The definitive reference in the field for more than 35 years, Creasy and Resnik's Maternal-Fetal Medicine provides today’s MFM practitioners with authoritative, comprehensive guidance on every aspect of this fast-changing field. The fully revised 9th Edition brings you up to date with the latest evidence-based guidelines and research as well as the fundamental scientific foundation needed for effective practice, helping you minimize complications and ensure the best possible outcomes for your patients. Renowned experts in obstetrics, gynecology, and perinatology provide valuable information in every area of complex obstetric care, highlighting the most commonly encountered anomalies and providing clear guidelines for obstetric and neonatal management.
Offers comprehensive updates on rapidly changing topics, including extensively revised genetic content throughout.
Includes two new chapters: maternal and fetal viral infections, including COVID-19; and sexually transmitted disease, covering the epidemiology, pathogenesis, diagnosis, and treatment of individual infectious diseases that may complicate pregnancy.
Contains user-friendly features such as numerous diagnostic and treatment algorithms for quick access to current protocols; key points at the end of each chapter; and counseling pearls with practical guidance on patient consultation.
Features a comprehensive imaging section, including a video library to aid in everyday diagnosis.
Shares the expertise of a renowned editorial team—including new co-editors Drs. Lorraine Dugoff and Judette M. Louis—who lead authors representing top institutions from around the globe.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. vi 7. Preface - p. xv 8. Videos - p. xv 9. Part 1. Scientific Basis of Perinatal Biology - p. xv 10. 1. Human Genetics and Patterns of Inheritance - p. xv 11. 2. Molecular Genetic Technology - p. 15 12. 3. Normal Early Development - p. 41.e4 13. 4. Amniotic Fluid Dynamics - p. 65.e3 14. 5. Multiple Gestation: The Biology of Twinning - p. 71.e3 15. 6. Physiology of Parturition - p. 84.e2 16. 7. Pathogenesis of Spontaneous Preterm Birth - p. 101.e7 17. Preterm Birth Syndrome: Phenotypic Classification - p. 101.e7 18. Mechanisms of Spontaneous Preterm Birth - p. 101.e7 19. Phenotypic Components of the Preterm Birth Syndrome - p. 122 20. 8. Immunology of Pregnancy - p. 126.e14 21. 9. Maternal Cardiovascular, Respiratory, and Renal Adaptation to Pregnancy - p. 142.e8 22. 10. Endocrinology of Pregnancy - p. 149.e3 23. 11. The Breast and the Physiology of Lactation - p. 162.e4 24. 12. Maternal Nutrition - p. 185.e5 25. 13. Fetal Cardiovascular Physiology - p. 193.e2 26. 14. Placental Respiratory Gas Exchange and Fetal Oxygenation - p. 203.e3 27. 15. Evidence-Based Practice in Perinatal Medicine - p. 216 28. Part 2. Obstetric Imaging - p. 230.e2 29. 16. Performing and Documenting the Fetal Anatomy Ultrasound Examination - p. 230.e2 30. 17. Doppler Ultrasound: Select Fetal and Maternal Applications - p. 235 31. 18. Clinical Applications of Three-Dimensional Sonography in Obstetrics - p. 253 32. 19. Role of Magnetic Resonance Imaging in Obstetric Imaging - p. 272.e3 33. 20. Fetal Central Nervous System Imaging - p. 282 34. 21. Imaging of the Fetal Face and Neck - p. 302.e17 35. 22. Fetal Thoracic Imaging - p. 314 36. 