Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers.
In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases.
1. Chapter 1: Cancer-leading proteases: An introduction - p. page_xxi 2. Chapter 2: Potential roles of protease inhibitors in anticancer therapy - p. page_11 3. Chapter 3: Studies on cysteine proteases and their inhibitors for anticancer drug design - p. page_49 4. Chapter 4: Ubiquitin-specific proteases as targets for anticancer drug therapies - p. page_71 5. Chapter 5: Aspartic proteases: Potential drug targets for anticancer drug development - p. page_120 6. Chapter 6: Inhibitors of HIV protease in cancer therapy - p. page_163 7. Chapter 7: Serine proteases in ovarian cancer - p. page_182 8. Chapter 8: Serine proteases leading to prostate cancer: Structures, functions, and development of anticancer drugs - p. page_213 9. Chapter 9: HCV NS3 serine protease as a drug target for the development of drugs against hepatocellular carcinoma (liver cancer) - p. page_242 10. Chapter 10: Collagenases and gelatinases and their inhibitors as anticancer agents - p. page_263 11. Chapter 11: c-Met as a potential therapeutic target in triple negative breast cancer - p. page_294 12. Chapter 12: Rhomboid proteases leading to cancer: Structures, functions, and inhibition - p. page_326 13. Chapter 13: KRAS: Structure, function, and development of anticancer drugs - p. page_357 14. Chapter 14: Tumor-suppressive proteases revisited: Role in inhibiting tumor progression and metastasis - p. page_389 15. Chapter 15: Vitamin D as therapeutic agent acting against cancers caused by proteases - p. page_416 16. Chapter 16: Molecular imaging of proteases in cancer - p. page_448 17. Index - p. page_491
Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers.
In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases.
1. Chapter 1: Cancer-leading proteases: An introduction - p. page_xxi 2. Chapter 2: Potential roles of protease inhibitors in anticancer therapy - p. page_11 3. Chapter 3: Studies on cysteine proteases and their inhibitors for anticancer drug design - p. page_49 4. Chapter 4: Ubiquitin-specific proteases as targets for anticancer drug therapies - p. page_71 5. Chapter 5: Aspartic proteases: Potential drug targets for anticancer drug development - p. page_120 6. Chapter 6: Inhibitors of HIV protease in cancer therapy - p. page_163 7. Chapter 7: Serine proteases in ovarian cancer - p. page_182 8. Chapter 8: Serine proteases leading to prostate cancer: Structures, functions, and development of anticancer drugs - p. page_213 9. Chapter 9: HCV NS3 serine protease as a drug target for the development of drugs against hepatocellular carcinoma (liver cancer) - p. page_242 10. Chapter 10: Collagenases and gelatinases and their inhibitors as anticancer agents - p. page_263 11. Chapter 11: c-Met as a potential therapeutic target in triple negative breast cancer - p. page_294 12. Chapter 12: Rhomboid proteases leading to cancer: Structures, functions, and inhibition - p. page_326 13. Chapter 13: KRAS: Structure, function, and development of anticancer drugs - p. page_357 14. Chapter 14: Tumor-suppressive proteases revisited: Role in inhibiting tumor progression and metastasis - p. page_389 15. Chapter 15: Vitamin D as therapeutic agent acting against cancers caused by proteases - p. page_416 16. Chapter 16: Molecular imaging of proteases in cancer - p. page_448 17. Index - p. page_491
