Now completely revised to bring you up to date with the latest advances in the field, Critical Care Medicine: Principles of Diagnosis and Management in the Adult, 5th Edition, delivers expert, practical guidance on virtually any clinical scenario you may encounter in the ICU. Designed for intensivists, critical care and pulmonology residents, fellows, practicing physicians, and nurse practitioners, this highly regarded text is clinically focused and easy to reference. Led by Drs. Joseph Parrillo and Phillip Dellinger, the 5th Edition introduces numerous new authors who lend a fresh perspective and contribute their expertise to that of hundreds of top authorities in the field.
1. Introduction - p. 1 2. 1 Cardiac Arrest and Cardiopulmonary Resuscitation - p. 2 3. 2 Airway Management in the Critically Ill Adult - p. 12 4. 3 Assessment of Cardiac Filling and Blood Flow - p. 29 5. 4 Arterial, Central Venous, and Pulmonary Artery Catheters - p. 40 6. 5 Cardiac Pacing - p. 50 7. 6 Pericardial Tamponade - p. 72 8. 7 Percutaneous Assist Devices - p. 80 9. 8 Echocardiography - p. 101 10. 9 General Principles of Mechanical Ventilation - p. 129 11. 10 Ventilatory Management of Obstructive Airway Disease - p. 144 12. 11 Mechanical Ventilation in Acute Respiratory Distress Syndrome - p. 158 13. 12 Bronchoscopy and Lung Biopsy in Critically Ill Patients - p. 170 14. 13 Noninvasive Respiratory Monitoring - p. 181 15. 14 Bedside Tracheostomy in the Intensive Care Unit - p. 193 16. 15 Chest Tube Thoracostomy - p. 201 17. 16 Multimodality Intracranial Monitoring - p. 212 18. 17 Gastrointestinal Endoscopy - p. 218 19. 18 Bedside Ultrasonography in the Critically Ill Patient - p. 226 20. 19 Continuous Renal Replacement Therapy - p. 239 21. 20 Use of Sedatives, Analgesics, and Neuromuscular Blockers - p. 251 22. 21 The Effect of Critical Illness on Pharmacokinetics and Pharmacodynamics - p. 267 23. Part 2 Critical Care Cardiovascular Disease - p. 286.e6 24. Introduction - p. 287 25. 22 Shock - p. 288 26. Abstract - p. 288 27. History - p. 288 28. Definitions and Categorization of Shock - p. 289 29. Classification - p. 290 30. Pathogenesis and Pathophysiology of Shock - p. 297 31. Organ System Dysfunction Owing to Shock (Table 22.3) - p. 300 32. Diagnostic Approach and Evaluation - p. 302 33. Management and Therapy - p. 305 34. Conclusion - p. 309 35. References - p. 310.e1 36. Review Questions - p. 310.e11 37. 23 Cardiogenic Shock - p. 311 38. 24 Severe Sepsis and Septic Shock - p. 323 39. 25 Cardiac Tamponade - p. 346 40. 26 Hypovolemia and Traumatic Shock - p. 359 41. 27 Severe Heart Failure - p. 387 42. 28 Anaphylaxis and Anaphylactic Shock - p. 420 43. 29 Acute Coronary Syndromes and Acute Myocardial Infarction - p. 424 44. Abstract - p. 424 45. Definitions - p. 424 46. ST-Segment Elevation Myocardial Infarction - p. 428 47. Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction - p. 457 48. References - p. 469.e1 49. Review Questions - p. 469.e17 50. 30 Valvular Heart Disease in Critical Care - p. 470 51. 31 Cardiac Arrhythmias - p. 504 52. Abstract - p. 504 53. Bradycardias - p. 505 54. Supraventricular Tachycardia - p. 509 55. Management of SVT - p. 517 56. Ventricular Arrhythmias - p. 525 57. Metabolic Derangements - p. 540 58. Conclusions - p. 540 59. References - p. 542.e1 60. Review Questions - p. 542.e9 61. 