Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care.
Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine.
1. Clinical Precision Medicine - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page v 7. List of Illustrations - p. Page vi 8. List of Tables - p. Page vii 9. Chapter 1 : Cytogenetics in precision medicine - p. Page vii 10. Chapter 2 : Molecular genetics—the basics of gene expression - p. Page 8 11. Chapter 3 : Fundamentals of epigenetics - p. Page 26 12. Chapter 4 : Fundamentals of heredity - p. Page 37 13. Chapter 5 : Clinical genetics - p. Page 46 14. Chapter 6 : Pharmacogenomics - p. Page 61 15. Chapter 7 : Immunogenomics: steps toward personalized medicines - p. Page 71 16. Chapter 8 : Technology of clinical genomic testing - p. Page 83 17. Index - p. Page 98
Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care.
Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine.
1. Clinical Precision Medicine - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page v 7. List of Illustrations - p. Page vi 8. List of Tables - p. Page vii 9. Chapter 1 : Cytogenetics in precision medicine - p. Page vii 10. Chapter 2 : Molecular genetics—the basics of gene expression - p. Page 8 11. Chapter 3 : Fundamentals of epigenetics - p. Page 26 12. Chapter 4 : Fundamentals of heredity - p. Page 37 13. Chapter 5 : Clinical genetics - p. Page 46 14. Chapter 6 : Pharmacogenomics - p. Page 61 15. Chapter 7 : Immunogenomics: steps toward personalized medicines - p. Page 71 16. Chapter 8 : Technology of clinical genomic testing - p. Page 83 17. Index - p. Page 98
