A must-have resource for residents and fellows, comprehensive ophthalmologists, and seasoned cornea specialists, Cornea, 6th Edition, remains the only reference available that synthesizes this vast subspecialty into a single, authoritative compendium. Drs. Mark J. Mannis, Edward J. Holland, and Albert Y. Cheung lead a team of more than 300 global experts to keep you up to date with both common and more obscure diseases and disorders and the best route to effective treatment and management. You’ll find current coverage of the expanding range of contemporary corneal surgery, new diagnostic and imaging technologies, and medical management of corneal and external disease as well as ocular surface disease, all highlighted by more than 2,300 exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs for superb visual guidance.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Inside front cover - p. iii 6. Copyright - p. iv 7. Dedication - p. v 8. PREFACE - p. v 9. Acknowledgements - p. vi 10. List of Contributors - p. viii 11. VIDEO TABLE OF CONTENTS - p. xxvii 12. volume 1: Fundamentals, Diagnosis and Management - p. V1 13. Part 1: Basic Science: Cornea, Sclera, Ocular Adnexa Anatomy, Physiology, and Pathophysiologic Responses - p. P1 14. 1. Cornea and Sclera: Anatomy and Physiology - p. 1 15. 2. The Conjunctiva: Anatomy and Physiology - p. 25 16. 3. Tear Film - p. 33 17. 4. Eyelids and the Corneal Surface - p. 45 18. 5. A Matrix of Pathologic Responses in the Cornea - p. 51 19. Part 2: Examining and Imaging the Cornea and External Eye - p. P77 20. Section 1: Basic Evaluation of the Corneaand External Eye - p. S77 21. 6. Examination of the Lids - p. 77 22. 7. Slit Lamp Examination and Photography - p. 84 23. 8. Tear Film and Corneal Diagnostic Techniques - p. 112 24. Section 2: Laboratory Investigations - p. S122 25. 9. Practical Ophthalmic Microbiology for the Detection of Corneal Pathogens - p. 122 26. 10. Molecular Genetics of Corneal Disease - p. 132 27. Section 3: Imaging Techniques of the Cornea - p. S145 28. 11. Keratometry and Topography - p. 145 29. 12. Corneal Shape Analysis and Biomechanical Assessment - p. 158 30. 13. Specular Microscopy - p. 165 31. 14. Clinical Applications of Confocal Microscopy - p. 191 32. 15. High-Resolution Ultrasound - p. 202 33. 16. Anterior Segment Optical Coherence Tomography - p. 211 34. Part 3: Differential Diagnosis of Selected Problems in Cornea and External Disease - p. P218 35. 17. Congenital Corneal Opacities Diagnosis and Management - p. 218 36. 18. Peripheral Corneal Disease - p. 243 37. 19. Evaluation of the Corneal Ulcer - p. 252 38. 20. Evaluation of Recurrent Corneal Erosions - p. 256 39. 21. Corneal Deposits - p. 261 40. 22. The Red Eye - p. 274 41. Part 4: Eye Banking - p. P282 42. 23. Eye Banking: Structure and Function - p. 282 43. 24. Medical Standards for Eye Banking - p. 287 44. Part 5: The Ocular Adnexa - p. P296 45. Section 1: Diseases of the Lid: Anatomic Abnormalities - p. S296 46. 25. Malposition of the Eyelids - p. 296 47. Section 2: Diseases of the Lid: Tumors, Inflammation and Infection - p. S314 48. 26. Benign Lid Tumors - p. 314 49. 27. Malignant Eyelid Tumors - p. 332 50. 28. Blepharitis:: Overview and Classification - p. 346 51. 29. Eyelid Infections - p. 350 52. Section 3: Disorders of Tear Production and the Lacrimal System - p. S360 53. Dry Eye Overview: Classification and Treatment Algorithm - p. 360 54. 31. Aqueous Tear Deficiency - p. 370 55. 32. Meibomian Gland Dysfunction and Evaporative Dry Eye Disease - p. 378 56. 33. Dacryoadenitis, Dacryocystitis, and Canaliculitis - p. 393 57. 34. Epiphora - p. 400 58. Part 6: The Conjunctiva - p. P407 59. Section 1: Conjunctivitis - p. S407 60. 35. Conjunctiva: An Overview and Classification - p. 407 61. 36. Bacterial Conjunctivitis - p. 414 62. 