Bioprocess Engineering of Reactions, Fourth Edition is a systematic and comprehensive resource that explores principles and analysis of reactions within the bioprocess and biotechnology industries. The book provides a step-by-step guide to understanding batch, continuous, and fed-batch reactor operations, reflecting the growth behavior of cells through various phases. It introduces innovative pinch methods for optimizing batch reactors without relying on complex mathematical models while also addressing the intricacies of enzymatic systems and the impact of phase separation on reaction dynamics. Topics covered include biomolecular reaction basics, ideal flow reactors, batch fermentation, continuous culture, and the engineering of cells.
Other sections emphasize sustainability and stability in bioprocess operations while discussing critical factors such as reactivity hazards and biohazards. With a focus on mass and heat transfer, reactor design, and real reactor deviations, the book equips readers with the knowledge to navigate the complexities of bioprocess engineering. It will be an invaluable resource for bioprocess engineers, researchers, and students in in biotechnology, chemical engineering, and molecular biology. By linking reactor operations to specific cell growth patterns and providing insights into optimization strategies, the book also empowers professionals to enhance productivity and ensure safety in their bioprocess endeavors.
1. Chapter 1. Introduction - p. 1 2. Chapter 2. Biomolecular reaction basics - p. 17 3. Abstract - p. 17 4. 2.1 Biomolecules - p. 17 5. 2.2 Chemical reactions - p. 19 6. 2.3 Reaction equilibrium thermodynamics - p. 21 7. 2.4 Reaction rates - p. 26 8. 2.5 Stoichiometry - p. 34 9. 2.6 Classification of multiple reactions and selectivity - p. 40 10. 2.7 Kinetics of molecular transformations - p. 41 11. 2.8 Reactors - p. 59 12. 2.9 Reactor mass balances - p. 59 13. 2.10 Reactor energy balances - p. 60 14. 2.11 Bioprocess system optimization - p. 65 15. 2.12 Summary - p. 68 16. Problems - p. 72 17. Chapter 3. Batch reactor - p. 77 18. Chapter 4. Ideal flow r̥reactors - p. 111 19. Abstract - p. 111 20. 4.1 Commonly useful parameters - p. 112 21. 4.2 Plug flow reactor - p. 114 22. 4.3 Continuous stirred tank reactor and chemostat - p. 121 23. 4.4 Multiple reactors - p. 130 24. 4.5 Recycle reactors - p. 135 25. 4.6 Plug flow reactor with distributed feeding and withdrawing - p. 138 26. 4.7 Reactive distillation - p. 144 27. 4.8 Plug flow reactor or continuous stirred tank reactor? - p. 146 28. 4.9 Steady nonisothermal flow reactors - p. 149 29. 4.10 Reactive extraction - p. 155 30. 4.11 Graphic solutions using batch concentration data - p. 157 31. 4.12 Summary - p. 160 32. 4.13 Problems - p. 161 33. Further reading - p. 170 34. Chapter 5. Enzymatic reaction engineering - p. 171 35. Chapter 6. Batch fermentation - p. 209 36. Chapter 7. Continuous culture - p. 239 37. Chapter 8. Semibatch cultivation - p. 287 38. Chapter 9. Engineering of cells - p. 317 39. Chapter 10. Sustainability and stability - p. 353 40. Abstract - p. 353 41. 10.1 Feed stability of a continuous stirred-tank reactor - p. 355 42. 10.3 Approaching steady state - p. 376 43. 10.4 Catalyst instability - p. 379 44. 10.5 Genetic instability - p. 384 45. 10.6 Mixed cultures - p. 395 46. 10.7 Sustainability of mixed culture - p. 403 47. 10.8 Summary - p. 407 48. Problems - p. 408 49. Further reading - p. 412 50. Chapter 11. Combustion, reactive hazard, and bioprocess safety - p. 416 51. Chapter 12. Mass transfer effects: immobilized and heterogeneous reaction systems - p. 473 52. Abstract - p. 473 53. 12.1 How reaction occurs in a heterogeneous system? - p. 473 54. 12.2 Molecular diffusion and mass transfer rate - p. 475 55. 12.3 External mass transfer - p. 477 56. 12.4 Are kinetic constants of microbial growth dependent on cell size? - p. 480 57. 12.5 Reactions in isothermal porous catalysts - p. 486 58. 12.6 Mass transfer effects in nonisothermal porous particles - p. 496 59. 12.7 Encapsulation immobilization - p. 501 60. 12.8 Combined external and internal mass transfer effects - p. 505 61. 12.9 The shrinking core model - p. 505 62. 12.10 Summary - p. 511 63. Problems - p. 514 64. References - p. 519 65. Further reading - p. 519 66. Chapter 13. Real reactors and residence-time distributions - p. 521 67. Chapter 14. Bioprocess analytics and control - p. 559 68. Chapter 15. Bioreactor design and operation - p. 595 69. Index - p. 639
Bioprocess Engineering of Reactions, Fourth Edition is a systematic and comprehensive resource that explores principles and analysis of reactions within the bioprocess and biotechnology industries. The book provides a step-by-step guide to understanding batch, continuous, and fed-batch reactor operations, reflecting the growth behavior of cells through various phases. It introduces innovative pinch methods for optimizing batch reactors without relying on complex mathematical models while also addressing the intricacies of enzymatic systems and the impact of phase separation on reaction dynamics. Topics covered include biomolecular reaction basics, ideal flow reactors, batch fermentation, continuous culture, and the engineering of cells.
