This volume explores some of the most exciting recent advances in basic research on animal models of molecular pathology.
1. I. Introduction 2. II. Classification of Epileptic Seizures 3. III. Classification of Epileptic Syndromes 4. IV. Models for Seizures and Epilepsies 5. V. Summary 6. Animal Models of Muscular Dystrophy 7. I. Dystrophin 8. II. The Sarcoglycans 9. III. Calcium and Dystrophic Pathology 10. IV. α-Actinin 11. V. Fukutin-Related Protein and Dystroglycan Processing 12. VI. Desmin 13. VII. Laminin α2 14. VIII. Collagen VI 15. IX. D4Z4 Repeats and FSHD 16. X. DMPK and Myotonic Dystrophy 17. XI. Conclusions 18. Acknowledgments 19. Acute Phase Proteins in Animals 20. I. The Acute Phase Response 21. II. Acute Phase Proteins 22. III. Clinical Value of APP 23. IV. APP in Animals 24. V. Concluding Remarks 25. Animal Models of Hemophilia 26. I. The Hemophilia A Mice 27. II. The Hemophilia B Mouse Model 28. III. The Hemophilia A and B Dogs 29. Animal Models of Lung Cancer 30. I. Lung Adenomas and Adenocarcinomas 31. II. Lung Squamous Cell Carcinoma 32. III. Lung Small Cell Carcinoma 33. IV. Chemopreventive Applications in Preclinical Lung Cancer Models 34. V. Conclusion 35. Cardiovascular Magnetic Resonance Imaging in Small Animals 36. I. Introduction 37. II. Principals of MRI 38. III. MRI Systems for Preclinical Imaging and Experimental Setup 39. IV. Cardiovascular MRI 40. V. Conclusion 41. Animal Models of Inflammatory Bowel Disease 42. I. Classification of Murine IBD Models 43. II. IL-10 KO Mice 44. III. IL-2 KO Mice 45. IV. TCRα KO Mice 46. V. TGFβ KO Mice 47. VI. TAK1 KO Mice 48. VII. WASP KO Mice 49. VIII. P110δ Mutant Mice 50. IX. PDK1 KO Mice 51. X. Cbl-b KO Mice 52. XI. Blimp-1 KO Mice 53. XII. A20 KO Mice 54. XIII. SHIP KO Mice 55. XIV. Gαi2 KO Mice 56. XV. TNF(ARE) Mice 57. XVI. LIGHT Tg Mice 58. XVII. TNFSF15 Tg Mice 59. XVIII. IL-7 Tg Mice 60. XIX. IL-15 Tg Mice 61. XX. CD40L Tg Mice 62. XXI. Soluble B7.2 Tg Mice 63. XXII. Integrin αV KO Mice 64. XXIII. Integrin β8 KO Mice 65. XXIV. STAT4 Tg Mice 66. XXV. STAT3 KO Mice 67. XXVI. SOCS1 Tg Mice 68. XXVII. Gp130 KI Mice 69. XXVIII. NFκB1 KO Mice 70. XXIX. Runx3 KO Mice 71. XXX. TLR5 KO Mice 72. XXXI. Enteric Glia KO 73. XXXII. XBP1 KO Mice 74. XXXIII. Atg5 KO Mice 75. XXXIV. mK8 KO Mice 76. XXXV. N-Cadherin Mutant Mice 77. XXXVI. Mdr1a KO Mice 78. XXXVII. GPX KO Mice 79. XXXVIII. Muc2 KO Mice 80. XXXIX. C1galt1 KO Mice 81. XL. NFATc2/RAG DKO Mice 82. XLI. T-bet/RAG DKO Mice 83. XLII. Anti-CD40mAb Model 84. XLIII. C3H/HeJBir Mice 85. XLIV. SAMP1/Yit Model 86. XLV. CD45RB Model 87. XLVI. Human CD3ε Model 88. XLVII. CD8-Transfer Models 89. XLVIII. ECOVA Model 90. XLIX. TNBS Model 91. L. Oxazolone Model 92. LI. DSS Model 93. LII. Conclusion 94. Acknowledgments 95. Animal Models of Molecular Pathology 96. I. Murine Models of Lupus 97. II. Role of the Major Histocompatibility Complex 98. III. Role of Cell Signaling 99. IV. Role of Sex Hormones 100. V. Role of Cytokines 101. VI. Tolerance Models 102. VII. Therapies 103. VIII. Conclusions 104. Animal Models of Cutaneous and Hepatic Fibrosis 105. I. Liver Fibrosis 106. II. Skin Fibrosis and Scleroderma 107. Animal Models of Schizophrenia 108. I. Introduction 109. II. The Schizophrenia Phenotype 110. III. Existing Animal Models for Schizophrenia 111. IV. An Example in Progress: A Psychosis Animal Model for Schizophrenia with High Construct Validity 112. V. Future Directions for Schizophrenia Models
This volume explores some of the most exciting recent advances in basic research on animal models of molecular pathology.