37. Viral Conjunctivitis - p. 421 63. 38. Chlamydial Infections - p. 432 64. 39. Ophthalmia Neonatorum - p. 438 65. 40. Parinaud Oculoglandular Syndrome - p. 444 66. 41. Seasonal and Perennial Allergic Conjunctivitis - p. 452 67. 42. Vernal and Atopic Keratoconjunctivitis - p. 458 68. 43. Giant Papillary Conjunctivitis - p. 468 69. 44. Mucous Membrane Pemphigoid - p. 474 70. 45. Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, and Related Mucocutaneous Diseases - p. 482 71. 46. Toxic Keratoconjunctivitis - p. 499 72. 47. Superior Limbic Keratoconjunctivitis - p. 509 73. 48. Ligneous Conjunctivitis - p. 517 74. 49. Conjunctivochalasis - p. 524 75. Section 2: Conjunctival Tumors - p. S532 76. 50. Epithelial Tumors of the Conjunctiva - p. 532 77. 51. Medical and Surgical Management of Ocular Surface Squamous Neoplasia - p. 554 78. 52. Melanocytic Neoplasms of the Conjunctiva - p. 567 79. 53. Subepithelial Tumors of the Conjunctiva - p. 577 80. Part 7: Diseases of the Cornea - p. P604 81. Section 1: Developmental Abnormalities of the Cornea - p. S604 82. 54. Developmental Corneal Anomalies of Size and Shape - p. 604 83. 55. Axenfeld-Rieger Syndrome - p. 616 84. 56. Peters Anomaly - p. 624 85. Section 2: Corneal Manifestations of Systemic Disease and Therapies - p. S627 86. 57. Corneal Manifestations of Metabolic Diseases - p. 627 87. 58. Skeletal and Connective Tissue Disorders With Anterior Segment Manifestations - p. 662 88. 59. Granulomatosis With Polyangiitis and Other Systemic Inflammatory Diseases - p. 681 89. 60. Nutritional Disorders - p. 692 90. 61. Hematologic Diseases and Malignancies - p. 704 91. 62. Endocrine Disease and the Cornea - p. 712 92. 63. Dermatologic Disorders and the Cornea - p. 722 93. 64. Infectious Disease: Ocular Manifestations - p. 736 94. 65. Ocular Graft-Versus-Host Disease - p. 749 95. 66. Corneal and Ocular Surface Manifestations of Local Eye Therapies - p. 765 96. 67. Corneal and Ocular Surface Manifestations of Systemic Eye Therapies - p. 771 97. Section 3: Corneal Dystrophies, Ectatic Disorders, and Degenerations - p. S787 98. 68. Corneal Dystrophy Classification - p. 787 99. 69. Anterior Corneal Dystrophies - p. 793 100. 70. The Stromal Dystrophies - p. 804 101. 71. Descemet Membrane and Endothelial Dystrophies - p. 823 102. 72. Noninflammatory Ectatic Disorders - p. 846 103. 73. Iridocorneal Endothelial Syndrome - p. 870 104. 74. Corneal and Conjunctival Degenerations - p. 884 105. Section 4: Corneal Infections - p. S904 106. 75. Bacterial Keratitis - p. 904 107. 76. Nontuberculous Mycobacteria Keratitis - p. 927 108. 77. Herpes Simplex Keratitis - p. 935 109. 78. Herpes Zoster Keratitis - p. 967 110. 79. Less Common Viral Corneal Infections - p. 977 111. 80. Fungal Keratitis - p. 986 112. Acanthamoeba and Other Parasitic Corneal Infections - p. 1006 113. 82. Corneal Diseases in the Developing World - p. 1019 114. Section 5: Interstitial Keratitis - p. S1032 115. 83. Syphilitic Keratitis - p. 1032 116. 84. Nonsyphilitic Interstitial Keratitis - p. 1043 117. Section 6: Noninfectious Keratopathy - p. S1055 118. 85. Filamentary Keratitis - p. 1055 119. 86. Superficial Punctate Keratitis of Thygeson - p. 1060 120. 87. Neurotrophic Keratopathy - p. 1064 121. 88. Diagnosis and Management of Neuropathic/Nociplastic Ocular Pain - p. 1073 122. 89. Factitious Keratoconjunctivitis - p. 1085 123. Section 7: Immunologic Disorders of the Cornea - p. S1092 124. 90. Corneal Disease in Rheumatoid Arthritis - p. 1092 125. 91. Corneal Disease Associated With Nonrheumatoid Collagen-Vascular Disease - p. 1106 126. 92. Phlyctenular Keratoconjunctivitis and Marginal Staphylococcal Keratitis - p. 1117 127. 93. Mooren Ulcer - p. 1124 128. Section 8: Corneal Trauma - p. S1131 129. 94. Mechanical Injury - p. 1131 130. 