Current, comprehensive, and evidence-based Braunwald’s Heart Disease remains the most trusted reference in the field and the leading source of reliable cardiology information for practitioners and trainees worldwide. The fully updated 12th Edition continues the tradition of excellence with dependable, state-of-the-art coverage of new drugs, new guidelines, more powerful imaging modalities, and recent developments in precision medicine that continue to change and advance the practice of cardiovascular medicine. Written and edited by global experts in the field, this award-winning text is an unparalleled multimedia reference for every aspect of this complex and fast-changing area.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Contributors - p. iii 7. Preface - p. iii 8. Preface to the First Edition - p. iii 9. Acknowledgments - p. iii 10. List of Illustrations - p. iii 11. List of Tables - p. iii 12. Part I: Foundations of Cardiovascular Medicine - p. iii 13. Chapter 1: Cardiovascular Disease: Past, Present, and Future - p. iii 14. Chapter 2: Global Burden of Cardiovascular Disease - p. g11 15. Chapter 3: Impact of the Environment on Cardiovascular Health - p. g29 16. Chapter 4: Clinical Trials in Cardiovascular Medicine - p. g39.e1 17. Chapter 5: Clinical Decision-Making in Cardiology - p. g52 18. Chapter 6: Impact of Health Care Policy on Quality, Outcomes, and Equity in Cardiovascular Disease - p. g61 19. Part II: Individualizing Approaches to Cardiovascular Disease - p. g68 20. Chapter 7: Applications of Genetics to Cardiovascular Medicine - p. g68 21. Chapter 8: Proteomics and Metabolomics in Cardiovascular Medicine - p. g85 22. Chapter 9: Principles of Drug Therapeutics, Pharmacogenomics, and Biologics - p. g91 23. Chapter 10: Biomarkers and Use in Precision Medicine - p. g101 24. Chapter 11: Artificial Intelligence in Cardiovascular Medicine - p. g107 25. Chapter 12: Wearable Devices in Cardiovascular Medicine - p. g114 26. Part III: Evaluation of The Patient - p. g122 27. Chapter 13: History and Physical Examination: An Evidence-Based Approach - p. g122 28. Chapter 14: Electrocardiography - p. g139 29. Chapter 15: Exercise Physiology and Exercise Electrocardiographic Testing - p. g174 30. Chapter 16: Echocardiography - p. g194 31. Chapter 17: Chest Radiography in Cardiovascular Disease - p. g266 32. Chapter 18: Nuclear Cardiology - p. g276 33. Chapter 19: Cardiovascular Magnetic Resonance Imaging - p. g312 34. Chapter 20: Cardiac Computed Tomography - p. g333 35. Chapter 21: Coronary Angiography and Intravascular Imaging - p. g360 36. Chapter 22: Invasive Hemodynamic Diagnosis of Cardiac Disease - p. g383 37. Chapter 23: Anesthesia and Noncardiac Surgery in Patients with Heart Disease - p. g409 38. Part IV: Preventive Cardiology - p. g423 39. Chapter 24: The Vascular Biology of Atherosclerosis - p. g423 40. Chapter 25: Primary Prevention of Cardiovascular Disease - p. g440 41. Chapter 26: Systemic Hypertension: Mechanisms, Diagnosis, and Treatment - p. g468 42. Chapter 27: Lipoprotein Disorders and Cardiovascular Disease - p. g498 43. Chapter 28: Cardiovascular Disease Risk of Nicotine and Tobacco Products - p. g523 44. Chapter 29: Nutrition and Cardiovascular and Metabolic Diseases - p. g530 45. Chapter 30: Obesity: Medical and Surgical Management - p. g541 46. Chapter 31: Diabetes and the Cardiovascular System - p. g555 47. Chapter 32: Exercise and Sports Cardiology - p. g577 48. Chapter 33: Comprehensive Cardiac Rehabilitation - p. g586 49. Chapter 34: Integrative Approaches to the Management