32 Hypertensive Crises - p. 543 62. 33 Acute (Thoracic) Aortic Dissection - p. 551 63. 34 General Principles of Postoperative Intensive Care Unit Care - p. 560 64. 35 Postoperative Management of the Cardiac Surgery Patient - p. 573 65. Part 3 Critical Care Pulmonary Disease - p. 589.e3 66. Introduction - p. 590 67. 36 Acute Respiratory Failure - p. 591 68. 37 Life-Threatening Asthma - p. 605 69. 38 Chronic Obstructive Pulmonary Disease - p. 613 70. 39 Hypoventilation and Respiratory Muscle Dysfunction - p. 624 71. 40 Pneumonia - p. 643 72. 41 Weaning from Mechanical Ventilation - p. 663 73. 42 Acute Pulmonary Embolism - p. 670 74. 43 Pulmonary Hypertension* - p. 690 75. 44 Massive Hemoptysis - p. 704 76. 45 Pneumothorax and Barotrauma - p. 717 77. 46 Toxic Gas, Fume, and Smoke Inhalation - p. 733 78. Part 4 Critical Care Infectious Disease - p. 743.e4 79. Introduction - p. 744 80. 47 Nosocomial Infection in the Intensive Care Unit - p. 745 81. Abstract - p. 745 82. Incidence and Profile - p. 745 83. Morbidity and Economic Impact - p. 749 84. Pathogenesis and Epidemiology - p. 749 85. Pathogenesis and Epidemiology - p. 749 86. General Infection Control Measures - p. 749.e2 87. Nosocomial Infections and Specific Infection Control Measures - p. 761 88. Avant Garde Infection Control Measures - p. 782 89. Approach to a Nosocomial Epidemic - p. 784 90. Approach to a Nosocomial Epidemic - p. 784 91. Protection of Health Care Workers in the Intensive Care Unit - p. 784.e2 92. Goals for the Future - p. 786 93. References - p. 787.e1 94. Review Questions - p. 787.e17 95. 48 Principles Governing Antimicrobial Therapy in the Intensive Care Unit - p. 788 96. 49 Antifungal and Antiviral Therapy - p. 807 97. 50 Critically Ill Immunosuppressed Host - p. 822 98. 51 Specific Infections With Critical Care Implications - p. 838 99. Part 5 Renal Disease and Metabolic Disorders in the Critically Ill - p. 864.e6 100. Introduction - p. 865 101. 52 Acute Kidney Injury - p. 866 102. Abstract - p. 866 103. Definition - p. 866 104. Pathogenesis - p. 868 105. Clinical Manifestations - p. 872 106. Diagnostic Approach - p. 874 107. Prevention - p. 878 108. Management of Established Acute Kidney Injury - p. 881 109. Prognosis and Outcomes - p. 888 110. References - p. 890.e1 111. Review Questions - p. 890.e14 112. 53 Chronic Kidney Disease - p. 891 113. 54 Acid-Base, Electrolyte, and Metabolic Abnormalities - p. 899 114. Abstract - p. 899 115. Metabolic Disorders of Acid-Base Homeostasis - p. 899 116. Disorders of Potassium Homeostasis - p. 905 117. Disorders of Water Homeostasis - p. 914 118. Calcium - p. 921 119. Disorders of Magnesium Homeostasis - p. 926 120. Phosphorus - p. 929 121. References - p. 932.e1 122. Review Questions - p. 932.e8 123. 55 Acute Diabetic Emergencies, Glycemic Control, and Hypoglycemia - p. 933 124. 56 Adrenal Insufficiency in the Critically Ill Patient - p. 950 125. 57 Thyroid Disorders - p. 960 126. Part 6 Neurologic Disease in the Critically Ill - p. 980.e6 127. Introduction - p. 981 128. 58 Coma - p. 982 129. 59 Neurologic Criteria for Death in Adults - p. 1000 130. 60 Stroke - p. 1009 131. 61 Myasthenia Gravis and Guillain-Barré Syndrome - p. 1020 132. 