95. Chemical and Thermal Injuries of the Eye - p. 1148 131. 96. Corneal Complications of Intraocular Surgery - p. 1161 132. 97. External Eye Manifestations of Biological and Chemical Warfare - p. 1182 133. Section 9: Contact Lenses - p. S1194 134. 98. Contact Lens Applications in Corneal Disease - p. 1194 135. 99. Scleral Contact Lenses - p. 1208 136. 100. Complications of Contact Lens Wear - p. 1215 137. Part 8: The Sclera and Anterior Uvea - p. P1228 138. Section 1: Disorders of the Sclera - p. S1228 139. 101. Episcleritis - p. 1228 140. 102. Scleritis - p. 1236 141. Section 2: Anterior Uveitis - p. S1250 142. 103. Classification and Diagnosis of Anterior Uveitis - p. 1250 143. 104. Idiopathic Anterior Uveitis - p. 1260 144. 105. Human Leukocyte Antigen-B27-Associated Uveitis - p. 1269 145. 106. Sarcoidosis - p. 1275 146. 107. Behçet Disease - p. 1281 147. 108. Fuchs Uveitis Syndrome - p. 1289 148. 109. Juvenile Idiopathic Arthritis-Associated Uveitis - p. 1293 149. volume 2: Surgery of the Cornea and Conjunctiva - p. V1301 150. Part 9: Keratoplasty - p. P1301 151. Section 1: Overview - p. S1301 152. 110. The Evolution of Contemporary Keratoplasty - p. 1301 153. 111. Preoperative Considerations and Decision-Making in Keratoplasty - p. 1310 154. Section 2: Penetrating Keratoplasty - p. S1319 155. 112. Penetrating Keratoplasty: The Fundamentals - p. 1319 156. 113. Intraoperative Complications of Penetrating Keratoplasty - p. 1332 157. 114. Femtosecond-Assisted Keratoplasty - p. 1339 158. Section 3: Penetrating Keratoplasty: Postoperative Management - p. S1347 159. 115. Postoperative Management - p. 1347 160. 116. Diagnosis and Management of Corneal Allograft Rejection - p. 1369 161. 117. Infections After Penetrating Keratoplasty - p. 1378 162. 118. Glaucoma After Corneal Transplantation - p. 1392 163. Section 4: Anterior Lamellar Keratoplasty - p. S1410 164. 119. Indications for Anterior Lamellar Keratoplasty - p. 1410 165. 120. Techniques of Anterior Lamellar Keratoplasty - p. 1419 166. 121. Intraoperative and Postoperative Complications of Anterior Lamellar Keratoplasty - p. 1427 167. 122. Recovery Techniques in Deep Anterior Lamellar Keratoplasty - p. 1431 168. 123. Outcomes of Anterior Lamellar Keratoplasty - p. 1437 169. Section 5: Complex Keratoplasty - p. S1442 170. 124. Pediatric Keratoplasty - p. 1442 171. 125. Keratoplasty in Herpes Simplex Infection - p. 1464 172. 126. Immunologically High-Risk Penetrating Keratoplasty and Large-Diameter Corneal Grafts - p. 1476 173. Section 6: Management of Endothelial Dysfunction - p. S1495 174. 127. Indications and Decision-Making for Endothelial Keratoplasty - p. 1495 175. 128. Eye Bank Preparation of Tissue for Endothelial Keratoplasty - p. 1500 176. 129. Surgical Techniques for Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) - p. 1509 177. 130. Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) - p. 1520 178. 131. Nanothin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) - p. 1529 179. 132. Complications of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) - p. 1535 180. 133. Outcomes of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) - p. 1541 181. 134. Pre-Descemet Endothelial Keratoplasty - p. 1546 182. 135. Surgical Technique for Descemet Membrane Endothelial Keratoplasty (DMEK) - p. 1552 183. 136. DMEK Graft Unfolding: A Systematic Approach - p. 1565 184. 137. Intraoperative and Postoperative Complications of Descemet Membrane Endothelial Keratoplasty (DMEK) - p. 1572 185. 138. Outcomes of Descemet Membrane Endothelial Keratoplasty (DMEK) - p. 1582 186. 139. Complex Endothelial Keratoplasty - p. 1595 187. 140. Descemet Stripping Only - p. 1603 188. 141. Cultivated Corneal Endothelial CellTransplantation - p. 1609 189. Part 10: Therapeutic Procedures - p. P1615 190. Section 1: Corneal Surgery - p. S1615 191. 