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This issue of Neurosurgery Clinics, edited by Drs. Shahid Nimjee and Russell Lonser, will cover Coagulation and Hematology in Neurological Surgery. Topics include Biology of coagulation and coagulopathy; Evaluation of the coagulation in the neurosurgery patient; Genetics of hyper- and hypo-coagulable states; Anticoagulants: pharmacokinetics, mechanisms of action and indications; Use of antiplatelet agents in the neurosurgical patient; Common conditions requiring long-term anti-coagulation in the neurosurgical patient; Reversal of systemic and antiplatelet anticoagulants; Intraoperative blood and factor replacement neurosurgery; Management of Intraoperative coagulopathy; Deep vein thrombosis prophylaxis in the neurosurgical patient; Postoperative anticoagulation after neurological surgery; Management of venous sinus thrombosis; Management of acute ischemic thrombosis; and Management of intracranial hemorrhage the anticoagulated patient.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Section I: Biology and Evaluation - p. xiv 9. Biology of Coagulation and Coagulopathy in Neurologic Surgery - p. 475 10. Evaluation of Coagulation in the Neurosurgery Patient - p. 485 11. Genetics of Hypercoagulable and Hypocoagulable States - p. 493 12. Section II: Anticoagulants - p. 501 13. Anticoagulants: Pharmacokinetics, Mechanisms of Action, and Indications - p. 503 14. Use of Antiplatelet Agents in the Neurosurgical Patient - p. 517 15. Common Conditions Requiring Long-Term Anticoagulation in Neurosurgical Patients - p. 529 16. Reversal of Systemic Anticoagulants and Antiplatelet Therapeutics - p. 537 17. Section III: Coagulation in the Perioperative patient - p. 545 18. Intraoperative Blood and Coagulation Factor Replacement During Neurosurgery - p. 547 19. Management of Intraoperative Coagulopathy - p. 557 20. Deep Vein Thrombosis Prophylaxis in the Neurosurgical Patient - p. 567 21. Postoperative Anticoagulation After Neurologic Surgery - p. 575 22. Section IV: Treatment of Thrombosis in the Neurosurgical Patient - p. 583 23. Management of Venous Sinus Thrombosis - p. 585 24. Management of Acute Ischemic Thrombosis - p. 595 25. Management of Intracranial Hemorrhage in the Anticoagulated Patient - p. 605

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This issue of Neurosurgery Clinics, edited by Drs. Shahid Nimjee and Russell Lonser, will cover Coagulation and Hematology in Neurological Surgery. Topics include Biology of coagulation and coagulopathy; Evaluation of the coagulation in the neurosurgery patient; Genetics of hyper- and hypo-coagulable states; Anticoagulants: pharmacokinetics, mechanisms of action and indications; Use of antiplatelet agents in the neurosurgical patient; Common conditions requiring long-term anti-coagulation in the neurosurgical patient; Reversal of systemic and antiplatelet anticoagulants; Intraoperative blood and factor replacement neurosurgery; Management of Intraoperative coagulopathy; Deep vein thrombosis prophylaxis in the neurosurgical patient; Postoperative anticoagulation after neurological surgery; Management of venous sinus thrombosis; Management of acute ischemic thrombosis; and Management of intracranial hemorrhage the anticoagulated patient.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Section I: Biology and Evaluation - p. xiv 9. Biology of Coagulation and Coagulopathy in Neurologic Surgery - p. 475 10. Evaluation of Coagulation in the Neurosurgery Patient - p. 485 11. Genetics of Hypercoagulable and Hypocoagulable States - p. 493 12. Section II: Anticoagulants - p. 501 13. Anticoagulants: Pharmacokinetics, Mechanisms of Action, and Indications - p. 503 14. Use of Antiplatelet Agents in the Neurosurgical Patient - p. 517 15. Common Conditions Requiring Long-Term Anticoagulation in Neurosurgical Patients - p. 529 16. Reversal of Systemic Anticoagulants and Antiplatelet Therapeutics - p. 537 17. Section III: Coagulation in the Perioperative patient - p. 545 18. Intraoperative Blood and Coagulation Factor Replacement During Neurosurgery - p. 547 19. Management of Intraoperative Coagulopathy - p. 557 20. Deep Vein Thrombosis Prophylaxis in the Neurosurgical Patient - p. 567 21. Postoperative Anticoagulation After Neurologic Surgery - p. 575 22. Section IV: Treatment of Thrombosis in the Neurosurgical Patient - p. 583 23. Management of Venous Sinus Thrombosis - p. 585 24. Management of Acute Ischemic Thrombosis - p. 595 25. Management of Intracranial Hemorrhage in the Anticoagulated Patient - p. 605

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