Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics.
Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. Foreword - p. xv 8. Chapter 1. Drug discovery and development: An overview of modern methods and principles - p. 1 9. Chapter 2. The drug discovery process: From ancient times to the present day - p. 43 10. Chapter 3. Classical targets in drug discovery - p. 111 11. In vitro screening systems - p. 185 12. Chapter 5. Medicinal chemistry - p. 257 13. In vitro ADME and in vivo pharmacokinetics - p. 305 14. Chapter 7. Animal models of disease states - p. 371 15. Chapter 8. Safety and toxicology - p. 421 16. Chapter 9. Antibody-drug discovery - p. 459 17. Chapter 10. Basics of clinical trials - p. 483 18. Chapter 11. Translational medicine and biomarkers - p. 523 19. Chapter 12. Organizational consideration and trends in the pharmaceutical industry - p. 561 20. Chapter 13. Intellectual property and patents in drug discovery - p. 595 21. Chapter 14. Case studies in drug discovery - p. 625 22. Answers to questions in textbook by chapter - p. 665 23. Subject Index - p. 693 24. Drug Index - p. 713
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics.
Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. Foreword - p. xv 8. Chapter 1. Drug discovery and development: An overview of modern methods and principles - p. 1 9. Chapter 2. The drug discovery process: From ancient times to the present day - p. 43 10. Chapter 3. Classical targets in drug discovery - p. 111 11. In vitro screening systems - p. 185 12. Chapter 5. Medicinal chemistry - p. 257 13. In vitro ADME and in vivo pharmacokinetics - p. 305 14. Chapter 7. Animal models of disease states - p. 371 15. Chapter 8. Safety and toxicology - p. 421 16. Chapter 9. Antibody-drug discovery - p. 459 17. Chapter 10. Basics of clinical trials - p. 483 18. Chapter 11. Translational medicine and biomarkers - p. 523 19. Chapter 12. Organizational consideration and trends in the pharmaceutical industry - p. 561 20. Chapter 13. Intellectual property and patents in drug discovery - p. 595 21. Chapter 14. Case studies in drug discovery - p. 625 22. Answers to questions in textbook by chapter - p. 665 23. Subject Index - p. 693 24. Drug Index - p. 713