of Patients with Heart Disease - p. g591 50. Part V: Atherosclerotic Cardiovascular Disease - p. g597 51. Chapter 35: Approach to the Patient with Chest Pain - p. g597 52. Chapter 36: Coronary Blood Flow and Myocardial Ischemia - p. g606 53. Chapter 37: ST-Elevation Myocardial Infarction: Pathophysiology and Clinical Evolution - p. g634 54. Chapter 38: ST-Elevation Myocardial Infarction: Management - p. g660 55. Chapter 39: Non–ST Elevation Acute Coronary Syndromes - p. g709.e1 56. Chapter 40: Stable Ischemic Heart Disease - p. g735.e1 57. Chapter 41: Percutaneous Coronary Intervention - p. g780.e1 58. Chapter 42: Diseases of the Aorta - p. g802.e1 59. Chapter 43: Peripheral Artery Diseases - p. g834.e1 60. Chapter 44: Treatment of Noncoronary Obstructive Vascular Disease - p. g856 61. Chapter 45: Prevention and Management of Ischemic Stroke - p. g867.e1 62. Part VI: Heart Failure - p. g887 63. Chapter 46: Mechanisms of Cardiac Contraction and Relaxation - p. g887 64. Chapter 47: Pathophysiology of Heart Failure - p. g911 65. Chapter 48: Approach to the Patient with Heart Failure - p. g930.e1 66. Chapter 49: Diagnosis and Management of Acute Heart Failure - p. g944 67. Chapter 50: Management of Heart Failure Patients with Reduced Ejection Fraction - p. g972 68. Chapter 51: Heart Failure with Preserved and Mildly Reduced Ejection Fraction - p. g1005 69. Chapter 52: The Dilated, Restrictive, and Infiltrative Cardiomyopathies - p. g1005 70. Chapter 53: Cardiac Amyloidosis - p. g1048.e1 71. Chapter 54: Hypertrophic Cardiomyopathy - p. g1060 72. Chapter 55: Myocarditis - p. g1075 73. Chapter 56: Cardio-Oncology: Managing Cardiotoxic Effects of Cancer Therapies - p. g1089 74. Chapter 57: Cardio-Oncology: Approach to the Patient - p. g1097.e1 75. Chapter 58: Devices for Monitoring and Managing Heart Failure - p. g1106 76. Chapter 59: Mechanical Circulatory Support - p. g1118 77. Chapter 60: Cardiac Transplantation - p. g1131 78. Part VII: Arrhythmias, Sudden Death, and Syncope - p. g1143 79. Chapter 61: Approach to the Patient with Cardiac Arrhythmias - p. g1143 80. Chapter 62: Mechanisms of Cardiac Arrhythmias - p. g1160 81. Chapter 63: Genetics of Cardiac Arrhythmias - p. g1189 82. Chapter 64: Therapy for Cardiac Arrhythmias - p. g1207 83. Chapter 65: Supraventricular Tachycardias - p. g1243 84. Chapter 66: Atrial Fibrillation: Clinical Features, Mechanisms, and Management - p. g1271 85. Chapter 67: Ventricular Arrhythmias - p. g1285 86. Chapter 68: Bradyarrhythmias and Atrioventricular Block - p. g1310 87. Chapter 69: Pacemakers and Implantable Cardioverter-Defibrillators - p. g1320 88. Chapter 70: Cardiac Arrest and Sudden Cardiac Death - p. g1347 89. Chapter 71: Hypotension and Syncope - p. g1384 90. Part VIII: Diseases of the Heart Valves - p. g1397 91. Chapter 72: Aortic Valve Stenosis - p. g1397 92. Chapter 73: Aortic Regurgitation - p. g1416 93. Chapter 74: Transcatheter Aortic Valve Replacement - p. g1429 94. Chapter 75: Mitral Stenosis - p. g1439 95. Chapter 76: Mitral Regurgitation - p. g1453 96. Chapter 77: Tricuspid, Pulmonic, and Multivalvular Disease - p. g1471 97. Chapter 78: Transcatheter Therapies for Mitral and Tricuspid Valvular Heart Disease - p. g1483 98. Chapter 79: Prosthetic Heart Valves - p. g1493 99. Chapter 80: Infectious Endocarditis and Infections of Indwelling Devices - p. g1503 100. Chapter 81: Rheumatic Fever - p. g1529 101. Part IX: Diseases of the Myocardium, Pericardium, and Pulmonary Vasculature Bed - p. g1538 102. Chapter 82: Congenital Heart Disease in the Adolescent