Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Preface: Looking at the clouds through kaleidoscope - p. page_xiii 7. Chapter One: Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis - p. page_1 8. Chapter Two: Transient knots in intrinsically disordered proteins and neurodegeneration - p. page_79 9. Chapter Three: IDPs and their complexes in GPCR and nuclear receptor signaling - p. page_105 10. Chapter Four: Intrinsic disorder-based design of stable globular proteins - p. page_157 11. Chapter Five: The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation - p. page_187 12. Chapter Six: Context-dependent HOX transcription factor function in health and disease - p. page_225 13. Chapter Seven: Dancing while self-eating: Protein intrinsic disorder in autophagy - p. page_263 14. Chapter Eight: Intrinsic disorder in the nickel-dependent urease network - p. page_307 15. Chapter Nine: Disorder and cysteines in proteins: A design for orchestration of conformational see-saw and modulatory functions - p. page_331 16. Index - p. page_375
Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Preface: Looking at the clouds through kaleidoscope - p. page_xiii 7. Chapter One: Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis - p. page_1 8. Chapter Two: Transient knots in intrinsically disordered proteins and neurodegeneration - p. page_79 9. Chapter Three: IDPs and their complexes in GPCR and nuclear receptor signaling - p. page_105 10. Chapter Four: Intrinsic disorder-based design of stable globular proteins - p. page_157 11. Chapter Five: The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation - p. page_187 12. Chapter Six: Context-dependent HOX transcription factor function in health and disease - p. page_225 13. Chapter Seven: Dancing while self-eating: Protein intrinsic disorder in autophagy - p. page_263 14. Chapter Eight: Intrinsic disorder in the nickel-dependent urease network - p. page_307 15. Chapter Nine: Disorder and cysteines in proteins: A design for orchestration of conformational see-saw and modulatory functions - p. page_331 16. Index - p. page_375