62 Seizures in the Critically Ill - p. 1030 133. 63 Head Injury - p. 1043 134. Abstract - p. 1043 135. Incidence - p. 1043 136. Diagnostic Approach - p. 1044 137. Primary Head Injury - p. 1045 138. Secondary Head Injury - p. 1060 139. Specific Treatment Considerations - p. 1067 140. Conclusions - p. 1071 141. References - p. 1072.e1 142. Review Questions - p. 1072.e11 143. Part 7 Physical and Toxic Injury in the Critically Ill Patient - p. 1072.e11 144. Introduction - p. 1073 145. 64 Critical Care of the Severely Burned - p. 1074 146. 65 Poisonings - p. 1093 147. 66 Hypothermia, Hyperthermia, and Rhabdomyolysis - p. 1111 148. Part 8 Administrative, Ethical, and Psychological Issues in the Care of the Critically Ill - p. 1125.e5 149. Introduction - p. 1126 150. 67 Performance Improvement and Severity Scores in Critical Care - p. 1127 151. 68 Ethical Considerations in Managing Critically Ill Patients - p. 1138 152. 69 Delirium, Sleep, and Mental Health Disturbances in Critical Illness - p. 1144 153. 70 Intensive Care Unit Administration and Education - p. 1160 154. Part 9 Other Critical Care Disorders and Issues in the Critically Ill - p. 1166.e2 155. Introduction - p. 1167 156. 71 Diagnosis and Management of Liver Failure in the Adult - p. 1168 157. 72 Gastrointestinal Bleeding - p. 1192 158. 73 Acute Pancreatitis - p. 1210 159. 74 Hemorrhagic and Thrombotic Disorders - p. 1219 160. 75 Use of Blood Components in the Intensive Care Unit - p. 1235 161. 76 Intensive Care of the Cancer Patient - p. 1250 162. 77 Critical Care Medicine in Pregnancy - p. 1263 163. 78 Nutrition Support - p. 1273 164. Index - p. 1287
Now completely revised to bring you up to date with the latest advances in the field, Critical Care Medicine: Principles of Diagnosis and Management in the Adult, 5th Edition, delivers expert, practical guidance on virtually any clinical scenario you may encounter in the ICU. Designed for intensivists, critical care and pulmonology residents, fellows, practicing physicians, and nurse practitioners, this highly regarded text is clinically focused and easy to reference. Led by Drs. Joseph Parrillo and Phillip Dellinger, the 5th Edition introduces numerous new authors who lend a fresh perspective and contribute their expertise to that of hundreds of top authorities in the field.
1. Introduction - p. 1 2. 1 Cardiac Arrest and Cardiopulmonary Resuscitation - p. 2 3. 2 Airway Management in the Critically Ill Adult - p. 12 4. 3 Assessment of Cardiac Filling and Blood Flow - p. 29 5. 4 Arterial, Central Venous, and Pulmonary Artery Catheters - p. 40 6. 5 Cardiac Pacing - p. 50 7. 6 Pericardial Tamponade - p. 72 8. 7 Percutaneous Assist Devices - p. 80 9. 8 Echocardiography - p. 101 10. 9 General Principles of Mechanical Ventilation - p. 129 11. 10 Ventilatory Management of Obstructive Airway Disease - p. 144 12. 11 Mechanical Ventilation in Acute Respiratory Distress Syndrome - p. 158 13. 12 Bronchoscopy and Lung Biopsy in Critically Ill Patients - p. 170 14. 13 Noninvasive Respiratory Monitoring - p. 181 15. 14 Bedside Tracheostomy in the Intensive Care Unit - p. 193 16. 15 Chest Tube Thoracostomy - p. 201 17. 16 Multimodality Intracranial Monitoring - p. 212 18. 17 Gastrointestinal Endoscopy - p. 218 19. 