Animal Models of Disease, Part E, Volume 203 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.
Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Series Page - p. iii 6. Copyright - p. iv 7. Contributors - p. xv 8. Chapter One: Establishment single lung tumors through orthotopic injection - p. 1 9. Chapter Two: Intracardiac injection as a metastatic model in lung cancer - p. 15 10. Chapter Three: Adeno-associated viral vector administration to the inner ear and phenotype evaluation in a mouse model of hearing loss - p. 25 11. Chapter Four: DiLiCre2.0 mouse model: An advanced genome-editing tool to induce mutagenesis in vivo with high spatio-temporal resolution - p. 41 12. Chapter Five: A new inducible mouse model of FH loss - p. 59 13. Chapter Six: Monitoring neuronal mitophagy and locomotion deficits in a C. elegans model of Alzheimer’s disease - p. 89 14. Chapter Seven: Experimental models and methods for infected wound modeling with Staphylococcus aureus - p. 111 15. Chapter Eight: Multiplex immunohistochemistry (IHC) profiling of murine tumour-infiltrating T cells - p. 129 16. Chapter Nine: Isolation of regulatory T cells from healthy murine mammary glands - p. 149 17. Chapter Ten: Metastasis mouse model of breast cancer derived from circulating tumor cells (CTCs) after primary orthotopic tumor resection - p. 163 18. Chapter Eleven: Establishment of humanized patient-derived xenografts (PDXs) from primary human colorectal cancer tumors - p. 175 19. Chapter Twelve: Modeling stress-induced proteinopathies in Caenorhabditis elegans - p. 201 20. Chapter Thirteen: Intravital imaging of mouse subcutaneous tumors placed in the ear for the study of immune cell interaction with blood vessels - p. 233 21. Chapter Fourteen: Induction of allergic dermatitis with dinitrofluorobenzene in Yama mice - p. 241
Animal Models of Disease, Part E, Volume 203 in the Methods in Cell Biology series, presents significant advancements in understanding disease mechanisms through animal models. The book features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.
Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Series Page - p. iii 6. Copyright - p. iv 7. Contributors - p. xv 8. Chapter One: Establishment single lung tumors through orthotopic injection - p. 1 9. Chapter Two: Intracardiac injection as a metastatic model in lung cancer - p. 15 10. Chapter Three: Adeno-associated viral vector administration to the inner ear and phenotype evaluation in a mouse model of hearing loss - p. 25 11. Chapter Four: DiLiCre2.0 mouse model: An advanced genome-editing tool to induce mutagenesis in vivo with high spatio-temporal resolution - p. 41 12. Chapter Five: A new inducible mouse model of FH loss - p. 59 13. Chapter Six: Monitoring neuronal mitophagy and locomotion deficits in a C. elegans model of Alzheimer’s disease - p. 89 14. Chapter Seven: Experimental models and methods for infected wound modeling with Staphylococcus aureus - p. 111 15. Chapter Eight: Multiplex immunohistochemistry (IHC) profiling of murine tumour-infiltrating T cells - p. 129 16. Chapter Nine: Isolation of regulatory T cells from healthy murine mammary glands - p. 149 17. Chapter Ten: Metastasis mouse model of breast cancer derived from circulating tumor cells (CTCs) after primary orthotopic tumor resection - p. 163 18. Chapter Eleven: Establishment of humanized patient-derived xenografts (PDXs) from primary human colorectal cancer tumors - p. 175 19. Chapter Twelve: Modeling stress-induced proteinopathies in Caenorhabditis elegans - p. 201 20. Chapter Thirteen: Intravital imaging of mouse subcutaneous tumors placed in the ear for the study of immune cell interaction with blood vessels - p. 233 21. Chapter Fourteen: Induction of allergic dermatitis with dinitrofluorobenzene in Yama mice - p. 241
