Accessible and user-friendly, Cell Biology, 4th Edition, provides a strong foundation for students entering health care career paths as well as higher level research areas. Clear, readable text and high-quality, detailed illustrations help readers quickly grasp challenging content—all focusing on cellular processes without delving into molecular processes. Drs. Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz, and author/illustrator Dr. Graham Johnson have thoroughly updated this popular text to ensure its relevance for students in biology, biotechnology, medicine, and pathophysiology, covering key principles of cellular function and explaining how molecular defects lead to cellular dysfunction and cause human disease.
Balances depth of detail with clear, readable explanations, providing a concise but comprehensive overview of this complex topic.
An intuitive chapter flow leads with genome organization, gene expression, and RNA processing as a foundation for understanding cellular interactions and cell physiology.
Brings cellular biology to life for students in clinically focused programs, as breakthroughs in areas like gene editing, epigenetics, and the understanding of the microbiome continue to grow in clinical application.
Features unique illustrations with realistic proportions and relationships, including many new instructive illustrations— from structure of volume-regulated LRRC8 Cl -1 channel and generation of circular RNAs from introns … to deadenylation cycles and assembly of SARS CoV-2).
Covers new topics such as optogenetics and super resolution fluorescence microscopy; predicting 3D protein structure; gene expression profiling by single-cell RNA sequencing; protein misfolding and human disease; mechanism of CFTR and new drugs to treat cystic fibrosis; new insights on carriers and channels and their clinical implications; mitochondrial genomes from sperm; and biogenesis of lipid droplets and lipid transfer between organelles.
Uses real examples to illustrate key cell biology concepts, includes beneficial cell physiology coverage, and relates cell biology to pathophysiology and medicine.
1. Section I Introduction to Cell Biology - p. 1 2. Chapter 1 Cells as the Basis of Life on Earth - p. 3 3. Chapter 2 Evolution of Life on Earth - p. 15 4. Section II Chemical and Physical Background - p. 29 5. Chapter 3 Molecules: Structures and Dynamics - p. 33 6. Chapter 4 Biophysical Principles - p. 55 7. Chapter 5 Macromolecular Assembly - p. 65 8. Chapter 6 Research Strategies - p. 79 9. Section III Chromatin, Chromosomes, and the Cell Nucleus - p. 107 10. Chapter 7 Chromosome Organization - p. 111 11. Chapter 8 DNA Packaging in Chromatin and Chromosomes - p. 131 12. Chapter 9 Nuclear Structure and Dynamics - p. 151 13. Section IV Central Dogma: From Gene to Protein - p. 169 14. Chapter 10 Gene Expression* - p. 173 15. Chapter 11 Eukaryotic RNA Processing - p. 199 16. Chapter 12 Protein Synthesis and Folding - p. 219 17. Section V Membrane Structure and Function - p. 233 18. Chapter 13 Membrane Structure and Dynamics - p. 237 19. Chapter 14 Membrane Pumps - p. 251 20. Chapter 15 Membrane Carriers - p. 263 21. Chapter 16 Membrane Channels - p. 271 22. Chapter 17 Membrane Physiology - p. 295 23. Section VI Cellular Organelles and Membrane Trafficking - p. 309 24. Chapter 18 Posttranslational Targeting of Proteins - p. 313 25. Chapter 19 Mitochondria, Chloroplasts, Peroxisomes - p. 327 26. Chapter 20 Endoplasmic Reticulum - p. 341 27. Chapter 21 Mechanisms of Vesicular Transport - p. 365 28. Chapter 22 Secretory Membrane System and Golgi Apparatus - p. 377 29. Chapter 23 Endocytosis and the Endosomal Membrane System - p. 393 30. Chapter 24 Processing and Degradation of Cellular Components - p. 411 31. Section VII Signaling Mechanisms - p. 425 32. Chapter 25 Plasma Membrane Receptors - p. 429 33. Chapter 26 Protein Hardware for Signaling - p. 445 34. Chapter 27 Second Messengers - p. 463 35. Chapter 28 Integration of Signals - p. 483 36. Section VIII Cellular Adhesion and the Extracellular Matrix - p. 507 37. Chapter 29 Cells of the Extracellular Matrix and Immune Systems of Animals - p. 511 38. Chapter 30 Extracellular Matrix Molecules - p. 527 39. Chapter 31 Cellular Adhesion - p. 547 40. Chapter 32 Intercellular Junctions - p. 565 41. Chapter 33 Connective Tissues - p. 577 42. Section IX Cytoskeleton and Cellular Motility - p. 593 43. Chapter 34 Actin and Actin-Binding Proteins - p. 597 44. Chapter 35 Microtubules and Centrosomes - p. 615 45. Chapter 36 Intermediate Filaments - p. 635 46. Chapter 37 Motor Proteins - p. 645 47. Chapter 38 Intracellular Motility - p. 661 48. Chapter 39 Cellular Motility - p. 673 49. Chapter 40 Muscles - p. 693 50. Section X Cell Cycle - p. 715 51. Chapter 41 Introduction to the Cell Cycle - p. 719 52. Chapter 42 G1 Phase and Regulation of Cell Proliferation - p. 735 53. Chapter 43 S Phase and DNA Replication - p. 751 54. Chapter 44 G2 Phase: Responses toDNA Damage and Control ofEntry Into Mitosis - p. 769 55. Chapter 45 Mitosis - p. 781 56. Chapter 46 Cytokinesis - p. 801 57. Chapter 47 Meiosis - p. 813 58. Chapter 48 Cell Death - p. 833 59. Cell SnapShots - p. 855 60. Glossary - p. 877 61. Index - p. 907
Accessible and user-friendly, Cell Biology, 4th Edition, provides a strong foundation for students entering health care career paths as well as higher level research areas. Clear, readable text and high-quality, detailed illustrations help readers quickly grasp challenging content—all focusing on cellular processes without delving into molecular processes. Drs. Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz, and author/illustrator Dr. Graham Johnson have thoroughly updated this popular text to ensure its relevance for students in biology, biotechnology, medicine, and pathophysiology, covering key principles of cellular function and explaining how molecular defects lead to cellular dysfunction and cause human disease.