142. Management of Corneal Perforations - p. 1615 192. 143. Therapeutic Keratoplasty - p. 1633 193. 144. Surgical Management of Superficial Corneal and Conjunctival Disease - p. 1649 194. 145. Management of Corneal Neovascularization - p. 1660 195. 146. In-Office Corneal Procedures - p. 1666 196. 147. Excimer Laser Phototherapeutic Keratectomy - p. 1673 197. Section 2: Conjunctival Surgery - p. S1686 198. 148. Management of Primary Pterygium - p. 1686 199. 149. Recurrent Pterygium - p. 1699 200. 150. Conjunctival Flaps - p. 1710 201. 151. Indications and Applications of Amniotic Membrane in the Clinic - p. 1718 202. 152. Indications for and Uses of Amniotic Membrane in the Operating Room - p. 1723 203. Section 3: Anterior Segment Surgery - p. S1732 204. 153. Surgical Management and Rehabilitation of Anterior Segment Trauma - p. 1732 205. 154. Iris Reconstruction Surgery - p. 1747 206. 155. Management of Scleral Perforation - p. 1756 207. Part 11: Collagen Crosslinking - p. P1764 208. 156. Collagen Crosslinking for Keratoconus - p. 1764 209. 157. Corneal Crosslinking in Children - p. 1774 210. 158. Collagen Crosslinking for Corneal Ectasia After Laser Refractive Surgery - p. 1786 211. 159. Collagen Crosslinking for Infectious Keratitis - p. 1792 212. Part 12: Keratoprosthesis - p. P1800 213. 160. Indications for Keratoprosthesis - p. 1800 214. 161. Boston Keratoprosthesis Type 1: Surgical Technique - p. 1805 215. 162. Postoperative Management of Boston Keratoprosthesis Type 1 - p. 1810 216. 163. Complications of Boston Keratoprosthesis Type 1 - p. 1818 217. 164. Outcomes of Boston Keratoprosthesis Type 1 - p. 1824 218. 165. Boston Keratoprosthesis Type 2 Surgical Techniques, Complications, and Outcomes - p. 1829 219. 166. Osteo-Odonto-Keratoprosthesis - p. 1833 220. 167. Contemporary Approaches to the Biosynthetic Cornea: Overview and Classification - p. 1838 221. Part 13: Ocular Surface Transplantation - p. P1842 222. 168. Classification and Staging of Ocular Surface Disease - p. 1842 223. 169. Conjunctival Limbal Autograft - p. 1857 224. 170. Living-Related Conjunctival Limbal Allograft - p. 1866 225. 171. Keratolimbal Allograft - p. 1874 226. 172. Cultivated Limbal Epithelial Transplantation - p. 1880 227. 173. Simple Limbal Epithelial Transplantation - p. 1886 228. 174. Perioperative Management of Ocular Surface Transplantation - p. 1893 229. 175. Corneal Transplantation in Ocular Surface Disease - p. 1903 230. 176. Outcomes of Ocular Surface Stem Cell Transplantation - p. 1908 231. Part 14: Refractive Surgery - p. P1919 232. Section 1: Preoperative Considerations - p. S1919 233. 177. Decision Making in Refractive Surgery - p. 1919 234. 178. Patient Evaluation and Selection in Refractive Surgery - p. 1924 235. 179. Topographic and Tomographic Analysis in Keratorefractive Surgery - p. 1933 236. Section 2: Laser Vision Correction - p. S1950 237. 180. Excimer Laser Surface Treatment: Photorefractive Keratectomy - p. 1950 238. 181. Laser In Situ Keratomileusis (LASIK) Technique - p. 1968 239. 182. LASIK for Myopia - p. 1979 240. 183. Laser In Situ Keratomileusis (LASIK) for Hyperopia - p. 1991 241. 184. LASIK Complications - p. 1999 242. 185. Corneal Ectasia: Prevention, Detection, and Management - p. 2018 243. 186. Keratorefractive Lenticule Extraction - p. 2032 244. Section 3: Additional Refractive Procedures - p. S2039 245. 187. Topography-Guided Photorefractive Keratectomy - p. 2039 246. 188. Intrastromal Corneal Ring Segments - p. 2047 247. 189. Combined Corneal Refractive Techniques - p. 2064 248. Allogeneic Corneal Tissue Addition Surgery (CAIRS – Corneal Allogeneic Intrastromal Ring Segments and BLT – Bowman Layer Transplantation) - p. 2075 249. 191. Incisional Keratotomy - p. 2088 250. 192. Phakic Intraocular Lenses - p. 2101 251. INDEX - p. I1
