heat Integrated Distillation Column “HIDiC” - p. 1782 313. Low Cost Retrofit Methods for Heat Exchanger Networks - p. 1788 314. Integrated thermo-economic design of ORC process, working fluid and equipment using PC-SAFT - p. 1794 315. Heat Integration optimization in a Multiproduct Biorefinery - p. 1800 316. Simulation-based analysis for operational decision support on scheduling in sugar crystallization considering quality of molasses and syrup - p. 1806 317. Definition of a Robustness Indicator for Assessment of Heat Exchanger Network Performances - p. 1812 318. Design and optimization of plate heat exchanger networks - p. 1818 319. Total Site Integration as a Process Synthesis and Scheduling Tool in Multiple-feedstock Biorefineries - p. 1824 320. An MILP model for simultaneous mass allocation and heat exchange networks design with regeneration units - p. 1830 321. Biomass to X: Gasification and Pyrolysis Integrated - p. 1836 322. Retrofit design of hydrogen distribution systems: a practical case study - p. 1842 323. Optimization for the flexibility analysis of processes: Application to the acetone-ethanol-butanol producing process - p. 1849 324. Ethylene from natural gas via oxidative coupling of methane and cold energy of LNG - p. 1855 325. A Stochastic Approach for Integration of Design and Control under Uncertainty: A Back-off Approach Using Power Series Expansions - p. 1861 326. Model-based multi-parametric programming strategies towards the integration of design, control and operational optimization - p. 1867 327. Systematic decision making models through Conceptual Constraints - p. 1873 328. Integrated Design, Planning, and Scheduling of Renewables-based Fuels and Power Production Networks - p. 1878 329. Multi-scale Modeling Approach for Design and Optimization of Oleochemical Processes - p. 1884 330. Integral System to Determine Feasible Regions for Biomass Utilization - p. 1890 331. Shared resource allocation in the process industries via price-based coordination for systems with discrete decisions - p. 1896 332. A Meta-ontology to Design Sustainable Project in a Competitive Stakeholder’s Context - p. 1902 333. Optimal Coupling of Demand Patterns for Improving the Performance of CHP Systems - p. 1908 334. Life Cycle Optimisation from A Noncooperative Perspective: Game Theory-Based Models and Applications - p. 1914 335. Optimal design and operation of water supply chain networks using scenario-based dynamic negotiation and multiple negotiation terms - p. 1920 336. Systematic Approach to the Extension of Material Exchange in Industrial Symbiosis - p. 1926 337. Design of Circular Economy Plants – The Case of the Textile Waste Biorefinery - p. 1932 338. An MILP model for the simultaneous design of mass and heat networks of a collaborative eco-industrial park - p. 1938 339. Techno-economic analysis of resource recovery technologies for wastewater treatment plants - p. 1944 340. Benefits analysis of optimal design of eco-industrial parks through life cycle indicators - p. 1950 341. Resilience Study Applied in Eco-Industrial Parks - p. 1956 342. A Natural Gas Monetization Approach with Carbon Dioxide and Excess Heat Integration in Industrial Parks - p. 1962 343. A Hybrid Methodology for Combined Interplant Heat, Water, and Power Integration - p. 1968 344. Economic linear objective function approach for structure optimization of renewables-to-chemicals (R2Chem) networks - p. 1974 345. Techno-economic Evaluation of an Integrated Microalga Biorefinery Targeting the Co-production of Specialty Chemicals - p. 1980 346. A design of rural energy system by industrial symbiosis considering availability of regional resources - p. 1986 347. A Process Integration Approach to the Optimization of CO2 Utilization via Tri-Reforming of Methane - p. 1992 348. Cradle-to-gate environmental impact prediction from chemical attributes using mixed-integer programming - p. 1998 349. Optimal Global Land Use, Cultivation, Transportation, and Production Strategies to Minimise Life Cycle Greenhouse Gas Emissions of Ethanol - p. 2004 350. Screening of Solvents for CO2 Capture considering Sustainability Criteria via Data Envelopment Analysis - p. 2010 351. Life Cycle Assessment of vinasse biogas production in sugarcane biorefineries - p. 2016 352. Addressing decision-making in the process industry using life cycle approach coupled to Linear Programming: A case study on anchovy canning industry in Cantabria Region (Northern Spain) - p. 2022 353. Modelling