Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Preface to the First Edition - p. ix 6. Preface to the Sixth Edition - p. xi 7. List Of Contributors - p. 13 8. Dedication - p. xxvii 9. Part I: Principles of Immune Response - p. xxvii 10. 1. The Human Immune Response - p. 2 11. 2. Organization of the Immune System - p. 12 12. 3. Innate Immunity - p. 39 13. 4. Antigen Receptor Genes, Gene Products, and Co-Receptors - p. 55 14. 5. The Major Histocompatibility Complex - p. 78 15. 6. Antigens and Antigen Presentation - p. 93 16. 7. B-Cell Development and Differentiation - p. 107 17. 8. Immunoglobulin Function - p. 120 18. 9. T-Cell Development - p. 130 19. 10. T-Cell Activation and Tolerance - p. 137 20. 11. Helper T-Cell Subsets and Control of the Inflammatory Response - p. 151 21. 12. Cytotoxic T Lymphocytes and Natural Killer Cells - p. 162 22. 13. Regulatory Immune Cells - p. 175 23. 14. Cytokines and Cytokine Receptors - p. 186 24. 15. Chemokines and Chemokine Receptors - p. 215 25. 16. Lymphocyte Adhesion and Trafficking - p. 228 26. 17. Death Pathways and Immunogenicity - p. 239 27. Part II: Fundamentals of Host-Environmental Interactions - p. 247 28. 18. Human Genomics in Immunology - p. 249 29. 19. Regulatory RNA in Immunologic Diseases - p. 258 30. 20. Immunometabolism - p. 265 31. 21. Immune Deficiencies at the Extremes of Age - p. 272 32. 22. The Microbiota in Immunity and Inflammation - p. 281 33. Part III: Host Defenses to Infectious Agents - p. 292 34. 23. Immunology of the Skin - p. 295 35. 24. Immunology of Mucosal Surfaces - p. 306 36. 25. Host Defenses to Viruses - p. 320 37. 26. Host Defenses to Intracellular Bacteria - p. 331 38. 27. Host Defenses to Extracellular Bacteria Including Spirochetes - p. 347 39. 28. Host Defenses to Fungi - p. 361 40. 29. Host Defenses to Protozoa - p. 375 41. 30. Host Defenses to Helminth Infection - p. 386 42. 31. Emerging Pandemic Infectious Disease Threats - p. 399 43. Part IV: Immune Deficiency and Immune Regulatory Disorders - p. 410 44. 32. Approach to the Evaluation of the Patient With Suspected Immunodeficiency - p. 413 45. 33. Primary Antibody Deficiencies - p. 420 46. 34. Primary T-Cell Immunodeficiencies - p. 438 47. 35. Genetic Disorders of Interferons-, Interleukin-17, Interleukin-18, and Nuclear Factor-κB-Mediated Immunity - p. 457 48. 36. Hemophagocytic Lymphohistiocytosis - p. 469 49. 37. Autoinflammatory Syndromes - p. 474 50. 38. Immune Regulatory Disorders - p. 484 51. 39. Neutrophils and Neutrophil Disorders - p. 491 52. 40. Complement and Complement Disorders - p. 506 53. 41. Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome - p. 525 54. 42. Autoantibody-Mediated Phenocopies of Primary Immunodeficiency Diseases - p. 542 55. Part V: Allergic Diseases - p. 548 56. 43. Allergic Airway Diseases - p. 551 57. 44. Mast Cells and Mast Cell Disorders - p. 561 58. 45. Eosinophils and Eosinophilic Disorders - p. 573 59. 46. Urticaria, Angioedema, and Anaphylaxis - p. 586 60. 47. Allergic Reactions to Stinging and Biting Insects - p. 601 61. 48. Atopic and Contact Dermatitis - p. 609 62. 49. Food Allergy - p. 623 63. 50. Drug Hypersensitivity - p. 630 64. Part VI: Systemic Immune Diseases - p. 646 65. 51. Mechanisms of Autoimmunity - p. 649 66. 52. Systemic Lupus Erythematosus - p. 657 67. 53. Rheumatoid Arthritis - p. 678 68. 54. Juvenile Idiopathic Arthritis - p. 693 69. 55. Sjögren’s Syndrome - p. 704 70. 56. Scleroderma–Systemic Sclerosis - p. 712 71. 57. Inflammatory Muscle Diseases - p. 723 72. 58. Spondyloarthritis - p. 734 73. 59. Small- and Medium-Vessel Primary Vasculitis - p. 754 74. 60. Large Vessel Vasculitides - p. 773 75. 61. Antiphospholipid Syndrome - p. 788 76. Part VII: Organ-Specific Inflammatory Disease - p. 794 77. 62. Immunohematologic Disorders - p. 796 78. 63. Bullous Diseases of the Skin and Mucous Membranes - p. 806 79. 64. Immunology of Psoriasis - p. 824 80. 65. Myasthenia Gravis - p. 832 81. 66. Multiple Sclerosis - p. 843 82. 