A must-have resource for residents and fellows, comprehensive ophthalmologists, and seasoned cornea specialists, Cornea, 6th Edition, remains the only reference available that synthesizes this vast subspecialty into a single, authoritative compendium. Drs. Mark J. Mannis, Edward J. Holland, and Albert Y. Cheung lead a team of more than 300 global experts to keep you up to date with both common and more obscure diseases and disorders and the best route to effective treatment and management. You’ll find current coverage of the expanding range of contemporary corneal surgery, new diagnostic and imaging technologies, and medical management of corneal and external disease as well as ocular surface disease, all highlighted by more than 2,300 exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs for superb visual guidance.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Inside front cover - p. iii 6. Copyright - p. iv 7. Dedication - p. v 8. PREFACE - p. v 9. Acknowledgements - p. vi 10. List of Contributors - p. viii 11. VIDEO TABLE OF CONTENTS - p. xxvii 12. volume 1: Fundamentals, Diagnosis and Management - p. V1 13. Part 1: Basic Science: Cornea, Sclera, Ocular Adnexa Anatomy, Physiology, and Pathophysiologic Responses - p. P1 14. 1. Cornea and Sclera: Anatomy and Physiology - p. 1 15. 2. The Conjunctiva: Anatomy and Physiology - p. 25 16. 3. Tear Film - p. 33 17. 4. Eyelids and the Corneal Surface - p. 45 18. 5. A Matrix of Pathologic Responses in the Cornea - p. 51 19. Part 2: Examining and Imaging the Cornea and External Eye - p. P77 20. Section 1: Basic Evaluation of the Corneaand External Eye - p. S77 21. 6. Examination of the Lids - p. 77 22. 7. Slit Lamp Examination and Photography - p. 84 23. 8. Tear Film and Corneal Diagnostic Techniques - p. 112 24. Section 2: Laboratory Investigations - p. S122 25. 9. Practical Ophthalmic Microbiology for the Detection of Corneal Pathogens - p. 122 26. 10. Molecular Genetics of Corneal Disease - p. 132 27. Section 3: Imaging Techniques of the Cornea - p. S145 28. 11. Keratometry and Topography - p. 145 29. 12. Corneal Shape Analysis and Biomechanical Assessment - p. 158 30. 13. Specular Microscopy - p. 165 31. 14. Clinical Applications of Confocal Microscopy - p. 191 32. 15. High-Resolution Ultrasound - p. 202 33. 16. Anterior Segment Optical Coherence Tomography - p. 211 34. Part 3: Differential Diagnosis of Selected Problems in Cornea and External Disease - p. P218 35. 17. Congenital Corneal Opacities Diagnosis and Management - p. 218 36. 18. Peripheral Corneal Disease - p. 243 37. 19. Evaluation of the Corneal Ulcer - p. 252 38. 20. Evaluation of Recurrent Corneal Erosions - p. 256 39. 21. Corneal Deposits - p. 261 40. 22. The Red Eye - p. 274 41. Part 4: Eye Banking - p. P282 42. 23. Eye Banking: Structure and Function - p. 282 43. 24. Medical Standards for Eye Banking - p. 287 44. Part 5: The Ocular Adnexa - p. P296 45. Section 1: Diseases of the Lid: Anatomic Abnormalities - p. S296 46. 25. Malposition of the Eyelids - p. 296 47. Section 2: Diseases of the Lid: Tumors, Inflammation and Infection - p. S314 48. 26. Benign Lid Tumors - p. 314 49. 27. Malignant Eyelid Tumors - p. 332 50. 28. Blepharitis:: Overview and Classification - p. 346 51. 29. Eyelid Infections - p. 350 52. Section 3: Disorders of Tear Production and the Lacrimal System - p. S360 53. Dry Eye Overview: Classification and Treatment Algorithm - p. 360 54. 31. Aqueous Tear Deficiency - p. 370 55. 32. Meibomian Gland Dysfunction and Evaporative Dry Eye Disease - p. 378 56. 33. Dacryoadenitis, Dacryocystitis, and Canaliculitis - p. 393 57. 34. Epiphora - p. 400 58. Part 6: The Conjunctiva - p. P407 59. Section 1: Conjunctivitis - p. S407 60. 35. Conjunctiva: An Overview and Classification - p. 407 61. 36. Bacterial Conjunctivitis - p. 414 62. 