Circadian rhythms, sleep, and sleep disorders covers the topic in two sections focusing on basic science and clinical application. In the basic section, new developments and research findings focusing on basic circadian rhythm and sleep physiology in animals and humans is highlighted. The chapters are written in short mini-review formats in order to concisely describe the fundamentals, and current hot topics.
The basic part starts with a chapter on the fundamentals and new discoveries on oscillating circuitries in the sleeping rodent and human brain. This sets the stage for chap 2, focusing on circadian and homeostatic aspects of human sleep regulation. Chap 3 extends these aspects to human cognition. The next chapter reports on visual and non-visual effects of light on human behavior, particularly endocrine and electrophysiological correlates. Chap 5 covers chronic sleep restriction effects on functional connectivity states. The last two chapters (6 and 7) give a broad overview on sleep modeling across physiological levels, with a focus on a quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system.
The clinical section of the book describes the circadian rhythm sleep-wake disorders, from epidemiology to clinical picture and treatment. Disorders covered include delayed and advanced sleep phase syndrome, Irregular sleep-wake rhythm disorder, shift work disorder, restless legs syndrome, nocturnal eating syndrome, narcolepsy, and sleep apnea. Pharmacological and non-pharmacological treatments of insomnia are explored, as well as the role of sleep-wake modulation in the pathogenesis and clinical profile of neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease.
1. Circadian Rhythms, Sleep, and Sleep Disorders - p. i 2. Cover image - p. i 3. Title page - p. i 4. Table of Contents - p. i 5. Series Page - p. ii 6. Copyright - p. iv 7. Handbook of Clinical Neurology 3rd Series - p. v 8. Foreword - p. ix 9. Preface - p. xi 10. Contributors - p. xiii 11. Section I: Basic science - p. 1 12. Chapter 1 Effects of light on biological functions and human sleep - p. 3 13. Chapter 2 Rhythms of light: Understanding the role of circadian timing in alertness and cognitive performance - p. 17 14. Chapter 3 Impact of sleep deprivation on dynamic functional connectivity states - p. 27 15. Chapter 4 Sleep and circadian rhythms modeling: From hypothalamic regulatory networks to cortical dynamics and behavior - p. 37 16. Section II: Clinical applications - p. 59 17. Chapter 5 Advanced sleep phase syndrome: Role of genetics and aging - p. 61 18. Chapter 6 Irregular sleep–wake rhythm disorder: From the pathophysiologic perspective to the treatment - p. 71 19. Chapter 7 Shift work sleep disorder - p. 89 20. Chapter 8 Human sleep and immunity: The role of circadian patterns - p. 93 21. Chapter 9 Circadian pattern in restless legs syndrome - p. 105 22. Chapter 10 Circadian rhythm disorders in the blind - p. 113 23. Chapter 11 Sleep and circadian rhythms after traumatic brain injury - p. 125 24. Chapter 12 Obstructive sleep apnea syndrome, orexin, and sleep–wake cycle: The link with the neurodegeneration - p. 141 25. Chapter 13 Circadian aspects in nonpharmacologic and pharmacologic treatment of insomnia - p. 162 26. Chapter 14 Chronobiologic treatments for mood disorders - p. 181 27. Chapter 15 Sleep and circadian dysfunction in Parkinson disease: New perspective and opportunities for treatment - p. 193 28. Chapter 16 Sleep–wake modulation and pathogenesis of Alzheimer disease: Suggestions for postponement and treatment - p. 211 29. Index - p. 231
Circadian rhythms, sleep, and sleep disorders covers the topic in two sections focusing on basic science and clinical application. In the basic section, new developments and research findings focusing on basic circadian rhythm and sleep physiology in animals and humans is highlighted. The chapters are written in short mini-review formats in order to concisely describe the fundamentals, and current hot topics.
The basic part starts with a chapter on the fundamentals and new discoveries on oscillating circuitries in the sleeping rodent and human brain. This sets the stage for chap 2, focusing on circadian and homeostatic aspects of human sleep regulation. Chap 3 extends these aspects to human cognition. The next chapter reports on visual and non-visual effects of light on human behavior, particularly endocrine and electrophysiological correlates. Chap 5 covers chronic sleep restriction effects on functional connectivity states. The last two chapters (6 and 7) give a broad overview on sleep modeling across physiological levels, with a focus on a quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system.
The clinical section of the book describes the circadian rhythm sleep-wake disorders, from epidemiology to clinical picture and treatment. Disorders covered include delayed and advanced sleep phase syndrome, Irregular sleep-wake rhythm disorder, shift work disorder, restless legs syndrome, nocturnal eating syndrome, narcolepsy, and sleep apnea. Pharmacological and non-pharmacological treatments of insomnia are explored, as well as the role of sleep-wake modulation in the pathogenesis and clinical profile of neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease.
1. Circadian Rhythms, Sleep, and Sleep Disorders - p. i 2. Cover image - p. i 3. Title page - p. i 4. Table of Contents - p. i 5. Series Page - p. ii 6. Copyright - p. iv 7. Handbook of Clinical Neurology 3rd Series - p. v 8. Foreword - p. ix 9. Preface - p. xi 10. Contributors - p. xiii 11. Section I: Basic science - p. 1 12. Chapter 1 Effects of light on biological functions and human sleep - p. 3 13. Chapter 2 Rhythms of light: Understanding the role of circadian timing in alertness and cognitive performance - p. 17 14. Chapter 3 Impact of sleep deprivation on dynamic functional connectivity states - p. 27 15. Chapter 4 Sleep and circadian rhythms modeling: From hypothalamic regulatory networks to cortical dynamics and behavior - p. 37 16. Section II: Clinical applications - p. 59 17. Chapter 5 Advanced sleep phase syndrome: Role of genetics and aging - p. 61 18. Chapter 6 Irregular sleep–wake rhythm disorder: From the pathophysiologic perspective to the treatment - p. 71 19. Chapter 7 Shift work sleep disorder - p. 89 20. Chapter 8 Human sleep and immunity: The role of circadian patterns - p. 93 21. Chapter 9 Circadian pattern in restless legs syndrome - p. 105 22. Chapter 10 Circadian rhythm disorders in the blind - p. 113 23. Chapter 11 Sleep and circadian rhythms after traumatic brain injury - p. 125 24. Chapter 12 Obstructive sleep apnea syndrome, orexin, and sleep–wake cycle: The link with the neurodegeneration - p. 141 25. Chapter 13 Circadian aspects in nonpharmacologic and pharmacologic treatment of insomnia - p. 162 26. Chapter 14 Chronobiologic treatments for mood disorders - p. 181 27. Chapter 15 Sleep and circadian dysfunction in Parkinson disease: New perspective and opportunities for treatment - p. 193 28. Chapter 16 Sleep–wake modulation and pathogenesis of Alzheimer disease: Suggestions for postponement and treatment - p. 211 29. Index - p. 231