Other sections emphasize sustainability and stability in bioprocess operations while discussing critical factors such as reactivity hazards and biohazards. With a focus on mass and heat transfer, reactor design, and real reactor deviations, the book equips readers with the knowledge to navigate the complexities of bioprocess engineering. It will be an invaluable resource for bioprocess engineers, researchers, and students in in biotechnology, chemical engineering, and molecular biology. By linking reactor operations to specific cell growth patterns and providing insights into optimization strategies, the book also empowers professionals to enhance productivity and ensure safety in their bioprocess endeavors.
1. Chapter 1. Introduction - p. 1 2. Chapter 2. Biomolecular reaction basics - p. 17 3. Abstract - p. 17 4. 2.1 Biomolecules - p. 17 5. 2.2 Chemical reactions - p. 19 6. 2.3 Reaction equilibrium thermodynamics - p. 21 7. 2.4 Reaction rates - p. 26 8. 2.5 Stoichiometry - p. 34 9. 2.6 Classification of multiple reactions and selectivity - p. 40 10. 2.7 Kinetics of molecular transformations - p. 41 11. 2.8 Reactors - p. 59 12. 2.9 Reactor mass balances - p. 59 13. 2.10 Reactor energy balances - p. 60 14. 2.11 Bioprocess system optimization - p. 65 15. 2.12 Summary - p. 68 16. Problems - p. 72 17. Chapter 3. Batch reactor - p. 77 18. Chapter 4. Ideal flow r̥reactors - p. 111 19. Abstract - p. 111 20. 4.1 Commonly useful parameters - p. 112 21. 4.2 Plug flow reactor - p. 114 22. 4.3 Continuous stirred tank reactor and chemostat - p. 121 23. 4.4 Multiple reactors - p. 130 24. 4.5 Recycle reactors - p. 135 25. 4.6 Plug flow reactor with distributed feeding and withdrawing - p. 138 26. 4.7 Reactive distillation - p. 144 27. 4.8 Plug flow reactor or continuous stirred tank reactor? - p. 146 28. 4.9 Steady nonisothermal flow reactors - p. 149 29. 4.10 Reactive extraction - p. 155 30. 4.11 Graphic solutions using batch concentration data - p. 157 31. 4.12 Summary - p. 160 32. 4.13 Problems - p. 161 33. Further reading - p. 170 34. Chapter 5. Enzymatic reaction engineering - p. 171 35. Chapter 6. Batch fermentation - p. 209 36. Chapter 7. Continuous culture - p. 239 37. Chapter 8. Semibatch cultivation - p. 287 38. Chapter 9. Engineering of cells - p. 317 39. Chapter 10. Sustainability and stability - p. 353 40. Abstract - p. 353 41. 10.1 Feed stability of a continuous stirred-tank reactor - p. 355 42. 10.3 Approaching steady state - p. 376 43. 10.4 Catalyst instability - p. 379 44. 10.5 Genetic instability - p. 384 45. 10.6 Mixed cultures - p. 395 46. 10.7 Sustainability of mixed culture - p. 403 47. 10.8 Summary - p. 407 48. Problems - p. 408 49. Further reading - p. 412 50. Chapter 11. Combustion, reactive hazard, and bioprocess safety - p. 416 51. Chapter 12. Mass transfer effects: immobilized and heterogeneous reaction systems - p. 473 52. Abstract - p. 473 53. 12.1 How reaction occurs in a heterogeneous system? - p. 473 54. 12.2 Molecular diffusion and mass transfer rate - p. 475 55. 12.3 External mass transfer - p. 477 56. 12.4 Are kinetic constants of microbial growth dependent on cell size? - p. 480 57. 12.5 Reactions in isothermal porous catalysts - p. 486 58. 12.6 Mass transfer effects in nonisothermal porous particles - p. 496 59. 12.7 Encapsulation immobilization - p. 501 60. 12.8 Combined external and internal mass transfer effects - p. 505 61. 12.9 The shrinking core model - p. 505 62. 12.10 Summary - p. 511 63. Problems - p. 514 64. References - p. 519 65. Further reading - p. 519 66. Chapter 13. Real reactors and residence-time distributions - p. 521 67. Chapter 14. Bioprocess analytics and control - p. 559 68. Chapter 15. Bioreactor design and operation - p. 595 69. Index - p. 639
