Bacterial Enzymes as Targets for Drug Discovery: Meeting the Challenges of Antibiotic Resistance addresses the gap between medical microbiology, structural biology, and genomic science in the development of new antibacterial drug development. This book consolidates detailed profiling of bacterial target enzyme families for the drug discovery process and methodologies for use and validation of the potential drug targets. The contents cover the foundations of the antibiotic drug discovery process and focus on bacterial enzymes as drug targets, building across these disciplines to provide a comprehensive resource in bacterial structural biology and genomics. This is the ideal reference for antibiotic drug discovery researchers in the pharma industry and academia. Biochemists, microbiologists, and medicinal chemists will also benefit from this books’ content.
1. Bacterial Enzymes as Targets for Drug Discovery - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. Preface - p. Page viii 8. List of Illustrations - p. Page xi 9. List of Tables - p. Page xii 10. Chapter 1 : Understanding antimicrobial resistance - p. Page xii 11. Chapter 2 : Current scenario and future prospective of drug discovery and development against bacterial enzymes - p. Page 16 12. Chapter 3 : Clinical diagnostics of bacterial infections and their resistance to antibiotics-Current state and novel enabling technologies implementation perspectives - p. Page 37 13. Chapter 4 : An Odyssey into phylogeny, structural and functional conservation of novel antibacterial targets - p. Page 48 14. Chapter 5 : Validation of drug targets using molecular methodologies and enzymatic activity assays for validation of inhibitory potential - p. Page 79 15. Chapter 6 : Computational tools to identify potential drug targets in bacteria - p. Page 107 16. Chapter 7 : Antimicrobial drug resistance and bypassing strategies - p. Page 136 17. Chapter 8 : Designing tomorrow's antibiotics: Cutting-edge strategies and technologies - p. Page 166 18. Chapter 9 : Topoisomerases as targets for halting bacterial DNA replication - p. Page 181 19. Chapter 10 : Lactamase and antibiotic resistance: A catalyst for drug discovery breakthroughs - p. Page 207 20. Chapter 11 : Selective versus broad-spectrum inhibition of novel outer membrane targets in Gram-negative bacteria - p. Page 243 21. Chapter 12 : Ribosome binding antibacterial agents - p. Page 262 22. Chapter 13 : Targeting RNA polymerase: A key approach for designing novel antimicrobial therapeutic strategies - p. Page 287 23. Chapter 14 : Colistin resistance and strategies against superbug, where we are? - p. Page 313 24. Chapter 15 : Deoxythymidine triphosphate pathway enzymes as an antibacterial target - p. Page 325 25. Chapter 16 : Arresting the peptidoglycan synthesis to kill the bacteria - p. Page 345 26. Chapter 17 : Clp protease complex as a therapeutic target for tuberculosis - p. Page 361 27. Chapter 18 : PlaF: A bacterial lands cycle phospholipase A mediating membrane phospholipid degradation and virulence adaptation∗ - p. Page 380 28. Chapter 19 : Bacterial TIR domain-containing proteins as drug targets - p. Page 413 29. Chapter 20 : Drug repurposing: Tackling antibiotic resistance with existing therapeutics - p. Page 427 30. List of abbreviations - p. Page 441 31. Index - p. Page 452
Bacterial Enzymes as Targets for Drug Discovery: Meeting the Challenges of Antibiotic Resistance addresses the gap between medical microbiology, structural biology, and genomic science in the development of new antibacterial drug development. This book consolidates detailed profiling of bacterial target enzyme families for the drug discovery process and methodologies for use and validation of the potential drug targets. The contents cover the foundations of the antibiotic drug discovery process and focus on bacterial enzymes as drug targets, building across these disciplines to provide a comprehensive resource in bacterial structural biology and genomics. This is the ideal reference for antibiotic drug discovery researchers in the pharma industry and academia. Biochemists, microbiologists, and medicinal chemists will also benefit from this books’ content.
1. Bacterial Enzymes as Targets for Drug Discovery - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. Preface - p. Page viii 8. List of Illustrations - p. Page xi 9. List of Tables - p. Page xii 10. Chapter 1 : Understanding antimicrobial resistance - p. Page xii 11. Chapter 2 : Current scenario and future prospective of drug discovery and development against bacterial enzymes - p. Page 16 12. Chapter 3 : Clinical diagnostics of bacterial infections and their resistance to antibiotics-Current state and novel enabling technologies implementation perspectives - p. Page 37 13. Chapter 4 : An Odyssey into phylogeny, structural and functional conservation of novel antibacterial targets - p. Page 48 14. Chapter 5 : Validation of drug targets using molecular methodologies and enzymatic activity assays for validation of inhibitory potential - p. Page 79 15. Chapter 6 : Computational tools to identify potential drug targets in bacteria - p. Page 107 16. Chapter 7 : Antimicrobial drug resistance and bypassing strategies - p. Page 136 17. Chapter 8 : Designing tomorrow's antibiotics: Cutting-edge strategies and technologies - p. Page 166 18. Chapter 9 : Topoisomerases as targets for halting bacterial DNA replication - p. Page 181 19. Chapter 10 : Lactamase and antibiotic resistance: A catalyst for drug discovery breakthroughs - p. Page 207 20. Chapter 11 : Selective versus broad-spectrum inhibition of novel outer membrane targets in Gram-negative bacteria - p. Page 243 21. Chapter 12 : Ribosome binding antibacterial agents - p. Page 262 22. Chapter 13 : Targeting RNA polymerase: A key approach for designing novel antimicrobial therapeutic strategies - p. Page 287 23. Chapter 14 : Colistin resistance and strategies against superbug, where we are? - p. Page 313 24. Chapter 15 : Deoxythymidine triphosphate pathway enzymes as an antibacterial target - p. Page 325 25. Chapter 16 : Arresting the peptidoglycan synthesis to kill the bacteria - p. Page 345 26. Chapter 17 : Clp protease complex as a therapeutic target for tuberculosis - p. Page 361 27. Chapter 18 : PlaF: A bacterial lands cycle phospholipase A mediating membrane phospholipid degradation and virulence adaptation∗ - p. Page 380 28. Chapter 19 : Bacterial TIR domain-containing proteins as drug targets - p. Page 413 29. Chapter 20 : Drug repurposing: Tackling antibiotic resistance with existing therapeutics - p. Page 427 30. List of abbreviations - p. Page 441 31. Index - p. Page 452