pyrolysis process for CFRP recycling in a closed-loop supply chain approach - p. 2028 354. Integral Management of Process Plants Systems through their Lifecycle using a Model-Based Engineering Approach - p. 2034 355. Copyright - p. 2040 356. CAPE Concepts, Methods and Tools - p. iv 357. Dynamic Optimization of Constrained Semi-Batch Processes using Pontryagin’s Minimum Principle and Parsimonious Parameterization - p. iv 358. Process Optimization by Applying a Simultaneous Dynamic Method - p. 2046 359. On the Solution of the PBE by Orthogonal Expansion of the Maximum Entropy Functional - p. 2052 360. Process Analysis on Multiple Solutions of Semialgebraic Systems - p. 2058 361. Enhanced Surrogate Assisted Global Optimization Algorithm Based on Maximizing Probability of Improvement - p. 2064 362. The Adjoint Method for Gradient-based Dynamic Optimization of UV Flash Processes - p. 2070 363. Integration of Design, Control and Scheduling: A Dynamic Optimization Framework for Multi-product Chemical Processes under Disturbances and Uncertainty - p. 2076 364. Source Code Generation for Parallelized Simulations of Large-Scale Nonlinear Equation Systems on a Supercomputer using MOSAIC, PETSc, and ADOL-C - p. 2082 365. Numerical Simulation of Two-phase Flow in Representative Elements of Structured Packings - p. 2088 366. Assessment of the Accuracy and Dynamic Simulation Capabilities of Liquid-Vapour Two-Phase Flow Separated and Mixture Models - p. 2094 367. Optimisation of Batch Extractive Distillation Process with Entrainer Recycle - p. 2100 368. Optimal sensor placement strategies for large scale systems - p. 2106 369. Efficient global optimization of a novel hydroformylation process - p. 2112 370. Global Identification of Kinetic Parameters via the Extent-based Incremental Approach - p. 2118 371. Multi-parametric programming based algorithms for the global solution of bi-level mixed-integer linear and quadratic programming problems - p. 2124 372. A center-cut algorithm for solving convex mixed-integer nonlinear programming problems - p. 2130 373. SHOT – A global solver for convex MINLP in Wolfram Mathematica - p. 2136 374. Incorporating detailed metabolic models into superstructure optimization of biorefineries - p. 2142 375. Deterministic and Stochastic Optimization of Acid Pretreatment for Lignocellulosic Ethanol Production - p. 2148 376. Bayesian Multi-Objective Optimisation of Neotissue Growth in a Perfusion Bioreactor Set-Up - p. 2154 377. Dynamic Optimization of the Production of Monoclonal Antibodies in Semi-batch Operation - p. 2160 378. A New Disjunctive Formulation for the Simultaneous Optimization and Heat Integration with Cold/Hot and Unclassified Streams - p. 2166 379. Investigating practical aspects of the exergy based multi-objective optimization of chemical processes - p. 2172 380. Developing a Multi-Objective Strategic-Tactical Optimization Model for Sustainable Production Supply Chains Considering Electricity Cogeneration: Sugar Cane Bioenergy Industry - p. 2178 381. Application of Genetic Algorithm to Layer Patterning of Plate Fin Heat Exchanger - p. 2184 382. A Systematic Approach for the Optimal Design of an Off-Grid Polygeneration System using Fuzzy Linear Programming Model - p. 2190 383. Solving Dynamic Constraint Trajectory Optimization Problems by Applying the Concept of Pareto Frontiers - p. 2196 384. Multi-objective Optimization of a Batch Transesterification Reactor Considering Reactor and Methanol Separation Unit Together - p. 2202 385. Selection of a minimum toxicity and high performance ionic liquid mixture for the separation of aromatic - aliphatic mixtures by extractive distillation - p. 2208 386. Dynamic Optimization of Batch Processes under Uncertainty via Meta-MultiParametric Approach - p. 2214 387. A Consistent Methodology Based Parameter Estimation for a Lactic Acid Bacteria Fermentation Model - p. 2220 388. Integrated process performance assessment considering uncertainty in biopharmaceutical manufacturing operations - p. 2226 389. Monte Carlo Based Framework to Support HAZOP Study - p. 2232 390. Using Semidefinite Programming to Calculate Bounds on Stochastic Chemical Kinetic Systems at Steady State - p. 2238 391. Probability Density Functions for Droplet Sizing in Aerosol Transport Modelling - p. 2244 392. Stochastic NMPC/DRTO of Batch Operations: Batch-to-Batch Dynamic Identification of the Optimal Description of Model Uncertainty - p. 2250 393. Optimal management of microgrids under uncertainty