This practical, easy-to-use guide addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.
Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management.
1. Cover image 2. Title page 3. Table of Contents 4. Copyright 5. Foreword 6. Preface 7. List of Contributors 8. Chapter 1. Variation, Errors, and Quality in the Clinical Laboratory 9. Chapter 2. Effect of Age, Gender, Diet, Exercise, and Ethnicity on Laboratory Test Results 10. Chapter 3. Effect of Patient Preparation, Specimen Collection, Anticoagulants, and Preservatives on Laboratory Test Results 11. Chapter 4. Sample Processing and Specimen Misidentification Issues 12. Chapter 5. Hemolysis, Lipemia, and High Bilirubin: Effect on Laboratory Tests 13. Chapter 6. Immunoassay Design and Mechanisms of Interferences 14. Chapter 7. Effect of Herbal Remedies on Clinical Laboratory Tests 15. Chapter 8. Challenges in Routine Clinical Chemistry Testing: Analysis of Small Molecules 16. Chapter 9. Challenges in Routine Clinical Chemistry Analysis: Proteins and Enzymes 17. Chapter 10. Sources of Inaccuracy in Biochemical Genetics Testing 18. Chapter 11. Challenges in Endocrinology Testing 19. Chapter 12. Pitfalls in Tumor Markers Testing 20. Chapter 13. Issues of Interferences in Therapeutic Drug Monitoring 21. Chapter 14. Limitations of Drugs of Abuse Testing 22. Chapter 15. Challenges in Confirmation Testing for Drugs of Abuse 23. Chapter 16. Alcohol Determination Using Automated Analyzers: Limitations and Pitfalls 24. Chapter 17. Pre-Analytical Issues and Interferences in Transfusion Medicine Tests 25. Chapter 18. Issues with Immunology and Serology Testing 26. Chapter 19. Sources of Errors in Hematology and Coagulation Testing 27. Chapter 20. Challenges in Clinical Microbiology Testing 28. Chapter 21. Sources of Errors in Molecular Testing 29. Chapter 22. Problems in Pharmacogenomics Testing 30. Index
This practical, easy-to-use guide addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.
Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management.
1. Cover image 2. Title page 3. Table of Contents 4. Copyright 5. Foreword 6. Preface 7. List of Contributors 8. Chapter 1. Variation, Errors, and Quality in the Clinical Laboratory 9. Chapter 2. Effect of Age, Gender, Diet, Exercise, and Ethnicity on Laboratory Test Results 10. Chapter 3. Effect of Patient Preparation, Specimen Collection, Anticoagulants, and Preservatives on Laboratory Test Results 11. Chapter 4. Sample Processing and Specimen Misidentification Issues 12. Chapter 5. Hemolysis, Lipemia, and High Bilirubin: Effect on Laboratory Tests 13. Chapter 6. Immunoassay Design and Mechanisms of Interferences 14. Chapter 7. Effect of Herbal Remedies on Clinical Laboratory Tests 15. Chapter 8. Challenges in Routine Clinical Chemistry Testing: Analysis of Small Molecules 16. Chapter 9. Challenges in Routine Clinical Chemistry Analysis: Proteins and Enzymes 17. Chapter 10. Sources of Inaccuracy in Biochemical Genetics Testing 18. Chapter 11. Challenges in Endocrinology Testing 19. Chapter 12. Pitfalls in Tumor Markers Testing 20. Chapter 13. Issues of Interferences in Therapeutic Drug Monitoring 21. Chapter 14. Limitations of Drugs of Abuse Testing 22. Chapter 15. Challenges in Confirmation Testing for Drugs of Abuse 23. Chapter 16. Alcohol Determination Using Automated Analyzers: Limitations and Pitfalls 24. Chapter 17. Pre-Analytical Issues and Interferences in Transfusion Medicine Tests 25. Chapter 18. Issues with Immunology and Serology Testing 26. Chapter 19. Sources of Errors in Hematology and Coagulation Testing 27. Chapter 20. Challenges in Clinical Microbiology Testing 28. Chapter 21. Sources of Errors in Molecular Testing 29. Chapter 22. Problems in Pharmacogenomics Testing 30. Index
