Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion of synthesizing biological catalysts using asymmetric synthesis, for applications across research and industry. Here, global experts in the field analyze a wide variety of biocatalysts and their physical states, process conditions for their asymmetric synthesis, solvents required during synthesis, and even downstream procedures for the recovery of final products. The book adopts an interdisciplinary approach, merging fundamental biology and its synthetic applications across industries, with a wide range of practical examples, from directed evolution to biotransformation and production of novel enzymes and non-conventional catalysts. Throughout the book, the impact and application of biocatalysis in sustainable processing is considered in-depth. This book will also help non-experts in biocatalysis to apply this knowledge in their own research, providing a thorough overview of the ways asymmetric biocatalytic approaches may be adapted for different disciplines and downstream products.
1. Chapter 1 : Introduction to asymmetric synthesis employing biocatalysts - p. Page xi 2. Chapter 2 : Biocatalysis and Green Chemistry: assessing the greenness of enzymatic processes - p. Page 34 3. Chapter 3 : Study of stereocontrol in enzymatic reactions using atomic models and computational methods - p. Page 60 4. Chapter 4 : Control of the activity and enantioselectivity in biocatalyzed procedures: immobilization, medium engineering, and protein engineering - p. Page 93 5. Chapter 5 : Hydrolases and their application in asymmetric synthesis - p. Page 125 6. Chapter 6 : Biocatalysis for the selective reduction of carbonyl groups - p. Page 166 7. Chapter 7 : Synthesis of chiral amines employing imine reductases and reductive aminases - p. Page 201 8. Chapter 8 : Biocatalyzed Carbon–Carbon bond formation in enantioselective synthesis - p. Page 233 9. Chapter 9 : Synthesis of chiral compounds through biooxidations - p. Page 284 10. Chapter 10 : Asymmetric biocatalysis in nonconventional media: neat conditions, eutectic solvents, and supercritical conditions - p. Page 316 11. Chapter 11 : Multienzyme-catalyzed processes in asymmetric synthesis: state of the art and future trends - p. Page 359 12. Chapter 12 : Development of asymmetric biotransformations: flow biocatalysis, photobiocatalysis, and microwave biocatalysis - p. Page 394 13. Chapter 13 : Industrial asymmetric biocatalysis - p. Page 424 14. Chapter 14 : Patents based on biocatalytic methods for the synthesis of valuable chiral compounds - p. Page 455 15. Index - p. Page 479
Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion of synthesizing biological catalysts using asymmetric synthesis, for applications across research and industry. Here, global experts in the field analyze a wide variety of biocatalysts and their physical states, process conditions for their asymmetric synthesis, solvents required during synthesis, and even downstream procedures for the recovery of final products. The book adopts an interdisciplinary approach, merging fundamental biology and its synthetic applications across industries, with a wide range of practical examples, from directed evolution to biotransformation and production of novel enzymes and non-conventional catalysts. Throughout the book, the impact and application of biocatalysis in sustainable processing is considered in-depth. This book will also help non-experts in biocatalysis to apply this knowledge in their own research, providing a thorough overview of the ways asymmetric biocatalytic approaches may be adapted for different disciplines and downstream products.
1. Chapter 1 : Introduction to asymmetric synthesis employing biocatalysts - p. Page xi 2. Chapter 2 : Biocatalysis and Green Chemistry: assessing the greenness of enzymatic processes - p. Page 34 3. Chapter 3 : Study of stereocontrol in enzymatic reactions using atomic models and computational methods - p. Page 60 4. Chapter 4 : Control of the activity and enantioselectivity in biocatalyzed procedures: immobilization, medium engineering, and protein engineering - p. Page 93 5. Chapter 5 : Hydrolases and their application in asymmetric synthesis - p. Page 125 6. Chapter 6 : Biocatalysis for the selective reduction of carbonyl groups - p. Page 166 7. Chapter 7 : Synthesis of chiral amines employing imine reductases and reductive aminases - p. Page 201 8. Chapter 8 : Biocatalyzed Carbon–Carbon bond formation in enantioselective synthesis - p. Page 233 9. Chapter 9 : Synthesis of chiral compounds through biooxidations - p. Page 284 10. Chapter 10 : Asymmetric biocatalysis in nonconventional media: neat conditions, eutectic solvents, and supercritical conditions - p. Page 316 11. Chapter 11 : Multienzyme-catalyzed processes in asymmetric synthesis: state of the art and future trends - p. Page 359 12. Chapter 12 : Development of asymmetric biotransformations: flow biocatalysis, photobiocatalysis, and microwave biocatalysis - p. Page 394 13. Chapter 13 : Industrial asymmetric biocatalysis - p. Page 424 14. Chapter 14 : Patents based on biocatalytic methods for the synthesis of valuable chiral compounds - p. Page 455 15. Index - p. Page 479
