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The 16 articles in this issue draw on the expertise of internationally recognized experts who have collectively provided cross-cutting reviews with a broad perspective on the current state of the field. The authors have provided succinct, up-to-date clinical perspectives and highlight current controversies and future challenges. As a result, this issue is a cutting-edge compendium of this complex and fast-moving field. Throughout the issue, the reader is encouraged to acquire a more comprehensive perspective by drawing connections between earlier and later articles that are thematically grouped around issues dealing with pathogenesis, diagnosis, and therapy. This issue underscores the vital importance of continued support to encourage and nurture collaboration among clinicians and scientists.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Contents - p. 5 6. CME Accreditation Page and Author Disclosure - p. 8 7. Forthcoming Issues - p. 9 8. Why the Human Fetus Has Such a Large Vulnerable Head And Why It Is Our Job to Protect It! - p. 10 9. Advances in Neonatal Neurology - p. 11 10. Cerebral White and Gray Matter Injury in Newborns - p. 12 11. Brain Development in Preterm Infants Assessed Using Advanced MRI Techniques - p. 27 12. Pathogenesis and Prevention of Intraventricular Hemorrhage - p. 37 13. Neuroimaging of White Matter Injury, Intraventricular and Cerebellar Hemorrhage - p. 48 14. Chorioamnionitis in the Pathogenesis of Brain Injury in Preterm Infants - p. 55 15. Fault and Blame, Insults to the Perinatal Brain may be Remote from Time of Birth - p. 61 16. Pharmacologic Neuroprotective Strategies in Neonatal Brain Injury - p. 67 17. Stem Cell Therapy for Neonatal Brain Injury - p. 74 18. Outcomes of Hypoxic-Ischemic Encephalopathy in Neonates Treated with Hypothermia - p. 81 19. Mechanisms of Hypothermic Neuroprotection - p. 88 20. Neonatal Seizures - p. 96 21. Steroids and Injury to the Developing Brain - p. 103 22. Neonatal Pain Control and Neurologic Effects of Anesthetics and Sedatives in Preterm Infants - p. 113 23. Neurogenesis and Maturation in Neonatal Brain Injury - p. 119 24. Neurodevelopmental Outcomes of Extremely Preterm Infants - p. 126 25. The Role of Neuroimaging in Predicting Neurodevelopmental Outcomes of Preterm Neonates - p. 133 26. Index - p. 146

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The 16 articles in this issue draw on the expertise of internationally recognized experts who have collectively provided cross-cutting reviews with a broad perspective on the current state of the field. The authors have provided succinct, up-to-date clinical perspectives and highlight current controversies and future challenges. As a result, this issue is a cutting-edge compendium of this complex and fast-moving field. Throughout the issue, the reader is encouraged to acquire a more comprehensive perspective by drawing connections between earlier and later articles that are thematically grouped around issues dealing with pathogenesis, diagnosis, and therapy. This issue underscores the vital importance of continued support to encourage and nurture collaboration among clinicians and scientists.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Contents - p. 5 6. CME Accreditation Page and Author Disclosure - p. 8 7. Forthcoming Issues - p. 9 8. Why the Human Fetus Has Such a Large Vulnerable Head And Why It Is Our Job to Protect It! - p. 10 9. Advances in Neonatal Neurology - p. 11 10. Cerebral White and Gray Matter Injury in Newborns - p. 12 11. Brain Development in Preterm Infants Assessed Using Advanced MRI Techniques - p. 27 12. Pathogenesis and Prevention of Intraventricular Hemorrhage - p. 37 13. Neuroimaging of White Matter Injury, Intraventricular and Cerebellar Hemorrhage - p. 48 14. Chorioamnionitis in the Pathogenesis of Brain Injury in Preterm Infants - p. 55 15. Fault and Blame, Insults to the Perinatal Brain may be Remote from Time of Birth - p. 61 16. Pharmacologic Neuroprotective Strategies in Neonatal Brain Injury - p. 67 17. Stem Cell Therapy for Neonatal Brain Injury - p. 74 18. Outcomes of Hypoxic-Ischemic Encephalopathy in Neonates Treated with Hypothermia - p. 81 19. Mechanisms of Hypothermic Neuroprotection - p. 88 20. Neonatal Seizures - p. 96 21. Steroids and Injury to the Developing Brain - p. 103 22. Neonatal Pain Control and Neurologic Effects of Anesthetics and Sedatives in Preterm Infants - p. 113 23. Neurogenesis and Maturation in Neonatal Brain Injury - p. 119 24. Neurodevelopmental Outcomes of Extremely Preterm Infants - p. 126 25. The Role of Neuroimaging in Predicting Neurodevelopmental Outcomes of Preterm Neonates - p. 133 26. Index - p. 146

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