37. Viral Conjunctivitis - p. 421 63. 38. Chlamydial Infections - p. 432 64. 39. Ophthalmia Neonatorum - p. 438 65. 40. Parinaud Oculoglandular Syndrome - p. 444 66. 41. Seasonal and Perennial Allergic Conjunctivitis - p. 452 67. 42. Vernal and Atopic Keratoconjunctivitis - p. 458 68. 43. Giant Papillary Conjunctivitis - p. 468 69. 44. Mucous Membrane Pemphigoid - p. 474 70. 45. Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, and Related Mucocutaneous Diseases - p. 482 71. 46. Toxic Keratoconjunctivitis - p. 499 72. 47. Superior Limbic Keratoconjunctivitis - p. 509 73. 48. Ligneous Conjunctivitis - p. 517 74. 49. Conjunctivochalasis - p. 524 75. Section 2: Conjunctival Tumors - p. S532 76. 50. Epithelial Tumors of the Conjunctiva - p. 532 77. 51. Medical and Surgical Management of Ocular Surface Squamous Neoplasia - p. 554 78. 52. Melanocytic Neoplasms of the Conjunctiva - p. 567 79. 53. Subepithelial Tumors of the Conjunctiva - p. 577 80. Part 7: Diseases of the Cornea - p. P604 81. Section 1: Developmental Abnormalities of the Cornea - p. S604 82. 54. Developmental Corneal Anomalies of Size and Shape - p. 604 83. 55. Axenfeld-Rieger Syndrome - p. 616 84. 56. Peters Anomaly - p. 624 85. Section 2: Corneal Manifestations of Systemic Disease and Therapies - p. S627 86. 57. Corneal Manifestations of Metabolic Diseases - p. 627 87. 58. Skeletal and Connective Tissue Disorders With Anterior Segment Manifestations - p. 662 88. 59. Granulomatosis With Polyangiitis and Other Systemic Inflammatory Diseases - p. 681 89. 60. Nutritional Disorders - p. 692 90. 61. Hematologic Diseases and Malignancies - p. 704 91. 62. Endocrine Disease and the Cornea - p. 712 92. 63. Dermatologic Disorders and the Cornea - p. 722 93. 64. Infectious Disease: Ocular Manifestations - p. 736 94. 65. Ocular Graft-Versus-Host Disease - p. 749 95. 66. Corneal and Ocular Surface Manifestations of Local Eye Therapies - p. 765 96. 67. Corneal and Ocular Surface Manifestations of Systemic Eye Therapies - p. 771 97. Section 3: Corneal Dystrophies, Ectatic Disorders, and Degenerations - p. S787 98. 68. Corneal Dystrophy Classification - p. 787 99. 69. Anterior Corneal Dystrophies - p. 793 100. 70. The Stromal Dystrophies - p. 804 101. 71. Descemet Membrane and Endothelial Dystrophies - p. 823 102. 72. Noninflammatory Ectatic Disorders - p. 846 103. 73. Iridocorneal Endothelial Syndrome - p. 870 104. 74. Corneal and Conjunctival Degenerations - p. 884 105. Section 4: Corneal Infections - p. S904 106. 75. Bacterial Keratitis - p. 904 107. 76. Nontuberculous Mycobacteria Keratitis - p. 927 108. 77. Herpes Simplex Keratitis - p. 935 109. 78. Herpes Zoster Keratitis - p. 967 110. 79. Less Common Viral Corneal Infections - p. 977 111. 80. Fungal Keratitis - p. 986 112. Acanthamoeba and Other Parasitic Corneal Infections - p. 1006 113. 82. Corneal Diseases in the Developing World - p. 1019 114. Section 5: Interstitial Keratitis - p. S1032 115. 83. Syphilitic Keratitis - p. 1032 116. 84. Nonsyphilitic Interstitial Keratitis - p. 1043 117. Section 6: Noninfectious Keratopathy - p. S1055 118. 85. Filamentary Keratitis - p. 1055 119. 86. Superficial Punctate Keratitis of Thygeson - p. 1060 120. 87. Neurotrophic Keratopathy - p. 1064 121. 88. Diagnosis and Management of Neuropathic/Nociplastic Ocular Pain - p. 1073 122. 89. Factitious Keratoconjunctivitis - p. 1085 123. Section 7: Immunologic Disorders of the Cornea - p. S1092 124. 90. Corneal Disease in Rheumatoid Arthritis - p. 1092 125. 91. Corneal Disease Associated With Nonrheumatoid Collagen-Vascular Disease - p. 1106 126. 92. Phlyctenular Keratoconjunctivitis and Marginal Staphylococcal Keratitis - p. 1117 127. 93. Mooren Ulcer - p. 1124 128. Section 8: Corneal Trauma - p. S1131 129. 94. Mechanical Injury - p. 1131 130. 