8-Membered Heterocycle Synthesis focuses on both the new and established methods for the synthesis of various 8-membered heterocycles. 8-membered heterocyclic compounds act as target molecules for a wide range of synthetic studies and are present in a broad range of natural products, showing a wide variety of pharmaceutical and biological properties. Covering an important and rapidly growing branch of heterocyclic chemistry, this book brings together every protocol for the synthesis of 8-membered heterocycles in one place, allowing the reader to see all the possibilities for making a particular compound using one particular reagent.
Providing up-to-date and comprehensive information about the synthesis of medium-ring heterocycles and the latest information on this fast-moving field, with easy access to the synthetic protocols for different 8-membered heterocycles, case studies, and application, this book will be essential reading for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Biography - p. xi 7. Preface - p. xii 8. List of abbreviations - p. xv 9. 1. Synthesis of azocines - p. 1 10. 2. Synthesis of azocines by diene metathesis - p. 41 11. 3. Synthesis of azocines by ring expansion - p. 89 12. 4. Synthesis of azocines and diazocines from amine-containing alkenes and alkynes - p. 139 13. 5. Synthesis of diazocines from amines - p. 183 14. 6. Synthesis of diazocines - p. 211 15. 7. Synthesis of diazocines and oxocines by cyclization of dienes - p. 243 16. 8. Synthesis of diazocines by ring contraction and ring expansion - p. 285 17. 9. Synthesis of oxocines by ring contraction and ring expansion - p. 303 18. 10. Synthesis of azocines and oxocines by ring closure of halo, amine, and oxo compounds - p. 333 19. 11. Synthesis of oxocines from hydroxy compounds - p. 375 20. 12. Synthesis of oxocines - p. 401 21. 13. Synthesis of oxazocines - p. 433 22. 14. Synthesis of thiocines - p. 475 23. 15. Synthesis of thiazocines - p. 501 24. Index - p. 525
8-Membered Heterocycle Synthesis focuses on both the new and established methods for the synthesis of various 8-membered heterocycles. 8-membered heterocyclic compounds act as target molecules for a wide range of synthetic studies and are present in a broad range of natural products, showing a wide variety of pharmaceutical and biological properties. Covering an important and rapidly growing branch of heterocyclic chemistry, this book brings together every protocol for the synthesis of 8-membered heterocycles in one place, allowing the reader to see all the possibilities for making a particular compound using one particular reagent.
Providing up-to-date and comprehensive information about the synthesis of medium-ring heterocycles and the latest information on this fast-moving field, with easy access to the synthetic protocols for different 8-membered heterocycles, case studies, and application, this book will be essential reading for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Biography - p. xi 7. Preface - p. xii 8. List of abbreviations - p. xv 9. 1. Synthesis of azocines - p. 1 10. 2. Synthesis of azocines by diene metathesis - p. 41 11. 3. Synthesis of azocines by ring expansion - p. 89 12. 4. Synthesis of azocines and diazocines from amine-containing alkenes and alkynes - p. 139 13. 5. Synthesis of diazocines from amines - p. 183 14. 6. Synthesis of diazocines - p. 211 15. 7. Synthesis of diazocines and oxocines by cyclization of dienes - p. 243 16. 8. Synthesis of diazocines by ring contraction and ring expansion - p. 285 17. 9. Synthesis of oxocines by ring contraction and ring expansion - p. 303 18. 10. Synthesis of azocines and oxocines by ring closure of halo, amine, and oxo compounds - p. 333 19. 11. Synthesis of oxocines from hydroxy compounds - p. 375 20. 12. Synthesis of oxocines - p. 401 21. 13. Synthesis of oxazocines - p. 433 22. 14. Synthesis of thiocines - p. 475 23. 15. Synthesis of thiazocines - p. 501 24. Index - p. 525
