Biological Research on Addiction examines the neurobiological mechanisms of drug use and drug addiction, describing how the brain responds to addictive substances as well as how it is affected by drugs of abuse. The book's four main sections examine behavioral and molecular biology; neuroscience; genetics; and neuroimaging and neuropharmacology as they relate to the addictive process.
This volume is especially effective in presenting current knowledge on the key neurobiological and genetic elements in an individual’s susceptibility to drug dependence, as well as the processes by which some individuals proceed from casual drug use to drug dependence.
Biological Research on Addiction is one of three volumes comprising the 2,500-page series, Comprehensive Addictive Behaviors and Disorders. This series provides the most complete collection of current knowledge on addictive behaviors and disorders to date. In short, it is the definitive reference work on addictions.
1. Chapter 1. Neurobiological Mechanisms of Drug Addiction: An Introduction - p. X 2. Chapter 2. Mice and Alcohol - p. 10 3. Chapter 3. Alcohol and Rats - p. 19 4. Chapter 4. Nonhuman Primate Models of Alcohol Abuse and Alcoholism - p. 28 5. Chapter 5. Zebrafish and Alcohol - p. 41 6. Chapter 6. Alcohol and Drosophila melanogaster - p. 50 7. Chapter 7. Animal Models of Addiction other than Alcohol: Amphetamines - p. 59 8. Chapter 8. Animal Models of Addiction: Cannabinoids - p. 68 9. Chapter 9. Animal Models of Drug Addiction: Cocaine - p. 78 10. Chapter 10. Effects of Nicotine in Animal Models of Drug Addiction Across Species - p. 87 11. Chapter 11. Preclinical Animal Studies: Alcohol - p. 97 12. Chapter 12. Preclinical Animal Studies: Cannabinoids - p. 107 13. Chapter 13. Preclinical Animal Studies: Cocaine - p. 119 14. Chapter 14. Preclinical Animal Studies: Nicotine - p. 126 15. Chapter 15. Preclinical Animal Studies: Opiates - p. 139 16. Chapter 16. Overview of Animal Models of Drug Addiction: Commonalities to Human Addiction - p. 148 17. Section II: Neuroscience - p. 157 18. Chapter 17. Common Mechanisms of Addiction - p. 157 19. Chapter 18. Neuroadaptive Changes that Result from Chronic Drug Exposure - p. 168 20. Chapter 19. The Dark Side of Addiction: Dysregulated Neuroadaptation of Emotional Neurocircuits - p. 178 21. Chapter 20. Integrating Body and Brain Systems in Addiction Neuroscience - p. 186 22. Chapter 21. Brain Sites and Neurotransmitter Systems Mediating the Reinforcing Effects of Alcohol - p. 197 23. Chapter 22. The Mesolimbic Dopamine Reward System and Drug Addiction - p. 207 24. Chapter 23. Molecular and Functional Changes in Receptors: GABA and Chronic Alcohol Consumption - p. 217 25. Chapter 24. Serotonin and Behavioral Stimulant Effects of Addictive Drugs - p. 229 26. Chapter 25. The Role of Glutamate Receptors in Addiction - p. 239 27. Chapter 26. Molecular and Cellular Mechanisms of Addiction - p. 249 28. Chapter 27. Common Molecular Mechanisms and Neurocircuitry in Alcohol and Nicotine Addiction - p. 259 29. Chapter 28. The Role of Brain Development in Drug Effect and Drug Response - p. 270 30. Chapter 29. Molecular Targets of Ethanol in the Developing Brain - p. 280 31. Chapter 30. Addiction, Hippocampal Neurogenesis, and Neuroplasticity in the Adult Brain - p. 290 32. Chapter 31. Neurogenesis and Addictive Disorders - p. 303 33. Chapter 32. Neural Mechanisms of Learning: Animal Models of Cocaine Addiction - p. 313 34. Chapter 33. Memory Reconsolidation and Drugs of Abuse - p. 322 35. Chapter 34. Binge Drinking and Withdrawal: Neural Mechanisms in Humans - p. 332 36. Chapter 35. The Neural Basis of Decision Making in Addiction - p. 340 37. Chapter 36. Addiction and the Human Adolescent Brain - p. 351 38. Chapter 37. Neuropsychological Precursors and Consequences of Addiction - p. 363 39. Chapter 38. Human Neurophysiology: EEG and Quantitative EEG in Addiction Research - p. 376 40. Chapter 39. Incentive Salience and the Transition to Addiction - p. 390 41. Chapter 40. The Neurobiological Basis of Personality Risk for Addiction - p. 399 42. Chapter 41. Neuroeconomics and Addiction: Integrating Neuroscience, Cognition, and Behavioral Economics - p. 412 43. Chapter 42. Common Neural Mechanisms in Obesity and Drug