23. Fetal Cardiac Malformations and Arrhythmias: Detection, Diagnosis, Management, and Prognosis - p. 321.e6 37. Incidence of Congenital Heart Disease in the Fetus - p. 321.e6 38. Risk Factors for Congenital Heart Disease in the Fetus - p. 321.e6 39. Screening for Congenital Heart Disease in the Fetus - p. 323 40. Technique of Fetal Echocardiography - p. 328 41. Fetal Cardiac Malformations: Diagnosis, Management, and Prognosis - p. 338 42. Fetal Arrhythmias: Diagnosis, Management, and Prognosis - p. 360 43. Conclusions - p. 365 44. 24. Fetal Abdominal Imaging - p. 365.e5 45. 25. Fetal Urogenital Imaging - p. 399.e2 46. 26. Skeletal Imaging - p. 432.e3 47. 27. Placenta and Umbilical Cord Imaging - p. 471.e2 48. 28. Uterus and Adnexae Imaging - p. 483.e8 49. 29. First-Trimester Imaging - p. 488 50. Part 3. Fetal Disorders: Diagnosis and Therapy - p. 500.e2 51. 30. Prenatal Diagnosis of Congenital Disorders - p. 500.e2 52. Screening for Fetal Genetic Disorders - p. 500.e2 53. Screening Tests - p. 503 54. Abnormal Screening Markers in Pregnancies With a Normal Karyotype - p. 509 55. Maternal Serum Alpha Fetoprotein Screening for Neural Tube Defects and Other Structural Defects - p. 520 56. Screening for Gene Mutations That Lead to Fetal Disease - p. 523 57. Specific Disorders for Which Carrier Screening is Recommended - p. 524 58. Diagnostic Tests - p. 534 59. 31. Teratogenesis and Environmental Exposure - p. 548.e10 60. 32. Assessment of Fetal Health - p. 559.e4 61. 33. Intrapartum Fetal Surveillance - p. 573.e2 62. 34. Invasive Fetal Therapy - p. 594.e3 63. Open Fetal Surgery - p. 594.e3 64. Complicated Monochorionic Twin Pregnancies - p. 600 65. Twin-Twin Transfusion Syndrome - p. 600 66. Selective Fetal Reduction for Other Complications - p. 607 67. Congenital Diaphragmatic Hernia - p. 612 68. Congenital Thoracic Malformations - p. 616 69. Lower Urinary Tract Obstruction - p. 619 70. Congenital Heart Defects - p. 621 71. Myelomeningocele Repair - p. 624 72. Sacrococcygeal Teratoma - p. 630 73. 35. Hemolytic Disease of the Fetus and Newborn - p. 633.e11 74. 36. Nonimmune Hydrops - p. 649.e3 75. 37. Multiple Gestation: Clinical Characteristics and Management - p. 659.e3 76. Perinatal Mortality and Morbidity - p. 659.e3 77. Maternal Mortality and Morbidity - p. 661 78. Maternal Adaptations - p. 662 79. Ultrasonography in Multiple Gestation - p. 662 80. Prenatal Diagnosis - p. 665 81. Antepartum Management - p. 667 82. Intrapartum Management - p. 670 83. Special Considerations in Management - p. 673 84. Part 4. Disorders at the Maternal-Fetal Interface - p. 686.e6 85. 38. Prevention and Management of Preterm Parturition - p. 686.e6 86. The Problem of Preterm Birth - p. 686.e6 87. Consequences of Preterm Birth - p. 690 88. Epidemiology and Risk Factors for Preterm Birth - p. 694 89. Prevention of Preterm Birth - p. 702 90. Primary Prevention of Preterm Birth - p. 703 91. Secondary Prevention of Preterm Birth - p. 708 92. Tertiary Prevention of Preterm Birth: Management of Preterm Labor - p. 712 93. 39. Premature (Prelabor) Rupture of the Membranes - p. 722.e12 94. 40. Clinical Aspects of Normal and Abnormal Labor - p. 733.e6 95. Normal Labor and Its Limits - p. 733.e6 96. Categorization of Labor Events - p. 733.e6 97. Role of Maternal Obesity - p. 736 98. Documentation of Labor Progression - p. 737 99. Management of Labor Abnormalities - p. 738 100. Induction of Labor - p. 746 101. Abnormal Presentation - p. 750 102. Operative Delivery - p. 755 103. Analgesia and Anesthesia for Low-Risk Labor and Vaginal Delivery - p. 764 104. Labor Monitoring - p. 766 105. 