A Comprehensive Guide to Rodent Models of Liver Diseases provides the why, what, and how of preclinical models of liver disease. These models have not only substantially improved understanding of human liver disease pathogenesis, but have also helped in developing and testing newer therapeutics and addressing some of the unanswered medical challenges and problems of today. This important reference gives a detailed and in-depth review of the various animal models of human liver disease. Well-reported animal models of several human liver diseases such as fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis, cholestasis, fibrosis, cirrhosis and end-stage primary liver cancer are described.
Preclinical models used for studying liver regeneration and liver failure are also discussed. For each model, the characteristic features, updated protocols, relevance, and limitations are provided for consideration. Finally, it provides an overview of the recently developed organoid models of liver pathology.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Foreword - p. ix 7. Preface - p. xi 8. Acknowledgments - p. xiii 9. Chapter 1. An overview and pathophysiology of liver diseases - p. 1 10. Chapter 2. Animal models for studying liver regeneration - p. 43 11. Chapter 3. Animal models of acute liver failure - p. 67 12. Chapter 4. Animal models of nonalcoholic fatty liver disease - p. 79 13. Chapter 5. Animal models of alcoholic liver disease - p. 105 14. Chapter 6. Preclinical models of portal hypertension - p. 131 15. Chapter 7. Animal models for complications of cirrhosis - p. 155 16. Chapter 8. Animal models of biliary/cholestatic disease - p. 185 17. Index - p. 215
A Comprehensive Guide to Rodent Models of Liver Diseases provides the why, what, and how of preclinical models of liver disease. These models have not only substantially improved understanding of human liver disease pathogenesis, but have also helped in developing and testing newer therapeutics and addressing some of the unanswered medical challenges and problems of today. This important reference gives a detailed and in-depth review of the various animal models of human liver disease. Well-reported animal models of several human liver diseases such as fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis, cholestasis, fibrosis, cirrhosis and end-stage primary liver cancer are described.
Preclinical models used for studying liver regeneration and liver failure are also discussed. For each model, the characteristic features, updated protocols, relevance, and limitations are provided for consideration. Finally, it provides an overview of the recently developed organoid models of liver pathology.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Foreword - p. ix 7. Preface - p. xi 8. Acknowledgments - p. xiii 9. Chapter 1. An overview and pathophysiology of liver diseases - p. 1 10. Chapter 2. Animal models for studying liver regeneration - p. 43 11. Chapter 3. Animal models of acute liver failure - p. 67 12. Chapter 4. Animal models of nonalcoholic fatty liver disease - p. 79 13. Chapter 5. Animal models of alcoholic liver disease - p. 105 14. Chapter 6. Preclinical models of portal hypertension - p. 131 15. Chapter 7. Animal models for complications of cirrhosis - p. 155 16. Chapter 8. Animal models of biliary/cholestatic disease - p. 185 17. Index - p. 215
