Bronchopulmonary dysplasia (BPD) as a chronic lung disease affecting preterm infants has been recognized for more than 45 years. However, little progress has been made in the prevention and treatment of the disease. BPD continues to be a major morbidity affecting preterm infants. Studies in pre-adolescent children demonstrate that the abnormal lung function from BPD persists well into childhood. Infants with BPD also have an increased risk for adverse neurodevelopmental outcome. Thus BPD imposes a significant burden of adverse health outcomes in preterm infants.
The major risk factors for BPD are prematurity, mechanical ventilation, exposure to noxious insults such as oxygen, infections. New research data both in basic science and clinical studies have shed light on the pathogenesis, and possible new treatment or management strategies for the future. In the proposed issue of the Clinics in Perinatology, we would like to comprehensively cover BPD both from a basic science and clinical perspective. Our attempt is to balance new information along with classic topics. The proposed authors for the issue are recognized experts in the topic area/s. We hope that the issue will be of interest to a broad array of readership.
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Contributors - p. Cover 6. CME Accreditation Page - p. Cover 7. Forthcoming Issues - p. Cover 8. Foreword. Why the Bronchopulmonary Dysplasia Improvement Curve Lags Behind - p. Cover 9. Preface. Bronchopulmonary Dysplasia—The Search for Answers Continues - p. Cover 10. Update on Molecular Biology of Lung Development—Transcriptomics - p. Cover 11. Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity - p. Cover 12. Role of Ureaplasma Respiratory Tract Colonization in Bronchopulmonary Dysplasia Pathogenesis: Current Concepts and Update - p. Cover 13. Biomarkers, Early Diagnosis, and Clinical Predictors of Bronchopulmonary Dysplasia - p. Cover 14. Evidence-Based Pharmacologic Therapies for Prevention of Bronchopulmonary Dysplasia: Application of the Grading of Recommendations Assessment, Development, and Evaluation Methodology - p. Cover 15. Mechanical Ventilation and Bronchopulmonary Dysplasia - p. Cover 16. Impact of Nutrition on Bronchopulmonary Dysplasia - p. Cover 17. Oxygen Saturation Targeting and Bronchopulmonary Dysplasia - p. Cover 18. Hypoxic Episodes in Bronchopulmonary Dysplasia - p. Cover 19. Pulmonary Hypertension and Vascular Abnormalities in Bronchopulmonary Dysplasia - p. Cover 20. Airway Disease and Management in Bronchopulmonary Dysplasia - p. Cover 21. Newer Imaging Techniques for Bronchopulmonary Dysplasia - p. Cover 22. Bronchopulmonary Dysplasia and Chronic Lung Disease: Stem Cell Therapy - p. Cover 23. The Natural History of Bronchopulmonary Dysplasia: The Case for Primary Prevention - p. Cover 24. Index - p. Cover
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Bronchopulmonary dysplasia (BPD) as a chronic lung disease affecting preterm infants has been recognized for more than 45 years. However, little progress has been made in the prevention and treatment of the disease. BPD continues to be a major morbidity affecting preterm infants. Studies in pre-adolescent children demonstrate that the abnormal lung function from BPD persists well into childhood. Infants with BPD also have an increased risk for adverse neurodevelopmental outcome. Thus BPD imposes a significant burden of adverse health outcomes in preterm infants.
The major risk factors for BPD are prematurity, mechanical ventilation, exposure to noxious insults such as oxygen, infections. New research data both in basic science and clinical studies have shed light on the pathogenesis, and possible new treatment or management strategies for the future. In the proposed issue of the Clinics in Perinatology, we would like to comprehensively cover BPD both from a basic science and clinical perspective. Our attempt is to balance new information along with classic topics. The proposed authors for the issue are recognized experts in the topic area/s. We hope that the issue will be of interest to a broad array of readership.
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Contributors - p. Cover 6. CME Accreditation Page - p. Cover 7. Forthcoming Issues - p. Cover 8. Foreword. Why the Bronchopulmonary Dysplasia Improvement Curve Lags Behind - p. Cover 9. Preface. Bronchopulmonary Dysplasia—The Search for Answers Continues - p. Cover 10. Update on Molecular Biology of Lung Development—Transcriptomics - p. Cover 11. Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity - p. Cover 12. Role of Ureaplasma Respiratory Tract Colonization in Bronchopulmonary Dysplasia Pathogenesis: Current Concepts and Update - p. Cover 13. Biomarkers, Early Diagnosis, and Clinical Predictors of Bronchopulmonary Dysplasia - p. Cover 14. Evidence-Based Pharmacologic Therapies for Prevention of Bronchopulmonary Dysplasia: Application of the Grading of Recommendations Assessment, Development, and Evaluation Methodology - p. Cover 15. Mechanical Ventilation and Bronchopulmonary Dysplasia - p. Cover 16. Impact of Nutrition on Bronchopulmonary Dysplasia - p. Cover 17. Oxygen Saturation Targeting and Bronchopulmonary Dysplasia - p. Cover 18. Hypoxic Episodes in Bronchopulmonary Dysplasia - p. Cover 19. Pulmonary Hypertension and Vascular Abnormalities in Bronchopulmonary Dysplasia - p. Cover 20. Airway Disease and Management in Bronchopulmonary Dysplasia - p. Cover 21. Newer Imaging Techniques for Bronchopulmonary Dysplasia - p. Cover 22. Bronchopulmonary Dysplasia and Chronic Lung Disease: Stem Cell Therapy - p. Cover 23. The Natural History of Bronchopulmonary Dysplasia: The Case for Primary Prevention - p. Cover 24. Index - p. Cover
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