41. Recurrent Pregnancy Loss - p. 767.e7 106. 42. Stillbirth - p. 781.e5 107. 43. Placenta Previa and Accreta, Vasa Previa, Subchorionic Hemorrhage, and Abruptio Placentae - p. 798.e4 108. 44. Fetal Growth Restriction - p. 809.e4 109. 45. Pregnancy-Related Hypertension - p. 825.e6 110. Classification of Hypertensive Disorders - p. 825.e6 111. Preeclampsia and Eclampsia - p. 828 112. Chronic Hypertension - p. 849 113. Part 5. Maternal Complications - p. 854.e9 114. 46. Patient Safety and Quality Improvement in Obstetrics - p. 854.e9 115. 47. Maternal Mortality - p. 866.e3 116. 48. Bacterial and Parasitic Infections in Pregnancy - p. 878.e2 117. Bacteria - p. 878.e2 118. Intraamniotic Infection - p. 885 119. Puerperal Endometritis - p. 888 120. Episiotomy and Perineal Infections - p. 889 121. Wound Infection - p. 891 122. Pelvic Abscess - p. 892 123. Sepsis - p. 892 124. Septic Pelvic Vein Thrombophlebitis - p. 893 125. Mastitis - p. 894 126. Group B Streptococcal Infection - p. 894 127. Listeriosis - p. 898 128. Syphilis - p. 899 129. Lyme Disease - p. 904 130. Parasites - p. 905 131. 49. Maternal and Fetal Viral Infections - p. 907.e4 132. - - p. 907.e4 133. Arboviral Diseases - p. 907.e4 134. 50. Sexually Transmitted Diseases - p. 937.e5 135. 51. Maternal-Fetal Infections - p. 958.e4 136. 52. Cardiac Diseases - p. 972.e4 137. Diagnosis of Heart Disease in Pregnancy - p. 972.e4 138. Preconception Counseling - p. 972.e4 139. Cardiovascular Adaptations to Pregnancy - p. 976 140. General Guidelines for Management - p. 977 141. Team Approach to Medical Care - p. 977 142. Congenital Heart Disease - p. 977 143. Eisenmenger Syndrome - p. 993 144. Primary Pulmonary Hypertension - p. 994 145. Congenital Obstructive Lesions - p. 995 146. Obstruction to Pulmonary Venous Flow - p. 995 147. Left Ventricular Outflow Tract Stenosis - p. 995 148. Pulmonary Stenosis - p. 995 149. Tetralogy of Fallot - p. 996 150. Coarctation of the Aorta - p. 997 151. Other Congenital Cardiac Malformations - p. 998 152. Rheumatic Heart Disease - p. 999 153. Mitral Valve Prolapse - p. 1000 154. Aortic Valve Disease - p. 1001 155. Drug-Induced Valvular Heart Disease - p. 1002 156. Cardiomyopathy - p. 1003 157. Coronary Artery Disease - p. 1005 158. Heart Failure - p. 1006 159. Disturbances of Cardiac Rhythm - p. 1007 160. Marfan Syndrome and Other Connective Tissue Disorders - p. 1007 161. Pregnancy in Patients with Artificial Heart Valves - p. 1008 162. Cardiac Surgery During Pregnancy - p. 1010 163. Use of Prophylactic Antibiotics to Prevent Infective Endocarditis in Pregnant Women With Heart Disease - p. 1010 164. Cardiovascular Sequelae of Kawasaki Disease - p. 1012 165. 53. Coagulation Disorders in Pregnancy - p. 1012.e3 166. Hemostatic System - p. 1012.e3 167. Disorders Promoting Thrombosis in Pregnancy - p. 1017 168. Bleeding Disorders - p. 1035 169. 54. Thromboembolic Disease in Pregnancy - p. 1.0380000001E10 170. 55. Anemia and Pregnancy - p. 105301 171. 56. Malignancy and Pregnancy - p. 1069.e3 172. 57. Renal Disorders - p. 1087.e5 173. 58. Respiratory Diseases in Pregnancy - p. 1.105001E6 174. 59. Diabetes in Pregnancy - p. 1131.e4 175. Global Prevalence of Diabetes - p. 1131.e4 176. Classification of Diabetes Mellitus - p. 1131.e4 177. Maternal-Fetal Metabolism in Normal and Diabetic Pregnancy - p. 1135 178. Complications of Diabetes During Pregnancy - p. 1138 179. Management - p. 1149 180. Pregnancy Management of the Diabetic Patient and Fetus - p. 1160 181. Management of the Neonate - p. 1164 182. 