Neonatal-perinatal medicine has a strong history of evidence based practice but unfortunately there remain many areas of uncertainty and unproven hypotheses and treatments that may harm our highly vulnerable patients. When new ideas are introduced into the labor and delivery room or the NICU we have to evaluate these procedures and therapies before they become accepted as standards of care. We need to learn from the past lessons of grey baby syndrome and chloramphenicol and of kernicterus and sulfonamide antibiotics where therapeutic good intentions actually did more harm than good and increased the mortality rate of premature babies in the NICU.This proposed edition addresses a broad range of current topics in perinatal neonatal practice. The AAP has just issued new guidelines for the approach to a neonate exposed to maternal genital herpes virus infection. The recommendations were not evidence based and are highly controversial as well as confusing. These topics are addressed in a scholarly and objective manner to both address the controversy and help the practitioner make informed decisions.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. CME Accreditation Page - p. 8 6. Forthcoming Issues - p. 9 7. Foreword: Current Controversies in Perinatology: Why They Don’t Go Away - p. 10 8. Preface: Current Controversies in Perinatology - p. 11 9. Global Challenges, Efforts, and Controversies in Neonatal Care - p. 12 10. Prevention of Preterm Birth in Modern Obstetrics - p. 23 11. Challenges and Controversies in Fetal Diagnosis and Treatment - p. 30 12. Borderline Viability - p. 35 13. Fetal Programming, Epigenetics, and Adult Onset Disease - p. 44 14. Comparative Effectiveness and Practice Variation in Neonatal Care - p. 53 15. Conquering Racial Disparities in Perinatal Outcomes - p. 62 16. It's Not Your Mother's Marijuana - p. 70 17. Pain Management in Newborns - p. 80 18. Vascular Endothelial Growth Factor Antagonist Therapy for Retinopathy of Prematurity - p. 91 19. Preventing Herpes Simplex Virus in the Newborn - p. 101 20. Use of Cell-Free Fetal DNA in Maternal Plasma for Noninvasive Prenatal Screening - p. 106 21. Probiotics and Necrotizing Enterocolitis - p. 111 22. Informing and Educating Parents About the Risks and Outcomes of Prematurity - p. 119 23. Ethical Issues in DNA Sequencing in the Neonate - p. 126 24. Screening for and Treatments of Congenital Immunodeficiency Diseases - p. 131 25. Pulse Oximetry in Very Low Birth Weight Infants - p. 138 26. Index - p. 148
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Neonatal-perinatal medicine has a strong history of evidence based practice but unfortunately there remain many areas of uncertainty and unproven hypotheses and treatments that may harm our highly vulnerable patients. When new ideas are introduced into the labor and delivery room or the NICU we have to evaluate these procedures and therapies before they become accepted as standards of care. We need to learn from the past lessons of grey baby syndrome and chloramphenicol and of kernicterus and sulfonamide antibiotics where therapeutic good intentions actually did more harm than good and increased the mortality rate of premature babies in the NICU.This proposed edition addresses a broad range of current topics in perinatal neonatal practice. The AAP has just issued new guidelines for the approach to a neonate exposed to maternal genital herpes virus infection. The recommendations were not evidence based and are highly controversial as well as confusing. These topics are addressed in a scholarly and objective manner to both address the controversy and help the practitioner make informed decisions.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. CME Accreditation Page - p. 8 6. Forthcoming Issues - p. 9 7. Foreword: Current Controversies in Perinatology: Why They Don’t Go Away - p. 10 8. Preface: Current Controversies in Perinatology - p. 11 9. Global Challenges, Efforts, and Controversies in Neonatal Care - p. 12 10. Prevention of Preterm Birth in Modern Obstetrics - p. 23 11. Challenges and Controversies in Fetal Diagnosis and Treatment - p. 30 12. Borderline Viability - p. 35 13. Fetal Programming, Epigenetics, and Adult Onset Disease - p. 44 14. Comparative Effectiveness and Practice Variation in Neonatal Care - p. 53 15. Conquering Racial Disparities in Perinatal Outcomes - p. 62 16. It's Not Your Mother's Marijuana - p. 70 17. Pain Management in Newborns - p. 80 18. Vascular Endothelial Growth Factor Antagonist Therapy for Retinopathy of Prematurity - p. 91 19. Preventing Herpes Simplex Virus in the Newborn - p. 101 20. Use of Cell-Free Fetal DNA in Maternal Plasma for Noninvasive Prenatal Screening - p. 106 21. Probiotics and Necrotizing Enterocolitis - p. 111 22. Informing and Educating Parents About the Risks and Outcomes of Prematurity - p. 119 23. Ethical Issues in DNA Sequencing in the Neonate - p. 126 24. Screening for and Treatments of Congenital Immunodeficiency Diseases - p. 131 25. Pulse Oximetry in Very Low Birth Weight Infants - p. 138 26. Index - p. 148
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