Topics in this clinically focused publication devoted to Anticoagulants are: Antithrombin clinical applications and anti-inflammatory effects; Pharmacology and laboratory testing of oral direct thrombin inhibitor Dabigatran; Pharmacology and laboratory testing of the oral Xa inhibitors; Clinical use of the new oral anticoagulants; Pharmacology and safety of new oral anticoagulants-the challenge of bleeding; Emergency reversal of Warfarin anticoagulation - prothrombin complex concentrate compared with plasma; Prothrombin complex concentrate as reversal agent for new oral anticoagulants - lessons from prelinical models; Bleeding with new oral anticoagulants - clinical presentation and management; Treatment of ICH with new oral anticoagulants - a neurologist's view; Management of anticoagulation agents in trauma patients; and Anticoagulation and pediatric patients.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 7 6. Preface: Anticoagulants - p. 8 7. Pharmacology and Safety of New Oral Anticoagulants - p. 9 8. Clinical Use of the Activated Partial Thromboplastin Time and Prothrombin Time for Screening - p. 15 9. Measurement of Dabigatran in Standardly Used Clinical Assays, Whole Blood Viscoelastic Coagulation, and Thrombin Generation Assays - p. 24 10. Pharmacology and Laboratory Testing of the Oral Xa Inhibitors - p. 37 11. Treatment and Long-Term Management of Venous Thromboembolism - p. 46 12. Anticoagulation Strategies for the Management of Postoperative Atrial Fibrillation - p. 54 13. Management of Anticoagulation Agents in Trauma Patients - p. 68 14. New Oral Anticoagulant–Induced Bleeding - p. 73 15. Treatment of Intracerebral Hemorrhage Associated with New Oral Anticoagulant Use - p. 81 16. Periprocedural Management of Patients on Anticoagulants - p. 86 17. Four-Factor Prothrombin Complex Concentrate Versus Plasma for Urgent Vitamin K Antagonist Reversal - p. 95 18. Prothrombin Complex Concentrates as Reversal Agents for New Oral Anticoagulants - p. 100 19. Perioperative Management of Patients Receiving New Oral Anticoagulants - p. 107 20. Management of Anticoagulation and Hemostasis for Pediatric Extracorporeal Membrane Oxygenation - p. 112 21. The Influence of Various Patient Characteristics on D-dimer Concentration in Critically Ill Patients and Its Role as a Prognostic Indicator in the Intensive Care Unit Setting - p. 120 22. Index - p. 127
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Topics in this clinically focused publication devoted to Anticoagulants are: Antithrombin clinical applications and anti-inflammatory effects; Pharmacology and laboratory testing of oral direct thrombin inhibitor Dabigatran; Pharmacology and laboratory testing of the oral Xa inhibitors; Clinical use of the new oral anticoagulants; Pharmacology and safety of new oral anticoagulants-the challenge of bleeding; Emergency reversal of Warfarin anticoagulation - prothrombin complex concentrate compared with plasma; Prothrombin complex concentrate as reversal agent for new oral anticoagulants - lessons from prelinical models; Bleeding with new oral anticoagulants - clinical presentation and management; Treatment of ICH with new oral anticoagulants - a neurologist's view; Management of anticoagulation agents in trauma patients; and Anticoagulation and pediatric patients.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 7 6. Preface: Anticoagulants - p. 8 7. Pharmacology and Safety of New Oral Anticoagulants - p. 9 8. Clinical Use of the Activated Partial Thromboplastin Time and Prothrombin Time for Screening - p. 15 9. Measurement of Dabigatran in Standardly Used Clinical Assays, Whole Blood Viscoelastic Coagulation, and Thrombin Generation Assays - p. 24 10. Pharmacology and Laboratory Testing of the Oral Xa Inhibitors - p. 37 11. Treatment and Long-Term Management of Venous Thromboembolism - p. 46 12. Anticoagulation Strategies for the Management of Postoperative Atrial Fibrillation - p. 54 13. Management of Anticoagulation Agents in Trauma Patients - p. 68 14. New Oral Anticoagulant–Induced Bleeding - p. 73 15. Treatment of Intracerebral Hemorrhage Associated with New Oral Anticoagulant Use - p. 81 16. Periprocedural Management of Patients on Anticoagulants - p. 86 17. Four-Factor Prothrombin Complex Concentrate Versus Plasma for Urgent Vitamin K Antagonist Reversal - p. 95 18. Prothrombin Complex Concentrates as Reversal Agents for New Oral Anticoagulants - p. 100 19. Perioperative Management of Patients Receiving New Oral Anticoagulants - p. 107 20. Management of Anticoagulation and Hemostasis for Pediatric Extracorporeal Membrane Oxygenation - p. 112 21. The Influence of Various Patient Characteristics on D-dimer Concentration in Critically Ill Patients and Its Role as a Prognostic Indicator in the Intensive Care Unit Setting - p. 120 22. Index - p. 127
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