Comprehensive Glycoscience, Second Edition, Five Volume Set assembles the top minds in this area who provide an update on the renowned 2007 first edition, including new discoveries and latest advances in glycoscience-related research areas such as glycan microarrays, carbohydrate materials, glycoengineering and microbiome research. The result is an up-to-date work which will impress readers with the many new advances that are outlined and taught in this second edition. Most areas of the original edition have been majorly updated, some overlapping topics have been consolidated, and several topics have been rearranged into more appropriate sections.
1. 1.01. Introduction to Comprehensive Glycoscience: The Good, the Better and What's to Come - p. iii 2. Bacterial Exopolysaccharides - p. iii 3. Fungal Polysaccharides - p. iii 4. 1.04. Seaweed Polysaccharides: Promising Molecules for Biotechnological Applications - p. iii 5. 1.05. Common Cellular Glycans: Biosynthesis, Modifications and Functions in Cancer and Inflammation - p. iii 6. C-Mannosyl Tryptophan: From Chemistry to Cell Biology - p. iii 7. O-Fucosylation of Proteins - p. iii 8. 1.08. Structure, Classification and Modification of Polysaccharides - p. iii 9. 1.09. Overview of Cellulose Types and Applications - p. iii 10. 1.10. Mucins: Structure and Function - p. iii 11. High-pH Anion-Exchange Chromatography (HPAEC) and Pulsed Amperometric Detection (PAD) for Carbohydrate Analysis - p. iii 12. 1.12. Capillary Electrophoresis - p. iii 13. 1.13. Modern Mass Spectrometry Techniques for Oligosaccharide Structure Determination: Logically Derived Sequence Tandem Mass Spectrometry for Automatic Oligosaccharide Structural Determination - p. iii 14. General NMR Spectroscopy of Carbohydrates and Conformational Analysis in Solution - p. iii 15. Computational Modeling in Glycoscience - p. iii 16. 1.16. Understanding the Structure and Function of Viral Glycosylation by Molecular Simulations: State-of-the-Art and Recent Case Studies - p. iii 17. 1.17. Tools and Methods to Study the Human Glycome - p. iii 18. 1.18. Glycosciences.de: Databases and Tools to Support Research in Glycomics and Glycoproteomics - p. iii 19. 1.19. Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional Effectors in Aging and Diseases - p. iii 20. Glycans of the Pathogenic Yeast Cryptococcus neoformans and Related Opportunities for Therapeutic Advances - p. iii 21. 1.21. Glycoinformatics Resources Integrated Through the GlySpace Alliance - p. iii 22. Glycosylation - p. iii 23. 2.01. Strategies in Oligosaccharide Synthesis - p. iii 24. 2.02. The Oxocarbenium Ion Intermediate - p. iii 25. 2.03. Stereoelectronic Effects in Glycosylation Reactions - p. iii 26. Methods for O-Glycoside Synthesis - p. iii 27. Synthesis of C- and S-Glycosides - p. iii 28. 2.06. Synthesis of Uronic Acid Containing Oligosaccharides - p. iii 29. Synthesis of Glycosides of Sialic Acid - p. iii 30. 2.08. Glycosylation With Furanosides - p. iii 31. 2.09. Synthesis of 2-Deoxyglycosides - p. iii 32. 2.10. Electrochemical Activation of Glycosyl Donors - p. iii 33. 2.11. Photochemical Glycosylation - p. iii 34. 1,2-cis O-Glycosylation Methods - p. iii 35. 2.13. Glycosylation Through Intramolecular Aglycon Delivery - p. iii 36. Oligosaccharide Synthesis - p. iii 37. 2.14. De Novo Synthesis of Oligosaccharides Via Metal Catalysis - p. iii 38. 2.15. Protecting Group Manipulations in Carbohydrate Synthesis - p. iii 39. 2.16. Chemo-Enzymatic Syntheses of Oligosaccharides and Glycoconjugates - p. iii 40. 2.17. Automated Oligosaccharide Synthesis: Development of the Glyconeer® - p. iii 41. 