67. Autoimmune Peripheral Neuropathies - p. 854 83. 68. Immunologic Renal Diseases - p. 866 84. 69. Immunologic Mechanisms ofAtherosclerosis and Myocarditis - p. 883 85. 70. Autoimmune Thyroid Diseases - p. 898 86. 71. Type 1 Diabetes - p. 909 87. 72. Immunologic Lung Diseases - p. 919 88. 73. Chronic Obstructive Pulmonary Disease and Emphysema - p. 936 89. 74. Immunologic Ocular Disease - p. 943 90. 75. Immunologic Diseases of the Gastrointestinal Tract - p. 959 91. 76. Inflammatory Hepatobiliary Diseases - p. 972 92. Part VIII: Immunology and Immunotherapy of Neoplasia - p. 981 93. 77. Lymphoid Leukemias - p. 984 94. 78. Lymphomas - p. 1000 95. 79. Monoclonal Gammopathies - p. 1014 96. 80. Immune Responses to Solid Tumors and Immune Checkpoint Therapy - p. 1028 97. 81. CAR T-Cell Therapy - p. 1042 98. Part IX: Medical Management of Immunological Diseases - p. 1049 99. 82. Immunoglobulin Therapy: Replacement and Immunomodulation - p. 1051 100. 83. Glucocorticoids - p. 1061 101. 84. Immunomodulating Drugs - p. 1072 102. 85. Protein Kinase Antagonists - p. 1080 103. 86. Biologic Response Modifiers - p. 1089 104. 87. Vaccines - p. 1102 105. 88. Allergen Immunotherapy for Allergic Diseases - p. 1117 106. Part X: Transplantation - p. 1125 107. 89. Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance - p. 1128 108. 90. Allogeneic Transplantation for Immunodeficiency - p. 1146 109. 91. Gene Therapy for Primary Immune Deficiency Diseases - p. 1161 110. 92. Hematopoietic Stem Cell Transplantation for Malignant Diseases - p. 1172 111. Part XI: Diagnostic Immunology - p. 1182 112. 93. Flow Cytometry - p. 1185 113. 94. Assessment of Functional Immune Responses in Lymphocytes - p. 1198 114. 95. Assessment of Neutrophil Function - p. 1214 115. 96. Assessment of Human Allergic Diseases - p. 1225 116. Appendix 1. Selected CD Molecules and Their Characteristics - p. 1235 117. Appendix 2. Laboratory Reference Values - p. 1241 118. Index - p. 1243
Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Preface to the First Edition - p. ix 6. Preface to the Sixth Edition - p. xi 7. List Of Contributors - p. 13 8. Dedication - p. xxvii 9. Part I: Principles of Immune Response - p. xxvii 10. 1. The Human Immune Response - p. 2 11. 2. Organization of the Immune System - p. 12 12. 3. Innate Immunity - p. 39 13. 4. Antigen Receptor Genes, Gene Products, and Co-Receptors - p. 55 14. 5. The Major Histocompatibility Complex - p. 78 15. 6. Antigens and Antigen Presentation - p. 93 16. 7. B-Cell Development and Differentiation - p. 107 17. 8. Immunoglobulin Function - p. 120 18. 9. T-Cell Development - p. 130 19. 10. T-Cell Activation and Tolerance - p. 137 20. 11. Helper T-Cell Subsets and Control of the Inflammatory Response - p. 151 21. 12. Cytotoxic T Lymphocytes and Natural Killer Cells - p. 162 22. 13. Regulatory Immune Cells - p. 175 23. 14. Cytokines and Cytokine Receptors - p. 186 24. 15. Chemokines and Chemokine Receptors - p. 215 25. 16. Lymphocyte Adhesion and Trafficking - p. 228 26. 17. Death Pathways and Immunogenicity - p. 239 27. Part II: Fundamentals of Host-Environmental Interactions - p. 247 28. 18. Human Genomics in Immunology - p. 249 29. 19. Regulatory RNA in Immunologic Diseases - p. 258 30. 20. Immunometabolism - p. 265 31. 21. Immune Deficiencies at the Extremes of Age - p. 272 32. 22. The Microbiota in Immunity and Inflammation - p. 281 33. Part III: Host Defenses to Infectious Agents - p. 292 34. 23. Immunology of the Skin - p. 295 35. 24. Immunology of Mucosal Surfaces - p. 306 36. 25. Host Defenses to Viruses - p. 320 37. 26. Host Defenses to Intracellular Bacteria - p. 331 38. 27. Host Defenses to Extracellular Bacteria Including Spirochetes - p. 347 39. 28. Host Defenses to Fungi - p. 361 40. 29. Host Defenses to Protozoa - p. 375 41. 30. Host Defenses to Helminth Infection - p. 386 42. 31. Emerging Pandemic Infectious Disease Threats - p. 399 43. Part IV: Immune Deficiency and Immune Regulatory Disorders - p. 410 44. 