Chalcones: From Drug Discovery to Pharmaceutical Applications serves as a comprehensive reference on chalcones, detailing their natural occurrence, synthetic methods, and therapeutic applications. The book provides both novice and experienced researchers with the foundational knowledge necessary to advance their work in this area. Sections cover the natural sources of chalcones, various extraction methods, structural characterization techniques, synthesis, and their role in organic chemistry and metal complexes, while also addressing pharmacokinetic properties, toxicity, and the medicinal uses of chalcones, including their effectiveness against viruses, bacteria, cancer, and neurodegenerative diseases.
Final sections explore chalcone-containing products, drug formulation strategies, and clinical trials involving chalcone-based drug candidates. This reference is an essential resource for pharmaceutical researchers, providing critical insights into the applications and potential of chalcones in drug development and therapeutic interventions.
1. Title of Book - p. i 2. Cover Image - p. i 3. Title Page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. ix 7. Part I: Foundations of chalcones research - p. P1 8. Chapter 1 Natural sources of chalcones - p. 3 9. Chapter 2 Extraction methods from traditional to green approaches - p. 25 10. Chapter 3 Structural and spectroscopic characterization of chalcones - p. 53 11. Chapter 4 Medicinal chemistry strategies in the chalcone scaffold - p. 69 12. Chapter 5 Chalcones as versatile intermediates in organic chemistry - p. 93 13. Chapter 6 Chalcone-based fluorescent chemosensors for metal ion detection - p. 145 14. Chapter 7 Pharmacokinetic properties, pharmacomicrobiomics, and bioavailability of natural and synthetic chalcones - p. 169 15. Part II: Pharmacology of chalcones - p. P2 16. Chapter 8 Chalcone toxicity - p. 203 17. Chapter 9 Natural chalcones in traditional medicine - p. 229 18. Chapter 10 Chalcones as antiviral agents - p. 245 19. Chapter 11 Chalcones as antibacterial and antitubercular agents - p. 285 20. Chapter 12 Anticancer potential of chalcones - p. 327 21. Chapter 13 Chalcones as neuroprotective and anti-Alzheimer’s disease agents - p. 351 22. Chapter 14 Chalcones as antiprotozoal, antiparasitic, and insecticidal agents - p. 405 23. Chapter 15 Chalcones as promising antifungal agents: Advances in structure and activity - p. 423 24. Chapter 16 Chalcones as antiinflammatory, antiulcer, and antioxidant agents - p. 449 25. Chapter 17 Chalcones as antihyperlipidemic, antidiabetic, and insulin regulating agents - p. 483 26. Chapter 18 Chalcone-containing edible plants (food, food supplements, nutraceuticals, functional food) - p. 511 27. Part III: Prospects - p. P3 28. Chapter 19 Nanotechnology-enabled drug delivery of chalcones: Advances, challenges, and future perspectives - p. 533 29. Chapter 20 Chalcone-protein co-crystals in the Protein Data Bank - p. 557 30. Chapter 21 Clinical trials of chalcone-based drug candidates - p. 587 31. Index - p. 607
Chalcones: From Drug Discovery to Pharmaceutical Applications serves as a comprehensive reference on chalcones, detailing their natural occurrence, synthetic methods, and therapeutic applications. The book provides both novice and experienced researchers with the foundational knowledge necessary to advance their work in this area. Sections cover the natural sources of chalcones, various extraction methods, structural characterization techniques, synthesis, and their role in organic chemistry and metal complexes, while also addressing pharmacokinetic properties, toxicity, and the medicinal uses of chalcones, including their effectiveness against viruses, bacteria, cancer, and neurodegenerative diseases.
Final sections explore chalcone-containing products, drug formulation strategies, and clinical trials involving chalcone-based drug candidates. This reference is an essential resource for pharmaceutical researchers, providing critical insights into the applications and potential of chalcones in drug development and therapeutic interventions.
1. Title of Book - p. i 2. Cover Image - p. i 3. Title Page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. ix 7. Part I: Foundations of chalcones research - p. P1 8. Chapter 1 Natural sources of chalcones - p. 3 9. Chapter 2 Extraction methods from traditional to green approaches - p. 25 10. Chapter 3 Structural and spectroscopic characterization of chalcones - p. 53 11. Chapter 4 Medicinal chemistry strategies in the chalcone scaffold - p. 69 12. Chapter 5 Chalcones as versatile intermediates in organic chemistry - p. 93 13. Chapter 6 Chalcone-based fluorescent chemosensors for metal ion detection - p. 145 14. Chapter 7 Pharmacokinetic properties, pharmacomicrobiomics, and bioavailability of natural and synthetic chalcones - p. 169 15. Part II: Pharmacology of chalcones - p. P2 16. Chapter 8 Chalcone toxicity - p. 203 17. Chapter 9 Natural chalcones in traditional medicine - p. 229 18. Chapter 10 Chalcones as antiviral agents - p. 245 19. Chapter 11 Chalcones as antibacterial and antitubercular agents - p. 285 20. Chapter 12 Anticancer potential of chalcones - p. 327 21. Chapter 13 Chalcones as neuroprotective and anti-Alzheimer’s disease agents - p. 351 22. Chapter 14 Chalcones as antiprotozoal, antiparasitic, and insecticidal agents - p. 405 23. Chapter 15 Chalcones as promising antifungal agents: Advances in structure and activity - p. 423 24. Chapter 16 Chalcones as antiinflammatory, antiulcer, and antioxidant agents - p. 449 25. Chapter 17 Chalcones as antihyperlipidemic, antidiabetic, and insulin regulating agents - p. 483 26. Chapter 18 Chalcone-containing edible plants (food, food supplements, nutraceuticals, functional food) - p. 511 27. Part III: Prospects - p. P3 28. Chapter 19 Nanotechnology-enabled drug delivery of chalcones: Advances, challenges, and future perspectives - p. 533 29. Chapter 20 Chalcone-protein co-crystals in the Protein Data Bank - p. 557 30. Chapter 21 Clinical trials of chalcone-based drug candidates - p. 587 31. Index - p. 607
