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This issue of Critical Care Clinics, guest edited by Drs. Hernando Gomez Danies and Joseph Carcillo, focuses on Coagulation/Endothelial Dysfunction. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Cell-cell communication breakdown and endothelial dysfunction; Role of the Tie2/Angiopoetin pathway in endothelial dysfunction; The Glycocalyx; Platelet activation and endothelial dysfunction; Role of antithrombin III and tissue factor pathway; Red blood cell dysfunction; Microvascular hemodynamics, autoregulation and mechanotransduction control of blood flow distribution; Nitric oxide and endothelial dysfunction; Microvascular dysfunction; Hemolytic Uremic Syndrome and atypical HUS; Thrombotic thrombocytopenic purpura, Heparin induced thrombocytopenia and Disseminated intravascular coagulation in the critically ill; Thrombocytopenia associated multiple organ failure (TAMOF); Meningococcemia; Immune consequences of endothelial dysfunction during sepsis; Therapeutic targets in thrombotic microangiopathies with a focus on endothelial disorders; and Coagulation disorders in HLH/Macrophage activation syndrome.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xiv 7. Preface - p. xv 8. Cell-Cell Communication Breakdown and Endothelial Dysfunction - p. 189 9. The Angiopoietin-Tie2 Pathway in Critical Illness - p. 201 10. Endothelial Glycocalyx - p. 217 11. Platelet Activation and Endothelial Cell Dysfunction - p. 233 12. Role of Antithrombin III and Tissue Factor Pathway in the Pathogenesis of Sepsis - p. 255 13. Red Blood Cell Dysfunction in Critical Illness - p. 267 14. A Review on Microvascular Hemodynamics: The Control of Blood Flow Distribution and Tissue Oxygenation - p. 293 15. Nitric Oxide and Endothelial Dysfunction - p. 307 16. Microvascular Dysfunction in the Critically Ill - p. 323 17. Typical and Atypical Hemolytic Uremic Syndrome in the Critically Ill - p. 333 18. Thrombotic Thrombocytopenic Purpura, Heparin-Induced Thrombocytopenia, and Disseminated Intravascular Coagulation - p. 357 19. Thrombocytopenia-Associated Multiple Organ Failure - p. 379 20. The Inflammatory and Hemostatic Response in Sepsis and Meningococcemia - p. 391 21. Immune Consequences of Endothelial Cells’ Activation and Dysfunction During Sepsis - p. 401 22. Coagulation Disorders in Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome - p. 415

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This issue of Critical Care Clinics, guest edited by Drs. Hernando Gomez Danies and Joseph Carcillo, focuses on Coagulation/Endothelial Dysfunction. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Cell-cell communication breakdown and endothelial dysfunction; Role of the Tie2/Angiopoetin pathway in endothelial dysfunction; The Glycocalyx; Platelet activation and endothelial dysfunction; Role of antithrombin III and tissue factor pathway; Red blood cell dysfunction; Microvascular hemodynamics, autoregulation and mechanotransduction control of blood flow distribution; Nitric oxide and endothelial dysfunction; Microvascular dysfunction; Hemolytic Uremic Syndrome and atypical HUS; Thrombotic thrombocytopenic purpura, Heparin induced thrombocytopenia and Disseminated intravascular coagulation in the critically ill; Thrombocytopenia associated multiple organ failure (TAMOF); Meningococcemia; Immune consequences of endothelial dysfunction during sepsis; Therapeutic targets in thrombotic microangiopathies with a focus on endothelial disorders; and Coagulation disorders in HLH/Macrophage activation syndrome.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xiv 7. Preface - p. xv 8. Cell-Cell Communication Breakdown and Endothelial Dysfunction - p. 189 9. The Angiopoietin-Tie2 Pathway in Critical Illness - p. 201 10. Endothelial Glycocalyx - p. 217 11. Platelet Activation and Endothelial Cell Dysfunction - p. 233 12. Role of Antithrombin III and Tissue Factor Pathway in the Pathogenesis of Sepsis - p. 255 13. Red Blood Cell Dysfunction in Critical Illness - p. 267 14. A Review on Microvascular Hemodynamics: The Control of Blood Flow Distribution and Tissue Oxygenation - p. 293 15. Nitric Oxide and Endothelial Dysfunction - p. 307 16. Microvascular Dysfunction in the Critically Ill - p. 323 17. Typical and Atypical Hemolytic Uremic Syndrome in the Critically Ill - p. 333 18. Thrombotic Thrombocytopenic Purpura, Heparin-Induced Thrombocytopenia, and Disseminated Intravascular Coagulation - p. 357 19. Thrombocytopenia-Associated Multiple Organ Failure - p. 379 20. The Inflammatory and Hemostatic Response in Sepsis and Meningococcemia - p. 391 21. Immune Consequences of Endothelial Cells’ Activation and Dysfunction During Sepsis - p. 401 22. Coagulation Disorders in Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome - p. 415

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