This issue of Cardiac Electrophysiology Clinics, edited by Drs. Mohammad Shenasa and Stanley Nattel, will review Cardiac Potassium Channel Disorders in depth. Topics covered include but are not limited to: Molecular Biology of Cardiac Potassium Channels; Genetic Control of Potassium Channels; Potassium Channel Remodeling in Heart Disease; Gender-specific Effects of Potassium Channel Blockers; Pharmacogenetics of Potassium Channel Blockers; Multichannel Blockers; Selective Potassium Channel Blockers; and Proarrhythmic and Torsadogenic Effects of Potassium Channel Blockers in Patients.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 6 7. Foreword: The K+ Channel: One Channel, Many Arrhythmias! - p. 7 8. Preface: Cardiac Potassium Channel Disorders: From Basics to Clinics - p. 8 9. Molecular Basis of Functional Myocardial Potassium Channel Diversity - p. 9 10. Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology - p. 22 11. Genetic Control of Potassium Channels - p. 30 12. Cardiac Delayed Rectifier Potassium Channels in Health and Disease - p. 45 13. Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection - p. 58 14. Potassium Channel Remodeling in Heart Disease - p. 68 15. Modulation of Cardiac Potassium Current by Neural Tone and Ischemia - p. 74 16. Clinical Features of Genetic Cardiac Diseases Related to Potassium Channelopathies - p. 83 17. Potassium Channel Block and Novel Autoimmune-Associated Long QT Syndrome - p. 92 18. Pharmacogenetics of Potassium Channel Blockers - p. 100 19. Mechanism of Proarrhythmic Effects of Potassium Channel Blockers - p. 107 20. Atrial-Selective Potassium Channel Blockers - p. 120 21. Dofetilide: Electrophysiologic Effect, Efficacy, and Safety in Patients with Cardiac Arrhythmias - p. 129 22. Sotalol - p. 138 23. Dronedarone - p. 151 24. Ranolazine: Electrophysiologic Effect, Efficacy, and Safety in Patients with Cardiac Arrhythmias - p. 161 25. Proarrhythmic and Torsadogenic Effects of Potassium Channel Blockers in Patients - p. 171 26. Guidelines for Potassium Channel Blocker Use - p. 181
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This issue of Cardiac Electrophysiology Clinics, edited by Drs. Mohammad Shenasa and Stanley Nattel, will review Cardiac Potassium Channel Disorders in depth. Topics covered include but are not limited to: Molecular Biology of Cardiac Potassium Channels; Genetic Control of Potassium Channels; Potassium Channel Remodeling in Heart Disease; Gender-specific Effects of Potassium Channel Blockers; Pharmacogenetics of Potassium Channel Blockers; Multichannel Blockers; Selective Potassium Channel Blockers; and Proarrhythmic and Torsadogenic Effects of Potassium Channel Blockers in Patients.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 6 7. Foreword: The K+ Channel: One Channel, Many Arrhythmias! - p. 7 8. Preface: Cardiac Potassium Channel Disorders: From Basics to Clinics - p. 8 9. Molecular Basis of Functional Myocardial Potassium Channel Diversity - p. 9 10. Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology - p. 22 11. Genetic Control of Potassium Channels - p. 30 12. Cardiac Delayed Rectifier Potassium Channels in Health and Disease - p. 45 13. Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection - p. 58 14. Potassium Channel Remodeling in Heart Disease - p. 68 15. Modulation of Cardiac Potassium Current by Neural Tone and Ischemia - p. 74 16. Clinical Features of Genetic Cardiac Diseases Related to Potassium Channelopathies - p. 83 17. Potassium Channel Block and Novel Autoimmune-Associated Long QT Syndrome - p. 92 18. Pharmacogenetics of Potassium Channel Blockers - p. 100 19. Mechanism of Proarrhythmic Effects of Potassium Channel Blockers - p. 107 20. Atrial-Selective Potassium Channel Blockers - p. 120 21. Dofetilide: Electrophysiologic Effect, Efficacy, and Safety in Patients with Cardiac Arrhythmias - p. 129 22. Sotalol - p. 138 23. Dronedarone - p. 151 24. Ranolazine: Electrophysiologic Effect, Efficacy, and Safety in Patients with Cardiac Arrhythmias - p. 161 25. Proarrhythmic and Torsadogenic Effects of Potassium Channel Blockers in Patients - p. 171 26. Guidelines for Potassium Channel Blocker Use - p. 181
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