Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections.
Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.
1. Chapter 1. Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1–4 - p. XXXV 2. Part I: Molecular Mechanisms - p. 30 3. Chapter 2. Autophagic Flux, Fusion Dynamics, and Cell Death - p. 30 4. Chapter 3. Architecture of the Atg12–Atg5–Atg16 Complex and its Molecular Role in Autophagy - p. 55 5. Chapter 4. The Molecular Mechanisms Underlying Autophagosome Formation in Yeast - p. 64 6. Part II: Role of Autophagy in Disease - p. 76 7. Chapter 5. Role of Autophagy in Cell Survival in Liver Injury - p. 76 8. Chapter 6. Polymorphisms in Autophagy-Related Genes in Crohn’s Disease: Impact on Intracellular Bacteria Persistence and Inflammatory Response - p. 90 9. Chapter 7. Functional Relevance of Autophagins in Life and Disease - p. 109 10. Chapter 8. Strategies to Block Autophagy in Tumor Cells - p. 118 11. Chapter 9. Autophagic Dysfunction in Gaucher Disease and its Rescue by Cathepsin B and D Proteases - p. 129 12. Chapter 10. Cargo Recognition Failure Underlies Macroautophagy Defects in Huntington’s Disease - p. 144 13. Chapter 11. Hepatitis C Virus Infection, Autophagy, and Innate Immune Response - p. 160 14. Chapter 12. Geranylgeranoic Acid Induces Incomplete Autophagy but Leads to the Accumulation of Autophagosomes in Human Hepatoma Cells - p. 171 15. Chapter 13. Defense Against Proteotoxic Stress in the Heart: Role of p62, Autophagy, and Ubiquitin–Proteasome System - p. 183 16. Chapter 14. Elimination of Intracellular Bacteria by Autophagy - p. 200 17. Chapter 15. Protein Phosphatase 2A Has Positive and Negative Roles in Autophagy - p. 210 18. Part III: Role of Autophagy in Cancer - p. 223 19. Chapter 16. Erufosine Induces Autophagy and Apoptosis in Oral Squamous Cell Carcinoma: Role of the Akt–mTOR Signaling Pathway - p. 223 20. Chapter 17. Emerging Role of Hypoxia-Induced Autophagy in Cancer Immunotherapy - p. 243 21. Chapter 18. Involvement of Autophagy and Apoptosis in Studies of Anticancer Drugs - p. 261 22. Chapter 19. Autophagy-Based Protein Biomarkers for In Vivo Detection of Cardiotoxicity in the Context of Cancer Therapy - p. 286 23. Chapter 20. Inhibition of mTOR Pathway and Induction of Autophagy Block Lymphoma Cell Growth: Role of AMPK Activation - p. 306 24. Part IV: Autophagy and Apoptosis - p. 319 25. Chapter 21. Autophagy Regulates Osteoarthritis-Like Gene Expression Changes: Role of Apoptosis and Reactive Oxygen Species - p. 319 26. Chapter 22. The Key Role of Autophagy and its Relationship with Apoptosis in Lepidopteran Larval Midgut Remodeling - p. 330 27. Chapter 23. Interferon Regulatory Factor 1 Regulates both Autophagy and Apoptosis in Splenocytes during Sepsis - p. 347 28. Chapter 24. The Interplay between Autophagy and Apoptosis - p. 367 29. Index - p. 381
Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections.
Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.
1. Chapter 1. Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1–4 - p. XXXV 2. Part I: Molecular Mechanisms - p. 30 3. Chapter 2. Autophagic Flux, Fusion Dynamics, and Cell Death - p. 30 4. Chapter 3. Architecture of the Atg12–Atg5–Atg16 Complex and its Molecular Role in Autophagy - p. 55 5. Chapter 4. The Molecular Mechanisms Underlying Autophagosome Formation in Yeast - p. 64 6. Part II: Role of Autophagy in Disease - p. 76 7. Chapter 5. Role of Autophagy in Cell Survival in Liver Injury - p. 76 8. Chapter 6. Polymorphisms in Autophagy-Related Genes in Crohn’s Disease: Impact on Intracellular Bacteria Persistence and Inflammatory Response - p. 90 9. Chapter 7. Functional Relevance of Autophagins in Life and Disease - p. 109 10. Chapter 8. Strategies to Block Autophagy in Tumor Cells - p. 118 11. Chapter 9. Autophagic Dysfunction in Gaucher Disease and its Rescue by Cathepsin B and D Proteases - p. 129 12. Chapter 10. Cargo Recognition Failure Underlies Macroautophagy Defects in Huntington’s Disease - p. 144 13. Chapter 11. Hepatitis C Virus Infection, Autophagy, and Innate Immune Response - p. 160 14. Chapter 12. Geranylgeranoic Acid Induces Incomplete Autophagy but Leads to the Accumulation of Autophagosomes in Human Hepatoma Cells - p. 171 15. Chapter 13. Defense Against Proteotoxic Stress in the Heart: Role of p62, Autophagy, and Ubiquitin–Proteasome System - p. 183 16. Chapter 14. Elimination of Intracellular Bacteria by Autophagy - p. 200 17. Chapter 15. Protein Phosphatase 2A Has Positive and Negative Roles in Autophagy - p. 210 18. Part III: Role of Autophagy in Cancer - p. 223 19. Chapter 16. Erufosine Induces Autophagy and Apoptosis in Oral Squamous Cell Carcinoma: Role of the Akt–mTOR Signaling Pathway - p. 223 20. Chapter 17. Emerging Role of Hypoxia-Induced Autophagy in Cancer Immunotherapy - p. 243 21. Chapter 18. Involvement of Autophagy and Apoptosis in Studies of Anticancer Drugs - p. 261 22. Chapter 19. Autophagy-Based Protein Biomarkers for In Vivo Detection of Cardiotoxicity in the Context of Cancer Therapy - p. 286 23. Chapter 20. Inhibition of mTOR Pathway and Induction of Autophagy Block Lymphoma Cell Growth: Role of AMPK Activation - p. 306 24. Part IV: Autophagy and Apoptosis - p. 319 25. Chapter 21. Autophagy Regulates Osteoarthritis-Like Gene Expression Changes: Role of Apoptosis and Reactive Oxygen Species - p. 319 26. Chapter 22. The Key Role of Autophagy and its Relationship with Apoptosis in Lepidopteran Larval Midgut Remodeling - p. 330 27. Chapter 23. Interferon Regulatory Factor 1 Regulates both Autophagy and Apoptosis in Splenocytes during Sepsis - p. 347 28. Chapter 24. The Interplay between Autophagy and Apoptosis - p. 367 29. Index - p. 381
