The sodium channel, a ubiquitous member of the cardiac, neural, and muscular conduction systems, has been implicated in the pathogenesis of an array of human diseases. Mutations associated with the cardiac sodium channel are responsible for a wide spectrum of disorders. The cardiac sodium channel and associated disorders are comprehensively examined in this issues of the Cardiac Electrophysiology Clinics.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 8 6. Foreword: The Sodium Channel: One Gene, Many Diseases! - p. 9 7. Preface: Cardiac Sodium Channel Disorders: One Gene with Many Genetic Variants Leading to Many Cardiac Phenotypes - p. 10 8. Role of the Cardiac Sodium Current in Excitability and Conduction - p. 11 9. Role of Rare and Common Genetic Variation in SCN5A in Cardiac Electrical Function and Arrhythmia - p. 17 10. NaV1.5 and Regulatory β Subunits in Cardiac Sodium Channelopathies - p. 27 11. Pharmacology and Toxicology of Nav1.5-Class 1 Antiarrhythmic Drugs - p. 41 12. Congenital Long QT Syndrome Type 3 - p. 50 13. Brugada Syndrome and Nav1.5 - p. 54 14. Conduction Disorders and Nav1.5 - p. 59 15. Dilated Cardiomyopathy and Nav1.5 - p. 65 16. Atrial Fibrillation and SCN5A Variants - p. 71 17. The Role of the Cardiac Sodium Channel in Perinatal Early Infant Mortality - p. 78 18. Cardiac Sodium Channel Overlap Syndrome - p. 85 19. Cardiac Sodium Channel Nav1.5 and Drug-Induced Long QT Syndrome - p. 95 20. Disease Caused by Mutations in NaV-β Subunit Genes - p. 100 21. Diseases Caused by Mutations in Nav1.5 Interacting Proteins - p. 107 22. Use of Drugs in Long QT Syndrome Type 3 and Brugada Syndrome - p. 117 23. Sodium Current Disorders - p. 123 24. Sodium Current Disorders - p. 128 25. Index - p. 134
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The sodium channel, a ubiquitous member of the cardiac, neural, and muscular conduction systems, has been implicated in the pathogenesis of an array of human diseases. Mutations associated with the cardiac sodium channel are responsible for a wide spectrum of disorders. The cardiac sodium channel and associated disorders are comprehensively examined in this issues of the Cardiac Electrophysiology Clinics.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 8 6. Foreword: The Sodium Channel: One Gene, Many Diseases! - p. 9 7. Preface: Cardiac Sodium Channel Disorders: One Gene with Many Genetic Variants Leading to Many Cardiac Phenotypes - p. 10 8. Role of the Cardiac Sodium Current in Excitability and Conduction - p. 11 9. Role of Rare and Common Genetic Variation in SCN5A in Cardiac Electrical Function and Arrhythmia - p. 17 10. NaV1.5 and Regulatory β Subunits in Cardiac Sodium Channelopathies - p. 27 11. Pharmacology and Toxicology of Nav1.5-Class 1 Antiarrhythmic Drugs - p. 41 12. Congenital Long QT Syndrome Type 3 - p. 50 13. Brugada Syndrome and Nav1.5 - p. 54 14. Conduction Disorders and Nav1.5 - p. 59 15. Dilated Cardiomyopathy and Nav1.5 - p. 65 16. Atrial Fibrillation and SCN5A Variants - p. 71 17. The Role of the Cardiac Sodium Channel in Perinatal Early Infant Mortality - p. 78 18. Cardiac Sodium Channel Overlap Syndrome - p. 85 19. Cardiac Sodium Channel Nav1.5 and Drug-Induced Long QT Syndrome - p. 95 20. Disease Caused by Mutations in NaV-β Subunit Genes - p. 100 21. Diseases Caused by Mutations in Nav1.5 Interacting Proteins - p. 107 22. Use of Drugs in Long QT Syndrome Type 3 and Brugada Syndrome - p. 117 23. Sodium Current Disorders - p. 123 24. Sodium Current Disorders - p. 128 25. Index - p. 134
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