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This issue of Hematology/Oncology Clinics of North America is devoted to Congenital and Acquired Disorders of Macrophages and Histiocytes. Guest Editors Nancy Berliner, MD and Barrett Rollins, MD have assembled a group of expert authors to review the following topics: Nosology of Langerhans Cell Histiocytosis (LCH); Cell of Origin of LCH; Genomic Changes in LCH; Clinical Treatment of LCH; Neurodegeneration in LCH; Pathogenesis of Hemophagocytic Lymphohistiocytosis (HLH); Familial HLH; HLH in Adults; Macrophage Activation Syndrome; and Stem Cell Transplant for HLH.

1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Contributors - p. Cover 6. Forthcoming Issues - p. Cover 7. Dedication - p. Cover 8. Preface. Congenital and Acquired Disorders of Macrophages and Histiocytes - p. Cover 9. Nosology and Pathology of Langerhans Cell Histiocytosis - p. Cover 10. Cell(s) of Origin of Langerhans Cell Histiocytosis - p. Cover 11. Genomic Alterations in Langerhans Cell Histiocytosis - p. Cover 12. Clinical Characteristics and Treatment of Langerhans Cell Histiocytosis - p. Cover 13. Strategies for the Prevention of Central Nervous System Complications in Patients with Langerhans Cell Histiocytosis: The Problem of Neurodegenerative Syndrome - p. Cover 14. Pathogenesis of Hemophagocytic Lymphohistiocytosis - p. Cover 15. Familial Hemophagocytic Lymphohistiocytosis - p. Cover 16. Hemophagocytic Lymphohistiocytosis in Adults - p. Cover 17. Macrophage Activation Syndrome - p. Cover 18. The Role of Hematopoietic Stem Cell Transplantation in Treatment of Hemophagocytic Lymphohistiocytosis - p. Cover 19. Index - p. Cover

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This issue of Hematology/Oncology Clinics of North America is devoted to Congenital and Acquired Disorders of Macrophages and Histiocytes. Guest Editors Nancy Berliner, MD and Barrett Rollins, MD have assembled a group of expert authors to review the following topics: Nosology of Langerhans Cell Histiocytosis (LCH); Cell of Origin of LCH; Genomic Changes in LCH; Clinical Treatment of LCH; Neurodegeneration in LCH; Pathogenesis of Hemophagocytic Lymphohistiocytosis (HLH); Familial HLH; HLH in Adults; Macrophage Activation Syndrome; and Stem Cell Transplant for HLH.

1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Contributors - p. Cover 6. Forthcoming Issues - p. Cover 7. Dedication - p. Cover 8. Preface. Congenital and Acquired Disorders of Macrophages and Histiocytes - p. Cover 9. Nosology and Pathology of Langerhans Cell Histiocytosis - p. Cover 10. Cell(s) of Origin of Langerhans Cell Histiocytosis - p. Cover 11. Genomic Alterations in Langerhans Cell Histiocytosis - p. Cover 12. Clinical Characteristics and Treatment of Langerhans Cell Histiocytosis - p. Cover 13. Strategies for the Prevention of Central Nervous System Complications in Patients with Langerhans Cell Histiocytosis: The Problem of Neurodegenerative Syndrome - p. Cover 14. Pathogenesis of Hemophagocytic Lymphohistiocytosis - p. Cover 15. Familial Hemophagocytic Lymphohistiocytosis - p. Cover 16. Hemophagocytic Lymphohistiocytosis in Adults - p. Cover 17. Macrophage Activation Syndrome - p. Cover 18. The Role of Hematopoietic Stem Cell Transplantation in Treatment of Hemophagocytic Lymphohistiocytosis - p. Cover 19. Index - p. Cover

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