60. Pregnancy in Women With Obesity - p. 1165.e6 183. 61. Thyroid Disease and Pregnancy - p. 1.18600001E8 184. Maternal Thyroid Physiology - p. 1.18600001E8 185. Placental Transfer - p. 1190 186. Fetal and Neonatal Thyroid Physiology and Development - p. 1190 187. Immune System and Thyroid Disease in Pregnancy - p. 1193 188. Laboratory Evaluation of Thyroid Function During Pregnancy - p. 1194 189. Hypothyroidism - p. 1195 190. Subclinical Hypothyroidism and Isolated Hypothyroxinemia - p. 1198 191. Hyperthyroidism - p. 1201 192. Postpartum Thyroid Dysfunction and Disease - p. 1208 193. Thyroid Nodules, Thyroid Cancer, and Risks of Radioactive Iodine Treatment - p. 1209 194. 62. Other Endocrine Disorders of Pregnancy - p. 1213.e6 195. Hypothalamic-Pituitary Disorders - p. 1213.e6 196. Disorders of the Adrenal Glands - p. 1224 197. Parathyroid Glands and Calcium Metabolism - p. 1232 198. 63. Gastrointestinal Disease in Pregnancy - p. 1240.e5 199. 64. Diseases of the Liver, Biliary System, and Pancreas - p. 1256.e4 200. 65. Pregnancy and Rheumatic Diseases - p. 1276.e4 201. 66. Neurologic Disorders - p. 1292.e4 202. 67. Management of Depression and Psychoses in Pregnancy and in the Puerperium - p. 1316.e2 203. 68. Substance Use and Addiction in Pregnancy and the Postpartum Period - p. 1327.e4 204. Extent of Substance Use, Misuse, and Addiction in the United States - p. 1327.e4 205. Screening of Pregnant Individuals - p. 1329 206. Tobacco and Nicotine-Containing Products - p. 1334 207. Alcohol - p. 1339 208. Cannabis - p. 1341 209. Opioids - p. 1346 210. Cocaine - p. 1352 211. Methamphetamine - p. 1354 212. Benzodiazepines - p. 1355 213. Conclusions - p. 1356 214. 69. The Skin and Pregnancy - p. 1356.e15 215. 70. Anesthesia Considerations for Complicated Pregnancies - p. 1367.e2 216. 71. Intensive Care Considerations in Obstetrics - p. 1386.e3 217. 72. Pregnancy as a Window to Future Health - p. 1400.e3 218. Part 6. The Neonate - p. 1408.e3 219. 73. Neonatal Morbidities of Prenatal and Perinatal Origin - p. 1408.e3 220. Obstetrical Decisions and Neonatal Outcomes - p. 1408.e3 221. The Perinatal Consultation and the Role of the Neonatologist - p. 1408.e3 222. Common Morbidities of Pregnancy and Neonatal Outcome - p. 1408.e3 223. Prematurity - p. 1412 224. Respiratory Problems - p. 1416 225. Gastrointestinal Problems in Neonatal Period - p. 1423 226. Neonatal Management of Neurologic Problems - p. 1425 227. Infectious Disease Problems - p. 1433 228. Viral Infections - p. 1434 229. Sexually Transmitted Infections - p. 1437 230. Index - p. 1438.e9 231. Normal Laboratory Values in Pregnancy - p. 1494
The definitive reference in the field for more than 35 years, Creasy and Resnik's Maternal-Fetal Medicine provides today’s MFM practitioners with authoritative, comprehensive guidance on every aspect of this fast-changing field. The fully revised 9th Edition brings you up to date with the latest evidence-based guidelines and research as well as the fundamental scientific foundation needed for effective practice, helping you minimize complications and ensure the best possible outcomes for your patients. Renowned experts in obstetrics, gynecology, and perinatology provide valuable information in every area of complex obstetric care, highlighting the most commonly encountered anomalies and providing clear guidelines for obstetric and neonatal management.
