Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity. Divided into two parts, the foundational aspects of this book cover the mechanism of toxicity in a detailed manner beginning with the history of acetaminophen to newly explored areas of genetics, proteomics, and metabolomics. The second half goes on to discuss clinical practices and examine where further research and therapeutic approaches may be headed. This part answers key questions about whom to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments. With contributions from experts in the field, this book is a thorough, well-researched, and valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with acetaminophen toxicity.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Dedication - p. iii 7. Contributors - p. xvii 8. Foreword - p. xxi 9. Part 1: Foundational aspects - p. xxiii 10. Chapter 1. History of acetaminophen toxicity studies - p. 3 11. Chapter 2. Intracellular signaling mechanisms of acetaminophen-induced cell death - p. 23 12. Chapter 3. Hepatic MAP kinase signaling pathways in APAP-induced cell death - p. 43 13. Chapter 4. Adaptive mechanisms modulating acetaminophen hepatotoxicity - p. 69 14. Chapter 5. Cell death in acetaminophen (APAP) toxicity - p. 87 15. Chapter 6. Role of sterile inflammation in acetaminophen hepatotoxicity - p. 125 16. Chapter 7. Liver regeneration after acetaminophen overdose - p. 143 17. Chapter 8. Translation of acetaminophen hepatotoxicity mechanisms from models to humans - p. 165 18. Chapter 9. Renal toxicity after acetaminophen overdose - p. 187 19. Chapter 10. ‘Omics of acetaminophen toxicity - p. 207 20. Part 2: Clinical therapeutics - p. 215 21. Chapter 11. Pharmacokinetics and pharmacodynamics of acetaminophen - p. 221 22. Chapter 12. Minimally invasive clinical biomarkers for use in acetaminophen hepatotoxicity - p. 275 23. Chapter 13. Development of clinical assays for determination of acetaminophen protein adducts - p. 303 24. Chapter 14. The Rumack-Matthew nomogram: Development, evolution, and clinical use - p. 317 25. Chapter 15. Pathophysiology of acetaminophen overdose in patients - p. 329 26. Chapter 16. Liver transplantation and the Kings College criteria - p. 341 27. Chapter 17. Sustained-release acetaminophen - p. 363 28. Chapter 18. Acetaminophen, ethanol and other co-ingestions - p. 383 29. Chapter 19. N-acetylcysteine (NAC) treatment of acetaminophen toxicity - p. 395 30. Chapter 20. The role of fomepizole in the management of acetaminophen toxicity - p. 417 31. Chapter 21. Guidelines for the management of acetaminophen poisoning - p. 431 32. Chapter 22. Epidemiology of acetaminophen toxicity - p. 455 33. Chapter 23. Acetaminophen use in patients with cirrhosis - p. 467 34. Index - p. 475
Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity. Divided into two parts, the foundational aspects of this book cover the mechanism of toxicity in a detailed manner beginning with the history of acetaminophen to newly explored areas of genetics, proteomics, and metabolomics. The second half goes on to discuss clinical practices and examine where further research and therapeutic approaches may be headed. This part answers key questions about whom to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments. With contributions from experts in the field, this book is a thorough, well-researched, and valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with acetaminophen toxicity.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Dedication - p. iii 7. Contributors - p. xvii 8. Foreword - p. xxi 9. Part 1: Foundational aspects - p. xxiii 10. Chapter 1. History of acetaminophen toxicity studies - p. 3 11. Chapter 2. Intracellular signaling mechanisms of acetaminophen-induced cell death - p. 23 12. Chapter 3. Hepatic MAP kinase signaling pathways in APAP-induced cell death - p. 43 13. Chapter 4. Adaptive mechanisms modulating acetaminophen hepatotoxicity - p. 69 14. Chapter 5. Cell death in acetaminophen (APAP) toxicity - p. 87 15. Chapter 6. Role of sterile inflammation in acetaminophen hepatotoxicity - p. 125 16. Chapter 7. Liver regeneration after acetaminophen overdose - p. 143 17. Chapter 8. Translation of acetaminophen hepatotoxicity mechanisms from models to humans - p. 165 18. Chapter 9. Renal toxicity after acetaminophen overdose - p. 187 19. Chapter 10. ‘Omics of acetaminophen toxicity - p. 207 20. Part 2: Clinical therapeutics - p. 215 21. Chapter 11. Pharmacokinetics and pharmacodynamics of acetaminophen - p. 221 22. Chapter 12. Minimally invasive clinical biomarkers for use in acetaminophen hepatotoxicity - p. 275 23. Chapter 13. Development of clinical assays for determination of acetaminophen protein adducts - p. 303 24. Chapter 14. The Rumack-Matthew nomogram: Development, evolution, and clinical use - p. 317 25. Chapter 15. Pathophysiology of acetaminophen overdose in patients - p. 329 26. Chapter 16. Liver transplantation and the Kings College criteria - p. 341 27. Chapter 17. Sustained-release acetaminophen - p. 363 28. Chapter 18. Acetaminophen, ethanol and other co-ingestions - p. 383 29. Chapter 19. N-acetylcysteine (NAC) treatment of acetaminophen toxicity - p. 395 30. Chapter 20. The role of fomepizole in the management of acetaminophen toxicity - p. 417 31. Chapter 21. Guidelines for the management of acetaminophen poisoning - p. 431 32. Chapter 22. Epidemiology of acetaminophen toxicity - p. 455 33. Chapter 23. Acetaminophen use in patients with cirrhosis - p. 467 34. Index - p. 475
