Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health.
Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs.
1. PART 1. Introduction - p. xix 2. Chapter 1. Carbonic anhydrases: an overview - p. 3 3. PART 2. Distribution, biochemistry, and structural features of carbonic anhydrase families - p. 16 4. Chapter 2. α-Carbonic anhydrases - p. 19 5. Chapter 3. β-Carbonic anhydrases - p. 55 6. Chapter 4. γ-Carbonic anhydrases - p. 79 7. Chapter 5. δ-Carbonic anhydrases - p. 107 8. Chapter 6. ζ-Carbonic anhydrases - p. 131 9. Chapter 7. η- and θ-carbonic anhydrases - p. 139 10. PART 3. Carbonic anhydrases as drug targets - p. 148 11. Chapter 8. Human carbonic anhydrases: tissue distribution, physiological role, and druggability - p. 151 12. Chapter 9. Mechanisms of action of carbonic anhydrase inhibitors: zinc binders - p. 187 13. Chapter 10. Mechanisms of action of carbonic anhydrase inhibitors: compounds that anchor to the zinc-bound nucleophile - p. 223 14. Chapter 11. Mechanism of action of carbonic anhydrase inhibitors: compounds occluding the entrance of the active site - p. 245 15. Chapter 12. Mechanisms of action of carbonic anhydrase inhibitors: compounds that bind “out of the binding site” and compounds with an unknown mechanism of action - p. 257 16. Chapter 13. Carbonic anhydrase inhibitors as ophthalmologic drugs for the treatment of glaucoma - p. 269 17. Chapter 14. Carbonic anhydrase inhibitors as diuretics - p. 287 18. Chapter 15. Carbonic anhydrase inhibitors for the treatment of epilepsy and obesity - p. 311 19. Chapter 16. Carbonic anhydrase inhibitors for the treatment of tumors: therapeutic, immunologic, and diagnostic tools targeting isoforms IX and XII - p. 331 20. Chapter 17. Carbonic anhydrase inhibitors for the treatment of neuropathic pain and arthritis - p. 367 21. Chapter 18. Carbonic anhydrases from pathogens: bacterial carbonic anhydrases and their inhibitors as potential antiinfectives - p. 387 22. Chapter 19. Carbonic anhydrases from pathogens: fungal carbonic anhydrases and their inhibitors as potential antifungal agents - p. 419 23. Chapter 20. Carbonic anhydrases from pathogens: protozoan CAs and related inhibitors as potential antiprotozoal agents - p. 449 24. Chapter 21. Carbonic anhydrase activators and their potential in the pharmaceutical field - p. 477 25. PART 4. Carbonic anhydrases for biotechnological applications - p. 492 26. Chapter 22. Biotechnologic applications of carbonic anhydrases from extremophiles - p. 495 27. Chapter 23. CO2-capture by engineered mammalian carbonic anhydrases - p. 515 28. Index - p. 531
Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health.
Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs.
1. PART 1. Introduction - p. xix 2. Chapter 1. Carbonic anhydrases: an overview - p. 3 3. PART 2. Distribution, biochemistry, and structural features of carbonic anhydrase families - p. 16 4. Chapter 2. α-Carbonic anhydrases - p. 19 5. Chapter 3. β-Carbonic anhydrases - p. 55 6. Chapter 4. γ-Carbonic anhydrases - p. 79 7. Chapter 5. δ-Carbonic anhydrases - p. 107 8. Chapter 6. ζ-Carbonic anhydrases - p. 131 9. Chapter 7. η- and θ-carbonic anhydrases - p. 139 10. PART 3. Carbonic anhydrases as drug targets - p. 148 11. Chapter 8. Human carbonic anhydrases: tissue distribution, physiological role, and druggability - p. 151 12. Chapter 9. Mechanisms of action of carbonic anhydrase inhibitors: zinc binders - p. 187 13. Chapter 10. Mechanisms of action of carbonic anhydrase inhibitors: compounds that anchor to the zinc-bound nucleophile - p. 223 14. Chapter 11. Mechanism of action of carbonic anhydrase inhibitors: compounds occluding the entrance of the active site - p. 245 15. Chapter 12. Mechanisms of action of carbonic anhydrase inhibitors: compounds that bind “out of the binding site” and compounds with an unknown mechanism of action - p. 257 16. Chapter 13. Carbonic anhydrase inhibitors as ophthalmologic drugs for the treatment of glaucoma - p. 269 17. Chapter 14. Carbonic anhydrase inhibitors as diuretics - p. 287 18. Chapter 15. Carbonic anhydrase inhibitors for the treatment of epilepsy and obesity - p. 311 19. Chapter 16. Carbonic anhydrase inhibitors for the treatment of tumors: therapeutic, immunologic, and diagnostic tools targeting isoforms IX and XII - p. 331 20. Chapter 17. Carbonic anhydrase inhibitors for the treatment of neuropathic pain and arthritis - p. 367 21. Chapter 18. Carbonic anhydrases from pathogens: bacterial carbonic anhydrases and their inhibitors as potential antiinfectives - p. 387 22. Chapter 19. Carbonic anhydrases from pathogens: fungal carbonic anhydrases and their inhibitors as potential antifungal agents - p. 419 23. Chapter 20. Carbonic anhydrases from pathogens: protozoan CAs and related inhibitors as potential antiprotozoal agents - p. 449 24. Chapter 21. Carbonic anhydrase activators and their potential in the pharmaceutical field - p. 477 25. PART 4. Carbonic anhydrases for biotechnological applications - p. 492 26. Chapter 22. Biotechnologic applications of carbonic anhydrases from extremophiles - p. 495 27. Chapter 23. CO2-capture by engineered mammalian carbonic anhydrases - p. 515 28. Index - p. 531