and Adult - p. g1538 103. Chapter 83: Catheter-Based Treatment of Congenital Heart Disease in Adults - p. g1585 104. Chapter 84: Cardiomyopathies Induced by Drugs or Toxins - p. g1592 105. Chapter 85: Cardiovascular Abnormalities in HIV-Infected Individuals - p. g1601 106. Chapter 86: Pericardial Diseases - p. g1613 107. Chapter 87: Pulmonary Embolism and Deep Vein Thrombosis - p. g1633 108. Chapter 88: Pulmonary Hypertension - p. g1653 109. Chapter 89: Sleep-Disordered Breathing and Cardiac Disease - p. g1676 110. Part X: Cardiovascular Disease in Select Populations - p. g1685 111. Chapter 90: Cardiovascular Disease in Older Adults - p. g1685 112. Chapter 91: Cardiovascular Disease in Women - p. g1707 113. Chapter 92: Pregnancy and Heart Disease - p. g1721 114. Chapter 93: Heart Disease in Racially and Ethnically Diverse Populations - p. g1740.e1 115. Part XI: Cardiovascular Disease and Disorders of Other Organs - p. g1748 116. Chapter 94: Endemic and Pandemic Viral Illnesses and Cardiovascular Disease: Influenza and COVID-19 - p. g1748 117. Chapter 95: Hemostasis, Thrombosis, Fibrinolysis, and Cardiovascular Disease - p. g1763 118. Chapter 96: Endocrine Disorders and Cardiovascular Disease - p. g1789 119. Chapter 97: Rheumatic Diseases and the Cardiovascular System - p. g1804.e1 120. Chapter 98: Tumors Affecting the Cardiovascular System - p. g1827 121. Chapter 99: Psychiatric and Psychosocial Aspects of Cardiovascular Disease - p. g1838 122. Chapter 100: Neuromuscular Disorders and Cardiovascular Disease - p. g1850.e1 123. Chapter 101: Interface Between Renal Disease and Cardiovascular Illness - p. g1870.e1 124. Chapter 102: Cardiovascular Manifestations of Autonomic Disorders - p. g1891 125. Disclosure Index - p. g1901 126. Index - p. gDI-4
Current, comprehensive, and evidence-based Braunwald’s Heart Disease remains the most trusted reference in the field and the leading source of reliable cardiology information for practitioners and trainees worldwide. The fully updated 12th Edition continues the tradition of excellence with dependable, state-of-the-art coverage of new drugs, new guidelines, more powerful imaging modalities, and recent developments in precision medicine that continue to change and advance the practice of cardiovascular medicine. Written and edited by global experts in the field, this award-winning text is an unparalleled multimedia reference for every aspect of this complex and fast-changing area.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedication - p. iii 6. Contributors - p. iii 7. Preface - p. iii 8. Preface to the First Edition - p. iii 9. Acknowledgments - p. iii 10. List of Illustrations - p. iii 11. List of Tables - p. iii 12. Part I: Foundations of Cardiovascular Medicine - p. iii 13. Chapter 1: Cardiovascular Disease: Past, Present, and Future - p. iii 14. Chapter 2: Global Burden of Cardiovascular Disease - p. g11 15. Chapter 3: Impact of the Environment on Cardiovascular Health - p. g29 16. Chapter 4: Clinical Trials in Cardiovascular Medicine - p. g39.e1 17. Chapter 5: Clinical Decision-Making in Cardiology - p. g52 18. Chapter 6: Impact of Health Care Policy on Quality, Outcomes, and Equity in Cardiovascular Disease - p. g61 19. Part II: Individualizing Approaches to Cardiovascular Disease - p. g68 20. Chapter 7: Applications of Genetics to Cardiovascular Medicine - p. g68 21. Chapter 8: Proteomics and Metabolomics in Cardiovascular Medicine - p. g85 22. Chapter 9: Principles of Drug Therapeutics, Pharmacogenomics, and Biologics - p. g91 23. Chapter 10: Biomarkers