1. I. Introduction 2. II. Classification of Epileptic Seizures 3. III. Classification of Epileptic Syndromes 4. IV. Models for Seizures and Epilepsies 5. V. Summary 6. Animal Models of Muscular Dystrophy 7. I. Dystrophin 8. II. The Sarcoglycans 9. III. Calcium and Dystrophic Pathology 10. IV. α-Actinin 11. V. Fukutin-Related Protein and Dystroglycan Processing 12. VI. Desmin 13. VII. Laminin α2 14. VIII. Collagen VI 15. IX. D4Z4 Repeats and FSHD 16. X. DMPK and Myotonic Dystrophy 17. XI. Conclusions 18. Acknowledgments 19. Acute Phase Proteins in Animals 20. I. The Acute Phase Response 21. II. Acute Phase Proteins 22. III. Clinical Value of APP 23. IV. APP in Animals 24. V. Concluding Remarks 25. Animal Models of Hemophilia 26. I. The Hemophilia A Mice 27. II. The Hemophilia B Mouse Model 28. III. The Hemophilia A and B Dogs 29. Animal Models of Lung Cancer 30. I. Lung Adenomas and Adenocarcinomas 31. II. Lung Squamous Cell Carcinoma 32. III. Lung Small Cell Carcinoma 33. IV. Chemopreventive Applications in Preclinical Lung Cancer Models 34. V. Conclusion 35. Cardiovascular Magnetic Resonance Imaging in Small Animals 36. I. Introduction 37. II. Principals of MRI 38. III. MRI Systems for Preclinical Imaging and Experimental Setup 39. IV. Cardiovascular MRI 40. V. Conclusion 41. Animal Models of Inflammatory Bowel Disease 42. I. Classification of Murine IBD Models 43. II. IL-10 KO Mice 44. III. IL-2 KO Mice 45. IV. TCRα KO Mice 46. V. TGFβ KO Mice 47. VI. TAK1 KO Mice 48. VII. WASP KO Mice 49. VIII. P110δ Mutant Mice 50. IX. PDK1 KO Mice 51. X. Cbl-b KO Mice 52. XI. Blimp-1 KO Mice 53. XII. A20 KO Mice 54. XIII. SHIP KO Mice 55. XIV. Gαi2 KO Mice 56. XV. TNF(ARE) Mice 57. XVI. LIGHT Tg Mice 58. XVII. TNFSF15 Tg Mice 59. XVIII. IL-7 Tg Mice 60. XIX. IL-15 Tg Mice 61. XX. CD40L Tg Mice 62. XXI. Soluble B7.2 Tg Mice 63. XXII. Integrin αV KO Mice 64. XXIII. Integrin β8 KO Mice 65. XXIV. STAT4 Tg Mice 66. XXV. STAT3 KO Mice 67. XXVI. SOCS1 Tg Mice 68. XXVII. Gp130 KI Mice 69. XXVIII. NFκB1 KO Mice 70. XXIX. Runx3 KO Mice 71. XXX. TLR5 KO Mice 72. XXXI. Enteric Glia KO 73. XXXII. XBP1 KO Mice 74. XXXIII. Atg5 KO Mice 75. XXXIV. mK8 KO Mice 76. XXXV. N-Cadherin Mutant Mice 77. XXXVI. Mdr1a KO Mice 78. XXXVII. GPX KO Mice 79. XXXVIII. Muc2 KO Mice 80. XXXIX. C1galt1 KO Mice 81. XL. NFATc2/RAG DKO Mice 82. XLI. T-bet/RAG DKO Mice 83. XLII. Anti-CD40mAb Model 84. XLIII. C3H/HeJBir Mice 85. XLIV. SAMP1/Yit Model 86. XLV. CD45RB Model 87. XLVI. Human CD3ε Model 88. XLVII. CD8-Transfer Models 89. XLVIII. ECOVA Model 90. XLIX. TNBS Model 91. L. Oxazolone Model 92. LI. DSS Model 93. LII. Conclusion 94. Acknowledgments 95. Animal Models of Molecular Pathology 96. I. Murine Models of Lupus 97. II. Role of the Major Histocompatibility Complex 98. III. Role of Cell Signaling 99. IV. Role of Sex Hormones 100. V. Role of Cytokines 101. VI. Tolerance Models 102. VII. Therapies 103. VIII. Conclusions 104. Animal Models of Cutaneous and Hepatic Fibrosis 105. I. Liver Fibrosis 106. II. Skin Fibrosis and Scleroderma 107. Animal Models of Schizophrenia 108. I. Introduction 109. II. The Schizophrenia Phenotype 110. III. Existing Animal Models for Schizophrenia 111. IV. An Example in Progress: A Psychosis Animal Model for Schizophrenia with High Construct Validity 112. V. Future Directions for Schizophrenia Models
