Biomarkers of Hip Implant Function brings together established and potential new biomarkers, critically evaluating their clinical usefulness based on recent evidence. Researchers will benefit from a comprehensive view of the topic to identify underexplored areas. Orthopedic surgeons and general practitioners will use the book to monitor implant performance and facilitate management of their patients. Additionally, the work will benefit engineers and joint implant manufacturers to guide improvements in design. This book will also be of interest to regulators and policymakers by helping them update their guidelines on follow-ups for hip implant recipients.
Nearly all orthopedic surgeons have implanted a cobalt-chromium hip and most general practitioners have at least one patient with cobalt-chromium implant on their books. The recent worldwide controversy surrounding metal-on-metal hips means that advice on how to manage patients with these implants is of great interest to these professionals. Hence, this book is a welcomed addition to the conversation.
Covers all established and candidate biomarkers of hip implant wear, periprosthetic infection, and toxicity Summarises recent research into blood titanium levels associated with well-functioning and malfunctioning hip implants to aid implant revision decisions Reviews over 50 cases of suspected systemic cobalt toxicity to raise awareness of its symptoms and clinical presentation, and guide investigations and treatment decisions
1. Chapter 1 Introduction to hip implants and biomarker testing - p. 3 2. Chapter 2 Degradation of metal hip implants - p. 41 3. Chapter 3 Implant metals and their potential toxicity - p. 75 4. Chapter 4 Markers of hip implant degradation: analytical considerations and clinical interpretation - p. 107 5. Chapter 5 Biomarkers of compromised implant fixation - p. 137 6. Chapter 6 Biomarkers of periprosthetic joint infection - p. 167 7. Chapter 7 Hip implants and systemic cobalt toxicity: a comprehensive review with case studies - p. 205 8. Chapter 8 Clinical guidelines on the use of biomarkers for surveillance of hip replacements - p. 251 9. Index - p. 273
Biomarkers of Hip Implant Function brings together established and potential new biomarkers, critically evaluating their clinical usefulness based on recent evidence. Researchers will benefit from a comprehensive view of the topic to identify underexplored areas. Orthopedic surgeons and general practitioners will use the book to monitor implant performance and facilitate management of their patients. Additionally, the work will benefit engineers and joint implant manufacturers to guide improvements in design. This book will also be of interest to regulators and policymakers by helping them update their guidelines on follow-ups for hip implant recipients.
Nearly all orthopedic surgeons have implanted a cobalt-chromium hip and most general practitioners have at least one patient with cobalt-chromium implant on their books. The recent worldwide controversy surrounding metal-on-metal hips means that advice on how to manage patients with these implants is of great interest to these professionals. Hence, this book is a welcomed addition to the conversation.
Covers all established and candidate biomarkers of hip implant wear, periprosthetic infection, and toxicity Summarises recent research into blood titanium levels associated with well-functioning and malfunctioning hip implants to aid implant revision decisions Reviews over 50 cases of suspected systemic cobalt toxicity to raise awareness of its symptoms and clinical presentation, and guide investigations and treatment decisions
1. Chapter 1 Introduction to hip implants and biomarker testing - p. 3 2. Chapter 2 Degradation of metal hip implants - p. 41 3. Chapter 3 Implant metals and their potential toxicity - p. 75 4. Chapter 4 Markers of hip implant degradation: analytical considerations and clinical interpretation - p. 107 5. Chapter 5 Biomarkers of compromised implant fixation - p. 137 6. Chapter 6 Biomarkers of periprosthetic joint infection - p. 167 7. Chapter 7 Hip implants and systemic cobalt toxicity: a comprehensive review with case studies - p. 205 8. Chapter 8 Clinical guidelines on the use of biomarkers for surveillance of hip replacements - p. 251 9. Index - p. 273