95. Chemical and Thermal Injuries of the Eye - p. 1148 131. 96. Corneal Complications of Intraocular Surgery - p. 1161 132. 97. External Eye Manifestations of Biological and Chemical Warfare - p. 1182 133. Section 9: Contact Lenses - p. S1194 134. 98. Contact Lens Applications in Corneal Disease - p. 1194 135. 99. Scleral Contact Lenses - p. 1208 136. 100. Complications of Contact Lens Wear - p. 1215 137. Part 8: The Sclera and Anterior Uvea - p. P1228 138. Section 1: Disorders of the Sclera - p. S1228 139. 101. Episcleritis - p. 1228 140. 102. Scleritis - p. 1236 141. Section 2: Anterior Uveitis - p. S1250 142. 103. Classification and Diagnosis of Anterior Uveitis - p. 1250 143. 104. Idiopathic Anterior Uveitis - p. 1260 144. 105. Human Leukocyte Antigen-B27-Associated Uveitis - p. 1269 145. 106. Sarcoidosis - p. 1275 146. 107. Behçet Disease - p. 1281 147. 108. Fuchs Uveitis Syndrome - p. 1289 148. 109. Juvenile Idiopathic Arthritis-Associated Uveitis - p. 1293 149. volume 2: Surgery of the Cornea and Conjunctiva - p. V1301 150. Part 9: Keratoplasty - p. P1301 151. Section 1: Overview - p. S1301 152. 110. The Evolution of Contemporary Keratoplasty - p. 1301 153. 111. Preoperative Considerations and Decision-Making in Keratoplasty - p. 1310 154. Section 2: Penetrating Keratoplasty - p. S1319 155. 112. Penetrating Keratoplasty: The Fundamentals - p. 1319 156. 113. Intraoperative Complications of Penetrating Keratoplasty - p. 1332 157. 114. Femtosecond-Assisted Keratoplasty - p. 1339 158. Section 3: Penetrating Keratoplasty: Postoperative Management - p. S1347 159. 115. Postoperative Management - p. 1347 160. 116. Diagnosis and Management of Corneal Allograft Rejection - p. 1369 161. 117. Infections After Penetrating Keratoplasty - p. 1378 162. 118. Glaucoma After Corneal Transplantation - p. 1392 163. Section 4: Anterior Lamellar Keratoplasty - p. S1410 164. 119. Indications for Anterior Lamellar Keratoplasty - p. 1410 165. 120. Techniques of Anterior Lamellar Keratoplasty - p. 1419 166. 121. Intraoperative and Postoperative Complications of Anterior Lamellar Keratoplasty - p. 1427 167. 122. Recovery Techniques in Deep Anterior Lamellar Keratoplasty - p. 1431 168. 123. Outcomes of Anterior Lamellar Keratoplasty - p. 1437 169. Section 5: Complex Keratoplasty - p. S1442 170. 124. Pediatric Keratoplasty - p. 1442 171. 125. Keratoplasty in Herpes Simplex Infection - p. 1464 172. 126. Immunologically High-Risk Penetrating Keratoplasty and Large-Diameter Corneal Grafts - p. 1476 173. Section 6: Management of Endothelial Dysfunction - p. S1495 174. 127. Indications and Decision-Making for Endothelial Keratoplasty - p. 1495 175. 128. Eye Bank Preparation of Tissue for Endothelial Keratoplasty - p. 1500 176. 129. Surgical Techniques for Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) - p. 1509 177. 130. Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) - p. 1520 178. 131. Nanothin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) - p. 1529 179. 132. Complications of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) - p. 1535 180. 133. Outcomes of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) - p. 1541 181. 134. Pre-Descemet Endothelial Keratoplasty - p. 1546 182. 135. Surgical Technique for Descemet Membrane Endothelial Keratoplasty (DMEK) - p. 1552 183. 136. DMEK Graft Unfolding: A Systematic Approach - p. 1565 184. 137. Intraoperative and Postoperative Complications of Descemet Membrane Endothelial Keratoplasty (DMEK) - p. 1572 185. 138. Outcomes of Descemet Membrane Endothelial Keratoplasty (DMEK) - p. 1582 186. 139. Complex Endothelial Keratoplasty - p. 1595 187. 140. Descemet Stripping Only - p. 1603 188. 141. Cultivated Corneal Endothelial CellTransplantation - p. 1609 189. Part 10: Therapeutic Procedures - p. P1615 190. Section 1: Corneal Surgery - p. S1615 191. 