Offers comprehensive updates on rapidly changing topics, including extensively revised genetic content throughout.
Includes two new chapters: maternal and fetal viral infections, including COVID-19; and sexually transmitted disease, covering the epidemiology, pathogenesis, diagnosis, and treatment of individual infectious diseases that may complicate pregnancy.
Contains user-friendly features such as numerous diagnostic and treatment algorithms for quick access to current protocols; key points at the end of each chapter; and counseling pearls with practical guidance on patient consultation.
Features a comprehensive imaging section, including a video library to aid in everyday diagnosis.
Shares the expertise of a renowned editorial team—including new co-editors Drs. Lorraine Dugoff and Judette M. Louis—who lead authors representing top institutions from around the globe.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. vi 7. Preface - p. xv 8. Videos - p. xv 9. Part 1. Scientific Basis of Perinatal Biology - p. xv 10. 1. Human Genetics and Patterns of Inheritance - p. xv 11. 2. Molecular Genetic Technology - p. 15 12. 3. Normal Early Development - p. 41.e4 13. 4. Amniotic Fluid Dynamics - p. 65.e3 14. 5. Multiple Gestation: The Biology of Twinning - p. 71.e3 15. 6. Physiology of Parturition - p. 84.e2 16. 7. Pathogenesis of Spontaneous Preterm Birth - p. 101.e7 17. Preterm Birth Syndrome: Phenotypic Classification - p. 101.e7 18. Mechanisms of Spontaneous Preterm Birth - p. 101.e7 19. Phenotypic Components of the Preterm Birth Syndrome - p. 122 20. 8. Immunology of Pregnancy - p. 126.e14 21. 9. Maternal Cardiovascular, Respiratory, and Renal Adaptation to Pregnancy - p. 142.e8 22. 10. Endocrinology of Pregnancy - p. 149.e3 23. 11. The Breast and the Physiology of Lactation - p. 162.e4 24. 12. Maternal Nutrition - p. 185.e5 25. 13. Fetal Cardiovascular Physiology - p. 193.e2 26. 14. Placental Respiratory Gas Exchange and Fetal Oxygenation - p. 203.e3 27. 15. Evidence-Based Practice in Perinatal Medicine - p. 216 28. Part 2. Obstetric Imaging - p. 230.e2 29. 16. Performing and Documenting the Fetal Anatomy Ultrasound Examination - p. 230.e2 30. 17. Doppler Ultrasound: Select Fetal and Maternal Applications - p. 235 31. 18. Clinical Applications of Three-Dimensional Sonography in Obstetrics - p. 253 32. 19. Role of Magnetic Resonance Imaging in Obstetric Imaging - p. 272.e3 33. 20. Fetal Central Nervous System Imaging - p. 282 34. 21. Imaging of the Fetal Face and Neck - p. 302.e17 35. 22. Fetal Thoracic Imaging - p. 314 36. 23. Fetal Cardiac Malformations and Arrhythmias: Detection, Diagnosis, Management, and Prognosis - p. 321.e6 37. Incidence of Congenital Heart Disease in the Fetus - p. 321.e6 38. Risk Factors for Congenital Heart Disease in the Fetus - p. 321.e6 39. Screening for Congenital Heart Disease in the Fetus - p. 323 40. Technique of Fetal Echocardiography - p. 328 41. Fetal Cardiac Malformations: Diagnosis, Management, and Prognosis - p. 338 42. Fetal Arrhythmias: Diagnosis, Management, and Prognosis - p. 360 43. Conclusions - p. 365 44. 