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Over the past several decades, advances in neonatal nutrition have focused on the provision of early parenteral nutrition and the development of formulas and supplements that most closely approximate maternal breast milk. The overall outcomes for infants, including premature infants, have greatly benefited from these advances, but there are still many nutritional unknowns that impact the lives of neonates. This is an exciting time in neonatal nutrition as the focus has shifted from survival and growth, which are still important goals, to effects of each micro/macronutrient on development, prevention of disease states such as ROP, the effects of neonatal nutrition on future health as an adult, and opportunities to improve long-term neurodevelopmental outcomes by optimal early nutrition. This issue focuses on aspects of enteral and parenteral nutrition that are at the forefront of neonatal care: assessing growth, parenteral nutrition components (including alternate lipid formulations), optimal storage and use of human milk (including donor milk), post-discharge nutrition, and the effects of various micro/macronutrients on long-term developmental outcomes. It is anticipated that the study and implementation of many of these novel concepts into the care of neonates, many of whom are severely premature, will be of value to practitioners, researchers, and, most of all, patients.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. CME Accreditation Page and Author Disclosure - p. 5 6. Forthcoming Issues - p. 6 7. Foreword - p. 7 8. Preface - p. 8 9. Assessment of Neonatal Growth in Prematurely Born Infants - p. 9 10. Linear Growth and Neurodevelopmental Outcomes - p. 15 11. Protein Intake and Neurodevelopmental Outcomes - p. 23 12. Complications Associated with Parenteral Nutrition in the Neonate - p. 28 13. Micronutrient Requirements of High-Risk Infants - p. 34 14. Fatty Acid Requirements in Preterm Infants and Their Role in Health and Disease - p. 42 15. High-Protein Formulas - p. 51 16. Fortification of Human Milk in Very Low Birth Weight Infants (VLBW <1500 g Birth Weight) - p. 63 17. Human Breast Milk and the Gastrointestinal Innate Immune System - p. 72 18. Donor Human Milk for Preterm Infants - p. 80 19. LCPUFAs as Conditionally Essential Nutrients for Very Low Birth Weight and Low Birth Weight Infants - p. 89 20. Post-discharge Nutrition and the VLBW Infant: To Supplement or Not Supplement? - p. 95 21. Index - p. 101

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Over the past several decades, advances in neonatal nutrition have focused on the provision of early parenteral nutrition and the development of formulas and supplements that most closely approximate maternal breast milk. The overall outcomes for infants, including premature infants, have greatly benefited from these advances, but there are still many nutritional unknowns that impact the lives of neonates. This is an exciting time in neonatal nutrition as the focus has shifted from survival and growth, which are still important goals, to effects of each micro/macronutrient on development, prevention of disease states such as ROP, the effects of neonatal nutrition on future health as an adult, and opportunities to improve long-term neurodevelopmental outcomes by optimal early nutrition. This issue focuses on aspects of enteral and parenteral nutrition that are at the forefront of neonatal care: assessing growth, parenteral nutrition components (including alternate lipid formulations), optimal storage and use of human milk (including donor milk), post-discharge nutrition, and the effects of various micro/macronutrients on long-term developmental outcomes. It is anticipated that the study and implementation of many of these novel concepts into the care of neonates, many of whom are severely premature, will be of value to practitioners, researchers, and, most of all, patients.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. CME Accreditation Page and Author Disclosure - p. 5 6. Forthcoming Issues - p. 6 7. Foreword - p. 7 8. Preface - p. 8 9. Assessment of Neonatal Growth in Prematurely Born Infants - p. 9 10. Linear Growth and Neurodevelopmental Outcomes - p. 15 11. Protein Intake and Neurodevelopmental Outcomes - p. 23 12. Complications Associated with Parenteral Nutrition in the Neonate - p. 28 13. Micronutrient Requirements of High-Risk Infants - p. 34 14. Fatty Acid Requirements in Preterm Infants and Their Role in Health and Disease - p. 42 15. High-Protein Formulas - p. 51 16. Fortification of Human Milk in Very Low Birth Weight Infants (VLBW <1500 g Birth Weight) - p. 63 17. Human Breast Milk and the Gastrointestinal Innate Immune System - p. 72 18. Donor Human Milk for Preterm Infants - p. 80 19. LCPUFAs as Conditionally Essential Nutrients for Very Low Birth Weight and Low Birth Weight Infants - p. 89 20. Post-discharge Nutrition and the VLBW Infant: To Supplement or Not Supplement? - p. 95 21. Index - p. 101

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