142. Management of Corneal Perforations - p. 1615 192. 143. Therapeutic Keratoplasty - p. 1633 193. 144. Surgical Management of Superficial Corneal and Conjunctival Disease - p. 1649 194. 145. Management of Corneal Neovascularization - p. 1660 195. 146. In-Office Corneal Procedures - p. 1666 196. 147. Excimer Laser Phototherapeutic Keratectomy - p. 1673 197. Section 2: Conjunctival Surgery - p. S1686 198. 148. Management of Primary Pterygium - p. 1686 199. 149. Recurrent Pterygium - p. 1699 200. 150. Conjunctival Flaps - p. 1710 201. 151. Indications and Applications of Amniotic Membrane in the Clinic - p. 1718 202. 152. Indications for and Uses of Amniotic Membrane in the Operating Room - p. 1723 203. Section 3: Anterior Segment Surgery - p. S1732 204. 153. Surgical Management and Rehabilitation of Anterior Segment Trauma - p. 1732 205. 154. Iris Reconstruction Surgery - p. 1747 206. 155. Management of Scleral Perforation - p. 1756 207. Part 11: Collagen Crosslinking - p. P1764 208. 156. Collagen Crosslinking for Keratoconus - p. 1764 209. 157. Corneal Crosslinking in Children - p. 1774 210. 158. Collagen Crosslinking for Corneal Ectasia After Laser Refractive Surgery - p. 1786 211. 159. Collagen Crosslinking for Infectious Keratitis - p. 1792 212. Part 12: Keratoprosthesis - p. P1800 213. 160. Indications for Keratoprosthesis - p. 1800 214. 161. Boston Keratoprosthesis Type 1: Surgical Technique - p. 1805 215. 162. Postoperative Management of Boston Keratoprosthesis Type 1 - p. 1810 216. 163. Complications of Boston Keratoprosthesis Type 1 - p. 1818 217. 164. Outcomes of Boston Keratoprosthesis Type 1 - p. 1824 218. 165. Boston Keratoprosthesis Type 2 Surgical Techniques, Complications, and Outcomes - p. 1829 219. 166. Osteo-Odonto-Keratoprosthesis - p. 1833 220. 167. Contemporary Approaches to the Biosynthetic Cornea: Overview and Classification - p. 1838 221. Part 13: Ocular Surface Transplantation - p. P1842 222. 168. Classification and Staging of Ocular Surface Disease - p. 1842 223. 169. Conjunctival Limbal Autograft - p. 1857 224. 170. Living-Related Conjunctival Limbal Allograft - p. 1866 225. 171. Keratolimbal Allograft - p. 1874 226. 172. Cultivated Limbal Epithelial Transplantation - p. 1880 227. 173. Simple Limbal Epithelial Transplantation - p. 1886 228. 174. Perioperative Management of Ocular Surface Transplantation - p. 1893 229. 175. Corneal Transplantation in Ocular Surface Disease - p. 1903 230. 176. Outcomes of Ocular Surface Stem Cell Transplantation - p. 1908 231. Part 14: Refractive Surgery - p. P1919 232. Section 1: Preoperative Considerations - p. S1919 233. 177. Decision Making in Refractive Surgery - p. 1919 234. 178. Patient Evaluation and Selection in Refractive Surgery - p. 1924 235. 179. Topographic and Tomographic Analysis in Keratorefractive Surgery - p. 1933 236. Section 2: Laser Vision Correction - p. S1950 237. 180. Excimer Laser Surface Treatment: Photorefractive Keratectomy - p. 1950 238. 181. Laser In Situ Keratomileusis (LASIK) Technique - p. 1968 239. 182. LASIK for Myopia - p. 1979 240. 183. Laser In Situ Keratomileusis (LASIK) for Hyperopia - p. 1991 241. 184. LASIK Complications - p. 1999 242. 185. Corneal Ectasia: Prevention, Detection, and Management - p. 2018 243. 186. Keratorefractive Lenticule Extraction - p. 2032 244. Section 3: Additional Refractive Procedures - p. S2039 245. 187. Topography-Guided Photorefractive Keratectomy - p. 2039 246. 188. Intrastromal Corneal Ring Segments - p. 2047 247. 189. Combined Corneal Refractive Techniques - p. 2064 248. Allogeneic Corneal Tissue Addition Surgery (CAIRS – Corneal Allogeneic Intrastromal Ring Segments and BLT – Bowman Layer Transplantation) - p. 2075 249. 191. Incisional Keratotomy - p. 2088 250. 192. Phakic Intraocular Lenses - p. 2101 251. INDEX - p. I1
