Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient, First Edition, is the first comprehensive text to focus on important biomechanical studies conducted in the last decade that have increased our understanding of coronary atherosclerotic plaque initiation, growth, and rupture, as well as improving the design of medical devices and clinical interventions, including surgical procedures. The book provides students, researchers, engineers, clinicians, and interventional cardiologists with an overview of the main topics related to the biomechanics of atherosclerosis, in a single volume written by several experts in the field.
This volume is part of the Biomechanics of Living Organs book series. The biomechanics of human soft tissues and organs has been an emerging research field since the publication of Y.C. Fung’s original book series in the 1990s. The publication of such books entirely dedicated to a specific biomechanical subject is necessary to advance scientific research in the field of biomechanics and to transfer important knowledge to future generations. Therefore, this series of volumes on the biomechanics of living organs has been created. This series began in July 2017 with the publication of a first volume on the fundamentals of Hyperelastic Constitutive Laws for Finite Element Modeling of Living Organs. The current volume on the Biomechanics of Coronary Atherosclerotic Plaque, is the latest in this new series.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. iii 4. Biomechanics of Living Organs Series - p. ii 5. Copyright - p. iv 6. Contributors - p. xix 7. Note of the Series Editors - p. xxv 8. Editor's Biography - p. xxvii 9. Foreword - p. xxix 10. Preface - p. xxxi 11. Part 1. Biology, Physiopathology, Hemodynamics, Myogenic Responses and Clinical Intravascular Imaging of The Coronary Vascular Wall - p. xxxii 12. Chapter 1. Biomechanical regulation of endothelial function in atherosclerosis - p. 3 13. Chapter 2. Molecular mechanisms of the vascular responses to hemodynamic forces - p. 49 14. Chapter 3. Advanced atherosclerotic plaques in animal models versus human lesions: Key elements to translation - p. 85 15. Chapter 4. Modeling the Glagov's compensatory enlargement of human coronary atherosclerotic plaque - p. 107 16. Chapter 5. Measuring coronary arterial compliance and vasomotor response noninvasively in clinical and research settings - p. 131 17. Chapter 6. Coronary intravascular ultrasound and optical coherence tomography imaging and clinical contexts in coronary hemodynamics - p. 149 18. Chapter 7. The interaction of biochemical, biomechanical, and clinical factors of coronary disease - p. 171 19. Part 2. Modeling Blood Flow in Arterial Branches and Bifurcations - p. 190 20. Chapter 8. Local blood flow parameters and atherosclerosis in coronary artery bifurcations - p. 193 21. Chapter 9. Effect of regional analysis methods on assessing the association between wall shear stress and coronary artery disease progression in the clinical setting - p. 203 22. Chapter 10. Hemodynamic disturbance due to serial stenosis in human coronary bifurcations: a computational fluid dynamics study - p. 225 23. Chapter 11. Hemodynamic perturbations due to the presence of stents - p. 251 24. Chapter 12. A new reduced-order model to assess the true fractional flow reserve of a left main coronary artery stenosis with downstream lesions and collateral circulations: an in vitro study - p. 273 25. Part 3. Fluid-Structure Interaction, Stress Distribution and Plaque Rupture in Arterial Wall - p. 295 26. Chapter 13. In vitro, primarily microfluidic models for atherosclerosis - p. 299 27. Chapter 14. Prediction of the coronary plaque growth and vulnerability change by using patient-specific 3D fluid–structure interaction models based on intravascular ultrasound and optical coherence tomography follow-up data - p. 315 28. Chapter 15. Atheromatous plaque initiation and growth: a multiphysical process explored by an in silico mass transport model - p. 335 29. Chapter 16. Emergent biomechanical factors predicting vulnerable coronary atherosclerotic plaque rupture - p. 361 30. Chapter 17. Microcalcifications and plaque rupture - p. 381 31. Chapter 18. Identification of coronary plaque mechanical properties from ex vivo testing - p. 411 32. Chapter 19. Importance of residual stress and basal tone in healthy and pathological human coronary arteries - p. 433 33. Part 4. Imaging Inflammatory Biomarkers For in Vivo Intravascular Plaque Characterization - p. 461 34. Chapter 20. Intravascular ultrasound imaging of human coronary atherosclerotic plaque: Novel morpho-elastic biomarkers of instability - p. 465 35. Chapter 21. Magnetic resonance elastography for arterial wall characterization - p. 491 36. Chapter 22. Noninvasive ultrafast ultrasound for imaging the coronary vasculature and assessing the arterial wall's biomechanics - p. 517 37. Chapter 23. Pulse wave imaging for the mechanical assessment of atherosclerotic plaques - p. 529 38. Part 5. Stenting, Coated Balloon Protocols and Modelling - p. 542 39. Chapter 24. Structure-function relation in the coronary artery tree: theory and applications in interventional cardiology - p. 545 40. Chapter 25. Sequential technique for the stenting of a coronary bifurcation: the re-proximal optimizing technique strategy - p. 555 41. Chapter 26. Modeling the stent deployment in coronary arteries and coronary bifurcations - p. 563 42. Chapter 27. The coated balloon protocol: an emergent clinical technique - p. 583 43. Chapter 28. Endovascular drug-delivery and drug-elution systems - p. 595 44. Index - p. 633
Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient, First Edition, is the first comprehensive text to focus on important biomechanical studies conducted in the last decade that have increased our understanding of coronary atherosclerotic plaque initiation, growth, and rupture, as well as improving the design of medical devices and clinical interventions, including surgical procedures. The book provides students, researchers, engineers, clinicians, and interventional cardiologists with an overview of the main topics related to the biomechanics of atherosclerosis, in a single volume written by several experts in the field.