2.18. Automated Oligosaccharide Synthesis: The Past, Present, and Future - p. iii 42. 2.19. Ionic Liquid Tags for Supported Oligosaccharide Synthesis - p. iii 43. 2.20. HPLC-Based Automated Oligosaccharide Synthesis - p. iii 44. 2.21. Synthesis of Carbohydrate Building Blocks for Automated Oligosaccharide Construction - p. iii 45. Synthesis of Glyconjugates - p. iii 46. 2.22. Bioorthogonal Chemical Ligations Towards Neoglycoproteins - p. iii 47. 2.23. Conjugation Techniques and Linker Strategies for Carbohydrate-Based Vaccines - p. iii 48. 2.24. Enzyme-Based Methods to Synthesize Homogeneous Glycosaminoglycan Oligosaccharides - p. iii 49. Biosynthesis, Catabolism and Cellular Dynamics of Mammalian Glycans - p. iii 50. Folding and Quality Control of Glycoproteins - p. iii 51. 3.02. Biosynthesis and Degradation of Glycans of the Extracellular Matrix: Sulfated Glycosaminoglycans, Hyaluronan, and Matriglycan - p. iii 52. 3.03. Biology of Proteoglycans and Associated Glycosaminoglycans - p. iii 53. 3.04. Glycosylphosphatidylinositol Anchors and Lipids - p. iii 54. Biosynthesis of Glycolipids - p. iii 55. 3.06. Nucleocytoplasmic Protein Glycosylation - p. iii 56. 3.07. Biosynthesis of Bacterial Polysaccharides - p. iii 57. 3.08. The Structure and Biosynthesis of Glycans in the Parasitic Protists - p. iii 58. 3.09. Controlling Glycosyltransferase Activity: Inhibition and Enzyme Engineering - p. iii 59. 3.10. Mucin-Type O-Glycans: Biosynthesis and Functions - p. iii 60. Cellular Glycan Engineering - p. iii 61. 3.11. Imaging Glycans With Metabolic Glycoengineering - p. iii 62. 3.12. Metabolic Engineering of Glycans - p. iii 63. 3.13. Transformative Technologies to Advance Our Understanding of the Functions of O-GlcNAc - p. iii 64. 3.14. Metabolic Labeling of Bacterial Glycans - p. iii 65. Carbohydrate-Binding Molecules and their Interactions - p. iii 66. 3.15. Nuclear Magnetic Resonance Techniques for the Study of Glycan Interactions - p. iii 67. Molecular and Mechanistic Basis of Lectin-Glycan Interactions - p. iii 68. 3.17. Design and Development of Divalent Lectin Ligands - p. iii 69. 3.18. Lectins as Analytical Tools - p. iii 70. 3.19. Human C-Type Lectins, MGL, DC-SIGN and Langerin, Their Interactions With Endogenous and Exogenous Ligand Patterns - p. iii 71. 3.20. Serum Anti-Carbohydrate Antibodies and Hyperacute Rejection - p. iii 72. 3.21. Zwitterionic Polysaccharides in Immunity - p. iii 73. 3.22. Glycolipids as Antigens for Semi-Invariant Natural Killer T Cells - p. iii 74. Polysaccharides and Hydrogels - p. iii 75. 4.01. Polysaccharides and Applications in Regenerative Medicine - p. iii 76. 4.02. Polysaccharides for Drug Delivery: The Development of Polysaccharide-Based Materials and Glycopolymer to Improve Drug Delivery Applications - p. iii 77. 4.03. Cationic Polysaccharides and Glycopolymers in Gene Therapy - p. iii 78. 4.04. Hydrogels Based on Natural Polysaccharides and Their Applications - p. iii 79. 4.05. Glycopolymer-Based Hydrogels, Microgels, and Nanogels and Their Applications - p. iii 80. Glycan Arrays and Biosensors - p. iii 81. 4.06. Glycan Arrays: Construction, Detection, and Analysis - p. iii 82. 4.07. Application of Glycan-Related Microarrays - p. iii 83. 4.08. Carbohydrate Biosensors and Applications - p. iii 84. 4.09. Microbial Glycan Arrays - p. iii 85. Glyconanotechnology - p. iii 86. 4.10. Synthesis, Characterization and Applications of Glycopolymers - p. iii 87. 4.11. Glycopolymer Functionalized Nanoparticles and Their Applications - p. iii 88. 4.12. Glycopolymer Conjugates: Preparation and Functions - p. iii 89. 