Advances in Heterocyclic Chemistry, Volume 147 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. New chapters in this release include Synthesis and chemistry of pyridazin-3(2H)-ones, Denitrogenative Transformations of Polynitrogen Heterocycles, Pyridinium-phenolate Dyes: Preparation and Properties, Recent Advances in the Mechanochemical Synthesis and Derivatization of Heterocycles, Recent Advances in the Synthesis of 7- and 8- Membered Heterocycles via Domino and Multicomponent Reactions (from 20?-2024), and Total Synthesis of Natural Products with Isoflavone Skeletons and Other Heterocycles.
1. 1 Introduction - p. 2 2. 2 Pyridazin-3(2H)-ones from γ-keto acids and hydrazines - p. 4 3. 3 Pyridazin-3(2H)-ones from α,β-unsaturated γ-keto acids and hydrazine derivatives - p. 29 4. 4 Pyridazin-3(2H)-ones from arylmethylidene γ-keto acids and hydrazine - p. 30 5. 5 Pyridazin-3(2H)-ones from isoxazolo[3,4-d]pyridazinones - p. 32 6. 6 Pyridazin-3(2H)-ones from maleic anhydrides and hydrazines - p. 34 7. 7 Pyridazin-3(2H)-ones from 5-hydroxyfuran-2(5H)-ones and hydrazines - p. 39 8. 8 Pyridazin-3(2H)-ones from 3-arylmethylidenefuran-2(3H)-ones or 5-arylmethylidenefuran-2(5H)-ones and hydrazines - p. 42 9. 9 Pyridazin-3(2H)-ones from hydrazones and active methylene compounds or ylides - p. 44 10. 10 Pyridazin-3(2H)-ones from 4-bromomethylcoumarins and hydrazines or hydrazides - p. 48 11. 11 Pyridazin-3(2H)-ones from potassium 2-furantrifluoroborate and aryldiazonium salts - p. 49 12. 12 4,5-Dihydropyridazin-3(2H)-ones from N-arylmaleimides and azines - p. 50 13. 13 4,5-Dihydropyridazin-3(2H)-ones via a [4 + 2] or [3 + 3] annulation reaction - p. 53 14. 14 4,5-Dihydropyridazin-3(2H)-ones from 4-pentynoic acid and hydrazines - p. 63 15. 15 Pyridazin-3(2H)-ones or 4,5-dihydropyridazin-3(2H)-ones via a one-pot multicomponent reaction - p. 65 16. References - p. 70 17. Chapter Two: Denitrogenative transformations of aryl-fused 1,2,3-triazoles - p. 77 18. Chapter Three: Recent advances in the mechanochemical synthesis and derivatization of heterocycles - p. 133 19. Abstract - p. 133 20. 1 Introduction - p. 134 21. 2 Mechanochemical synthesis of heterocycles - p. 136 22. 3 Mechanochemical derivatization/functionalization of heterocycles - p. 184 23. 4 Synthesis of functional heterocycles by mechanochemical methods - p. 203 24. 5 Summary and future perspective - p. 212 25. Acknowledgements - p. 213 26. References - p. 213 27. Further reading - p. 224 28. Chapter Four: Divergent total synthesis of natural products bearing isoflavone and 2-oxabicyclo[3.3.1]nonane skeleton using phloroglucinol and their application in drug discovery - p. 225 29. Chapter Five: New trends in the synthesis of azulene-fused heterocycles - p. 263 30. Chapter Six: Recent advances in the synthesis of seven-membered heterocycles by multicomponent and domino reactions (from 2017 to 2024) - p. 331 31. Index - p. 369
Advances in Heterocyclic Chemistry, Volume 147 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. New chapters in this release include Synthesis and chemistry of pyridazin-3(2H)-ones, Denitrogenative Transformations of Polynitrogen Heterocycles, Pyridinium-phenolate Dyes: Preparation and Properties, Recent Advances in the Mechanochemical Synthesis and Derivatization of Heterocycles, Recent Advances in the Synthesis of 7- and 8- Membered Heterocycles via Domino and Multicomponent Reactions (from 20?-2024), and Total Synthesis of Natural Products with Isoflavone Skeletons and Other Heterocycles.
1. 1 Introduction - p. 2 2. 2 Pyridazin-3(2H)-ones from γ-keto acids and hydrazines - p. 4 3. 3 Pyridazin-3(2H)-ones from α,β-unsaturated γ-keto acids and hydrazine derivatives - p. 29 4. 4 Pyridazin-3(2H)-ones from arylmethylidene γ-keto acids and hydrazine - p. 30 5. 5 Pyridazin-3(2H)-ones from isoxazolo[3,4-d]pyridazinones - p. 32 6. 6 Pyridazin-3(2H)-ones from maleic anhydrides and hydrazines - p. 34 7. 7 Pyridazin-3(2H)-ones from 5-hydroxyfuran-2(5H)-ones and hydrazines - p. 39 8. 8 Pyridazin-3(2H)-ones from 3-arylmethylidenefuran-2(3H)-ones or 5-arylmethylidenefuran-2(5H)-ones and hydrazines - p. 42 9. 9 Pyridazin-3(2H)-ones from hydrazones and active methylene compounds or ylides - p. 44 10. 10 Pyridazin-3(2H)-ones from 4-bromomethylcoumarins and hydrazines or hydrazides - p. 48 11. 11 Pyridazin-3(2H)-ones from potassium 2-furantrifluoroborate and aryldiazonium salts - p. 49 12. 12 4,5-Dihydropyridazin-3(2H)-ones from N-arylmaleimides and azines - p. 50 13. 13 4,5-Dihydropyridazin-3(2H)-ones via a [4 + 2] or [3 + 3] annulation reaction - p. 53 14. 14 4,5-Dihydropyridazin-3(2H)-ones from 4-pentynoic acid and hydrazines - p. 63 15. 15 Pyridazin-3(2H)-ones or 4,5-dihydropyridazin-3(2H)-ones via a one-pot multicomponent reaction - p. 65 16. References - p. 70 17. Chapter Two: Denitrogenative transformations of aryl-fused 1,2,3-triazoles - p. 77 18. Chapter Three: Recent advances in the mechanochemical synthesis and derivatization of heterocycles - p. 133 19. Abstract - p. 133 20. 1 Introduction - p. 134 21. 2 Mechanochemical synthesis of heterocycles - p. 136 22. 3 Mechanochemical derivatization/functionalization of heterocycles - p. 184 23. 4 Synthesis of functional heterocycles by mechanochemical methods - p. 203 24. 5 Summary and future perspective - p. 212 25. Acknowledgements - p. 213 26. References - p. 213 27. Further reading - p. 224 28. Chapter Four: Divergent total synthesis of natural products bearing isoflavone and 2-oxabicyclo[3.3.1]nonane skeleton using phloroglucinol and their application in drug discovery - p. 225 29. Chapter Five: New trends in the synthesis of azulene-fused heterocycles - p. 263 30. Chapter Six: Recent advances in the synthesis of seven-membered heterocycles by multicomponent and domino reactions (from 2017 to 2024) - p. 331 31. Index - p. 369