Balances depth of detail with clear, readable explanations, providing a concise but comprehensive overview of this complex topic.
An intuitive chapter flow leads with genome organization, gene expression, and RNA processing as a foundation for understanding cellular interactions and cell physiology.
Brings cellular biology to life for students in clinically focused programs, as breakthroughs in areas like gene editing, epigenetics, and the understanding of the microbiome continue to grow in clinical application.
Features unique illustrations with realistic proportions and relationships, including many new instructive illustrations— from structure of volume-regulated LRRC8 Cl -1 channel and generation of circular RNAs from introns … to deadenylation cycles and assembly of SARS CoV-2).
Covers new topics such as optogenetics and super resolution fluorescence microscopy; predicting 3D protein structure; gene expression profiling by single-cell RNA sequencing; protein misfolding and human disease; mechanism of CFTR and new drugs to treat cystic fibrosis; new insights on carriers and channels and their clinical implications; mitochondrial genomes from sperm; and biogenesis of lipid droplets and lipid transfer between organelles.
Uses real examples to illustrate key cell biology concepts, includes beneficial cell physiology coverage, and relates cell biology to pathophysiology and medicine.
1. Section I Introduction to Cell Biology - p. 1 2. Chapter 1 Cells as the Basis of Life on Earth - p. 3 3. Chapter 2 Evolution of Life on Earth - p. 15 4. Section II Chemical and Physical Background - p. 29 5. Chapter 3 Molecules: Structures and Dynamics - p. 33 6. Chapter 4 Biophysical Principles - p. 55 7. Chapter 5 Macromolecular Assembly - p. 65 8. Chapter 6 Research Strategies - p. 79 9. Section III Chromatin, Chromosomes, and the Cell Nucleus - p. 107 10. Chapter 7 Chromosome Organization - p. 111 11. Chapter 8 DNA Packaging in Chromatin and Chromosomes - p. 131 12. Chapter 9 Nuclear Structure and Dynamics - p. 151 13. Section IV Central Dogma: From Gene to Protein - p. 169 14. Chapter 10 Gene Expression* - p. 173 15. Chapter 11 Eukaryotic RNA Processing - p. 199 16. Chapter 12 Protein Synthesis and Folding - p. 219 17. Section V Membrane Structure and Function - p. 233 18. Chapter 13 Membrane Structure and Dynamics - p. 237 19. Chapter 14 Membrane Pumps - p. 251 20. Chapter 15 Membrane Carriers - p. 263 21. Chapter 16 Membrane Channels - p. 271 22. Chapter 17 Membrane Physiology - p. 295 23. Section VI Cellular Organelles and Membrane Trafficking - p. 309 24. Chapter 18 Posttranslational Targeting of Proteins - p. 313 25. Chapter 19 Mitochondria, Chloroplasts, Peroxisomes - p. 327 26. Chapter 20 Endoplasmic Reticulum - p. 341 27. Chapter 21 Mechanisms of Vesicular Transport - p. 365 28. Chapter 22 Secretory Membrane System and Golgi Apparatus - p. 377 29. Chapter 23 Endocytosis and the Endosomal Membrane System - p. 393 30. Chapter 24 Processing and Degradation of Cellular Components - p. 411 31. Section VII Signaling Mechanisms - p. 425 32. Chapter 25 Plasma Membrane Receptors - p. 429 33. Chapter 26 Protein Hardware for Signaling - p. 445 34. Chapter 27 Second Messengers - p. 463 35. Chapter 28 Integration of Signals - p. 483 36. Section VIII Cellular Adhesion and the Extracellular Matrix - p. 507 37. Chapter 29 Cells of the Extracellular Matrix and Immune Systems of Animals - p. 511 38. Chapter 30 Extracellular Matrix Molecules - p. 527 39. Chapter 31 Cellular Adhesion - p. 547 40. Chapter 32 Intercellular Junctions - p. 565 41. Chapter 33 Connective Tissues - p. 577 42. Section IX Cytoskeleton and Cellular Motility - p. 593 43. Chapter 34 Actin and Actin-Binding Proteins - p. 597 44. Chapter 35 Microtubules and Centrosomes - p. 615 45. Chapter 36 Intermediate Filaments - p. 635 46. Chapter 37 Motor Proteins - p. 645 47. Chapter 38 Intracellular Motility - p. 661 48. Chapter 39 Cellular Motility - p. 673 49. Chapter 40 Muscles - p. 693 50. Section X Cell Cycle - p. 715 51. Chapter 41 Introduction to the Cell Cycle - p. 719 52. Chapter 42 G1 Phase and Regulation of Cell Proliferation - p. 735 53. Chapter 43 S Phase and DNA Replication - p. 751 54. Chapter 44 G2 Phase: Responses toDNA Damage and Control ofEntry Into Mitosis - p. 769 55. Chapter 45 Mitosis - p. 781 56. Chapter 46 Cytokinesis - p. 801 57. Chapter 47 Meiosis - p. 813 58. Chapter 48 Cell Death - p. 833 59. Cell SnapShots - p. 855 60. Glossary - p. 877 61. Index - p. 907
