Clinical Biochemistry

1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Preface to the sixth edition - p. vii 6. Preface to the seventh edition - p. ix 7. Acknowledgements - p. xi 8. Videos - p. xii 9. Self Assessment - p. xii 10. Chapter 3: Interpretation of Results: General - p. xii 11. Chapter 4: Interpretation of Results: Diagnosis - p. xii 12. Chapter 5: Interpretation of Results: Monitoring - p. xii 13. Chapter 6: Analytical Aspects - p. xii 14. Chapter 7: Fluid and Electrolytes: Basic Concepts - p. xii 15. Chapter 8: Water and Sodium Balance: Physiological Mechanisms - p. xii 16. Chapter 9: Hyponatraemia: Pathophysiology - p. xii 17. Chapter 10: Hyponatraemia: Assessment and Management - p. xii 18. Chapter 11: Hypernatraemia - p. xii 19. Chapter 12: Hyperkalaemia - p. xii 20. Chapter 13: Hypokalaemia - p. xii 21. Chapter 15: Investigation of Renal Function (1) - p. xii 22. Chapter 16: Investigation of Renal Function (2) - p. xii 23. Chapter 17: Urinalysis - p. xii 24. Chapter 18: Proteinuria - p. xii 25. Chapter 19: Acute Kidney Injury - p. xii 26. Chapter 20: Chronic Kidney Disease - p. xii 27. Chapter 21: Acid–Base: Concepts and Vocabulary - p. xii 28. Chapter 22: Metabolic Acid–base Disorders - p. xii 29. Chapter 25: Proteins and Enzymes - p. xii 30. Chapter 26: Immunoglobulins - p. xii 31. Chapter 27: Myocardial Infarction - p. xii 32. Chapter 28: Liver Function Tests - p. xii 33. Chapter 29: Jaundice - p. xii 34. Chapter 30: Liver Disease - p. xii 35. Chapter 31: Glucose Metabolism and Diabetes Mellitus - p. xii 36. Chapter 32: Diagnosis and Monitoring of Diabetes Mellitus - p. xii 37. Chapter 33: Diabetic Ketoacidosis - p. xii 38. Chapter 34: Hypoglycaemia - p. xii 39. Chapter 35: Calcium Regulation and Hypocalcaemia - p. xii 40. Chapter 36: Hypercalcaemia - p. xii 41. Chapter 37: Phosphate and Magnesium - p. xii 42. Chapter 38: Metabolic Bone Disease - p. xii 43. Chapter 40: Endocrine Control - p. xii 44. Chapter 41: Dynamic Function Tests - p. xii 45. Chapter 42: Pituitary Function - p. xii 46. Chapter 43: Growth Disorders and Acromegaly - p. xii 47. Chapter 44: Thyroid Pathophysiology - p. xii 48. Chapter 45: Hypothyroidism - p. xii 49. Chapter 46: Hyperthyroidism - p. xii 50. Chapter 47: Adrenocortical Pathophysiology - p. xii 51. Chapter 48: Hypofunction of the Adrenal Cortex - p. xii 52. Chapter 49: Hyperfunction of the Adrenal Cortex - p. xii 53. Chapter 50: Gonadal Function - p. xii 54. Chapter 51: Subfertility - p. xii 55. Chapter 52: Nutritional Assessment - p. xii 56. Chapter 53: Nutritional Support - p. xii 57. Chapter 54: Parenteral Nutrition - p. xii 58. Chapter 55: The Metabolic Response to Injury - p. xii 59. Chapter 56: Gastrointestinal Disorders - p. xii 60. Chapter 58: Iron - p. xii 61. Chapter 59: Zinc and Copper - p. xii 62. Chapter 60: Therapeutic Drug Monitoring - p. xii 63. Chapter 61: Toxicology - p. xii 64. Chapter 62: Metal Poisoning - p. xii 65. Chapter 63: Alcohol - p. xii 66. Chapter 64: Ascites - p. xii 67. Chapter 65: Pleural Fluid - p. xii 68. Chapter 66: Cerebrospinal Fluid - p. xii 69. Chapter 67: Identification of Body Fluids - p. xii 70. Chapter 68: Lipoprotein Metabolism - p. xii 71. Chapter 69: Clinical Disorders of Lipid Metabolism - p. xii 72. Chapter 70: Hypertension - p. xii 73. Chapter 71: Cancer and its consequences - p. xii 74. Chapter 72: Tumour Markers - p. xii 75. Chapter 73: Multiple Endocrine Neoplasia - p. xii 76. Chapter 74: Hyperuricaemia - p. xii 77. Chapter 75: Myopathy - p. xii 78. Chapter 77: Pregnancy - p. xii 79. Chapter 78: Antenatal Screening - p. xii 80. Chapter 79: Screening the newborn for disease - p. xii 81. Chapter 80: Paediatric Biochemistry - p. xii 82. Chapter 81: Inborn Errors of Metabolism - p. xii 83. Additional MCQs - p. xii 84. Part 1: Introducing clinical biochemistry - p. 1 85. 