using scenario reduction - p. 2257 394. When Robust Statistics Meets with Robust Optimization: Data-Driven Batch Process Scheduling in The Presence of Outliers - p. 2262 395. Design of Experiments Based on Dynamic Real-time Optimization Approach - p. 2269 396. Future of control and operations in the era of industrial internet of things - p. 2274 397. Industry 4.0: Sustainable material handling processes in industrial environments - p. 2280 398. Know-how Protection and Software Architectures in Industry 4.0 - p. 2286 399. Recipe Management based on ISA-88 using Semantic Technologies - p. 2292 400. The Development of an Online Design Tool for Organic Rankine Cycle - p. 2299 401. LCSoft – the Life Cycle Assessment Software: New developments and status - p. 2304 402. Linking Process Simulation and Automatic 3D Design for Chemical Plants - p. 2310 403. From Ontology to Executable Program Code - p. 2316 404. A Semantic Repository for Model Integration in Biorefining - p. 2322 405. Towards an Ontological Backbone for Pharmaceutical Digital Supply Chains - p. 2328 406. ANSI/ISA 88-95 Standards Based-Approach for Improved Integration of Recipes and Operational Tasks Supported by Knowledge Management - p. 2334 407. Integration of CAPE Models and Data for the Domain of Biorefining: InterCAPEmodel Ontology Design - p. 2340 408. Towards Advanced Enterprise Wide Optimization Based On Explicit Concept-Object Oriented Mathematical Modeling - p. 2346 409. Knowledge-Driven Multi-Label Classification of Process Scheduling Problems - p. 2352 410. Constraint Identification and Integration Procedures in Multi-Level Hierarchical Systems - p. 2358 411. Decision Support based on a Semantically-Enriched Notification Platform at a Process Plant Floor - p. 2364 412. CAPE applications addressing Global Grand Challenges - p. 2370 413. Optimal design of urban energy systems with demand side management and distributed generation - p. 2370 414. Waste-Energy-Water systems in sustainable city development using the resilience.io platform - p. 2376 415. Trade-offs in the Design of Urban Energy Systems - p. 2382 416. A three-stage stochastic optimization model for the design of smart energy districts under uncertainty - p. 2388 417. Design and operational scheduling of power systems incorporating interconnection options - p. 2394 418. Power Generation Expansion Considering Endogenous Technology Cost Learning - p. 2400 419. A general superstructure for the optimal synthesis and design of power and inverse Rankine cycles - p. 2406 420. Rigorous synthesis of energy supply systems by time-series aggregation - p. 2412 421. Comparison of Energy Performance of Organic Rankine and Kalina Cycles Considering Combined Heat Sources at Different Temperature - p. 2418 422. Managing Uncertain Industrial Flares during Abnormal Process Operations using an Integrated Optimization and Monte Carlo Simulation Approach - p. 2424 423. A Mathematical Technique for Optimal Design of Hybrid Power Systems Considering Demand-side Management - p. 2430 424. A MILP model for the design of multi-energy systems with long-term energy storage - p. 2436 425. The Impact of Novel and Conventional Working Fluids on the Control Performance in Organic Rankine Cycles - p. 2442 426. Optimal design and operation of A-frame systems for solar power plants - p. 2448 427. Operation Data based Modelling and Optimization of Thermal Power Units under Full Working Conditions - p. 2454 428. Lessons Learnt from Alarm Management in a Combined-Cycle Gas Turbine Power Plant - p. 2460 429. Integration of Decision Tools in EMS - p. 2466 430. Energy Management Strategies for RES-enabled Smart-grids empowered by an Internet of Things (IoT) Architecture - p. 2472 431. Modelling and Optimal Operation of a Crude Oil Hydrotreating Process with Atmospheric Distillation Unit Utilising Stacked Neural Networks - p. 2478 432. A computer-aided socio-technical analysis on national and regional energy systems considering local availability of renewable resources - p. 2485 433. Assessing Technological Options in Biomass-Based Energy Supply Chains through a Quantitative Methodology for Risk and Regret Evaluation - p. 2490 434. Potential of Milking of Microalgae Grown on Biofilm Photobioreactor for Renewable Hydrocarbon Production - p. 2496 435. Economic optimization of integrated lignocellulosic biorefinery - p. 2502 436. Process Modeling of Fluidized Bed Biomass-CO2 Gasification using ASPEN Plus - p. 2508 437. Process Simulation and