24. Fetal Abdominal Imaging - p. 365.e5 45. 25. Fetal Urogenital Imaging - p. 399.e2 46. 26. Skeletal Imaging - p. 432.e3 47. 27. Placenta and Umbilical Cord Imaging - p. 471.e2 48. 28. Uterus and Adnexae Imaging - p. 483.e8 49. 29. First-Trimester Imaging - p. 488 50. Part 3. Fetal Disorders: Diagnosis and Therapy - p. 500.e2 51. 30. Prenatal Diagnosis of Congenital Disorders - p. 500.e2 52. Screening for Fetal Genetic Disorders - p. 500.e2 53. Screening Tests - p. 503 54. Abnormal Screening Markers in Pregnancies With a Normal Karyotype - p. 509 55. Maternal Serum Alpha Fetoprotein Screening for Neural Tube Defects and Other Structural Defects - p. 520 56. Screening for Gene Mutations That Lead to Fetal Disease - p. 523 57. Specific Disorders for Which Carrier Screening is Recommended - p. 524 58. Diagnostic Tests - p. 534 59. 31. Teratogenesis and Environmental Exposure - p. 548.e10 60. 32. Assessment of Fetal Health - p. 559.e4 61. 33. Intrapartum Fetal Surveillance - p. 573.e2 62. 34. Invasive Fetal Therapy - p. 594.e3 63. Open Fetal Surgery - p. 594.e3 64. Complicated Monochorionic Twin Pregnancies - p. 600 65. Twin-Twin Transfusion Syndrome - p. 600 66. Selective Fetal Reduction for Other Complications - p. 607 67. Congenital Diaphragmatic Hernia - p. 612 68. Congenital Thoracic Malformations - p. 616 69. Lower Urinary Tract Obstruction - p. 619 70. Congenital Heart Defects - p. 621 71. Myelomeningocele Repair - p. 624 72. Sacrococcygeal Teratoma - p. 630 73. 35. Hemolytic Disease of the Fetus and Newborn - p. 633.e11 74. 36. Nonimmune Hydrops - p. 649.e3 75. 37. Multiple Gestation: Clinical Characteristics and Management - p. 659.e3 76. Perinatal Mortality and Morbidity - p. 659.e3 77. Maternal Mortality and Morbidity - p. 661 78. Maternal Adaptations - p. 662 79. Ultrasonography in Multiple Gestation - p. 662 80. Prenatal Diagnosis - p. 665 81. Antepartum Management - p. 667 82. Intrapartum Management - p. 670 83. Special Considerations in Management - p. 673 84. Part 4. Disorders at the Maternal-Fetal Interface - p. 686.e6 85. 38. Prevention and Management of Preterm Parturition - p. 686.e6 86. The Problem of Preterm Birth - p. 686.e6 87. Consequences of Preterm Birth - p. 690 88. Epidemiology and Risk Factors for Preterm Birth - p. 694 89. Prevention of Preterm Birth - p. 702 90. Primary Prevention of Preterm Birth - p. 703 91. Secondary Prevention of Preterm Birth - p. 708 92. Tertiary Prevention of Preterm Birth: Management of Preterm Labor - p. 712 93. 39. Premature (Prelabor) Rupture of the Membranes - p. 722.e12 94. 40. Clinical Aspects of Normal and Abnormal Labor - p. 733.e6 95. Normal Labor and Its Limits - p. 733.e6 96. Categorization of Labor Events - p. 733.e6 97. Role of Maternal Obesity - p. 736 98. Documentation of Labor Progression - p. 737 99. Management of Labor Abnormalities - p. 738 100. Induction of Labor - p. 746 101. Abnormal Presentation - p. 750 102. Operative Delivery - p. 755 103. Analgesia and Anesthesia for Low-Risk Labor and Vaginal Delivery - p. 764 104. Labor Monitoring - p. 766 105. 