1. The clinical biochemistry laboratory - p. 1a 86. 2. The use of the laboratory - p. 4 87. 3. Interpretation of results: general - p. 6 88. 4. Interpretation of results: diagnosis - p. 8 89. 5. Interpretation of results: monitoring - p. 10 90. 6. Analytical aspects - p. 12 91. Part 2: Core biochemistry - p. 14 92. 7. Fluid and electrolytes: basic concepts - p. 14a 93. 8. Water and sodium balance: physiological mechanisms - p. 16 94. 9. Hyponatraemia: pathophysiology - p. 18 95. 10. Hyponatraemia: assessment and management - p. 20 96. 11. Hypernatraemia - p. 22 97. 12. Hyperkalaemia - p. 24 98. 13. Hypokalaemia - p. 26 99. 14. Intravenous fluid therapy - p. 28 100. 15. Investigation of renal function (1) - p. 30 101. 16. Investigation of renal function (2) - p. 32 102. 17. Urinalysis - p. 34 103. 18. Proteinuria - p. 36 104. 19. Acute kidney injury - p. 38 105. 20. Chronic kidney disease - p. 40 106. 21. Acid–base: concepts and vocabulary - p. 42 107. 22. Metabolic acid–base disorders - p. 44 108. 23. Respiratory and mixed acid–base disorders - p. 46 109. 24. Acid–base disorders: diagnosis and management - p. 48 110. 25. Proteins and enzymes - p. 50 111. 26. Immunoglobulins - p. 52 112. 27. Myocardial infarction - p. 54 113. 28. Liver function tests - p. 56 114. 29. Jaundice - p. 58 115. 30. Liver disease - p. 60 116. 31. Glucose metabolism and diabetes mellitus - p. 62 117. 32. Diagnosis and monitoring of diabetes mellitus - p. 64 118. 33. Diabetic ketoacidosis - p. 66 119. 34. Hypoglycaemia - p. 68 120. 35. Calcium regulation and hypocalcaemia - p. 70 121. 36. Hypercalcaemia - p. 72 122. 37. Phosphate and magnesium - p. 74 123. 38. Metabolic bone disease - p. 76 124. 39. Osteoporosis and fragility fractures - p. 78 125. Part 3: Endocrinology - p. 80 126. 40. Endocrine control - p. 80a 127. 41. Dynamic function tests - p. 82 128. 42. Pituitary function - p. 84 129. 43. Growth disorders and acromegaly - p. 86 130. 44. Thyroid pathophysiology - p. 88 131. 45. Hypothyroidism - p. 90 132. 46. Hyperthyroidism - p. 92 133. 47. Adrenocortical pathophysiology - p. 94 134. 48. Hypofunction of the adrenal cortex - p. 96 135. 49. Hyperfunction of the adrenal cortex - p. 98 136. 50. Gonadal function - p. 100 137. 51. Subfertility - p. 102 138. Part 4: Specialised investigations - p. 104 139. 52. Nutritional assessment - p. 104a 140. 53. Nutritional support - p. 106 141. 54. Parenteral nutrition - p. 108 142. 55. The metabolic response to injury - p. 110 143. 56. Gastrointestinal disorders - p. 112 144. 57. Disorders of the pancreas - p. 114 145. 58. Iron - p. 116 146. 59. Zinc and copper - p. 118 147. 60. Therapeutic drug monitoring - p. 120 148. 61. Toxicology - p. 122 149. 62. Metal poisoning - p. 124 150. 63. Alcohol - p. 126 151. 64. Ascites - p. 128 152. 65. Pleural fluid - p. 130 153. 66. Cerebrospinal fluid - p. 132 154. 67. Identification of body fluids - p. 134 155. 68. Lipoprotein metabolism - p. 136 156. 69. Clinical disorders of lipid metabolism - p. 138 157. 70. Hypertension - p. 140 158. 71. Cancer and its consequences - p. 142 159. 72. Tumour markers - p. 144 160. 73. Multiple endocrine neoplasia - p. 146 161. 74. Hyperuricaemia - p. 148 162. 75. Myopathy - p. 150 163. 76. Fetal monitoring and prenatal diagnosis - p. 152 164. 77. Pregnancy - p. 154 165. 78. Antenatal screening - p. 156 166. 79. Screening the newborn for disease - p. 158 167. 80. Paediatric biochemistry - p. 160 168. 81. Inborn errors of metabolism - p. 162 169. 82. Methods involving antibodies: immunoassay - p. 164 170. 83. Methods to separate and identify molecules - p. 166 171. 84. Selected inherited disorders - p. 168 172. Case history comments - p. 169 173. Index - p. 177