Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more.
This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery.
1. Chapter 1 : Connectomic DBS: An introduction - p. Page xvi 2. Chapter 2 : Network neuroscience and the connectomics revolution - p. Page 20 3. Chapter 3 : Neurophysiological mechanisms of DBS from a connectomic perspective - p. Page 48 4. Chapter 4 : DBS imaging: An overview - p. Page 78 5. Chapter 5 : DBS imaging methods I: Preprocessing - p. Page 106 6. Chapter 6 : DBS imaging methods II: Electrode localization - p. Page 124 7. Chapter 7 : DBS imaging methods III: Estimating the electric field and volume of tissue activated - p. Page 143 8. Chapter 8 : Stereotactic spaces - p. Page 167 9. Chapter 9 : DBS imaging methods IV: Group analyses - p. Page 181 10. Chapter 10 : Resting-state functional MRI-based connectivity - p. Page 197 11. Chapter 11 : Diffusion MRI-based connectivity - p. Page 218 12. Chapter 12 : Normative connectomes and their use in DBS - p. Page 241 13. Chapter 13 : Investigating network effects of DBS with fMRI - p. Page 266 14. Chapter 14 : High-resolution resources and histological mesh tractography - p. Page 297 15. Chapter 15 : Using brain lesions to inform connectomic DBS - p. Page 320 16. Chapter 16 : Electrophysiological connectivity measures from deep brain stimulation (DBS)-targets in Parkinson’s disease and dystonia - p. Page 334 17. Chapter 17 : Mapping and predicting treatment response on a local level - p. Page 351 18. Chapter 18 : Predicting treatment response based on DBS connectivity - p. Page 374 19. Chapter 19 : Connectomic DBS in Parkinson’s disease, essential tremor and dystonia - p. Page 399 20. Chapter 20 : Connectomic DBS in major depression - p. Page 423 21. Chapter 21 : Connectomic deep brain stimulation in obsessive compulsive disorder - p. Page 445 22. Chapter 22 : Fiber tractography-assisted deep brain stimulation surgery: Connectomics in the operating room - p. Page 461 23. Chapter 23 : Investigating cognitive neuroscience concepts using connectomic DBS - p. Page 476 24. Chapter 24 : Combining invasive and noninvasive brain stimulation - p. Page 498 25. Chapter 25 : Outlook: Towards personalized connectomic deep brain stimulation - p. Page 519 26. Chapter 26 : Whole-brain modeling to predict optimal deep brain stimulation targeting - p. Page 539 27. Index - p. Page 557
Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more.
This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery.
1. Chapter 1 : Connectomic DBS: An introduction - p. Page xvi 2. Chapter 2 : Network neuroscience and the connectomics revolution - p. Page 20 3. Chapter 3 : Neurophysiological mechanisms of DBS from a connectomic perspective - p. Page 48 4. Chapter 4 : DBS imaging: An overview - p. Page 78 5. Chapter 5 : DBS imaging methods I: Preprocessing - p. Page 106 6. Chapter 6 : DBS imaging methods II: Electrode localization - p. Page 124 7. Chapter 7 : DBS imaging methods III: Estimating the electric field and volume of tissue activated - p. Page 143 8. Chapter 8 : Stereotactic spaces - p. Page 167 9. Chapter 9 : DBS imaging methods IV: Group analyses - p. Page 181 10. Chapter 10 : Resting-state functional MRI-based connectivity - p. Page 197 11. Chapter 11 : Diffusion MRI-based connectivity - p. Page 218 12. Chapter 12 : Normative connectomes and their use in DBS - p. Page 241 13. Chapter 13 : Investigating network effects of DBS with fMRI - p. Page 266 14. Chapter 14 : High-resolution resources and histological mesh tractography - p. Page 297 15. Chapter 15 : Using brain lesions to inform connectomic DBS - p. Page 320 16. Chapter 16 : Electrophysiological connectivity measures from deep brain stimulation (DBS)-targets in Parkinson’s disease and dystonia - p. Page 334 17. Chapter 17 : Mapping and predicting treatment response on a local level - p. Page 351 18. Chapter 18 : Predicting treatment response based on DBS connectivity - p. Page 374 19. Chapter 19 : Connectomic DBS in Parkinson’s disease, essential tremor and dystonia - p. Page 399 20. Chapter 20 : Connectomic DBS in major depression - p. Page 423 21. Chapter 21 : Connectomic deep brain stimulation in obsessive compulsive disorder - p. Page 445 22. Chapter 22 : Fiber tractography-assisted deep brain stimulation surgery: Connectomics in the operating room - p. Page 461 23. Chapter 23 : Investigating cognitive neuroscience concepts using connectomic DBS - p. Page 476 24. Chapter 24 : Combining invasive and noninvasive brain stimulation - p. Page 498 25. Chapter 25 : Outlook: Towards personalized connectomic deep brain stimulation - p. Page 519 26. Chapter 26 : Whole-brain modeling to predict optimal deep brain stimulation targeting - p. Page 539 27. Index - p. Page 557