18 Bedside Ultrasonography in the Critically Ill Patient - p. 226 20. 19 Continuous Renal Replacement Therapy - p. 239 21. 20 Use of Sedatives, Analgesics, and Neuromuscular Blockers - p. 251 22. 21 The Effect of Critical Illness on Pharmacokinetics and Pharmacodynamics - p. 267 23. Part 2 Critical Care Cardiovascular Disease - p. 286.e6 24. Introduction - p. 287 25. 22 Shock - p. 288 26. Abstract - p. 288 27. History - p. 288 28. Definitions and Categorization of Shock - p. 289 29. Classification - p. 290 30. Pathogenesis and Pathophysiology of Shock - p. 297 31. Organ System Dysfunction Owing to Shock (Table 22.3) - p. 300 32. Diagnostic Approach and Evaluation - p. 302 33. Management and Therapy - p. 305 34. Conclusion - p. 309 35. References - p. 310.e1 36. Review Questions - p. 310.e11 37. 23 Cardiogenic Shock - p. 311 38. 24 Severe Sepsis and Septic Shock - p. 323 39. 25 Cardiac Tamponade - p. 346 40. 26 Hypovolemia and Traumatic Shock - p. 359 41. 27 Severe Heart Failure - p. 387 42. 28 Anaphylaxis and Anaphylactic Shock - p. 420 43. 29 Acute Coronary Syndromes and Acute Myocardial Infarction - p. 424 44. Abstract - p. 424 45. Definitions - p. 424 46. ST-Segment Elevation Myocardial Infarction - p. 428 47. Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction - p. 457 48. References - p. 469.e1 49. Review Questions - p. 469.e17 50. 30 Valvular Heart Disease in Critical Care - p. 470 51. 31 Cardiac Arrhythmias - p. 504 52. Abstract - p. 504 53. Bradycardias - p. 505 54. Supraventricular Tachycardia - p. 509 55. Management of SVT - p. 517 56. Ventricular Arrhythmias - p. 525 57. Metabolic Derangements - p. 540 58. Conclusions - p. 540 59. References - p. 542.e1 60. Review Questions - p. 542.e9 61. 32 Hypertensive Crises - p. 543 62. 33 Acute (Thoracic) Aortic Dissection - p. 551 63. 34 General Principles of Postoperative Intensive Care Unit Care - p. 560 64. 35 Postoperative Management of the Cardiac Surgery Patient - p. 573 65. Part 3 Critical Care Pulmonary Disease - p. 589.e3 66. Introduction - p. 590 67. 36 Acute Respiratory Failure - p. 591 68. 37 Life-Threatening Asthma - p. 605 69. 38 Chronic Obstructive Pulmonary Disease - p. 613 70. 39 Hypoventilation and Respiratory Muscle Dysfunction - p. 624 71. 40 Pneumonia - p. 643 72. 41 Weaning from Mechanical Ventilation - p. 663 73. 42 Acute Pulmonary Embolism - p. 670 74. 43 Pulmonary Hypertension* - p. 690 75. 44 Massive Hemoptysis - p. 704 76. 45 Pneumothorax and Barotrauma - p. 717 77. 46 Toxic Gas, Fume, and Smoke Inhalation - p. 733 78. Part 4 Critical Care Infectious Disease - p. 743.e4 79. Introduction - p. 744 80. 47 Nosocomial Infection in the Intensive Care Unit - p. 745 81. Abstract - p. 745 82. Incidence and Profile - p. 745 83. Morbidity and Economic Impact - p. 749 84. Pathogenesis and Epidemiology - p. 749 85. Pathogenesis and Epidemiology - p. 749 86. General Infection Control Measures - p. 749.e2 87. Nosocomial Infections and Specific Infection Control Measures - p. 761 88. Avant Garde Infection Control Measures - p. 782 89. Approach to a Nosocomial Epidemic - p. 784 90. Approach to a Nosocomial Epidemic - p. 784 91. Protection of Health Care Workers in the Intensive Care Unit - p. 784.e2 92. Goals for the Future - p. 786 93. References - p. 787.e1 94. Review Questions - p. 787.e17 95. 