and Use in Precision Medicine - p. g101 24. Chapter 11: Artificial Intelligence in Cardiovascular Medicine - p. g107 25. Chapter 12: Wearable Devices in Cardiovascular Medicine - p. g114 26. Part III: Evaluation of The Patient - p. g122 27. Chapter 13: History and Physical Examination: An Evidence-Based Approach - p. g122 28. Chapter 14: Electrocardiography - p. g139 29. Chapter 15: Exercise Physiology and Exercise Electrocardiographic Testing - p. g174 30. Chapter 16: Echocardiography - p. g194 31. Chapter 17: Chest Radiography in Cardiovascular Disease - p. g266 32. Chapter 18: Nuclear Cardiology - p. g276 33. Chapter 19: Cardiovascular Magnetic Resonance Imaging - p. g312 34. Chapter 20: Cardiac Computed Tomography - p. g333 35. Chapter 21: Coronary Angiography and Intravascular Imaging - p. g360 36. Chapter 22: Invasive Hemodynamic Diagnosis of Cardiac Disease - p. g383 37. Chapter 23: Anesthesia and Noncardiac Surgery in Patients with Heart Disease - p. g409 38. Part IV: Preventive Cardiology - p. g423 39. Chapter 24: The Vascular Biology of Atherosclerosis - p. g423 40. Chapter 25: Primary Prevention of Cardiovascular Disease - p. g440 41. Chapter 26: Systemic Hypertension: Mechanisms, Diagnosis, and Treatment - p. g468 42. Chapter 27: Lipoprotein Disorders and Cardiovascular Disease - p. g498 43. Chapter 28: Cardiovascular Disease Risk of Nicotine and Tobacco Products - p. g523 44. Chapter 29: Nutrition and Cardiovascular and Metabolic Diseases - p. g530 45. Chapter 30: Obesity: Medical and Surgical Management - p. g541 46. Chapter 31: Diabetes and the Cardiovascular System - p. g555 47. Chapter 32: Exercise and Sports Cardiology - p. g577 48. Chapter 33: Comprehensive Cardiac Rehabilitation - p. g586 49. Chapter 34: Integrative Approaches to the Management of Patients with Heart Disease - p. g591 50. Part V: Atherosclerotic Cardiovascular Disease - p. g597 51. Chapter 35: Approach to the Patient with Chest Pain - p. g597 52. Chapter 36: Coronary Blood Flow and Myocardial Ischemia - p. g606 53. Chapter 37: ST-Elevation Myocardial Infarction: Pathophysiology and Clinical Evolution - p. g634 54. Chapter 38: ST-Elevation Myocardial Infarction: Management - p. g660 55. Chapter 39: Non–ST Elevation Acute Coronary Syndromes - p. g709.e1 56. Chapter 40: Stable Ischemic Heart Disease - p. g735.e1 57. Chapter 41: Percutaneous Coronary Intervention - p. g780.e1 58. Chapter 42: Diseases of the Aorta - p. g802.e1 59. Chapter 43: Peripheral Artery Diseases - p. g834.e1 60. Chapter 44: Treatment of Noncoronary Obstructive Vascular Disease - p. g856 61. Chapter 45: Prevention and Management of Ischemic Stroke - p. g867.e1 62. Part VI: Heart Failure - p. g887 63. Chapter 46: Mechanisms of Cardiac Contraction and Relaxation - p. g887 64. Chapter 47: Pathophysiology of Heart Failure - p. g911 65. Chapter 48: Approach to the Patient with Heart Failure - p. g930.e1 66. Chapter 49: Diagnosis and Management of Acute Heart Failure - p. g944 67. Chapter 50: Management of Heart Failure Patients with Reduced Ejection Fraction - p. g972 68. Chapter 51: Heart Failure with Preserved and Mildly Reduced Ejection Fraction - p. g1005 69. Chapter 52: The Dilated, Restrictive, and Infiltrative Cardiomyopathies - p. g1005 70. Chapter 53: Cardiac Amyloidosis - p. g1048.e1 71. Chapter 54: Hypertrophic Cardiomyopathy - p. g1060 72. Chapter 55: Myocarditis - p. g1075 73. Chapter 56: Cardio-Oncology: Managing Cardiotoxic Effects of Cancer Therapies - p. g1089 74. Chapter 57: Cardio-Oncology: Approach to the Patient - p. g1097.e1 