Economic Analysis of Producing Liquid Transportation Fuels from Biomass - p. 2514 438. Dynamic Modelling and Experimental Validation of Mass Flow in a Pilot-Scale Pretreatment Continuous Tubular Reactor - p. 2520 439. Optimal Design and Operation of Heat Networks Utilising Hydrogen as an Energy Carrier - p. 2526 440. Solar Hydrogen Production via Aqueous Methanol Electrolysis - p. 2532 441. Cluster Analysis of Process Operational Data to Identify Representative Scenarios for Pinch Analysis and Energy Optimisation Studies - p. 2538 442. Challenges and Potentials of Modelling Tools Total Site Integration and Utility System Optimisation - p. 2544 443. Multi-objective optimization of the water scrubbing process for biogas upgrading - p. 2550 444. Application of Cryogenic Energy Storage to Liquefied Natural Gas Regasification Power Plant - p. 2556 445. Model-based Optimization of Battery Energy Storage Systems - p. 2562 446. Dynamic modelling of a hybrid diabatic compressed air energy storage and wind turbine system - p. 2568 447. Modelling of the Thermal Performance of SGSP using COMSOL Multiphysics - p. 2574 448. Capacity Fade Minimizing Model Predictive Control Approach for the Identification and Realization of Charge-Discharge Cycles in Lithium Ion Batteries - p. 2580 449. A systems engineering framework for applicationdependent identification and design of electrochemical energy conversion systems - p. 2586 450. Assessing the CO2 Emissions Reduction from Cement Industry by Carbon Capture Technologies: Conceptual Design, Process Integration and Techno-economic and Environmental Analysis - p. 2592 451. A low-carbon power generation pathway for China: Scenario analysis with carbon pricing mechanism - p. 2599 452. Addressing the Minimum Environmental Impacts of Algal Renewable Diesel Production from a Consequential Perspective - p. 2604 453. Techno-Economic and Environmental Optimization of Palm-based Biorefineries in the Brazilian Context - p. 2610 454. Minimizing CO2 emissions for syngas production units using Dry Reforming of Methane - p. 2616 455. Development of a conceptual process for CO2 capture from flue gases using ionic liquid - p. 2622 456. Multi-Objective Optimization of a Pressure-Temperature Swing Adsorption Process for Biogas Upgrading - p. 2628 457. Analysis of power production and emission reduction through the use of biogas and carbon capture and storage - p. 2634 458. Performance Analysis of Industrial CO2 Capture from Natural Gas using Diglycolamine - p. 2640 459. Modelling, Simulation and Optimisation of an Integrated Two-Stage P/VSA Process for Post-Combustion CO2 Capture Using Combinations of Adsorbents - p. 2646 460. Application of a computer-aided framework for the design of CO2 capture and utilization processes - p. 2652 461. Production of Fuels from CO2-rich Natural Gas using Fischer-Tropsch Synthesis Coupled to Trireforming Process - p. 2658 462. Optimal bio-based supply chain with carbon capture and use: An economic and environmental approach - p. 2664 463. On the relevance of thermodynamics to predict the behaviour of inorganics during CO2 gasification of willow wood - p. 2670 464. Integrated production planning and water management in the food industry: A cheese production case study - p. 2676 465. Interplant Water Networks Coupled with Two-Stage Treatment and ZLD Options - p. 2682 466. Optimising the total benefit of water resources management in combination with the local energy systems in remote communities taking into account sustainability considerations - p. 2688 467. Pharmaceuticals removal from water effluents by adsorption in activated carbons using Monte Carlo simulations - p. 2694 468. Optimization of a Distributed Wastewater Treatment Network Considering Lumped Parameters Interrelations - p. 2700 469. Assessment of sustainable wastewater treatment networks design applying LCA - p. 2706 470. Optimisation of membrane design parameters of a spiral-wound reverse osmosis module for high rejection of dimethylphenol from wastewater at low energy consumption - p. 2712 471. Towards Sustainable Flux Determination for Dynamic Ultrafiltration through Multivariable System Identification - p. 2717 472. Combining Forward and Reverse Osmosis for Shale Gas Wastewater Treatment to Minimize Cost and Freshwater Consumption - p. 2724 473. Implementation of linear programming and life cycle approach in an Excel application to determine ecoefficiency - p. 2730 474. A model for the effect of light on the growth of