Biological Fluid-Mediated Transport Mechanisms for Targeted Drug Delivery in Next-Generation Cancer Immunotherapy addresses the critical need for innovative therapeutic platforms that improve efficacy and reduce toxicity in cancer treatment. The volume explores how natural biofluids and derived carriers, like exosomes and extracellular vesicles, can serve as highly biocompatible vehicles for delivering immunotherapeutics. It emphasizes their roles in overcoming barriers such as immune evasion, rapid clearance, and systemic side effects, while also leveraging biofluid signatures for real-time diagnostics through liquid biopsies. The book encompasses topics from the composition and biomolecular content of biofluids to the engineering strategies for functionalization, targeting, and controlled release, integrating cutting-edge nanotechnologies and microfluidics.
This reference book supports the advancement of next-generation precision cancer immunotherapies by providing insights into biofluid dynamics, bioresponsive carriers, and personalized approaches. It bridges basic science with translational potential, fostering innovation in nanomedicine, immunology, and biomedical engineering, and aims to accelerate the clinical impact of biofluid-inspired drug delivery systems.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. About the authors and acknowledgments - p. xix 7. Preface - p. xxiii 8. Chapter 1. Biofluids and cancer immunotherapy: Fundamentals and clinical relevance - p. 1 9. Chapter 2. Navigating the lymphatic system: Targeting antigen presentation pathways - p. 43 10. Chapter 3. Bloodstream delivery strategies for sustained immunomodulation - p. 81 11. Chapter 4. Mucosal biofluid routes: Oral, pulmonary, and intranasal immunotherapy - p. 119 12. Chapter 5. Exosomes and extracellular vesicles as natural delivery vehicles - p. 157 13. Chapter 6. Lipid nanoparticles and mRNA platforms in cancer vaccination - p. 193 14. Chapter 7. Hydrogels and implantable depots for local immune modulation - p. 225 15. Chapter 8. Stimuli responsive carriers tuned to biofluid microenvironments - p. 255 16. Chapter 9. Combination immunotherapy delivery via biofluid compatible systems - p. 287 17. Chapter 10. Imaging and pharmacokinetic modeling in biofluid mediated delivery - p. 317 18. Chapter 11. Safety, manufacturing, and regulatory considerations in clinical translation - p. 337 19. Chapter 12. Future perspectives: Personalized and AI enabled biofluid based immunotherapy - p. 363 20. Index - p. 393
Biological Fluid-Mediated Transport Mechanisms for Targeted Drug Delivery in Next-Generation Cancer Immunotherapy addresses the critical need for innovative therapeutic platforms that improve efficacy and reduce toxicity in cancer treatment. The volume explores how natural biofluids and derived carriers, like exosomes and extracellular vesicles, can serve as highly biocompatible vehicles for delivering immunotherapeutics. It emphasizes their roles in overcoming barriers such as immune evasion, rapid clearance, and systemic side effects, while also leveraging biofluid signatures for real-time diagnostics through liquid biopsies. The book encompasses topics from the composition and biomolecular content of biofluids to the engineering strategies for functionalization, targeting, and controlled release, integrating cutting-edge nanotechnologies and microfluidics.
This reference book supports the advancement of next-generation precision cancer immunotherapies by providing insights into biofluid dynamics, bioresponsive carriers, and personalized approaches. It bridges basic science with translational potential, fostering innovation in nanomedicine, immunology, and biomedical engineering, and aims to accelerate the clinical impact of biofluid-inspired drug delivery systems.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. About the authors and acknowledgments - p. xix 7. Preface - p. xxiii 8. Chapter 1. Biofluids and cancer immunotherapy: Fundamentals and clinical relevance - p. 1 9. Chapter 2. Navigating the lymphatic system: Targeting antigen presentation pathways - p. 43 10. Chapter 3. Bloodstream delivery strategies for sustained immunomodulation - p. 81 11. Chapter 4. Mucosal biofluid routes: Oral, pulmonary, and intranasal immunotherapy - p. 119 12. Chapter 5. Exosomes and extracellular vesicles as natural delivery vehicles - p. 157 13. Chapter 6. Lipid nanoparticles and mRNA platforms in cancer vaccination - p. 193 14. Chapter 7. Hydrogels and implantable depots for local immune modulation - p. 225 15. Chapter 8. Stimuli responsive carriers tuned to biofluid microenvironments - p. 255 16. Chapter 9. Combination immunotherapy delivery via biofluid compatible systems - p. 287 17. Chapter 10. Imaging and pharmacokinetic modeling in biofluid mediated delivery - p. 317 18. Chapter 11. Safety, manufacturing, and regulatory considerations in clinical translation - p. 337 19. Chapter 12. Future perspectives: Personalized and AI enabled biofluid based immunotherapy - p. 363 20. Index - p. 393
