Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room.
Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer.
Incorporates the latest classifications of breast pathology and molecular diagnosis.
Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry.
Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter.
Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting.
Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval.
Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease.
Includes biomarker guideline updates throughout.
Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Any screen, Any time, Anywhere - p. iii 5. Copyright - p. IFC1 6. Contributors - p. iv 7. List of Illustrations - p. iv 8. List of Tables - p. iv 9. Chapter 1: Breast Development, Physiology, and Histology - p. iv 10. Chapter 2: Reactive and Inflammatory Conditions of the Breast - p. 22 11. Chapter 3: Infections of the Breast - p. 45 12. Chapter 4: Epidemiology of Breast Cancer - p. 60 13. Chapter 5: Patient Safety in Breast Pathology - p. 74 14. Chapter 6: Gross Examination of Breast Specimens - p. 87 15. Chapter 7: Sentinel Lymph Node Biopsy - p. 115 16. Chapter 8: Breast Imaging Modalities for Pathologists - p. 134 17. Chapter 9: Predictive and Prognostic Marker Testing in Breast Pathology: Immunophenotypic Subclasses of Disease - p. 173 18. Chapter 10: Molecular-Based Testing in Breast Disease for Therapeutic Decisions - p. 200 19. Chapter 11: Diagnostic Immunohistology of the Breast - p. 240 20. Chapter 12: Fibroepithelial Lesions - p. 292 21. Chapter 13: Papilloma and Papillary Lesions - p. 327 22. Chapter 14: Adenosis and Microglandular Adenosis - p. 349 23. Chapter 15: Nipple Adenoma (Florid Papillomatosis of the Nipple) - p. 374 24. Chapter 16: Radial Scar - p. 386 25. Chapter 17: Myoepithelial Lesions of the Breast - p. 402 26. Chapter 18: Fibrocystic Change and Usual Epithelial Hyperplasia of Ductal Type Fibrocystic Change - p. 421 27. Chapter 19: Columnar Cell Change, Flat Epithelial Atypia, and Atypical Ductal Epithelial Hyperplasia - p. 451 28. Chapter 20: Molecular Classification of Breast Carcinoma - p. 472 29. Chapter 21: Lobular Neoplasia and Invasive Lobular Carcinoma - p. 497 30. Chapter 22: Ductal Carcinoma In Situ - p. 533 31. Chapter 23: Invasive Ductal Carcinoma of No Special Type and Histological Grade - p. 564 32. Chapter 24: Triple-Negative and Basal-like Carcinoma - p. 585 33. Chapter 25: Metaplastic Breast Carcinoma - p. 605 34. Chapter 26: Apocrine Carcinoma of the Breast - p. 638 35. Chapter 27: Paget’s Disease of the Breast - p. 653 36. Chapter 28: Pathology of Neoadjuvant Therapeutic Response of Breast Carcinoma - p. 662 37. Chapter 29: Special Types of Invasive Breast Carcinoma: Tubular Carcinoma, Cribriform Carcinoma, Mucinous Carcinoma, Micropapillary Carcinoma - p. 683 38. Chapter 30: Rare Breast Carcinomas: Adenoid Cystic Carcinoma, Neuroendocrine Carcinoma, Secretory Carcinoma, Carcinoma With Osteoclast-like Giant Cells, Lipid-Rich Carcinoma, and Glycogen-Rich Clear Cell Carcinoma - p. 716 39. Chapter 31: Mesenchymal Tumors of the Breast - p. 744 40. Chapter 32: Neoplasia of the Male Breast - p. 807 41. Chapter 33: Breast Tumors in Children and Adolescents - p. 860 42. Chapter 34: Hematolymphoid Tumors of the Breast - p. 893 43. Chapter 35: Metastatic Tumors in the Breast - p. 923 44. Chapter 36: Next-Generation Sequencing and the Management of Patients With Clinically Advanced Breast Cancer - p. 947 45. Index - p. 970 46. Confidence is ClinicalKey - p. 970
Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room.
Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer.
Incorporates the latest classifications of breast pathology and molecular diagnosis.
Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry.
Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter.
Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting.
Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval.
Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease.
Includes biomarker guideline updates throughout.
Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Any screen, Any time, Anywhere - p. iii 5. Copyright - p. IFC1 6. Contributors - p. iv 7. List of Illustrations - p. iv 8. List of Tables - p. iv 9. Chapter 1: Breast Development, Physiology, and Histology - p. iv 10. Chapter 2: Reactive and Inflammatory Conditions of the Breast - p. 22 11. Chapter 3: Infections of the Breast - p. 45 12. Chapter 4: Epidemiology of Breast Cancer - p. 60 13. Chapter 5: Patient Safety in Breast Pathology - p. 74 14. Chapter 6: Gross Examination of Breast Specimens - p. 87 15. Chapter 7: Sentinel Lymph Node Biopsy - p. 115 16. Chapter 8: Breast Imaging Modalities for Pathologists - p. 134 17. Chapter 9: Predictive and Prognostic Marker Testing in Breast Pathology: Immunophenotypic Subclasses of Disease - p. 173 18. Chapter 10: Molecular-Based Testing in Breast Disease for Therapeutic Decisions - p. 200 19. Chapter 11: Diagnostic Immunohistology of the Breast - p. 240 20. Chapter 12: Fibroepithelial Lesions - p. 292 21. Chapter 13: Papilloma and Papillary Lesions - p. 327 22. Chapter 14: Adenosis and Microglandular Adenosis - p. 349 23. Chapter 15: Nipple Adenoma (Florid Papillomatosis of the Nipple) - p. 374 24. Chapter 16: Radial Scar - p. 386 25. Chapter 17: Myoepithelial Lesions of the Breast - p. 402 26. Chapter 18: Fibrocystic Change and Usual Epithelial Hyperplasia of Ductal Type Fibrocystic Change - p. 421 27. Chapter 19: Columnar Cell Change, Flat Epithelial Atypia, and Atypical Ductal Epithelial Hyperplasia - p. 451 28. Chapter 20: Molecular Classification of Breast Carcinoma - p. 472 29. Chapter 21: Lobular Neoplasia and Invasive Lobular Carcinoma - p. 497 30. Chapter 22: Ductal Carcinoma In Situ - p. 533 31. Chapter 23: Invasive Ductal Carcinoma of No Special Type and Histological Grade - p. 564 32. Chapter 24: Triple-Negative and Basal-like Carcinoma - p. 585 33. Chapter 25: Metaplastic Breast Carcinoma - p. 605 34. Chapter 26: Apocrine Carcinoma of the Breast - p. 638 35. Chapter 27: Paget’s Disease of the Breast - p. 653 36. Chapter 28: Pathology of Neoadjuvant Therapeutic Response of Breast Carcinoma - p. 662 37. Chapter 29: Special Types of Invasive Breast Carcinoma: Tubular Carcinoma, Cribriform Carcinoma, Mucinous Carcinoma, Micropapillary Carcinoma - p. 683 38. Chapter 30: Rare Breast Carcinomas: Adenoid Cystic Carcinoma, Neuroendocrine Carcinoma, Secretory Carcinoma, Carcinoma With Osteoclast-like Giant Cells, Lipid-Rich Carcinoma, and Glycogen-Rich Clear Cell Carcinoma - p. 716 39. Chapter 31: Mesenchymal Tumors of the Breast - p. 744 40. Chapter 32: Neoplasia of the Male Breast - p. 807 41. Chapter 33: Breast Tumors in Children and Adolescents - p. 860 42. Chapter 34: Hematolymphoid Tumors of the Breast - p. 893 43. Chapter 35: Metastatic Tumors in the Breast - p. 923 44. Chapter 36: Next-Generation Sequencing and the Management of Patients With Clinically Advanced Breast Cancer - p. 947 45. Index - p. 970 46. Confidence is ClinicalKey - p. 970