32. Approach to the Evaluation of the Patient With Suspected Immunodeficiency - p. 413 45. 33. Primary Antibody Deficiencies - p. 420 46. 34. Primary T-Cell Immunodeficiencies - p. 438 47. 35. Genetic Disorders of Interferons-, Interleukin-17, Interleukin-18, and Nuclear Factor-κB-Mediated Immunity - p. 457 48. 36. Hemophagocytic Lymphohistiocytosis - p. 469 49. 37. Autoinflammatory Syndromes - p. 474 50. 38. Immune Regulatory Disorders - p. 484 51. 39. Neutrophils and Neutrophil Disorders - p. 491 52. 40. Complement and Complement Disorders - p. 506 53. 41. Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome - p. 525 54. 42. Autoantibody-Mediated Phenocopies of Primary Immunodeficiency Diseases - p. 542 55. Part V: Allergic Diseases - p. 548 56. 43. Allergic Airway Diseases - p. 551 57. 44. Mast Cells and Mast Cell Disorders - p. 561 58. 45. Eosinophils and Eosinophilic Disorders - p. 573 59. 46. Urticaria, Angioedema, and Anaphylaxis - p. 586 60. 47. Allergic Reactions to Stinging and Biting Insects - p. 601 61. 48. Atopic and Contact Dermatitis - p. 609 62. 49. Food Allergy - p. 623 63. 50. Drug Hypersensitivity - p. 630 64. Part VI: Systemic Immune Diseases - p. 646 65. 51. Mechanisms of Autoimmunity - p. 649 66. 52. Systemic Lupus Erythematosus - p. 657 67. 53. Rheumatoid Arthritis - p. 678 68. 54. Juvenile Idiopathic Arthritis - p. 693 69. 55. Sjögren’s Syndrome - p. 704 70. 56. Scleroderma–Systemic Sclerosis - p. 712 71. 57. Inflammatory Muscle Diseases - p. 723 72. 58. Spondyloarthritis - p. 734 73. 59. Small- and Medium-Vessel Primary Vasculitis - p. 754 74. 60. Large Vessel Vasculitides - p. 773 75. 61. Antiphospholipid Syndrome - p. 788 76. Part VII: Organ-Specific Inflammatory Disease - p. 794 77. 62. Immunohematologic Disorders - p. 796 78. 63. Bullous Diseases of the Skin and Mucous Membranes - p. 806 79. 64. Immunology of Psoriasis - p. 824 80. 65. Myasthenia Gravis - p. 832 81. 66. Multiple Sclerosis - p. 843 82. 67. Autoimmune Peripheral Neuropathies - p. 854 83. 68. Immunologic Renal Diseases - p. 866 84. 69. Immunologic Mechanisms ofAtherosclerosis and Myocarditis - p. 883 85. 70. Autoimmune Thyroid Diseases - p. 898 86. 71. Type 1 Diabetes - p. 909 87. 72. Immunologic Lung Diseases - p. 919 88. 73. Chronic Obstructive Pulmonary Disease and Emphysema - p. 936 89. 74. Immunologic Ocular Disease - p. 943 90. 75. Immunologic Diseases of the Gastrointestinal Tract - p. 959 91. 76. Inflammatory Hepatobiliary Diseases - p. 972 92. Part VIII: Immunology and Immunotherapy of Neoplasia - p. 981 93. 77. Lymphoid Leukemias - p. 984 94. 78. Lymphomas - p. 1000 95. 79. Monoclonal Gammopathies - p. 1014 96. 80. Immune Responses to Solid Tumors and Immune Checkpoint Therapy - p. 1028 97. 81. CAR T-Cell Therapy - p. 1042 98. Part IX: Medical Management of Immunological Diseases - p. 1049 99. 82. Immunoglobulin Therapy: Replacement and Immunomodulation - p. 1051 100. 83. Glucocorticoids - p. 1061 101. 84. Immunomodulating Drugs - p. 1072 102. 85. Protein Kinase Antagonists - p. 1080 103. 86. Biologic Response Modifiers - p. 1089 104. 87. Vaccines - p. 1102 105. 88. Allergen Immunotherapy for Allergic Diseases - p. 1117 106. Part X: Transplantation - p. 1125 107. 89. Solid Organ Transplantation: Rejection, Immunosuppression, and Tolerance - p. 1128 108. 90. Allogeneic Transplantation for Immunodeficiency - p. 1146 109. 91. Gene Therapy for Primary Immune Deficiency Diseases - p. 1161 110. 92. Hematopoietic Stem Cell Transplantation for Malignant Diseases - p. 1172 111. Part XI: Diagnostic Immunology - p. 1182 112. 93. Flow Cytometry - p. 1185 113. 94. Assessment of Functional Immune Responses in Lymphocytes - p. 1198 114. 95. Assessment of Neutrophil Function - p. 1214 115. 96. Assessment of Human Allergic Diseases - p. 1225 116. Appendix 1. Selected CD Molecules and Their Characteristics - p. 1235 117. Appendix 2. Laboratory Reference Values - p. 1241 118. Index - p. 1243