75. Chapter 58: Devices for Monitoring and Managing Heart Failure - p. g1106 76. Chapter 59: Mechanical Circulatory Support - p. g1118 77. Chapter 60: Cardiac Transplantation - p. g1131 78. Part VII: Arrhythmias, Sudden Death, and Syncope - p. g1143 79. Chapter 61: Approach to the Patient with Cardiac Arrhythmias - p. g1143 80. Chapter 62: Mechanisms of Cardiac Arrhythmias - p. g1160 81. Chapter 63: Genetics of Cardiac Arrhythmias - p. g1189 82. Chapter 64: Therapy for Cardiac Arrhythmias - p. g1207 83. Chapter 65: Supraventricular Tachycardias - p. g1243 84. Chapter 66: Atrial Fibrillation: Clinical Features, Mechanisms, and Management - p. g1271 85. Chapter 67: Ventricular Arrhythmias - p. g1285 86. Chapter 68: Bradyarrhythmias and Atrioventricular Block - p. g1310 87. Chapter 69: Pacemakers and Implantable Cardioverter-Defibrillators - p. g1320 88. Chapter 70: Cardiac Arrest and Sudden Cardiac Death - p. g1347 89. Chapter 71: Hypotension and Syncope - p. g1384 90. Part VIII: Diseases of the Heart Valves - p. g1397 91. Chapter 72: Aortic Valve Stenosis - p. g1397 92. Chapter 73: Aortic Regurgitation - p. g1416 93. Chapter 74: Transcatheter Aortic Valve Replacement - p. g1429 94. Chapter 75: Mitral Stenosis - p. g1439 95. Chapter 76: Mitral Regurgitation - p. g1453 96. Chapter 77: Tricuspid, Pulmonic, and Multivalvular Disease - p. g1471 97. Chapter 78: Transcatheter Therapies for Mitral and Tricuspid Valvular Heart Disease - p. g1483 98. Chapter 79: Prosthetic Heart Valves - p. g1493 99. Chapter 80: Infectious Endocarditis and Infections of Indwelling Devices - p. g1503 100. Chapter 81: Rheumatic Fever - p. g1529 101. Part IX: Diseases of the Myocardium, Pericardium, and Pulmonary Vasculature Bed - p. g1538 102. Chapter 82: Congenital Heart Disease in the Adolescent and Adult - p. g1538 103. Chapter 83: Catheter-Based Treatment of Congenital Heart Disease in Adults - p. g1585 104. Chapter 84: Cardiomyopathies Induced by Drugs or Toxins - p. g1592 105. Chapter 85: Cardiovascular Abnormalities in HIV-Infected Individuals - p. g1601 106. Chapter 86: Pericardial Diseases - p. g1613 107. Chapter 87: Pulmonary Embolism and Deep Vein Thrombosis - p. g1633 108. Chapter 88: Pulmonary Hypertension - p. g1653 109. Chapter 89: Sleep-Disordered Breathing and Cardiac Disease - p. g1676 110. Part X: Cardiovascular Disease in Select Populations - p. g1685 111. Chapter 90: Cardiovascular Disease in Older Adults - p. g1685 112. Chapter 91: Cardiovascular Disease in Women - p. g1707 113. Chapter 92: Pregnancy and Heart Disease - p. g1721 114. Chapter 93: Heart Disease in Racially and Ethnically Diverse Populations - p. g1740.e1 115. Part XI: Cardiovascular Disease and Disorders of Other Organs - p. g1748 116. Chapter 94: Endemic and Pandemic Viral Illnesses and Cardiovascular Disease: Influenza and COVID-19 - p. g1748 117. Chapter 95: Hemostasis, Thrombosis, Fibrinolysis, and Cardiovascular Disease - p. g1763 118. Chapter 96: Endocrine Disorders and Cardiovascular Disease - p. g1789 119. Chapter 97: Rheumatic Diseases and the Cardiovascular System - p. g1804.e1 120. Chapter 98: Tumors Affecting the Cardiovascular System - p. g1827 121. Chapter 99: Psychiatric and Psychosocial Aspects of Cardiovascular Disease - p. g1838 122. Chapter 100: Neuromuscular Disorders and Cardiovascular Disease - p. g1850.e1 123. Chapter 101: Interface Between Renal Disease and Cardiovascular Illness - p. g1870.e1 124. Chapter 102: Cardiovascular Manifestations of Autonomic Disorders - p. g1891 125. Disclosure Index - p. g1901 126. Index - p. gDI-4