4.13. Glycoclusters and Glycodendrimers - p. iii 90. 4.14. Surface Immobilized Glycopolymers - p. iii 91. 4.15. Carbohydrate Functionalized Liposomes and Applications - p. iii 92. 4.16. Carbohydrate-Presenting Metal Nanoparticles: Synthesis, Characterization and Applications - p. iii 93. 4.17. Carbohydrate Modified Non-Metallic Nanomaterials and Their Application Against Infectious Diseases - p. iii 94. 4.18. Carbohydrate Functionalized Quantum Dots in Sensing, Imaging and Therapy Applications - p. iii 95. 4.19. Nanostructured Materials for Glycan Based Applications - p. iii 96. 4.20. Nanocellulose: Preparation, Functionalization and Applications - p. iii 97. 4.21. Profiling Carbohydrate-Protein Interaction Using Nanotechnology - p. iii 98. 4.22. Glyco-Nanomedicines and Their Applications in Cancer Treatment - p. iii 99. Cell Glycobiology and Development - p. iii 100. Drosophila melanogaster in Glycobiology: Their Mutants Are Excellent Models for Human Diseases - p. iii 101. Glycobiology of Caenorhabditis elegans - p. iii 102. Glycobiology of Yeast: Applications to Glycoprotein Expression and Remodeling - p. iii 103. Lectin Repertoires in Invertebrates and Ectothermic Vertebrates: Structural and Functional Aspects - p. iii 104. 5.05. Structure and Biological Functions of Plant Glycans and Polysaccharides - p. iii 105. 5.06. Glycan-Mediated Interactions Between Fungal and Higher Animal Cells - p. iii 106. Health and Disease in Glycomedicine - p. iii 107. Glycation in Disease - p. iii 108. O-GlcNAcylation and Diabetes - p. iii 109. 5.09. Mammalian Cytosolic Galectins Act as Damage-Associated Molecular Patterns, Resolution-Associated Molecular Patterns, and Pattern-Recognition Receptors in Innate Immunity - p. iii 110. 5.10. Glycoconjugates for Adjuvants and Self-Adjuvanting Vaccines - p. iii 111. 5.11. C-Type Lectins and Their Roles in Disease and Immune Homeostasis - p. iii 112. Human IgG Glycosylation in Inflammation and Inflammatory Disease - p. iii 113. 5.13. Glycans in Bacterial Infections: Gram-Negative Infections in the Respiratory Tract - p. iii 114. 5.14. Glycans in Chronic Obstructive Pulmonary Disease (COPD) - p. iii 115. Neural Functions of Glycolipids - p. iii 116. 5.16. Glycan-Related Demyelination and Remyelination - p. iii 117. 5.17. Role of Polysialic Acid in Schizophrenia - p. iii 118. 5.18. The Involvement of Cellular Glycans in Alzheimer's Disease - p. iii 119. 5.19. Congenital Disorders of Glycosylation - p. iii 120. 5.20. α-Dystroglycanopathy: Molecular Mechanism, Clinical Manifestations, and Therapeutic Approaches - p. iii 121. Diseases Associated With GPI Anchors - p. iii 122. 5.22. The Enzyme-Mediated Activation of Radical Sources (EMARS) Reaction: A New Tool for Identification of Membrane Microdomain-Associated GPI-Anchored Glycoprotein Partners - p. iii 123. 5.23. Human Milk Oligosaccharides and Microbiome Homeostasis - p. iii 124. 5.24. Human Milk Oligosaccharides and Innate Immunity - p. iii 125. 5.25. N-Linked Glycans in the Epithelial-Mesenchymal Transition: Implications for Cancer Metastasis - p. iii 126. 5.26. The Role of Glycans in Chronic Inflammatory Gastrointestinal and Liver Disorders and Cancer - p. iii 127. 5.27. Glycan Biomarkers in Pancreatic Cancer - p. iii 128. Xenotransplantation and Glycomedicine - p. iii 129. 5.29. Glycans as Targets and Mediators of T-Cell Immunotherapy - p. iii 130. 5.30. Glycotherapeutics and Verotoxin - p. iii 131. Structural and Functional Roles of the N-Glycans in Therapeutic Antibodies - p. iii 132. Index - p. iii 133. Authors - p. iii