This volume is part of the Biomechanics of Living Organs book series. The biomechanics of human soft tissues and organs has been an emerging research field since the publication of Y.C. Fung’s original book series in the 1990s. The publication of such books entirely dedicated to a specific biomechanical subject is necessary to advance scientific research in the field of biomechanics and to transfer important knowledge to future generations. Therefore, this series of volumes on the biomechanics of living organs has been created. This series began in July 2017 with the publication of a first volume on the fundamentals of Hyperelastic Constitutive Laws for Finite Element Modeling of Living Organs. The current volume on the Biomechanics of Coronary Atherosclerotic Plaque, is the latest in this new series.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. iii 4. Biomechanics of Living Organs Series - p. ii 5. Copyright - p. iv 6. Contributors - p. xix 7. Note of the Series Editors - p. xxv 8. Editor's Biography - p. xxvii 9. Foreword - p. xxix 10. Preface - p. xxxi 11. Part 1. Biology, Physiopathology, Hemodynamics, Myogenic Responses and Clinical Intravascular Imaging of The Coronary Vascular Wall - p. xxxii 12. Chapter 1. Biomechanical regulation of endothelial function in atherosclerosis - p. 3 13. Chapter 2. Molecular mechanisms of the vascular responses to hemodynamic forces - p. 49 14. Chapter 3. Advanced atherosclerotic plaques in animal models versus human lesions: Key elements to translation - p. 85 15. Chapter 4. Modeling the Glagov's compensatory enlargement of human coronary atherosclerotic plaque - p. 107 16. Chapter 5. Measuring coronary arterial compliance and vasomotor response noninvasively in clinical and research settings - p. 131 17. Chapter 6. Coronary intravascular ultrasound and optical coherence tomography imaging and clinical contexts in coronary hemodynamics - p. 149 18. Chapter 7. The interaction of biochemical, biomechanical, and clinical factors of coronary disease - p. 171 19. Part 2. Modeling Blood Flow in Arterial Branches and Bifurcations - p. 190 20. Chapter 8. Local blood flow parameters and atherosclerosis in coronary artery bifurcations - p. 193 21. Chapter 9. Effect of regional analysis methods on assessing the association between wall shear stress and coronary artery disease progression in the clinical setting - p. 203 22. Chapter 10. Hemodynamic disturbance due to serial stenosis in human coronary bifurcations: a computational fluid dynamics study - p. 225 23. Chapter 11. Hemodynamic perturbations due to the presence of stents - p. 251 24. Chapter 12. A new reduced-order model to assess the true fractional flow reserve of a left main coronary artery stenosis with downstream lesions and collateral circulations: an in vitro study - p. 273 25. Part 3. Fluid-Structure Interaction, Stress Distribution and Plaque Rupture in Arterial Wall - p. 295 26. Chapter 13. In vitro, primarily microfluidic models for atherosclerosis - p. 299 27. Chapter 14. Prediction of the coronary plaque growth and vulnerability change by using patient-specific 3D fluid–structure interaction models based on intravascular ultrasound and optical coherence tomography follow-up data - p. 315 28. Chapter 15. Atheromatous plaque initiation and growth: a multiphysical process explored by an in silico mass transport model - p. 335 29. Chapter 16. Emergent biomechanical factors predicting vulnerable coronary atherosclerotic plaque rupture - p. 361 30. Chapter 17. Microcalcifications and plaque rupture - p. 381 31. Chapter 18. Identification of coronary plaque mechanical properties from ex vivo testing - p. 411 32. Chapter 19. Importance of residual stress and basal tone in healthy and pathological human coronary arteries - p. 433 33. Part 4. Imaging Inflammatory Biomarkers For in Vivo Intravascular Plaque Characterization - p. 461 34. Chapter 20. Intravascular ultrasound imaging of human coronary atherosclerotic plaque: Novel morpho-elastic biomarkers of instability - p. 465 35. Chapter 21. Magnetic resonance elastography for arterial wall characterization - p. 491 36. Chapter 22. Noninvasive ultrafast ultrasound for imaging the coronary vasculature and assessing the arterial wall's biomechanics - p. 517 37. Chapter 23. Pulse wave imaging for the mechanical assessment of atherosclerotic plaques - p. 529 38. Part 5. Stenting, Coated Balloon Protocols and Modelling - p. 542 39. Chapter 24. Structure-function relation in the coronary artery tree: theory and applications in interventional cardiology - p. 545 40. Chapter 25. Sequential technique for the stenting of a coronary bifurcation: the re-proximal optimizing technique strategy - p. 555 41. Chapter 26. Modeling the stent deployment in coronary arteries and coronary bifurcations - p. 563 42. Chapter 27. The coated balloon protocol: an emergent clinical technique - p. 583 43. Chapter 28. Endovascular drug-delivery and drug-elution systems - p. 595 44. Index - p. 633
