Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. It’s an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists.
Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout.
Employs a highly accessible writing style that makes difficult concepts easier to understand, and provides clear implications of immunologic science to the management of human disease and clinical practice.
Features updates from cover to cover, including new information on intracellular sensors of innate immunity, therapeutic use of monoclonal antibodies, regulation of migration events during T cell-B cell interactions, regulatory and transcriptional events in germinal center formation, immunology of infectious diseases including coronaviruses, human immunodeficiency disorders, and immunology of HIV.
Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program, including many new and extensively revised illustrations.
Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions.
Includes summary boxes that assist with rapid review and mastery of key material.
1. Cover image - p. ii 2. Title page - p. iii 3. Table of Contents - p. iv 4. Copyright - p. v 5. Dedication - p. vi 6. Preface - p. vi 7. Online Resources for Instructors and Students - p. ix 8. Glossary - p. 511 9. Self-Assessments - p. x 10. Clinical Cases - p. xi 11. Case 1: Lymphoma - p. xi 12. Case 2: Heart Transplantation Complicated by Allograft Rejection - p. xi 13. Case 3: Allergic Asthma - p. xi 14. Case 4: Systemic Lupus Erythematosus - p. xi 15. Case 5: Human Immunodeficiency Virus Infection: Acquired Immunodeficiency Syndrome - p. xi 16. Chapter 1. Properties and Overview of Immune Responses - p. 1 17. Chapter 2. Cells and Tissues of the Immune System - p. 13 18. Chapter 3. Leukocyte Circulation and Migration Into Tissues - p. 43 19. Chapter 4. Innate Immunity - p. 63 20. Chapter 5. Antibodies and Antigens - p. 103 21. Chapter 6. Antigen Presentation to T Lymphocytes and the Function of Major Histocompatibility Complex Molecules - p. 123 22. Chapter 7. Immune Receptors and Signal Transduction - p. 151 23. Chapter 8. Lymphocyte Development and Antigen Receptor Gene Rearrangement - p. 187 24. Chapter 9. Activation of T Lymphocytes - p. 217 25. Chapter 10. Differentiation and Functions of CD4+ Effector T Cells - p. 233 26. Chapter 11. Differentiation and Functions of CD8+ Effector T Cells - p. 251 27. Chapter 12. B Cell Activation and Antibody Production - p. 261 28. Chapter 13. Effector Mechanisms of Humoral Immunity - p. 287 29. Chapter 14. Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues - p. 313 30. Chapter 15. Immunologic Tolerance and Autoimmunity - p. 337 31. Chapter 16. Immunity to Microbes - p. 365 32. Chapter 17. Transplantation Immunology - p. 389 33. Chapter 18. Tumor Immunology - p. 415 34. Chapter 19. Hypersensitivity Disorders - p. 437 35. Chapter 20. Allergy - p. 459 36. Chapter 21. Primary and Acquired Immunodeficiencies - p. 481 37. Appendix I. Principal Features of Selected CD Molecules - p. 543 38. Appendix II. Cytokines - p. 551 39. Appendix III. Laboratory Techniques Commonly Used in Immunology - p. 555 40. Index - p. 571
Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. It’s an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists.
Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout.
Employs a highly accessible writing style that makes difficult concepts easier to understand, and provides clear implications of immunologic science to the management of human disease and clinical practice.
Features updates from cover to cover, including new information on intracellular sensors of innate immunity, therapeutic use of monoclonal antibodies, regulation of migration events during T cell-B cell interactions, regulatory and transcriptional events in germinal center formation, immunology of infectious diseases including coronaviruses, human immunodeficiency disorders, and immunology of HIV.
Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program, including many new and extensively revised illustrations.
Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions.
Includes summary boxes that assist with rapid review and mastery of key material.
1. Cover image - p. ii 2. Title page - p. iii 3. Table of Contents - p. iv 4. Copyright - p. v 5. Dedication - p. vi 6. Preface - p. vi 7. Online Resources for Instructors and Students - p. ix 8. Glossary - p. 511 9. Self-Assessments - p. x 10. Clinical Cases - p. xi 11. Case 1: Lymphoma - p. xi 12. Case 2: Heart Transplantation Complicated by Allograft Rejection - p. xi 13. Case 3: Allergic Asthma - p. xi 14. Case 4: Systemic Lupus Erythematosus - p. xi 15. Case 5: Human Immunodeficiency Virus Infection: Acquired Immunodeficiency Syndrome - p. xi 16. Chapter 1. Properties and Overview of Immune Responses - p. 1 17. Chapter 2. Cells and Tissues of the Immune System - p. 13 18. Chapter 3. Leukocyte Circulation and Migration Into Tissues - p. 43 19. Chapter 4. Innate Immunity - p. 63 20. Chapter 5. Antibodies and Antigens - p. 103 21. Chapter 6. Antigen Presentation to T Lymphocytes and the Function of Major Histocompatibility Complex Molecules - p. 123 22. Chapter 7. Immune Receptors and Signal Transduction - p. 151 23. Chapter 8. Lymphocyte Development and Antigen Receptor Gene Rearrangement - p. 187 24. Chapter 9. Activation of T Lymphocytes - p. 217 25. Chapter 10. Differentiation and Functions of CD4+ Effector T Cells - p. 233 26. Chapter 11. Differentiation and Functions of CD8+ Effector T Cells - p. 251 27. Chapter 12. B Cell Activation and Antibody Production - p. 261 28. Chapter 13. Effector Mechanisms of Humoral Immunity - p. 287 29. Chapter 14. Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues - p. 313 30. Chapter 15. Immunologic Tolerance and Autoimmunity - p. 337 31. Chapter 16. Immunity to Microbes - p. 365 32. Chapter 17. Transplantation Immunology - p. 389 33. Chapter 18. Tumor Immunology - p. 415 34. Chapter 19. Hypersensitivity Disorders - p. 437 35. Chapter 20. Allergy - p. 459 36. Chapter 21. Primary and Acquired Immunodeficiencies - p. 481 37. Appendix I. Principal Features of Selected CD Molecules - p. 543 38. Appendix II. Cytokines - p. 551 39. Appendix III. Laboratory Techniques Commonly Used in Immunology - p. 555 40. Index - p. 571
