Cannabis, Volume Five in the Neurobiology of Addiction series, explores the molecular and cellular systems in the brain that are responsible for both nicotine and marijuana addiction. The book includes thorough descriptions of the physiological effects and behavioral effects of nicotine and marijuana addiction. The authors clearly define the neurobiological effects into three distinct steps: Binge/Intoxication Stage, Withdrawal/Negative Affect Stage, and finally, the Preoccupation/Anticipation Stage.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. i 4. Table of Contents - p. iii 5. Cannabis - p. ii 6. Copyright - p. iv 7. Preface - p. vii 8. Acknowledgments - p. ix 9. VOLUME FIVE. Cannabis - p. 1 10. 1 Definitions - p. 2 11. 2 History of cannabinoid use, misuse, and addiction - p. 11 12. 3 Intoxication - p. 15 13. 4 Pharmacokinetics - p. 20 14. 5 Cannabinoid tolerance - p. 22 15. 6 Cannabinoid withdrawal - p. 24 16. 7 Cannabis use disorder - p. 30 17. 8 Pathology and psychopathology - p. 37 18. 9 Medical uses - p. 49 19. 10 Endocannabinoids - p. 53 20. 11 Behavioral mechanism of action - p. 66 21. 12 Neurobiological effects - p. 67 22. 12.1 Binge/intoxication stage - p. 67 23. 12.1.1 Animal models of the binge/intoxication stage - p. 67 24. 12.1.2 Analgesia - p. 82 25. 12.1.3 Adolescent exposure to cannabinoids and cannabinoid reward - p. 84 26. 12.1.4 Neurobiological mechanisms of the binge/intoxication stage: Neurocircuitry - p. 86 27. 12.1.5 Neurobiological mechanisms of the binge/intoxication stage: Cellular - p. 107 28. 12.1.6 Neurobiological mechanisms of the binge/intoxication stage: Molecular - p. 115 29. 12.1.7 Sex differences in the neurobiology of the binge/intoxication stage - p. 134 30. 12.1.8 Summary: Neurobiology of the binge/intoxication stage - p. 138 31. 12.2 Withdrawal/negative affect stage - p. 139 32. 12.2.1 Tolerance to cannabinoids - p. 139 33. 12.2.2 Cross-tolerance to cannabinoids and opioids - p. 142 34. 12.2.3 Animal models of the withdrawal/negative affect stage - p. 149 35. 12.2.4 Neurobiological mechanisms of the withdrawal/negative affect stage: Neurocircuitry - p. 153 36. 12.2.5 Neurobiological mechanisms of the withdrawal/negative affect stage: Cellular - p. 173 37. 12.2.6 Neurobiological mechanisms of the withdrawal/negative affect stage: Molecular - p. 179 38. 12.2.7 Sex differences in the neurobiology of the withdrawal/negative affect stage - p. 183 39. 12.2.8 Summary: Neurobiology of the withdrawal/negative affect stage - p. 187 40. 12.3 Preoccupation/anticipation stage - p. 188 41. 12.3.1 Animal models of the preoccupation/anticipation stage - p. 188 42. 12.3.2 Neurobiological mechanisms of the preoccupation/anticipation stage: Neurocircuitry - p. 190 43. 12.3.3 Neuropharmacology of craving in humans - p. 204 44. 12.3.4 Cannabis and drug-associated memories - p. 204 45. 12.3.5 Neurobiological mechanisms of the preoccupation/anticipation stage: Cellular - p. 212 46. 12.3.6 Neurobiological mechanisms of the preoccupation/anticipation stage: Molecular - p. 215 47. 12.3.7 Sex differences in the neurobiology of the preoccupation/anticipation stage - p. 217 48. 12.3.8 Summary: Neurobiology of the preoccupation/anticipation stage - p. 222 49. 13 Overall summary - p. 224 50. Index - p. 285
Cannabis, Volume Five in the Neurobiology of Addiction series, explores the molecular and cellular systems in the brain that are responsible for both nicotine and marijuana addiction. The book includes thorough descriptions of the physiological effects and behavioral effects of nicotine and marijuana addiction. The authors clearly define the neurobiological effects into three distinct steps: Binge/Intoxication Stage, Withdrawal/Negative Affect Stage, and finally, the Preoccupation/Anticipation Stage.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. i 4. Table of Contents - p. iii 5. Cannabis - p. ii 6. Copyright - p. iv 7. Preface - p. vii 8. Acknowledgments - p. ix 9. VOLUME FIVE. Cannabis - p. 1 10. 1 Definitions - p. 2 11. 2 History of cannabinoid use, misuse, and addiction - p. 11 12. 3 Intoxication - p. 15 13. 4 Pharmacokinetics - p. 20 14. 5 Cannabinoid tolerance - p. 22 15. 6 Cannabinoid withdrawal - p. 24 16. 7 Cannabis use disorder - p. 30 17. 8 Pathology and psychopathology - p. 37 18. 9 Medical uses - p. 49 19. 10 Endocannabinoids - p. 53 20. 11 Behavioral mechanism of action - p. 66 21. 12 Neurobiological effects - p. 67 22. 12.1 Binge/intoxication stage - p. 67 23. 12.1.1 Animal models of the binge/intoxication stage - p. 67 24. 12.1.2 Analgesia - p. 82 25. 12.1.3 Adolescent exposure to cannabinoids and cannabinoid reward - p. 84 26. 12.1.4 Neurobiological mechanisms of the binge/intoxication stage: Neurocircuitry - p. 86 27. 12.1.5 Neurobiological mechanisms of the binge/intoxication stage: Cellular - p. 107 28. 12.1.6 Neurobiological mechanisms of the binge/intoxication stage: Molecular - p. 115 29. 12.1.7 Sex differences in the neurobiology of the binge/intoxication stage - p. 134 30. 12.1.8 Summary: Neurobiology of the binge/intoxication stage - p. 138 31. 12.2 Withdrawal/negative affect stage - p. 139 32. 12.2.1 Tolerance to cannabinoids - p. 139 33. 12.2.2 Cross-tolerance to cannabinoids and opioids - p. 142 34. 12.2.3 Animal models of the withdrawal/negative affect stage - p. 149 35. 12.2.4 Neurobiological mechanisms of the withdrawal/negative affect stage: Neurocircuitry - p. 153 36. 12.2.5 Neurobiological mechanisms of the withdrawal/negative affect stage: Cellular - p. 173 37. 12.2.6 Neurobiological mechanisms of the withdrawal/negative affect stage: Molecular - p. 179 38. 12.2.7 Sex differences in the neurobiology of the withdrawal/negative affect stage - p. 183 39. 12.2.8 Summary: Neurobiology of the withdrawal/negative affect stage - p. 187 40. 12.3 Preoccupation/anticipation stage - p. 188 41. 12.3.1 Animal models of the preoccupation/anticipation stage - p. 188 42. 12.3.2 Neurobiological mechanisms of the preoccupation/anticipation stage: Neurocircuitry - p. 190 43. 12.3.3 Neuropharmacology of craving in humans - p. 204 44. 12.3.4 Cannabis and drug-associated memories - p. 204 45. 12.3.5 Neurobiological mechanisms of the preoccupation/anticipation stage: Cellular - p. 212 46. 12.3.6 Neurobiological mechanisms of the preoccupation/anticipation stage: Molecular - p. 215 47. 12.3.7 Sex differences in the neurobiology of the preoccupation/anticipation stage - p. 217 48. 12.3.8 Summary: Neurobiology of the preoccupation/anticipation stage - p. 222 49. 13 Overall summary - p. 224 50. Index - p. 285
