Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more.
1. 1 Introduction - p. 3 2. 2 Therapy-induced autophagy (TIA) - p. 6 3. 3 Therapy-induced senescence in cancer - p. 25 4. 4 Autophagy and senescence: The connection - p. 48 5. Acknowledgments - p. 51 6. References - p. 52 7. Chapter Two: Targeting the stress support network regulated by autophagy and senescence for cancer treatment - p. 75 8. Chapter Three: Autophagy and senescence, converging roles in pathophysiology as seen through mouse models - p. 113 9. Chapter Four: Autophagy and senescence: Insights from normal and cancer stem cells - p. 173 10. Chapter Five: The role of autophagy in escaping therapy-induced polyploidy/senescence - p. 209 11. Chapter Six: Autophagy and PTEN in DNA damage-induced senescence - p. 249 12. Chapter Seven: Cellular senescence and tumor promotion: Role of the Unfolded Protein Response - p. 294 13. Chapter Eight: mTOR as a senescence manipulation target: A forked road - p. 335
Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more.
1. 1 Introduction - p. 3 2. 2 Therapy-induced autophagy (TIA) - p. 6 3. 3 Therapy-induced senescence in cancer - p. 25 4. 4 Autophagy and senescence: The connection - p. 48 5. Acknowledgments - p. 51 6. References - p. 52 7. Chapter Two: Targeting the stress support network regulated by autophagy and senescence for cancer treatment - p. 75 8. Chapter Three: Autophagy and senescence, converging roles in pathophysiology as seen through mouse models - p. 113 9. Chapter Four: Autophagy and senescence: Insights from normal and cancer stem cells - p. 173 10. Chapter Five: The role of autophagy in escaping therapy-induced polyploidy/senescence - p. 209 11. Chapter Six: Autophagy and PTEN in DNA damage-induced senescence - p. 249 12. Chapter Seven: Cellular senescence and tumor promotion: Role of the Unfolded Protein Response - p. 294 13. Chapter Eight: mTOR as a senescence manipulation target: A forked road - p. 335