Addiction - p. 423 44. Chapter 43. Brain Mechanisms of Addiction Treatment Effects - p. 429 45. Chapter 44. Genetics of Ecstasy (MDMA) Use - p. 439 46. Chapter 45. Genetics of Nicotine Addiction - p. 451 47. Section III: Genetics - p. 459 48. Chapter 46. Intermediate Phenotypes/Endophenotypes and Pathways to Addiction - p. 459 49. Chapter 47. Twin Studies and the Heritability of Substance Use Disorders - p. 473 50. Chapter 48. The Epigenetic Consequences of Drinking - p. 486 51. Chapter 49. Genetics of Alcohol Use Disorders - p. 498 52. Chapter 50. Genetics of Opioid Addiction - p. 508 53. Chapter 51. The Genetics of Cannabis Use and Cannabis Use Disorders - p. 521 54. Chapter 52. The Genetics of Drugs of Abuse Metabolism - p. 530 55. Chapter 53. Addiction Neuroethics: Ethical and Social Implications of Genetic and Neuroscience Research on Addiction - p. 540 56. Section IV: Neuropharmacology/Imaging/Genetics - p. 548 57. Chapter 54. Multinuclear Magnetic Resonance Methods and the Study of Mechanisms of Addiction in Humans - p. 548 58. Chapter 55. Neuropharmacology of Nicotine - p. 560 59. Chapter 56. Neuropharmacology of Cocaine and Amphetamine - p. 571 60. Chapter 57. Neurobiology of Methamphetamine - p. 577 61. Chapter 58. Neuropharmacology of Cannabinoids - p. 591 62. Chapter 59. Neuropharmacology of Benzodiazepines - p. 603 63. Chapter 60. Neuropharmacology of Ecstasy (MDMA) and Other Designer Drugs - p. 614 64. Chapter 61. Neuropharmacology of Lysergic Acid Diethylamide (LSD) and Other Hallucinogens - p. 623 65. Chapter 62. Neuropharmacology of Inhalants - p. 635 66. Chapter 63. Alcohol Neuroimaging in Humans - p. 645 67. Chapter 64. Neuroimaging of Nicotine and Tobacco Smoking in Humans - p. 654 68. Chapter 65. Ecstasy (MDMA) and other designer drugs: Neuroimaging - p. 664 69. Chapter 66. Opioids Neuroimaging - p. 672 70. Chapter 67. Neuroimaging in Problem Gambling - p. 687 71. Chapter 68. Cocaine and Amphetamine Neuroimaging in Small Rodents - p. 697 72. Chapter 69. The Impact of Regular Cannabis Use on the Human Brain: A Review of Structural Neuroimaging Studies - p. 710 73. Index - p. 727
Biological Research on Addiction examines the neurobiological mechanisms of drug use and drug addiction, describing how the brain responds to addictive substances as well as how it is affected by drugs of abuse. The book's four main sections examine behavioral and molecular biology; neuroscience; genetics; and neuroimaging and neuropharmacology as they relate to the addictive process.
This volume is especially effective in presenting current knowledge on the key neurobiological and genetic elements in an individual’s susceptibility to drug dependence, as well as the processes by which some individuals proceed from casual drug use to drug dependence.
Biological Research on Addiction is one of three volumes comprising the 2,500-page series, Comprehensive Addictive Behaviors and Disorders. This series provides the most complete collection of current knowledge on addictive behaviors and disorders to date. In short, it is the definitive reference work on addictions.
1. Chapter 1. Neurobiological Mechanisms of Drug Addiction: An Introduction - p. X 2. Chapter 2. Mice and Alcohol - p. 10 3. Chapter 3. Alcohol and Rats - p. 19 4. Chapter 4. Nonhuman Primate Models of Alcohol Abuse and Alcoholism - p. 28 5. Chapter 5. Zebrafish and Alcohol - p. 41 6. Chapter 6. Alcohol and Drosophila melanogaster - p. 50 7. Chapter 7. Animal Models of Addiction other than Alcohol: Amphetamines - p. 59 8. Chapter 8. Animal Models of Addiction: Cannabinoids - p. 68 9. Chapter 9. Animal Models of Drug Addiction: Cocaine - p. 78 10. Chapter 10. Effects of Nicotine in Animal Models of Drug Addiction Across Species - p. 87 11. Chapter 11. Preclinical Animal Studies: Alcohol - p. 97 12. Chapter 12. Preclinical Animal Studies: Cannabinoids - p. 107 13. Chapter 13. Preclinical Animal Studies: Cocaine - p. 119 14. Chapter 14. Preclinical Animal Studies: Nicotine - p. 126 15. Chapter 15. Preclinical Animal Studies: Opiates - p. 139 16. Chapter 16. Overview of Animal Models of Drug Addiction: Commonalities to Human Addiction - p. 148 17. Section II: Neuroscience - p. 157 18. Chapter 17. Common Mechanisms of Addiction - p. 157 19. Chapter 