48 Principles Governing Antimicrobial Therapy in the Intensive Care Unit - p. 788 96. 49 Antifungal and Antiviral Therapy - p. 807 97. 50 Critically Ill Immunosuppressed Host - p. 822 98. 51 Specific Infections With Critical Care Implications - p. 838 99. Part 5 Renal Disease and Metabolic Disorders in the Critically Ill - p. 864.e6 100. Introduction - p. 865 101. 52 Acute Kidney Injury - p. 866 102. Abstract - p. 866 103. Definition - p. 866 104. Pathogenesis - p. 868 105. Clinical Manifestations - p. 872 106. Diagnostic Approach - p. 874 107. Prevention - p. 878 108. Management of Established Acute Kidney Injury - p. 881 109. Prognosis and Outcomes - p. 888 110. References - p. 890.e1 111. Review Questions - p. 890.e14 112. 53 Chronic Kidney Disease - p. 891 113. 54 Acid-Base, Electrolyte, and Metabolic Abnormalities - p. 899 114. Abstract - p. 899 115. Metabolic Disorders of Acid-Base Homeostasis - p. 899 116. Disorders of Potassium Homeostasis - p. 905 117. Disorders of Water Homeostasis - p. 914 118. Calcium - p. 921 119. Disorders of Magnesium Homeostasis - p. 926 120. Phosphorus - p. 929 121. References - p. 932.e1 122. Review Questions - p. 932.e8 123. 55 Acute Diabetic Emergencies, Glycemic Control, and Hypoglycemia - p. 933 124. 56 Adrenal Insufficiency in the Critically Ill Patient - p. 950 125. 57 Thyroid Disorders - p. 960 126. Part 6 Neurologic Disease in the Critically Ill - p. 980.e6 127. Introduction - p. 981 128. 58 Coma - p. 982 129. 59 Neurologic Criteria for Death in Adults - p. 1000 130. 60 Stroke - p. 1009 131. 61 Myasthenia Gravis and Guillain-Barré Syndrome - p. 1020 132. 62 Seizures in the Critically Ill - p. 1030 133. 63 Head Injury - p. 1043 134. Abstract - p. 1043 135. Incidence - p. 1043 136. Diagnostic Approach - p. 1044 137. Primary Head Injury - p. 1045 138. Secondary Head Injury - p. 1060 139. Specific Treatment Considerations - p. 1067 140. Conclusions - p. 1071 141. References - p. 1072.e1 142. Review Questions - p. 1072.e11 143. Part 7 Physical and Toxic Injury in the Critically Ill Patient - p. 1072.e11 144. Introduction - p. 1073 145. 64 Critical Care of the Severely Burned - p. 1074 146. 65 Poisonings - p. 1093 147. 66 Hypothermia, Hyperthermia, and Rhabdomyolysis - p. 1111 148. Part 8 Administrative, Ethical, and Psychological Issues in the Care of the Critically Ill - p. 1125.e5 149. Introduction - p. 1126 150. 67 Performance Improvement and Severity Scores in Critical Care - p. 1127 151. 68 Ethical Considerations in Managing Critically Ill Patients - p. 1138 152. 69 Delirium, Sleep, and Mental Health Disturbances in Critical Illness - p. 1144 153. 70 Intensive Care Unit Administration and Education - p. 1160 154. Part 9 Other Critical Care Disorders and Issues in the Critically Ill - p. 1166.e2 155. Introduction - p. 1167 156. 71 Diagnosis and Management of Liver Failure in the Adult - p. 1168 157. 72 Gastrointestinal Bleeding - p. 1192 158. 73 Acute Pancreatitis - p. 1210 159. 74 Hemorrhagic and Thrombotic Disorders - p. 1219 160. 75 Use of Blood Components in the Intensive Care Unit - p. 1235 161. 76 Intensive Care of the Cancer Patient - p. 1250 162. 77 Critical Care Medicine in Pregnancy - p. 1263 163. 78 Nutrition Support - p. 1273 164. Index - p. 1287