Comprehensive Glycoscience, Second Edition, Five Volume Set assembles the top minds in this area who provide an update on the renowned 2007 first edition, including new discoveries and latest advances in glycoscience-related research areas such as glycan microarrays, carbohydrate materials, glycoengineering and microbiome research. The result is an up-to-date work which will impress readers with the many new advances that are outlined and taught in this second edition. Most areas of the original edition have been majorly updated, some overlapping topics have been consolidated, and several topics have been rearranged into more appropriate sections.
1. 1.01. Introduction to Comprehensive Glycoscience: The Good, the Better and What's to Come - p. iii 2. Bacterial Exopolysaccharides - p. iii 3. Fungal Polysaccharides - p. iii 4. 1.04. Seaweed Polysaccharides: Promising Molecules for Biotechnological Applications - p. iii 5. 1.05. Common Cellular Glycans: Biosynthesis, Modifications and Functions in Cancer and Inflammation - p. iii 6. C-Mannosyl Tryptophan: From Chemistry to Cell Biology - p. iii 7. O-Fucosylation of Proteins - p. iii 8. 1.08. Structure, Classification and Modification of Polysaccharides - p. iii 9. 1.09. Overview of Cellulose Types and Applications - p. iii 10. 1.10. Mucins: Structure and Function - p. iii 11. High-pH Anion-Exchange Chromatography (HPAEC) and Pulsed Amperometric Detection (PAD) for Carbohydrate Analysis - p. iii 12. 1.12. Capillary Electrophoresis - p. iii 13. 1.13. Modern Mass Spectrometry Techniques for Oligosaccharide Structure Determination: Logically Derived Sequence Tandem Mass Spectrometry for Automatic Oligosaccharide Structural Determination - p. iii 14. General NMR Spectroscopy of Carbohydrates and Conformational Analysis in Solution - p. iii 15. Computational Modeling in Glycoscience - p. iii 16. 1.16. Understanding the Structure and Function of Viral Glycosylation by Molecular Simulations: State-of-the-Art and Recent Case Studies - p. iii 17. 1.17. Tools and Methods to Study the Human Glycome - p. iii 18. 1.18. Glycosciences.de: Databases and Tools to Support Research in Glycomics and Glycoproteomics - p. iii 19. 1.19. Systems Glycobiology: Immunoglobulin G Glycans as Biomarkers and Functional Effectors in Aging and Diseases - p. iii 20. Glycans of the Pathogenic Yeast Cryptococcus neoformans and Related Opportunities for Therapeutic Advances - p. iii 21. 1.21. Glycoinformatics Resources Integrated Through the GlySpace Alliance - p. iii 22. Glycosylation - p. iii 23. 2.01. Strategies in Oligosaccharide Synthesis - p. iii 24. 2.02. The Oxocarbenium Ion Intermediate - p. iii 25. 2.03. Stereoelectronic Effects in Glycosylation Reactions - p. iii 26. Methods for O-Glycoside Synthesis - p. iii 27. Synthesis of C- and S-Glycosides - p. iii 28. 2.06. Synthesis of Uronic Acid Containing Oligosaccharides - p. iii 29. Synthesis of Glycosides of Sialic Acid - p. iii 30. 2.08. Glycosylation With Furanosides - p. iii 31. 2.09. Synthesis of 2-Deoxyglycosides - p. iii 32. 2.10. Electrochemical Activation of Glycosyl Donors - p. iii 33. 2.11. Photochemical Glycosylation - p. iii 34. 1,2-cis O-Glycosylation Methods - p. iii 35. 2.13. Glycosylation Through Intramolecular Aglycon Delivery - p. iii 36. Oligosaccharide Synthesis - p. iii 37. 2.14. De Novo Synthesis of Oligosaccharides Via Metal Catalysis - p. iii 38. 2.15. Protecting Group Manipulations in Carbohydrate Synthesis - p. iii 39. 2.16. Chemo-Enzymatic Syntheses of Oligosaccharides and Glycoconjugates - p. iii 40. 2.17. Automated Oligosaccharide Synthesis: Development of the Glyconeer® - p. iii 41. 