41. Recurrent Pregnancy Loss - p. 767.e7 106. 42. Stillbirth - p. 781.e5 107. 43. Placenta Previa and Accreta, Vasa Previa, Subchorionic Hemorrhage, and Abruptio Placentae - p. 798.e4 108. 44. Fetal Growth Restriction - p. 809.e4 109. 45. Pregnancy-Related Hypertension - p. 825.e6 110. Classification of Hypertensive Disorders - p. 825.e6 111. Preeclampsia and Eclampsia - p. 828 112. Chronic Hypertension - p. 849 113. Part 5. Maternal Complications - p. 854.e9 114. 46. Patient Safety and Quality Improvement in Obstetrics - p. 854.e9 115. 47. Maternal Mortality - p. 866.e3 116. 48. Bacterial and Parasitic Infections in Pregnancy - p. 878.e2 117. Bacteria - p. 878.e2 118. Intraamniotic Infection - p. 885 119. Puerperal Endometritis - p. 888 120. Episiotomy and Perineal Infections - p. 889 121. Wound Infection - p. 891 122. Pelvic Abscess - p. 892 123. Sepsis - p. 892 124. Septic Pelvic Vein Thrombophlebitis - p. 893 125. Mastitis - p. 894 126. Group B Streptococcal Infection - p. 894 127. Listeriosis - p. 898 128. Syphilis - p. 899 129. Lyme Disease - p. 904 130. Parasites - p. 905 131. 49. Maternal and Fetal Viral Infections - p. 907.e4 132. - - p. 907.e4 133. Arboviral Diseases - p. 907.e4 134. 50. Sexually Transmitted Diseases - p. 937.e5 135. 51. Maternal-Fetal Infections - p. 958.e4 136. 52. Cardiac Diseases - p. 972.e4 137. Diagnosis of Heart Disease in Pregnancy - p. 972.e4 138. Preconception Counseling - p. 972.e4 139. Cardiovascular Adaptations to Pregnancy - p. 976 140. General Guidelines for Management - p. 977 141. Team Approach to Medical Care - p. 977 142. Congenital Heart Disease - p. 977 143. Eisenmenger Syndrome - p. 993 144. Primary Pulmonary Hypertension - p. 994 145. Congenital Obstructive Lesions - p. 995 146. Obstruction to Pulmonary Venous Flow - p. 995 147. Left Ventricular Outflow Tract Stenosis - p. 995 148. Pulmonary Stenosis - p. 995 149. Tetralogy of Fallot - p. 996 150. Coarctation of the Aorta - p. 997 151. Other Congenital Cardiac Malformations - p. 998 152. Rheumatic Heart Disease - p. 999 153. Mitral Valve Prolapse - p. 1000 154. Aortic Valve Disease - p. 1001 155. Drug-Induced Valvular Heart Disease - p. 1002 156. Cardiomyopathy - p. 1003 157. Coronary Artery Disease - p. 1005 158. Heart Failure - p. 1006 159. Disturbances of Cardiac Rhythm - p. 1007 160. Marfan Syndrome and Other Connective Tissue Disorders - p. 1007 161. Pregnancy in Patients with Artificial Heart Valves - p. 1008 162. Cardiac Surgery During Pregnancy - p. 1010 163. Use of Prophylactic Antibiotics to Prevent Infective Endocarditis in Pregnant Women With Heart Disease - p. 1010 164. Cardiovascular Sequelae of Kawasaki Disease - p. 1012 165. 53. Coagulation Disorders in Pregnancy - p. 1012.e3 166. Hemostatic System - p. 1012.e3 167. Disorders Promoting Thrombosis in Pregnancy - p. 1017 168. Bleeding Disorders - p. 1035 169. 54. Thromboembolic Disease in Pregnancy - p. 1.0380000001E10 170. 55. Anemia and Pregnancy - p. 105301 171. 56. Malignancy and Pregnancy - p. 1069.e3 172. 57. Renal Disorders - p. 1087.e5 173. 