Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational and clinical research, this volume begins with history and basic signaling principles and then expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins. Experts in their respective fields are featured throughout, making this book essential reading for anyone who wants to explore the basic science underlying these signaling proteins.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. ix 7. Preface - p. x 8. Chapter 1. History of arrestins - p. 1 9. Chapter 2. Arrestin-mediated trafficking and compartmentalized biology of GPCRs - p. 9 10. Chapter 3. The structural basis of arrestin–GPCR interactions - p. 25 11. Chapter 4. Arrestin scaffolding and activation of MAPK cascades - p. 47 12. Chapter 5. β-Arrestins as regulators of key metabolic processes - p. 69 13. Chapter 6. Arrestins in cardiac function: the current state of affairs - p. 87 14. Chapter 7. Signaling-biased arrestin-based molecular tools - p. 105 15. Index - p. 125
Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational and clinical research, this volume begins with history and basic signaling principles and then expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins. Experts in their respective fields are featured throughout, making this book essential reading for anyone who wants to explore the basic science underlying these signaling proteins.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. ix 7. Preface - p. x 8. Chapter 1. History of arrestins - p. 1 9. Chapter 2. Arrestin-mediated trafficking and compartmentalized biology of GPCRs - p. 9 10. Chapter 3. The structural basis of arrestin–GPCR interactions - p. 25 11. Chapter 4. Arrestin scaffolding and activation of MAPK cascades - p. 47 12. Chapter 5. β-Arrestins as regulators of key metabolic processes - p. 69 13. Chapter 6. Arrestins in cardiac function: the current state of affairs - p. 87 14. Chapter 7. Signaling-biased arrestin-based molecular tools - p. 105 15. Index - p. 125