18. Neuroadaptive Changes that Result from Chronic Drug Exposure - p. 168 20. Chapter 19. The Dark Side of Addiction: Dysregulated Neuroadaptation of Emotional Neurocircuits - p. 178 21. Chapter 20. Integrating Body and Brain Systems in Addiction Neuroscience - p. 186 22. Chapter 21. Brain Sites and Neurotransmitter Systems Mediating the Reinforcing Effects of Alcohol - p. 197 23. Chapter 22. The Mesolimbic Dopamine Reward System and Drug Addiction - p. 207 24. Chapter 23. Molecular and Functional Changes in Receptors: GABA and Chronic Alcohol Consumption - p. 217 25. Chapter 24. Serotonin and Behavioral Stimulant Effects of Addictive Drugs - p. 229 26. Chapter 25. The Role of Glutamate Receptors in Addiction - p. 239 27. Chapter 26. Molecular and Cellular Mechanisms of Addiction - p. 249 28. Chapter 27. Common Molecular Mechanisms and Neurocircuitry in Alcohol and Nicotine Addiction - p. 259 29. Chapter 28. The Role of Brain Development in Drug Effect and Drug Response - p. 270 30. Chapter 29. Molecular Targets of Ethanol in the Developing Brain - p. 280 31. Chapter 30. Addiction, Hippocampal Neurogenesis, and Neuroplasticity in the Adult Brain - p. 290 32. Chapter 31. Neurogenesis and Addictive Disorders - p. 303 33. Chapter 32. Neural Mechanisms of Learning: Animal Models of Cocaine Addiction - p. 313 34. Chapter 33. Memory Reconsolidation and Drugs of Abuse - p. 322 35. Chapter 34. Binge Drinking and Withdrawal: Neural Mechanisms in Humans - p. 332 36. Chapter 35. The Neural Basis of Decision Making in Addiction - p. 340 37. Chapter 36. Addiction and the Human Adolescent Brain - p. 351 38. Chapter 37. Neuropsychological Precursors and Consequences of Addiction - p. 363 39. Chapter 38. Human Neurophysiology: EEG and Quantitative EEG in Addiction Research - p. 376 40. Chapter 39. Incentive Salience and the Transition to Addiction - p. 390 41. Chapter 40. The Neurobiological Basis of Personality Risk for Addiction - p. 399 42. Chapter 41. Neuroeconomics and Addiction: Integrating Neuroscience, Cognition, and Behavioral Economics - p. 412 43. Chapter 42. Common Neural Mechanisms in Obesity and Drug Addiction - p. 423 44. Chapter 43. Brain Mechanisms of Addiction Treatment Effects - p. 429 45. Chapter 44. Genetics of Ecstasy (MDMA) Use - p. 439 46. Chapter 45. Genetics of Nicotine Addiction - p. 451 47. Section III: Genetics - p. 459 48. Chapter 46. Intermediate Phenotypes/Endophenotypes and Pathways to Addiction - p. 459 49. Chapter 47. Twin Studies and the Heritability of Substance Use Disorders - p. 473 50. Chapter 48. The Epigenetic Consequences of Drinking - p. 486 51. Chapter 49. Genetics of Alcohol Use Disorders - p. 498 52. Chapter 50. Genetics of Opioid Addiction - p. 508 53. Chapter 51. The Genetics of Cannabis Use and Cannabis Use Disorders - p. 521 54. Chapter 52. The Genetics of Drugs of Abuse Metabolism - p. 530 55. Chapter 53. Addiction Neuroethics: Ethical and Social Implications of Genetic and Neuroscience Research on Addiction - p. 540 56. Section IV: Neuropharmacology/Imaging/Genetics - p. 548 57. Chapter 54. Multinuclear Magnetic Resonance Methods and the Study of Mechanisms of Addiction in Humans - p. 548 58. Chapter 55. Neuropharmacology of Nicotine - p. 560 59. Chapter 56. Neuropharmacology of Cocaine and Amphetamine - p. 571 60. Chapter 57. Neurobiology of Methamphetamine - p. 577 61. Chapter 58. Neuropharmacology of Cannabinoids - p. 591 62. Chapter 59. Neuropharmacology of Benzodiazepines - p. 603 63. Chapter 60. Neuropharmacology of Ecstasy (MDMA) and Other Designer Drugs - p. 614 64. Chapter 61. Neuropharmacology of Lysergic Acid Diethylamide (LSD) and Other Hallucinogens - p. 623 65. Chapter 62. Neuropharmacology of Inhalants - p. 635 66. Chapter 63. Alcohol Neuroimaging in Humans - p. 645 67. Chapter 64. Neuroimaging of Nicotine and Tobacco Smoking in Humans - p. 654 68. Chapter 65. Ecstasy (MDMA) and other designer drugs: Neuroimaging - p. 664 69. Chapter 66. Opioids Neuroimaging - p. 672 70. Chapter 67. Neuroimaging in Problem Gambling - p. 687 71. Chapter 68. Cocaine and Amphetamine Neuroimaging in Small Rodents - p. 697 72. Chapter 69. The Impact of Regular Cannabis Use on the Human Brain: A Review of Structural Neuroimaging Studies - p. 710 73. Index - p. 727
