Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research.
1. Introduction - p. 61 2. Binary Cell Fate Specification via Asymmetric Cell Division - p. 61 3. PAR Proteins Polarize Caenorhabditis elegans Zygotes - p. 63 4. Delta/Notch Signaling Drives Asymmetric Cell Division in Fly Neuroblasts - p. 64 5. Morphogens as Cell Polarizers - p. 65 6. Wnt/β-Catenin Signal Transduction - p. 66 7. Wnt/β-Catenin Asymmetry and Asymmetric Cell Division in Caenorhabditis elegans - p. 72 8. The Caenorhabditis elegans Epidermal Seam Stem Cell Lineage Undergoes Reiterative Asymmetric Cell Divisions - p. 76 9. Asymmetric Cell Divisions in the Caenorhabditis elegans Seam Require Wnt Signaling - p. 78 10. SYS-1/β-Catenin Inheritance Is Limited by Centrosomal Degradation - p. 81 11. Caenorhabditis elegans/Asymmetric Cell Division-Specific Phenomena - p. 82 12. The Future of Wnt/β-Catenin and Asymmetric Cell Division - p. 85 13. Chapter 4. Cell Polarity in Morphogenesis—Planar Cell Polarity - p. 103 14. Chapter 5. Polarized Membrane Trafficking in Development and Disease: From Epithelia Polarization to Cancer Cell Invasion - p. 121 15. Chapter 6. Planar Cell Polarity and the Cell Biology of Nervous System Development and Disease - p. 147 16. Chapter 7. Planar Cell Polarity in Ciliated Epithelia - p. 177 17. Index - p. 211
Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research.
1. Introduction - p. 61 2. Binary Cell Fate Specification via Asymmetric Cell Division - p. 61 3. PAR Proteins Polarize Caenorhabditis elegans Zygotes - p. 63 4. Delta/Notch Signaling Drives Asymmetric Cell Division in Fly Neuroblasts - p. 64 5. Morphogens as Cell Polarizers - p. 65 6. Wnt/β-Catenin Signal Transduction - p. 66 7. Wnt/β-Catenin Asymmetry and Asymmetric Cell Division in Caenorhabditis elegans - p. 72 8. The Caenorhabditis elegans Epidermal Seam Stem Cell Lineage Undergoes Reiterative Asymmetric Cell Divisions - p. 76 9. Asymmetric Cell Divisions in the Caenorhabditis elegans Seam Require Wnt Signaling - p. 78 10. SYS-1/β-Catenin Inheritance Is Limited by Centrosomal Degradation - p. 81 11. Caenorhabditis elegans/Asymmetric Cell Division-Specific Phenomena - p. 82 12. The Future of Wnt/β-Catenin and Asymmetric Cell Division - p. 85 13. Chapter 4. Cell Polarity in Morphogenesis—Planar Cell Polarity - p. 103 14. Chapter 5. Polarized Membrane Trafficking in Development and Disease: From Epithelia Polarization to Cancer Cell Invasion - p. 121 15. Chapter 6. Planar Cell Polarity and the Cell Biology of Nervous System Development and Disease - p. 147 16. Chapter 7. Planar Cell Polarity in Ciliated Epithelia - p. 177 17. Index - p. 211