58. Respiratory Diseases in Pregnancy - p. 1.105001E6 174. 59. Diabetes in Pregnancy - p. 1131.e4 175. Global Prevalence of Diabetes - p. 1131.e4 176. Classification of Diabetes Mellitus - p. 1131.e4 177. Maternal-Fetal Metabolism in Normal and Diabetic Pregnancy - p. 1135 178. Complications of Diabetes During Pregnancy - p. 1138 179. Management - p. 1149 180. Pregnancy Management of the Diabetic Patient and Fetus - p. 1160 181. Management of the Neonate - p. 1164 182. 60. Pregnancy in Women With Obesity - p. 1165.e6 183. 61. Thyroid Disease and Pregnancy - p. 1.18600001E8 184. Maternal Thyroid Physiology - p. 1.18600001E8 185. Placental Transfer - p. 1190 186. Fetal and Neonatal Thyroid Physiology and Development - p. 1190 187. Immune System and Thyroid Disease in Pregnancy - p. 1193 188. Laboratory Evaluation of Thyroid Function During Pregnancy - p. 1194 189. Hypothyroidism - p. 1195 190. Subclinical Hypothyroidism and Isolated Hypothyroxinemia - p. 1198 191. Hyperthyroidism - p. 1201 192. Postpartum Thyroid Dysfunction and Disease - p. 1208 193. Thyroid Nodules, Thyroid Cancer, and Risks of Radioactive Iodine Treatment - p. 1209 194. 62. Other Endocrine Disorders of Pregnancy - p. 1213.e6 195. Hypothalamic-Pituitary Disorders - p. 1213.e6 196. Disorders of the Adrenal Glands - p. 1224 197. Parathyroid Glands and Calcium Metabolism - p. 1232 198. 63. Gastrointestinal Disease in Pregnancy - p. 1240.e5 199. 64. Diseases of the Liver, Biliary System, and Pancreas - p. 1256.e4 200. 65. Pregnancy and Rheumatic Diseases - p. 1276.e4 201. 66. Neurologic Disorders - p. 1292.e4 202. 67. Management of Depression and Psychoses in Pregnancy and in the Puerperium - p. 1316.e2 203. 68. Substance Use and Addiction in Pregnancy and the Postpartum Period - p. 1327.e4 204. Extent of Substance Use, Misuse, and Addiction in the United States - p. 1327.e4 205. Screening of Pregnant Individuals - p. 1329 206. Tobacco and Nicotine-Containing Products - p. 1334 207. Alcohol - p. 1339 208. Cannabis - p. 1341 209. Opioids - p. 1346 210. Cocaine - p. 1352 211. Methamphetamine - p. 1354 212. Benzodiazepines - p. 1355 213. Conclusions - p. 1356 214. 69. The Skin and Pregnancy - p. 1356.e15 215. 70. Anesthesia Considerations for Complicated Pregnancies - p. 1367.e2 216. 71. Intensive Care Considerations in Obstetrics - p. 1386.e3 217. 72. Pregnancy as a Window to Future Health - p. 1400.e3 218. Part 6. The Neonate - p. 1408.e3 219. 73. Neonatal Morbidities of Prenatal and Perinatal Origin - p. 1408.e3 220. Obstetrical Decisions and Neonatal Outcomes - p. 1408.e3 221. The Perinatal Consultation and the Role of the Neonatologist - p. 1408.e3 222. Common Morbidities of Pregnancy and Neonatal Outcome - p. 1408.e3 223. Prematurity - p. 1412 224. Respiratory Problems - p. 1416 225. Gastrointestinal Problems in Neonatal Period - p. 1423 226. Neonatal Management of Neurologic Problems - p. 1425 227. Infectious Disease Problems - p. 1433 228. Viral Infections - p. 1434 229. Sexually Transmitted Infections - p. 1437 230. Index - p. 1438.e9 231. Normal Laboratory Values in Pregnancy - p. 1494