2.18. Automated Oligosaccharide Synthesis: The Past, Present, and Future - p. iii 42. 2.19. Ionic Liquid Tags for Supported Oligosaccharide Synthesis - p. iii 43. 2.20. HPLC-Based Automated Oligosaccharide Synthesis - p. iii 44. 2.21. Synthesis of Carbohydrate Building Blocks for Automated Oligosaccharide Construction - p. iii 45. Synthesis of Glyconjugates - p. iii 46. 2.22. Bioorthogonal Chemical Ligations Towards Neoglycoproteins - p. iii 47. 2.23. Conjugation Techniques and Linker Strategies for Carbohydrate-Based Vaccines - p. iii 48. 2.24. Enzyme-Based Methods to Synthesize Homogeneous Glycosaminoglycan Oligosaccharides - p. iii 49. Biosynthesis, Catabolism and Cellular Dynamics of Mammalian Glycans - p. iii 50. Folding and Quality Control of Glycoproteins - p. iii 51. 3.02. Biosynthesis and Degradation of Glycans of the Extracellular Matrix: Sulfated Glycosaminoglycans, Hyaluronan, and Matriglycan - p. iii 52. 3.03. Biology of Proteoglycans and Associated Glycosaminoglycans - p. iii 53. 3.04. Glycosylphosphatidylinositol Anchors and Lipids - p. iii 54. Biosynthesis of Glycolipids - p. iii 55. 3.06. Nucleocytoplasmic Protein Glycosylation - p. iii 56. 3.07. Biosynthesis of Bacterial Polysaccharides - p. iii 57. 3.08. The Structure and Biosynthesis of Glycans in the Parasitic Protists - p. iii 58. 3.09. Controlling Glycosyltransferase Activity: Inhibition and Enzyme Engineering - p. iii 59. 3.10. Mucin-Type O-Glycans: Biosynthesis and Functions - p. iii 60. Cellular Glycan Engineering - p. iii 61. 3.11. Imaging Glycans With Metabolic Glycoengineering - p. iii 62. 3.12. Metabolic Engineering of Glycans - p. iii 63. 3.13. Transformative Technologies to Advance Our Understanding of the Functions of O-GlcNAc - p. iii 64. 3.14. Metabolic Labeling of Bacterial Glycans - p. iii 65. Carbohydrate-Binding Molecules and their Interactions - p. iii 66. 3.15. Nuclear Magnetic Resonance Techniques for the Study of Glycan Interactions - p. iii 67. Molecular and Mechanistic Basis of Lectin-Glycan Interactions - p. iii 68. 3.17. Design and Development of Divalent Lectin Ligands - p. iii 69. 3.18. Lectins as Analytical Tools - p. iii 70. 3.19. Human C-Type Lectins, MGL, DC-SIGN and Langerin, Their Interactions With Endogenous and Exogenous Ligand Patterns - p. iii 71. 3.20. Serum Anti-Carbohydrate Antibodies and Hyperacute Rejection - p. iii 72. 3.21. Zwitterionic Polysaccharides in Immunity - p. iii 73. 3.22. Glycolipids as Antigens for Semi-Invariant Natural Killer T Cells - p. iii 74. Polysaccharides and Hydrogels - p. iii 75. 4.01. Polysaccharides and Applications in Regenerative Medicine - p. iii 76. 4.02. Polysaccharides for Drug Delivery: The Development of Polysaccharide-Based Materials and Glycopolymer to Improve Drug Delivery Applications - p. iii 77. 4.03. Cationic Polysaccharides and Glycopolymers in Gene Therapy - p. iii 78. 4.04. Hydrogels Based on Natural Polysaccharides and Their Applications - p. iii 79. 4.05. Glycopolymer-Based Hydrogels, Microgels, and Nanogels and Their Applications - p. iii 80. Glycan Arrays and Biosensors - p. iii 81. 4.06. Glycan Arrays: Construction, Detection, and Analysis - p. iii 82. 4.07. Application of Glycan-Related Microarrays - p. iii 83. 4.08. Carbohydrate Biosensors and Applications - p. iii 84. 4.09. Microbial Glycan Arrays - p. iii 85. Glyconanotechnology - p. iii 86. 4.10. Synthesis, Characterization and Applications of Glycopolymers - p. iii 87. 4.11. Glycopolymer Functionalized Nanoparticles and Their Applications - p. iii 88. 4.12. Glycopolymer Conjugates: Preparation and Functions - p. iii 89. 