Biomechanics and Mechanobiology of Bone: From Model to Patient provides readers with a comprehensive overview of the modelling and assessment of bone biomechanics. It addresses topics such as biosubstitutes and bone implants from the point of view of design, properties, computational modeling, and choice of biomaterials. It concentrates on the biomechanics and mechanobiology modeling approaches of bone, including biological models, multiphysical approaches, surface and volumetric growth models, and bone fluid flow models. This is augmented by case studies and examples of models for computer-aided diagnosis, treatment, and monitoring of bone diseases. Readers are introduced to bone physiology, adaptation, and disease, including cellular aspects at the root of bone mechanotransduction and leading to bone growth and remodeling, and management of diseases. Chapters also cover the mechanical, multiphysical multiscale properties of bone and constitutive laws including bone viscoelasticity, poroelasticity, bone damage, fatigue and fracture, as well as measurement techniques of bone properties.
1. 1 Introduction - p. 397 2. 2 Homogenization of trabecular bone microstructure within cauchy elasticity framework - p. 398 3. 3 Topology optimization approaches for bone structure design - p. 404 4. 4 Trabecular bone plasticity and failure analysis - p. 419 5. 5 Conclusions - p. 423 6. 6 Appendix A - p. 424 7. 7 Appendix B - p. 429 8. Chapter 15. Shape and topology optimization approaches - p. 437 9. Chapter 16. Bone fluid flow models: Calculation of interstitial fluid flow around osteocytes - p. 463 10. Chapter 17. Simulation platform for in-silico trials of osteoporosis treatments—Biochemical signaling pathways: Mechanobiological bone cell population modeling framework - p. 505 11. 1 Introduction - p. 506 12. 2 Bone cell population model of bone remodeling - p. 508 13. 3 Biochemical signaling pathways - p. 510 14. 4 Mechanobiological feedback—The mechanostat - p. 517 15. 5 Composition and mechanical properties of bone - p. 519 16. 6 Microstructural damage - p. 523 17. 7 Modeling bone diseases—osteoporosis - p. 525 18. Chapter 18. Simulation platform for in-silico trials of osteoporosis treatments—PK-PD models: Towards optimizing single and multiple-drug treatments - p. 535 19. Part 4. Bone diseases, fractures, and frontiers of bone biomechanics - p. P4 20. Chapter 19. Pathology and management of bone fractures - p. 561 21. Chapter 20. Clinical advances and technical challenges of quantitative computed tomography - p. 589 22. Chapter 21. Importance of reproducibility in bone fracture prediction using numerical models for clinical applications - p. 623 23. Chapter 22. Biomaterials for bone regeneration - p. 655 24. Chapter 23. Additive manufacturing of scaffolds for bone tissue engineering - p. 693 25. Chapter 24. Frontiers of bone biomechanics: overview of challenges - p. 733 26. Index - p. 761
Biomechanics and Mechanobiology of Bone: From Model to Patient provides readers with a comprehensive overview of the modelling and assessment of bone biomechanics. It addresses topics such as biosubstitutes and bone implants from the point of view of design, properties, computational modeling, and choice of biomaterials. It concentrates on the biomechanics and mechanobiology modeling approaches of bone, including biological models, multiphysical approaches, surface and volumetric growth models, and bone fluid flow models. This is augmented by case studies and examples of models for computer-aided diagnosis, treatment, and monitoring of bone diseases. Readers are introduced to bone physiology, adaptation, and disease, including cellular aspects at the root of bone mechanotransduction and leading to bone growth and remodeling, and management of diseases. Chapters also cover the mechanical, multiphysical multiscale properties of bone and constitutive laws including bone viscoelasticity, poroelasticity, bone damage, fatigue and fracture, as well as measurement techniques of bone properties.
1. 1 Introduction - p. 397 2. 2 Homogenization of trabecular bone microstructure within cauchy elasticity framework - p. 398 3. 3 Topology optimization approaches for bone structure design - p. 404 4. 4 Trabecular bone plasticity and failure analysis - p. 419 5. 5 Conclusions - p. 423 6. 6 Appendix A - p. 424 7. 7 Appendix B - p. 429 8. Chapter 15. Shape and topology optimization approaches - p. 437 9. Chapter 16. Bone fluid flow models: Calculation of interstitial fluid flow around osteocytes - p. 463 10. Chapter 17. Simulation platform for in-silico trials of osteoporosis treatments—Biochemical signaling pathways: Mechanobiological bone cell population modeling framework - p. 505 11. 1 Introduction - p. 506 12. 2 Bone cell population model of bone remodeling - p. 508 13. 3 Biochemical signaling pathways - p. 510 14. 4 Mechanobiological feedback—The mechanostat - p. 517 15. 5 Composition and mechanical properties of bone - p. 519 16. 6 Microstructural damage - p. 523 17. 7 Modeling bone diseases—osteoporosis - p. 525 18. Chapter 18. Simulation platform for in-silico trials of osteoporosis treatments—PK-PD models: Towards optimizing single and multiple-drug treatments - p. 535 19. Part 4. Bone diseases, fractures, and frontiers of bone biomechanics - p. P4 20. Chapter 19. Pathology and management of bone fractures - p. 561 21. Chapter 20. Clinical advances and technical challenges of quantitative computed tomography - p. 589 22. Chapter 21. Importance of reproducibility in bone fracture prediction using numerical models for clinical applications - p. 623 23. Chapter 22. Biomaterials for bone regeneration - p. 655 24. Chapter 23. Additive manufacturing of scaffolds for bone tissue engineering - p. 693 25. Chapter 24. Frontiers of bone biomechanics: overview of challenges - p. 733 26. Index - p. 761
