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This issue of Hematology/Oncology Clinics of North America, guest edited by Dr. Joaquin Bellmunt, is devoted to Bladder Cancer. Articles in this issue include: Diagnosis and Staging of Bladder Cancer; Epidemiology of Bladder Cancer; Molecular Biology of Bladder Cancer; Pharmacogenomics in Bladder Cancer; Management of Non-muscle Invasive Bladder Cancer; Non-urothelial Bladder Cancer and Rare Variant Histologies; Management of UUT; New Trends in Surgical Management of Bladder Cancer; Bladder Preservation Strategies; Perioperative Therapy of Bladder Cancer (Neoadjuvant and Adjuvant); First Line Treatment and Prognostic Factors of Metastatic Disease: Platinum Eligible Patients; First Line Treatment of Metastatic Disease: Platinum Ineligible Patients; Salvage Therapy in Metastatic Disease; and Future Directions and Targeted Therapies in Bladder Cancer.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 8 7. Preface: Bladder Cancer - p. 9 8. Erratum - p. 10 9. Epidemiology of Bladder Cancer - p. 11 10. Molecular Biology of Bladder Cancer - p. 18 11. Diagnosis and Staging of Bladder Cancer - p. 25 12. Management of Low-risk and Intermediate-risk Non–Muscle-invasive Bladder Carcinoma - p. 34 13. High-Risk Nonmuscle Invasive Bladder Cancer - p. 38 14. Nonurothelial Bladder Cancer and Rare Variant Histologies - p. 43 15. New Trends in the Surgical Management of Invasive Bladder Cancer - p. 52 16. Diagnosis and Management of Upper Tract Urothelial Carcinoma - p. 61 17. Bladder Preservation Strategies - p. 73 18. Perioperative Therapy for Muscle Invasive Bladder Cancer - p. 80 19. First-Line Treatment and Prognostic Factors of Metastatic Bladder Cancer for Platinum-Eligible Patients - p. 90 20. First-line Treatment of Metastatic Disease - p. 96 21. Second-Line Therapies in Metastatic Urothelial Carcinoma - p. 103 22. Future Directions and Targeted Therapies in Bladder Cancer - p. 113 23. Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer - p. 123 24. Index - p. 133

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This issue of Hematology/Oncology Clinics of North America, guest edited by Dr. Joaquin Bellmunt, is devoted to Bladder Cancer. Articles in this issue include: Diagnosis and Staging of Bladder Cancer; Epidemiology of Bladder Cancer; Molecular Biology of Bladder Cancer; Pharmacogenomics in Bladder Cancer; Management of Non-muscle Invasive Bladder Cancer; Non-urothelial Bladder Cancer and Rare Variant Histologies; Management of UUT; New Trends in Surgical Management of Bladder Cancer; Bladder Preservation Strategies; Perioperative Therapy of Bladder Cancer (Neoadjuvant and Adjuvant); First Line Treatment and Prognostic Factors of Metastatic Disease: Platinum Eligible Patients; First Line Treatment of Metastatic Disease: Platinum Ineligible Patients; Salvage Therapy in Metastatic Disease; and Future Directions and Targeted Therapies in Bladder Cancer.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 8 7. Preface: Bladder Cancer - p. 9 8. Erratum - p. 10 9. Epidemiology of Bladder Cancer - p. 11 10. Molecular Biology of Bladder Cancer - p. 18 11. Diagnosis and Staging of Bladder Cancer - p. 25 12. Management of Low-risk and Intermediate-risk Non–Muscle-invasive Bladder Carcinoma - p. 34 13. High-Risk Nonmuscle Invasive Bladder Cancer - p. 38 14. Nonurothelial Bladder Cancer and Rare Variant Histologies - p. 43 15. New Trends in the Surgical Management of Invasive Bladder Cancer - p. 52 16. Diagnosis and Management of Upper Tract Urothelial Carcinoma - p. 61 17. Bladder Preservation Strategies - p. 73 18. Perioperative Therapy for Muscle Invasive Bladder Cancer - p. 80 19. First-Line Treatment and Prognostic Factors of Metastatic Bladder Cancer for Platinum-Eligible Patients - p. 90 20. First-line Treatment of Metastatic Disease - p. 96 21. Second-Line Therapies in Metastatic Urothelial Carcinoma - p. 103 22. Future Directions and Targeted Therapies in Bladder Cancer - p. 113 23. Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer - p. 123 24. Index - p. 133

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