4.13. Glycoclusters and Glycodendrimers - p. iii 90. 4.14. Surface Immobilized Glycopolymers - p. iii 91. 4.15. Carbohydrate Functionalized Liposomes and Applications - p. iii 92. 4.16. Carbohydrate-Presenting Metal Nanoparticles: Synthesis, Characterization and Applications - p. iii 93. 4.17. Carbohydrate Modified Non-Metallic Nanomaterials and Their Application Against Infectious Diseases - p. iii 94. 4.18. Carbohydrate Functionalized Quantum Dots in Sensing, Imaging and Therapy Applications - p. iii 95. 4.19. Nanostructured Materials for Glycan Based Applications - p. iii 96. 4.20. Nanocellulose: Preparation, Functionalization and Applications - p. iii 97. 4.21. Profiling Carbohydrate-Protein Interaction Using Nanotechnology - p. iii 98. 4.22. Glyco-Nanomedicines and Their Applications in Cancer Treatment - p. iii 99. Cell Glycobiology and Development - p. iii 100. Drosophila melanogaster in Glycobiology: Their Mutants Are Excellent Models for Human Diseases - p. iii 101. Glycobiology of Caenorhabditis elegans - p. iii 102. Glycobiology of Yeast: Applications to Glycoprotein Expression and Remodeling - p. iii 103. Lectin Repertoires in Invertebrates and Ectothermic Vertebrates: Structural and Functional Aspects - p. iii 104. 5.05. Structure and Biological Functions of Plant Glycans and Polysaccharides - p. iii 105. 5.06. Glycan-Mediated Interactions Between Fungal and Higher Animal Cells - p. iii 106. Health and Disease in Glycomedicine - p. iii 107. Glycation in Disease - p. iii 108. O-GlcNAcylation and Diabetes - p. iii 109. 5.09. Mammalian Cytosolic Galectins Act as Damage-Associated Molecular Patterns, Resolution-Associated Molecular Patterns, and Pattern-Recognition Receptors in Innate Immunity - p. iii 110. 5.10. Glycoconjugates for Adjuvants and Self-Adjuvanting Vaccines - p. iii 111. 5.11. C-Type Lectins and Their Roles in Disease and Immune Homeostasis - p. iii 112. Human IgG Glycosylation in Inflammation and Inflammatory Disease - p. iii 113. 5.13. Glycans in Bacterial Infections: Gram-Negative Infections in the Respiratory Tract - p. iii 114. 5.14. Glycans in Chronic Obstructive Pulmonary Disease (COPD) - p. iii 115. Neural Functions of Glycolipids - p. iii 116. 5.16. Glycan-Related Demyelination and Remyelination - p. iii 117. 5.17. Role of Polysialic Acid in Schizophrenia - p. iii 118. 5.18. The Involvement of Cellular Glycans in Alzheimer's Disease - p. iii 119. 5.19. Congenital Disorders of Glycosylation - p. iii 120. 5.20. α-Dystroglycanopathy: Molecular Mechanism, Clinical Manifestations, and Therapeutic Approaches - p. iii 121. Diseases Associated With GPI Anchors - p. iii 122. 5.22. The Enzyme-Mediated Activation of Radical Sources (EMARS) Reaction: A New Tool for Identification of Membrane Microdomain-Associated GPI-Anchored Glycoprotein Partners - p. iii 123. 5.23. Human Milk Oligosaccharides and Microbiome Homeostasis - p. iii 124. 5.24. Human Milk Oligosaccharides and Innate Immunity - p. iii 125. 5.25. N-Linked Glycans in the Epithelial-Mesenchymal Transition: Implications for Cancer Metastasis - p. iii 126. 5.26. The Role of Glycans in Chronic Inflammatory Gastrointestinal and Liver Disorders and Cancer - p. iii 127. 5.27. Glycan Biomarkers in Pancreatic Cancer - p. iii 128. Xenotransplantation and Glycomedicine - p. iii 129. 5.29. Glycans as Targets and Mediators of T-Cell Immunotherapy - p. iii 130. 5.30. Glycotherapeutics and Verotoxin - p. iii 131. Structural and Functional Roles of the N-Glycans in Therapeutic Antibodies - p. iii 132. Index - p. iii 133. Authors - p. iii