microalgae in outdoor condition - p. 2736 475. Powder stickiness in milk drying: uncertainty and sensitivity analysis for process understanding - p. 2742 476. Identifying Gene Regulatory Networks - p. 2748 477. Performance of classical and physiologically-based PK-PD modelling for prediction of remifentanil hemodynamic effects - p. 2754 478. A Population Balance Model for Stem Cell Differentiation Bioprocesses - p. 2760 479. Developing QSPR for Predicting DNA Drug Binding Affinity of 9-Anilinoacridine Derivatives Using Correlation-Based Adaptive LASSO Algorithm - p. 2766 480. Multi-scale modelling of solute partition equilibria of micelle-water and microemulsion-water systems using molecular dynamics and COSMOtherm - p. 2772 481. A Model-Based Support for Diagnosing von Willebrand Disease - p. 2778 482. Process systems engineering approaches for drug product manufacturing: from tablets to injectables - p. 2784 483. Risk Evaluation Models for the Design of Parenterals Manufacturing Processes - p. 2790 484. Surrogate-based Optimization for Pharmaceutical Manufacturing Processes - p. 2796 485. Dynamic Optimization of Continuous Manufacturing of Pharmaceuticals - p. 2802 486. A multi-period model for the optimization of the products and information flows in a healthcare system - p. 2808 487. Model-based optimization of the recombinant protein production in Pichia pastoris based on dynamic flux balance analysis and elementary process functions - p. 2814 488. Multi-stage population balance model to understand the dynamics of fed-batch CHO cell culture - p. 2820 489. An Efficient Experimental Design Strategy for Modelling and Characterization of Processes - p. 2826 490. Kinetic Modelling and Scaled-up Experimental Studies of Microalgal Fuels and Chemicals Production - p. 2833 491. How to Use Mechanistic Metabolic Modeling to Ensure High Quality Glycoprotein Production - p. 2838 492. Modelling of the imperfect mixing in a hybrid exothermic chemical reactor with simulated heat of reaction - p. 2845 493. Separation and recovery of intracellular beta-carotene using a process synthesis framework - p. 2850 494. Metabolic Network design of Synechocystis sp. PCC 6803 to obtain bioethanol under autotrophic conditions - p. 2856 495. Transesterification of Castor Oil Catalyzed by Liquid Enzymes: Optimization of Reaction Conditions - p. 2862 496. Improving the Prediction of Phosphate Dynamics in Biotechnological Processes: A Case Study Based on Antibiotic Production Using Streptomyces coelicolor - p. 2868 497. Experimental Work Towards the Improvement of a Kinetic Model for Acetone-Butanol-Ethanol Pathway - p. 2874 498. Modeling Biodiesel Production and Purification – Towards a Predictive Tool - p. 2880 499. Model-assisted operational design of bacterial PHA-production processes: the obstacle of heterogeneity inducing modules - p. 2886 500. Attainable Region for Biobutanol Production - p. 2892 501. Optimisation of microalgal starch formation for the biochemical production of biobutanol - p. 2897 502. A Green Desuperheater for an Energetic Efficient Alternative to the Decompression Valve in Supercritical Water Hydrolysis Process. CFD Simulation. - p. 2904 503. Uncertainty & sensitivity analysis of economic assessment of lactic acid production from crude glycerol – impact of price correlations - p. 2910 504. Heat integration for the production process of 2G bioethanol from wheat straw - p. 2916 505. CAPE/PSE Education and Training - p. 2922 506. Flipping the Capstone Process Design Course - p. 2922 507. Support of Education in Process Simulation and Optimization via Language Independent Modelling and Versatile Code Generation - p. 2928 508. Web-based Operator Training System - p. 2934 509. Recent Evolutions and Trends in the Use of Computer Aided Chemical Engineering for Educational Purposes at the University of Liège - p. 2940 510. Discrete optimization in the chemical engineering curriculum - p. 2946 511. Computer Aided Control Projects as Main Assessment Component of Master’s Advanced Control Courses - p. 2952 512. CAPE in the Chemical Engineering Master’s Integrated Programme at IST-ULisboa - p. 2958 513. Energy systems optimisation: Highlights from an interdisciplinary postgraduate module development - p. 2964 514. Implementation of performance indicators for automatic assessment - p. 2970 515. Cognitive Behavior Based Framework for Operator Learning: Knowledge and Capability Assessment through Eye Tracking - p. 2977 516. Author Index - p. 2982